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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ECE1-NIPAL3 (FusionGDB2 ID:24855)

Fusion Gene Summary for ECE1-NIPAL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ECE1-NIPAL3
Fusion gene ID: 24855
HgeneTgene
Gene symbol

ECE1

NIPAL3

Gene ID

1889

57185

Gene nameendothelin converting enzyme 1NIPA like domain containing 3
SynonymsECEDJ462O23.2|NPAL3
Cytomap

1p36.12

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionendothelin-converting enzyme 1ECE-1NIPA-like protein 3
Modification date2020031320200313
UniProtAcc.

Q6P499

Ensembl transtripts involved in fusion geneENST00000415912, ENST00000264205, 
ENST00000357071, ENST00000374893, 
ENST00000436918, ENST00000528294, 
ENST00000488155, ENST00000003912, 
ENST00000339255, ENST00000358028, 
ENST00000374399, ENST00000428131, 
Fusion gene scores* DoF score16 X 15 X 9=21607 X 8 X 5=280
# samples 187
** MAII scorelog2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ECE1 [Title/Abstract] AND NIPAL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointECE1(21671869)-NIPAL3(24766662), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneECE1

GO:0010814

substance P catabolic process

18039931

HgeneECE1

GO:0010815

bradykinin catabolic process

18039931

HgeneECE1

GO:0010816

calcitonin catabolic process

18039931

HgeneECE1

GO:0016485

protein processing

7805846

HgeneECE1

GO:0016486

peptide hormone processing

7864876

HgeneECE1

GO:0034959

endothelin maturation

7805846

HgeneECE1

GO:0042447

hormone catabolic process

7864876


check buttonFusion gene breakpoints across ECE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NIPAL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-75-5147-01AECE1chr1

21671869

-NIPAL3chr1

24745781

+
ChimerDB4LUADTCGA-75-5147-01AECE1chr1

21671869

-NIPAL3chr1

24766662

+


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Fusion Gene ORF analysis for ECE1-NIPAL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000415912ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24745781

+
5CDS-5UTRENST00000415912ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24745781

+
5CDS-5UTRENST00000415912ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24766662

+
5CDS-5UTRENST00000415912ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24745781

+
5CDS-5UTRENST00000415912ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24766662

+
5CDS-5UTRENST00000415912ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24745781

+
5CDS-5UTRENST00000415912ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24766662

+
5CDS-5UTRENST00000415912ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24745781

+
5CDS-5UTRENST00000415912ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24766662

+
5CDS-intronENST00000415912ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24745781

+
5CDS-intronENST00000415912ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24766662

+
In-frameENST00000415912ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-3CDSENST00000264205ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-3CDSENST00000357071ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-3CDSENST00000374893ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-3CDSENST00000436918ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-3CDSENST00000528294ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-3UTRENST00000264205ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-3UTRENST00000357071ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-3UTRENST00000374893ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-3UTRENST00000436918ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-3UTRENST00000528294ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000264205ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000264205ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000264205ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000264205ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000264205ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000264205ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000264205ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000264205ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000357071ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000357071ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000357071ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000357071ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000357071ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000357071ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000357071ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000357071ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000374893ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000374893ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000374893ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000374893ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000374893ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000374893ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000374893ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000374893ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000436918ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000436918ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000436918ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000436918ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000436918ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000436918ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000436918ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000436918ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000528294ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000528294ENST00000003912ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000528294ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000528294ENST00000339255ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000528294ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000528294ENST00000358028ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-5UTRENST00000528294ENST00000374399ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-5UTRENST00000528294ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-intronENST00000264205ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-intronENST00000264205ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-intronENST00000357071ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-intronENST00000357071ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-intronENST00000374893ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-intronENST00000374893ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-intronENST00000436918ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-intronENST00000436918ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24766662

+
intron-intronENST00000528294ENST00000428131ECE1chr1

21671869

-NIPAL3chr1

24745781

+
intron-intronENST00000528294ENST00000488155ECE1chr1

21671869

-NIPAL3chr1

24766662

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415912ECE1chr121671869-ENST00000374399NIPAL3chr124766662+13791291261256376

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415912ENST00000374399ECE1chr121671869-NIPAL3chr124766662+0.0066713670.9933287

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Fusion Genomic Features for ECE1-NIPAL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ECE1chr121671868-NIPAL3chr124745780+3.49E-050.9999652
ECE1chr121671868-NIPAL3chr124766661+1.12E-070.9999999
ECE1chr121671868-NIPAL3chr124745780+3.49E-050.9999652
ECE1chr121671868-NIPAL3chr124766661+1.12E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ECE1-NIPAL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:21671869/chr1:24766662)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NIPAL3

Q6P499

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000000391221318_210325.0Compositional biasNote=Poly-Ser
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213101_1210325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213135_1550325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213171_1910325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213202_2220325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213240_2600325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213271_2910325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000003912213300_3200325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000000391221333_530325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000000391221376_960325.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818101_12131227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818135_15531227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818171_19131227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818202_22231227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818240_26031227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818271_29131227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000035802818300_32031227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST000003580281833_5331227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST000003580281876_9631227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112101_12131407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112135_15531407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112171_19131407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112202_22231407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112240_26031407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112271_29131407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST00000374399112300_32031407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000037439911233_5331407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000037439911276_9631407.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107101_12131227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107135_15531227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107171_19131227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107202_22231227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107240_26031227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107271_29131227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000042813107300_32031227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST000004281310733_5331227.0TransmembraneHelical
TgeneNIPAL3chr1:21671869chr1:24766662ENST000004281310776_9631227.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneECE1chr1:21671869chr1:24766662ENST00000264205-11898_7700768.0DomainPeptidase M13
HgeneECE1chr1:21671869chr1:24766662ENST00000357071-11798_7700759.0DomainPeptidase M13
HgeneECE1chr1:21671869chr1:24766662ENST00000374893-11998_7700771.0DomainPeptidase M13
HgeneECE1chr1:21671869chr1:24766662ENST00000415912-11998_7701755.0DomainPeptidase M13
HgeneECE1chr1:21671869chr1:24766662ENST00000264205-1181_680768.0Topological domainCytoplasmic
HgeneECE1chr1:21671869chr1:24766662ENST00000264205-11890_7700768.0Topological domainExtracellular
HgeneECE1chr1:21671869chr1:24766662ENST00000357071-1171_680759.0Topological domainCytoplasmic
HgeneECE1chr1:21671869chr1:24766662ENST00000357071-11790_7700759.0Topological domainExtracellular
HgeneECE1chr1:21671869chr1:24766662ENST00000374893-1191_680771.0Topological domainCytoplasmic
HgeneECE1chr1:21671869chr1:24766662ENST00000374893-11990_7700771.0Topological domainExtracellular
HgeneECE1chr1:21671869chr1:24766662ENST00000415912-1191_681755.0Topological domainCytoplasmic
HgeneECE1chr1:21671869chr1:24766662ENST00000415912-11990_7701755.0Topological domainExtracellular
HgeneECE1chr1:21671869chr1:24766662ENST00000264205-11869_890768.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21671869chr1:24766662ENST00000357071-11769_890759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21671869chr1:24766662ENST00000374893-11969_890771.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneECE1chr1:21671869chr1:24766662ENST00000415912-11969_891755.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNIPAL3chr1:21671869chr1:24766662ENST000003580281818_2131227.0Compositional biasNote=Poly-Ser
TgeneNIPAL3chr1:21671869chr1:24766662ENST0000037439911218_2131407.0Compositional biasNote=Poly-Ser
TgeneNIPAL3chr1:21671869chr1:24766662ENST000004281310718_2131227.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for ECE1-NIPAL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24855_24855_1_ECE1-NIPAL3_ECE1_chr1_21671869_ENST00000415912_NIPAL3_chr1_24766662_ENST00000374399_length(transcript)=1379nt_BP=129nt
GAGCGCGCCGCCTGGGCCAGGCAGCCGAGCCGTCCGAGCAGCTGGGCTGGGAGCAGGGAACCCGGAGCTGGGAATCGGGAGCCGGGCGCG
GGGAGCTGCGCGAAGCCGGGGCGGAGCACGCGAGCTATGGAAAACCTGATTGGCGCCCTCTTGGCGATCTTCGGGCACCTCGTGGTCAGC
ATTGCACTTAACCTCCAGAAGTACTGCCACATCCGCCTGGCAGGCTCCAAGGATCCCCGGGCCTATTTCAAGACCAAGACATGGTGGCTG
GGCCTGTTCCTGATGCTTCTGGGCGAGCTGGGTGTGTTCGCCTCCTACGCCTTCGCGCCGCTGTCACTCATCGTGCCCCTCAGCGCAGTT
TCTGTGATAGCTAGTGCCATCATAGGAATCATATTCATCAAGGAAAAGTGGAAACCGAAAGACTTTCTGAGGCGCTACGTCTTGTCCTTT
GTTGGCTGCGGTTTGGCTGTCGTGGGTACCTACCTGCTGGTGACATTCGCACCCAACAGTCACGAGAAGATGACAGGCGAGAATGTCACC
AGGCACCTCGTGAGCTGGCCTTTCCTTTTGTACATGCTGGTGGAGATCATTCTGTTCTGCTTGCTGCTCTACTTCTACAAGGAGAAGAAC
GCCAACAACATTGTCGTGATTCTTCTCTTGGTGGCGTTACTTGGCTCCATGACAGTGGTGACAGTCAAGGCCGTGGCTGGGATGCTTGTC
TTGTCCATTCAAGGGAACCTGCAGCTTGACTACCCCATCTTCTACGTGATGTTCGTGTGCATGGTGGCAACCGCCGTCTATCAGGCTGCG
TTTTTGAGTCAAGCCTCACAGATGTACGACTCCTCTTTGATTGCCAGTGTGGGCTACATTCTGTCCACAACCATTGCTATCACAGCAGGT
GCAATATTTTACCTGGACTTCATCGGGGAGGACGTGCTGCACATCTGCATGTTTGCACTGGGGTGCCTCATTGCATTCTTGGGCGTCTTC
TTAATCACGCGTAACAGGAAGAAGCCCATTCCATTTGAGCCCTATATTTCCATGGATGCCATGCCAGGTATGCAGAACATGCACGATAAA
GGGATGACTGTCCAGCCTGAACTTAAAGCTTCTTTTTCCTATGGGGCTCTGGAAAACAATGACAACATTTCTGAGATCTACGCTCCTGCC
ACCCTGCCAGTCATGCAAGAAGAGCACGGCTCCAGAAGTGCCTCTGGGGTCCCCTACCGAGTCCTAGAGCACACCAAGAAGGAATGAGAC
TCGCCTCCCTCTATTTATAACTGTCCCCTCCAGGCTGACAGTGGTTCAACCCTGAATCCTAAAACTTGCCTTTCAAGTCTCATTTTGTTT

>24855_24855_1_ECE1-NIPAL3_ECE1_chr1_21671869_ENST00000415912_NIPAL3_chr1_24766662_ENST00000374399_length(amino acids)=376AA_BP=1
MENLIGALLAIFGHLVVSIALNLQKYCHIRLAGSKDPRAYFKTKTWWLGLFLMLLGELGVFASYAFAPLSLIVPLSAVSVIASAIIGIIF
IKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWPFLLYMLVEIILFCLLLYFYKEKNANNIVVILLLVA
LLGSMTVVTVKAVAGMLVLSIQGNLQLDYPIFYVMFVCMVATAVYQAAFLSQASQMYDSSLIASVGYILSTTIAITAGAIFYLDFIGEDV
LHICMFALGCLIAFLGVFLITRNRKKPIPFEPYISMDAMPGMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSR

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Fusion Gene PPI Analysis for ECE1-NIPAL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ECE1-NIPAL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ECE1-NIPAL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource