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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EEF1A1-RPS4X (FusionGDB2 ID:25147)

Fusion Gene Summary for EEF1A1-RPS4X

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1A1-RPS4X
Fusion gene ID: 25147
HgeneTgene
Gene symbol

EEF1A1

RPS4X

Gene ID

1915

6191

Gene nameeukaryotic translation elongation factor 1 alpha 1ribosomal protein S4 X-linked
SynonymsCCS-3|CCS3|EE1A1|EEF-1|EEF1A|EF-Tu|EF1A|GRAF-1EF|LENG7|PTI1|eEF1A-1CCG2|DXS306|RPS4|S4|SCAR|SCR10
Cytomap

6q13

Xq13.1

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 1-alpha 1CTCL tumor antigenEF-1-alpha-1EF1a-like proteincervical cancer suppressor 3elongation factor 1 alpha subunitelongation factor Tuepididymis secretory sperm binding proteineukaryotic elongation factor 1 A-1eukaryotic tran40S ribosomal protein S4, X isoformcell cycle gene 2ribosomal protein S4X isoformsingle copy abundant mRNA proteinsingle-copy abundant mRNAsmall ribosomal subunit protein eS4
Modification date2020032720200313
UniProtAcc

P68104

.
Ensembl transtripts involved in fusion geneENST00000309268, ENST00000316292, 
ENST00000331523, ENST00000491404, 
ENST00000373626, ENST00000486733, 
ENST00000316084, 
Fusion gene scores* DoF score24 X 34 X 12=979220 X 17 X 7=2380
# samples 3822
** MAII scorelog2(38/9792*10)=-4.6875322343617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2380*10)=-3.43538614467065
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF1A1 [Title/Abstract] AND RPS4X [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEEF1A1(74227755)-RPS4X(71494945), # samples:1
EEF1A1(74227751)-RPS4X(71494941), # samples:1
Anticipated loss of major functional domain due to fusion event.EEF1A1-RPS4X seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EEF1A1-RPS4X seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EEF1A1-RPS4X seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
EEF1A1-RPS4X seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EEF1A1-RPS4X seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEEF1A1

GO:0071364

cellular response to epidermal growth factor stimulus

9852145

HgeneEEF1A1

GO:1900022

regulation of D-erythro-sphingosine kinase activity

18263879


check buttonFusion gene breakpoints across EEF1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS4X (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR188311EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
ChimerDB4Non-CancerERR188410EEF1A1chr6

74227755

-RPS4XchrX

71494945

-


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Fusion Gene ORF analysis for EEF1A1-RPS4X

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309268ENST00000373626EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
5CDS-5UTRENST00000309268ENST00000373626EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
5CDS-5UTRENST00000309268ENST00000486733EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
5CDS-5UTRENST00000309268ENST00000486733EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
5CDS-5UTRENST00000316292ENST00000373626EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
5CDS-5UTRENST00000316292ENST00000373626EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
5CDS-5UTRENST00000316292ENST00000486733EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
5CDS-5UTRENST00000316292ENST00000486733EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
5CDS-5UTRENST00000331523ENST00000373626EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
5CDS-5UTRENST00000331523ENST00000373626EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
5CDS-5UTRENST00000331523ENST00000486733EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
5CDS-5UTRENST00000331523ENST00000486733EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
Frame-shiftENST00000309268ENST00000316084EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
Frame-shiftENST00000309268ENST00000316084EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
Frame-shiftENST00000331523ENST00000316084EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
Frame-shiftENST00000331523ENST00000316084EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
In-frameENST00000316292ENST00000316084EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
In-frameENST00000316292ENST00000316084EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
intron-3CDSENST00000491404ENST00000316084EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
intron-3CDSENST00000491404ENST00000316084EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
intron-5UTRENST00000491404ENST00000373626EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
intron-5UTRENST00000491404ENST00000373626EEF1A1chr6

74227755

-RPS4XchrX

71494945

-
intron-5UTRENST00000491404ENST00000486733EEF1A1chr6

74227751

-RPS4XchrX

71494941

-
intron-5UTRENST00000491404ENST00000486733EEF1A1chr6

74227755

-RPS4XchrX

71494945

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316292EEF1A1chr674227755-ENST00000316084RPS4XchrX71494945-336022569922314440
ENST00000316292EEF1A1chr674227751-ENST00000316084RPS4XchrX71494941-335622569922314440

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316292ENST00000316084EEF1A1chr674227755-RPS4XchrX71494945-0.0007474560.9992525
ENST00000316292ENST00000316084EEF1A1chr674227751-RPS4XchrX71494941-0.0007636490.99923635

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Fusion Genomic Features for EEF1A1-RPS4X


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EEF1A1-RPS4X


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:74227755/chrX:71494945)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1A1

P68104

.
FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PubMed:17177976). {ECO:0000269|PubMed:17177976}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-785_242421463.0DomainNote=tr-type G
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-675_242421463.0DomainNote=tr-type G
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-785_242421463.0DomainNote=tr-type G
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-785_242421463.0DomainNote=tr-type G
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-675_242421463.0DomainNote=tr-type G
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-785_242421463.0DomainNote=tr-type G
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-7891_95421463.0Nucleotide bindingGTP
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-6791_95421463.0Nucleotide bindingGTP
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-7891_95421463.0Nucleotide bindingGTP
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-7891_95421463.0Nucleotide bindingGTP
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-6791_95421463.0Nucleotide bindingGTP
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-7891_95421463.0Nucleotide bindingGTP
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-7814_21421463.0RegionG1
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-78153_156421463.0RegionG4
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-78194_196421463.0RegionG5
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-7870_74421463.0RegionG2
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000309268-7891_94421463.0RegionG3
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-6714_21421463.0RegionG1
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-67153_156421463.0RegionG4
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-67194_196421463.0RegionG5
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-6770_74421463.0RegionG2
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000316292-6791_94421463.0RegionG3
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-7814_21421463.0RegionG1
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-78153_156421463.0RegionG4
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-78194_196421463.0RegionG5
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-7870_74421463.0RegionG2
HgeneEEF1A1chr6:74227751chrX:71494941ENST00000331523-7891_94421463.0RegionG3
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-7814_21421463.0RegionG1
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-78153_156421463.0RegionG4
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-78194_196421463.0RegionG5
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-7870_74421463.0RegionG2
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000309268-7891_94421463.0RegionG3
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-6714_21421463.0RegionG1
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-67153_156421463.0RegionG4
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-67194_196421463.0RegionG5
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-6770_74421463.0RegionG2
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000316292-6791_94421463.0RegionG3
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-7814_21421463.0RegionG1
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-78153_156421463.0RegionG4
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-78194_196421463.0RegionG5
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-7870_74421463.0RegionG2
HgeneEEF1A1chr6:74227755chrX:71494945ENST00000331523-7891_94421463.0RegionG3
TgeneRPS4Xchr6:74227751chrX:71494941ENST000003160840742_1040264.0DomainNote=S4 RNA-binding
TgeneRPS4Xchr6:74227755chrX:71494945ENST000003160840742_1040264.0DomainNote=S4 RNA-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EEF1A1-RPS4X


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25147_25147_1_EEF1A1-RPS4X_EEF1A1_chr6_74227751_ENST00000316292_RPS4X_chrX_71494941_ENST00000316084_length(transcript)=3356nt_BP=2256nt
GTTTGCCGCCAGAACACAGGTAAGTGCCGTGTGTGGTTCCCGCGGGCCTGGCCTCTTTACGGGTTATGGCCCTTGCGTGCCTTGAATTAC
TTCCACGCCCCTGGCTGCAGTACGTGATTCTTGATCCCGAGCTTCGGGTTGGAAGTGGGTGGGAGAGTTCGAGGCCTTGCGCTTAAGGAG
CCCCTTCGCCTCGTGCTTGAGTTGAGGCCTGGCTTGGGCGCTGGGGCCGCCGCGTGCGAATCTGGTGGCACCTTCGCGCCTGTCTCGCTG
CTTTCGATAAGTCTCTAGCCATTTAAAATTTTTGATGACCTGCTGCGACGCTTTTTTTCTGGCAAGATAGTCTTGTAAATGCGGGCCAAG
ATCTGCACACTGGTATTTCGGTTTTTGGGGCCGCGGGCGGCGACGGGGCCCGTGCGTCCCAGCGCACATGTTCGGCGAGGCGGGGCCTGC
GAGCGCGGCCACCGAGAATCGGACGGGGGTAGTCTCAAGCTGGCCGGCCTGCTCTGGTGCCTGGCCTCGCGCCGCCGTGTATCGCCCCGC
CCTGGGCGGCAAGGCTGGCCCGGTCGGCACCAGTTGCGTGAGCGGAAAGATGGCCGCTTCCCGGCCCTGCTGCAGGGAGCTCAAAATGGA
GGACGCGGCGCTCGGGAGAGCGGGCGGGTGAGTCACCCACACAAAGGAAAAGGGCCTTTCCGTCCTCAGCCGTCGCTTCATGTGACTCCA
CGGAGTACCGGGCGCCGTCCAGGCACCTCGATTAGTTCTCGAGCTTTTGGAGTACGTCGTCTTTAGGTTGGGGGGAGGGGTTTTATGCGA
TGGAGTTTCCCCACACTGAGTGGGTGGAGACTGAAGTTAGGCCAGCTTGGCACTTGATGTAATTCTCCTTGGAATTTGCCCTTTTTGAGT
TTGGATCTTGGTTCATTCTCAAGCCTCAGACAGTGGTTCAAAGTTTTTTTCTTCCATTTCAGGTGTCGTGAAAACTACCCCTAAAAGCCA
AAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACTACTGGCCATCTGATCTATA
AATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCT
TGGATAAACTGAAAGCTGAGCGTGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTGAGACCAGCAAGTACTATGTGACTATCA
TTGATGCCCCAGGACACAGAGACTTTATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTG
TTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCCCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTG
TCGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATATGAGGAAATTGTTAAGGAAGTCAGCACTTACATTAAGA
AAATTGGCTACAACCCCGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTT
GGTTCAAGGGATGGAAAGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTC
GTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTG
GTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACGGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGA
GTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCA
AAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGCGCCGGCTATGCCCCTG
TATTGGATTGCCACACGGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAGCTGGAAGATG
GCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCCATGTGTGTTGAGAGCTTCTCAGACTATCCAC
CTTTGGGGCAACAAACCATGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAAGACTGGCGGCC
AAACAGAGCAGTGGGTGAAATGGGTCCCTGGGTGACATGTCAGATCTTTGTACGTAATTAAAAATATTGTGGCAGGATTAATAGCATTTT
GGTTTTGTGGGTTGTTTTTTTTTTTAATTCAGTTTCCTGCTATTTTACTGTATAACATGAACAGTGATTAAGTTCTCAGGCAGGCTTAGG
CAGTCTGTTATTGGCTGGGCTTAGTTAGTGGTGGGAAGTAGAAGATACCAGACTTGGGAAAGGAACAGCAACTAACCAAGGAGTAGAAAG
AGCCAAGAAATCCCGGAGTATTTATCTCCCCCGCCTTGACTTGGCCAAGAACTTCTCTACACAGTGGACCCCTCTGCCCTGTTAAGTTCC
CTTGGCTTTCTAAAAATCTGCCCTCATTTTCTTCTCCAGTCTGTATTGCACTAGCCCATCCACAAGCCTGGCTCATCTGTTTTTCCCACT
CCTGTGCCCATCTTGCCAAACGCAGGATGAAAATCTCCAGTTGCCATTAAAGGTGGTCATAAATGGGCTGTTGATGTTGCAAAGCATTGC
AGTTCCTTGGACTTAGTGCCCTTATTCTCCAGCTGCCGCTGCAGTCCTCAACTCTGTTTTTCAGAGGACAGAGATGTAGAACATAAACTT
GTTCTTGCTTGTCCAAAGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCACCAACAGAGAGAGGCACCC
TGGATCTTTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACATTTTTGTTATTGGCAAGTACAA
GTTGTGCAAAGTGAGAAAGATCTTTGTGGGCACAAAAGGAATCCCTCATCTGGTGACTCATGATGCCCGCACCATCCGCTACCCCGATCC
CCTCATCAAGGTGAATGATACCATTCAGATTGATTTGGAGACTGGCAAGATTACTGATTTCATCAAGTTCGACACTGCGCTTTGCTGTAC

>25147_25147_1_EEF1A1-RPS4X_EEF1A1_chr6_74227751_ENST00000316292_RPS4X_chrX_71494941_ENST00000316084_length(amino acids)=440AA_BP=
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTII
DAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETG
VLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV

--------------------------------------------------------------
>25147_25147_2_EEF1A1-RPS4X_EEF1A1_chr6_74227755_ENST00000316292_RPS4X_chrX_71494945_ENST00000316084_length(transcript)=3360nt_BP=2256nt
GTTTGCCGCCAGAACACAGGTAAGTGCCGTGTGTGGTTCCCGCGGGCCTGGCCTCTTTACGGGTTATGGCCCTTGCGTGCCTTGAATTAC
TTCCACGCCCCTGGCTGCAGTACGTGATTCTTGATCCCGAGCTTCGGGTTGGAAGTGGGTGGGAGAGTTCGAGGCCTTGCGCTTAAGGAG
CCCCTTCGCCTCGTGCTTGAGTTGAGGCCTGGCTTGGGCGCTGGGGCCGCCGCGTGCGAATCTGGTGGCACCTTCGCGCCTGTCTCGCTG
CTTTCGATAAGTCTCTAGCCATTTAAAATTTTTGATGACCTGCTGCGACGCTTTTTTTCTGGCAAGATAGTCTTGTAAATGCGGGCCAAG
ATCTGCACACTGGTATTTCGGTTTTTGGGGCCGCGGGCGGCGACGGGGCCCGTGCGTCCCAGCGCACATGTTCGGCGAGGCGGGGCCTGC
GAGCGCGGCCACCGAGAATCGGACGGGGGTAGTCTCAAGCTGGCCGGCCTGCTCTGGTGCCTGGCCTCGCGCCGCCGTGTATCGCCCCGC
CCTGGGCGGCAAGGCTGGCCCGGTCGGCACCAGTTGCGTGAGCGGAAAGATGGCCGCTTCCCGGCCCTGCTGCAGGGAGCTCAAAATGGA
GGACGCGGCGCTCGGGAGAGCGGGCGGGTGAGTCACCCACACAAAGGAAAAGGGCCTTTCCGTCCTCAGCCGTCGCTTCATGTGACTCCA
CGGAGTACCGGGCGCCGTCCAGGCACCTCGATTAGTTCTCGAGCTTTTGGAGTACGTCGTCTTTAGGTTGGGGGGAGGGGTTTTATGCGA
TGGAGTTTCCCCACACTGAGTGGGTGGAGACTGAAGTTAGGCCAGCTTGGCACTTGATGTAATTCTCCTTGGAATTTGCCCTTTTTGAGT
TTGGATCTTGGTTCATTCTCAAGCCTCAGACAGTGGTTCAAAGTTTTTTTCTTCCATTTCAGGTGTCGTGAAAACTACCCCTAAAAGCCA
AAATGGGAAAGGAAAAGACTCATATCAACATTGTCGTCATTGGACACGTAGATTCGGGCAAGTCCACCACTACTGGCCATCTGATCTATA
AATGCGGTGGCATCGACAAAAGAACCATTGAAAAATTTGAGAAGGAGGCTGCTGAGATGGGAAAGGGCTCCTTCAAGTATGCCTGGGTCT
TGGATAAACTGAAAGCTGAGCGTGAACGTGGTATCACCATTGATATCTCCTTGTGGAAATTTGAGACCAGCAAGTACTATGTGACTATCA
TTGATGCCCCAGGACACAGAGACTTTATCAAAAACATGATTACAGGGACATCTCAGGCTGACTGTGCTGTCCTGATTGTTGCTGCTGGTG
TTGGTGAATTTGAAGCTGGTATCTCCAAGAATGGGCAGACCCGAGAGCATGCCCTTCTGGCTTACACACTGGGTGTGAAACAACTAATTG
TCGGTGTTAACAAAATGGATTCCACTGAGCCACCCTACAGCCAGAAGAGATATGAGGAAATTGTTAAGGAAGTCAGCACTTACATTAAGA
AAATTGGCTACAACCCCGACACAGTAGCATTTGTGCCAATTTCTGGTTGGAATGGTGACAACATGCTGGAGCCAAGTGCTAACATGCCTT
GGTTCAAGGGATGGAAAGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTC
GTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTGGTATTGGTACTGTTCCTGTTGGCCGAGTGGAGACTG
GTGTTCTCAAACCCGGTATGGTGGTCACCTTTGCTCCAGTCAACGTTACAACGGAAGTAAAATCTGTCGAAATGCACCATGAAGCTTTGA
GTGAAGCTCTTCCTGGGGACAATGTGGGCTTCAATGTCAAGAATGTGTCTGTCAAGGATGTTCGTCGTGGCAACGTTGCTGGTGACAGCA
AAAATGACCCACCAATGGAAGCAGCTGGCTTCACTGCTCAGGTGATTATCCTGAACCATCCAGGCCAAATAAGCGCCGGCTATGCCCCTG
TATTGGATTGCCACACGGCTCACATTGCATGCAAGTTTGCTGAGCTGAAGGAAAAGATTGATCGCCGTTCTGGTAAAAAGCTGGAAGATG
GCCCTAAATTCTTGAAGTCTGGTGATGCTGCCATTGTTGATATGGTTCCTGGCAAGCCCATGTGTGTTGAGAGCTTCTCAGACTATCCAC
CTTTGGGGCAACAAACCATGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAAGACTGGCGGCC
AAACAGAGCAGTGGGTGAAATGGGTCCCTGGGTGACATGTCAGATCTTTGTACGTAATTAAAAATATTGTGGCAGGATTAATAGCATTTT
GGTTTTGTGGGTTGTTTTTTTTTTTAATTCAGTTTCCTGCTATTTTACTGTATAACATGAACAGTGATTAAGTTCTCAGGCAGGCTTAGG
CAGTCTGTTATTGGCTGGGCTTAGTTAGTGGTGGGAAGTAGAAGATACCAGACTTGGGAAAGGAACAGCAACTAACCAAGGAGTAGAAAG
AGCCAAGAAATCCCGGAGTATTTATCTCCCCCGCCTTGACTTGGCCAAGAACTTCTCTACACAGTGGACCCCTCTGCCCTGTTAAGTTCC
CTTGGCTTTCTAAAAATCTGCCCTCATTTTCTTCTCCAGTCTGTATTGCACTAGCCCATCCACAAGCCTGGCTCATCTGTTTTTCCCACT
CCTGTGCCCATCTTGCCAAACGCAGGATGAAAATCTCCAGTTGCCATTAAAGGTGGTCATAAATGGGCTGTTGATGTTGCAAAGCATTGC
AGTTCCTTGGACTTAGTGCCCTTATTCTCCAGCTGCCGCTGCAGTCCTCAACTCTGTTTTTCAGAGGACAGAGATGTAGAACATAAACTT
GTTCTTGCTTGTCCAAAGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCACCAACAGAGAGAGGCACCC
TGGATCTTTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACATTTTTGTTATTGGCAAGTACAA
GTTGTGCAAAGTGAGAAAGATCTTTGTGGGCACAAAAGGAATCCCTCATCTGGTGACTCATGATGCCCGCACCATCCGCTACCCCGATCC
CCTCATCAAGGTGAATGATACCATTCAGATTGATTTGGAGACTGGCAAGATTACTGATTTCATCAAGTTCGACACTGGGGTCGCTTTGCT

>25147_25147_2_EEF1A1-RPS4X_EEF1A1_chr6_74227755_ENST00000316292_RPS4X_chrX_71494945_ENST00000316084_length(amino acids)=440AA_BP=
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTII
DAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETG
VLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV

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Fusion Gene PPI Analysis for EEF1A1-RPS4X


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EEF1A1-RPS4X


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EEF1A1-RPS4X


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource