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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EEF1A1-FN1 (FusionGDB2 ID:25032)

Fusion Gene Summary for EEF1A1-FN1

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1A1-FN1
Fusion gene ID: 25032
HgeneTgene
Gene symbol

EEF1A1

FN1

Gene ID

1915

2335

Gene nameeukaryotic translation elongation factor 1 alpha 1fibronectin 1
SynonymsCCS-3|CCS3|EE1A1|EEF-1|EEF1A|EF-Tu|EF1A|GRAF-1EF|LENG7|PTI1|eEF1A-1CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF
Cytomap

6q13

2q35

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 1-alpha 1CTCL tumor antigenEF-1-alpha-1EF1a-like proteincervical cancer suppressor 3elongation factor 1 alpha subunitelongation factor Tuepididymis secretory sperm binding proteineukaryotic elongation factor 1 A-1eukaryotic tranfibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor
Modification date2020032720200329
UniProtAcc

P68104

P02751

Ensembl transtripts involved in fusion geneENST00000309268, ENST00000316292, 
ENST00000331523, ENST00000491404, 
ENST00000323926, ENST00000336916, 
ENST00000345488, ENST00000346544, 
ENST00000354785, ENST00000356005, 
ENST00000357009, ENST00000357867, 
ENST00000359671, ENST00000421182, 
ENST00000432072, ENST00000443816, 
ENST00000446046, ENST00000426059, 
ENST00000490833, 
Fusion gene scores* DoF score24 X 34 X 12=979235 X 39 X 9=12285
# samples 3842
** MAII scorelog2(38/9792*10)=-4.6875322343617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(42/12285*10)=-4.8703647195834
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF1A1 [Title/Abstract] AND FN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEEF1A1(74227853)-FN1(216230291), # samples:1
EEF1A1(74228310)-FN1(216236832), # samples:1
EEF1A1(74228278)-FN1(216242985), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEEF1A1

GO:0071364

cellular response to epidermal growth factor stimulus

9852145

HgeneEEF1A1

GO:1900022

regulation of D-erythro-sphingosine kinase activity

18263879

TgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

TgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

TgeneFN1

GO:0010628

positive regulation of gene expression

25834989

TgeneFN1

GO:0018149

peptide cross-linking

3997886

TgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

TgeneFN1

GO:0035987

endodermal cell differentiation

23154389

TgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

TgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

TgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

TgeneFN1

GO:1901166

neural crest cell migration involved in autonomic nervous system development

26571399

TgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

TgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989


check buttonFusion gene breakpoints across EEF1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-DJ-A2PY-01AEEF1A1chr6

74228310

-FN1chr2

216236832

-
ChimerDB4THCATCGA-EL-A3CT-01AEEF1A1chr6

74228278

-FN1chr2

216242985

-
ChimerDB4THCATCGA-EL-A3GP-01AEEF1A1chr6

74227853

-FN1chr2

216230291

-


Top

Fusion Gene ORF analysis for EEF1A1-FN1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000309268ENST00000323926EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000323926EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000309268ENST00000336916EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000336916EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000309268ENST00000345488EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000346544EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000354785EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000354785EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000309268ENST00000356005EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000357009EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000357867EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000357867EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000309268ENST00000359671EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000421182EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000421182EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000309268ENST00000432072EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000443816EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000309268ENST00000446046EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000323926EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000323926EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000316292ENST00000336916EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000336916EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000316292ENST00000345488EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000346544EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000354785EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000354785EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000316292ENST00000356005EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000357009EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000357867EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000357867EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000316292ENST00000359671EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000421182EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000421182EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000316292ENST00000432072EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000443816EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000316292ENST00000446046EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000323926EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000323926EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000331523ENST00000336916EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000336916EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000331523ENST00000345488EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000346544EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000354785EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000354785EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000331523ENST00000356005EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000357009EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000357867EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000357867EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000331523ENST00000359671EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000421182EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000421182EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000331523ENST00000432072EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000443816EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000331523ENST00000446046EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000323926EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000323926EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000491404ENST00000336916EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000336916EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000491404ENST00000345488EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000346544EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000354785EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000354785EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000491404ENST00000356005EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000357009EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000357867EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000357867EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000491404ENST00000359671EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000421182EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000421182EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3CDSENST00000491404ENST00000432072EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000443816EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3CDSENST00000491404ENST00000446046EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-3UTRENST00000309268ENST00000345488EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000346544EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000356005EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000357009EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000359671EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000432072EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000443816EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000309268ENST00000446046EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000345488EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000346544EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000356005EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000357009EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000359671EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000432072EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000443816EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000316292ENST00000446046EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000345488EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000346544EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000356005EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000357009EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000359671EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000432072EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000443816EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000331523ENST00000446046EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000345488EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000346544EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000356005EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000357009EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000359671EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000432072EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000443816EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-3UTRENST00000491404ENST00000446046EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000309268ENST00000323926EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000336916EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000345488EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000346544EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000354785EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000356005EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000357009EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000357867EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000359671EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000421182EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000426059EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000426059EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000309268ENST00000426059EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000309268ENST00000432072EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000443816EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000446046EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000490833EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000309268ENST00000490833EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000309268ENST00000490833EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000316292ENST00000323926EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000336916EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000345488EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000346544EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000354785EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000356005EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000357009EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000357867EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000359671EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000421182EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000426059EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000426059EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000316292ENST00000426059EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000316292ENST00000432072EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000443816EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000446046EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000490833EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000316292ENST00000490833EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000316292ENST00000490833EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000331523ENST00000323926EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000336916EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000345488EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000346544EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000354785EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000356005EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000357009EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000357867EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000359671EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000421182EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000426059EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000426059EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000331523ENST00000426059EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000331523ENST00000432072EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000443816EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000446046EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000490833EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000331523ENST00000490833EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000331523ENST00000490833EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000491404ENST00000323926EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000336916EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000345488EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000346544EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000354785EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000356005EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000357009EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000357867EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000359671EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000421182EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000426059EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000426059EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000491404ENST00000426059EEF1A1chr6

74227853

-FN1chr2

216230291

-
intron-intronENST00000491404ENST00000432072EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000443816EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000446046EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000490833EEF1A1chr6

74228310

-FN1chr2

216236832

-
intron-intronENST00000491404ENST00000490833EEF1A1chr6

74228278

-FN1chr2

216242985

-
intron-intronENST00000491404ENST00000490833EEF1A1chr6

74227853

-FN1chr2

216230291

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EEF1A1-FN1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EEF1A1-FN1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:74227853/:216230291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1A1

P68104

FN1

P02751

FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). {ECO:0000269|PubMed:17177976}.FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250|UniProtKB:P11276, ECO:0000269|PubMed:3024962, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:3593230, ECO:0000269|PubMed:3900070, ECO:0000269|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269|PubMed:11209058, ECO:0000269|PubMed:15665290, ECO:0000269|PubMed:19379667, ECO:0000269|PubMed:8114919}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EEF1A1-FN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EEF1A1-FN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EEF1A1-FN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EEF1A1-FN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource