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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ECE2-HTR3E (FusionGDB2 ID:24867)

Fusion Gene Summary for ECE2-HTR3E

check button Fusion gene summary
Fusion gene informationFusion gene name: ECE2-HTR3E
Fusion gene ID: 24867
HgeneTgene
Gene symbol

ECE2

HTR3E

Gene ID

110599583

285242

Gene nameEEF1AKMT4-ECE2 readthrough5-hydroxytryptamine receptor 3E
SynonymsECE-2|ECE25-HT3-E|5-HT3E|5-HT3c1
Cytomap

3q27.1

3q27.1

Type of geneprotein-codingprotein-coding
DescriptionEEF1AKMT4-ECE2 readthrough transcript proteinEndothelin-converting enzyme 25-hydroxytryptamine receptor 3E5-hydroxytryptamine (serotonin) receptor 3, family member E5-hydroxytryptamine (serotonin) receptor 3E, ionotropic5-hydroxytryptamine receptor 3 subunit E
Modification date2020030320200313
UniProtAcc

P0DPD6

.
Ensembl transtripts involved in fusion geneENST00000324557, ENST00000402825, 
ENST00000357474, ENST00000359140, 
ENST00000404464, 		ENST00000335304, 
ENST00000415389, ENST00000425359, 
ENST00000436361, ENST00000440596, 
Fusion gene scores* DoF score4 X 3 X 1=122 X 4 X 2=16
# samples 23
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/16*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ECE2 [Title/Abstract] AND HTR3E [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointECE2(183967678)-HTR3E(183823915), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ECE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTR3E (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-5898ECE2chr3

183967678

+HTR3Echr3

183823915

+


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Fusion Gene ORF analysis for ECE2-HTR3E

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324557ENST00000335304ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000324557ENST00000415389ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000324557ENST00000425359ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000324557ENST00000436361ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000324557ENST00000440596ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000402825ENST00000335304ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000402825ENST00000415389ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000402825ENST00000425359ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000402825ENST00000436361ECE2chr3

183967678

+HTR3Echr3

183823915

+
In-frameENST00000402825ENST00000440596ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000357474ENST00000335304ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000357474ENST00000415389ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000357474ENST00000425359ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000357474ENST00000436361ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000357474ENST00000440596ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000359140ENST00000335304ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000359140ENST00000415389ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000359140ENST00000425359ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000359140ENST00000436361ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000359140ENST00000440596ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000404464ENST00000335304ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000404464ENST00000415389ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000404464ENST00000425359ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000404464ENST00000436361ECE2chr3

183967678

+HTR3Echr3

183823915

+
intron-3CDSENST00000404464ENST00000440596ECE2chr3

183967678

+HTR3Echr3

183823915

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324557ECE2chr3183967678+ENST00000415389HTR3Echr3183823915+98924145686213
ENST00000324557ECE2chr3183967678+ENST00000425359HTR3Echr3183823915+68724145686213
ENST00000324557ECE2chr3183967678+ENST00000335304HTR3Echr3183823915+98924145686213
ENST00000324557ECE2chr3183967678+ENST00000436361HTR3Echr3183823915+68724145686213
ENST00000324557ECE2chr3183967678+ENST00000440596HTR3Echr3183823915+68724145686213
ENST00000402825ECE2chr3183967678+ENST00000415389HTR3Echr3183823915+9441960641213
ENST00000402825ECE2chr3183967678+ENST00000425359HTR3Echr3183823915+6421960641213
ENST00000402825ECE2chr3183967678+ENST00000335304HTR3Echr3183823915+9441960641213
ENST00000402825ECE2chr3183967678+ENST00000436361HTR3Echr3183823915+6421960641213
ENST00000402825ECE2chr3183967678+ENST00000440596HTR3Echr3183823915+6421960641213

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324557ENST00000415389ECE2chr3183967678+HTR3Echr3183823915+0.039529330.9604707
ENST00000324557ENST00000425359ECE2chr3183967678+HTR3Echr3183823915+0.032801820.96719813
ENST00000324557ENST00000335304ECE2chr3183967678+HTR3Echr3183823915+0.039529330.9604707
ENST00000324557ENST00000436361ECE2chr3183967678+HTR3Echr3183823915+0.032801820.96719813
ENST00000324557ENST00000440596ECE2chr3183967678+HTR3Echr3183823915+0.032801820.96719813
ENST00000402825ENST00000415389ECE2chr3183967678+HTR3Echr3183823915+0.0557741370.94422585
ENST00000402825ENST00000425359ECE2chr3183967678+HTR3Echr3183823915+0.0417609440.9582391
ENST00000402825ENST00000335304ECE2chr3183967678+HTR3Echr3183823915+0.0557741370.94422585
ENST00000402825ENST00000436361ECE2chr3183967678+HTR3Echr3183823915+0.0417609440.9582391
ENST00000402825ENST00000440596ECE2chr3183967678+HTR3Echr3183823915+0.0417609440.9582391

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Fusion Genomic Features for ECE2-HTR3E


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ECE2chr3183967678+HTR3Echr3183823915+1.64E-070.9999999
ECE2chr3183967678+HTR3Echr3183823915+1.64E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ECE2-HTR3E


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183967678/chr3:183823915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECE2

P0DPD6

.
FUNCTION: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity). {ECO:0000250|UniProtKB:B2RQR8, ECO:0000269|PubMed:12560336}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458329_433323472.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458455_456323472.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969329_433308457.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969455_456308457.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958304_307293442.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958329_433293442.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958455_456293442.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147329_433308457.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147455_456308457.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647455_456334483.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458434_454323472.0TransmembraneHelical%3B Name%3D4
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969308_328308457.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969434_454308457.0TransmembraneHelical%3B Name%3D4
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958308_328293442.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958434_454293442.0TransmembraneHelical%3B Name%3D4
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147308_328308457.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147434_454308457.0TransmembraneHelical%3B Name%3D4
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647434_454334483.0TransmembraneHelical%3B Name%3D4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHTR3Echr3:183967678chr3:183823915ENST000003353045826_248323472.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458270_282323472.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458304_307323472.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST000004153896926_248308457.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969270_282308457.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969304_307308457.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST000004253595826_248293442.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958270_282293442.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST000004363614726_248308457.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147270_282308457.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147304_307308457.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST000004405964726_248334483.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647270_282334483.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647304_307334483.0Topological domainExtracellular
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647329_433334483.0Topological domainCytoplasmic
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458249_269323472.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458283_303323472.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Echr3:183967678chr3:183823915ENST0000033530458308_328323472.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969249_269308457.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Echr3:183967678chr3:183823915ENST0000041538969283_303308457.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958249_269293442.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Echr3:183967678chr3:183823915ENST0000042535958283_303293442.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147249_269308457.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Echr3:183967678chr3:183823915ENST0000043636147283_303308457.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647249_269334483.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647283_303334483.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Echr3:183967678chr3:183823915ENST0000044059647308_328334483.0TransmembraneHelical%3B Name%3D3


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Fusion Gene Sequence for ECE2-HTR3E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>24867_24867_1_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000335304_length(transcript)=989nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTC
TACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCCAACTTCAGTCTGGAGC
TTCTCTTGCCTCCAGGGACTGGCCAGGTCTCCCCCCTTTCCTGAGTACCAACTATCATATCCCCAAAGATGACTGAGTCTCTGCTGTATT
CCATGTATCCCAATCCGGTCCTGCTGATCAATTCCAATCCCAGACATTTCTCCCTGTTCCTGCATTTTGTTGGCTTCCTTCAGTCCTACC

>24867_24867_1_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000335304_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_2_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000415389_length(transcript)=989nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTC
TACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCCAACTTCAGTCTGGAGC
TTCTCTTGCCTCCAGGGACTGGCCAGGTCTCCCCCCTTTCCTGAGTACCAACTATCATATCCCCAAAGATGACTGAGTCTCTGCTGTATT
CCATGTATCCCAATCCGGTCCTGCTGATCAATTCCAATCCCAGACATTTCTCCCTGTTCCTGCATTTTGTTGGCTTCCTTCAGTCCTACC

>24867_24867_2_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000415389_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_3_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000425359_length(transcript)=687nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTC

>24867_24867_3_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000425359_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_4_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000436361_length(transcript)=687nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTC

>24867_24867_4_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000436361_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_5_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000440596_length(transcript)=687nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACTGCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCGGGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTGTGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTC

>24867_24867_5_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000324557_HTR3E_chr3_183823915_ENST00000440596_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_6_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000335304_length(transcript)=944nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCG
GGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTG
TGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTC
TGGAACACCTAGGCAGGTGCTCACCTGCCAACTTCAGTCTGGAGCTTCTCTTGCCTCCAGGGACTGGCCAGGTCTCCCCCCTTTCCTGAG
TACCAACTATCATATCCCCAAAGATGACTGAGTCTCTGCTGTATTCCATGTATCCCAATCCGGTCCTGCTGATCAATTCCAATCCCAGAC
ATTTCTCCCTGTTCCTGCATTTTGTTGGCTTCCTTCAGTCCTACCATATGGTTCTAGGTCCCTCTTACGTCATCTGCATAGCAGACTATA

>24867_24867_6_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000335304_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_7_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000415389_length(transcript)=944nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCG
GGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTG
TGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTC
TGGAACACCTAGGCAGGTGCTCACCTGCCAACTTCAGTCTGGAGCTTCTCTTGCCTCCAGGGACTGGCCAGGTCTCCCCCCTTTCCTGAG
TACCAACTATCATATCCCCAAAGATGACTGAGTCTCTGCTGTATTCCATGTATCCCAATCCGGTCCTGCTGATCAATTCCAATCCCAGAC
ATTTCTCCCTGTTCCTGCATTTTGTTGGCTTCCTTCAGTCCTACCATATGGTTCTAGGTCCCTCTTACGTCATCTGCATAGCAGACTATA

>24867_24867_7_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000415389_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_8_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000425359_length(transcript)=642nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCG
GGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTG
TGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTC

>24867_24867_8_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000425359_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_9_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000436361_length(transcript)=642nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCG
GGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTG
TGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTC

>24867_24867_9_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000436361_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>24867_24867_10_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000440596_length(transcript)=642nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCCACCCCTGCCTCGGTGGCTCCACTCCCTGCTGCTCCACTGCAACAGCCCGGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGAAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCG
GGCCCTGCGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCAGTGGAGCTG
TGGTTGCAGTTCAGCCACGCGATGGACGCCATGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCTATCATCACCGTCATATGCCTC

>24867_24867_10_ECE2-HTR3E_ECE2_chr3_183967678_ENST00000402825_HTR3E_chr3_183823915_ENST00000440596_length(amino acids)=213AA_BP=65
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ECE2-HTR3E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ECE2-HTR3E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ECE2-HTR3E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource