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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EEF1B2-ABCF2 (FusionGDB2 ID:25158)

Fusion Gene Summary for EEF1B2-ABCF2

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1B2-ABCF2
Fusion gene ID: 25158
HgeneTgene
Gene symbol

EEF1B2

ABCF2

Gene ID

1933

10061

Gene nameeukaryotic translation elongation factor 1 beta 2ATP binding cassette subfamily F member 2
SynonymsEEF1B|EEF1B1|EF1BABC28|EST133090|HUSSY-18|HUSSY18
Cytomap

2q33.3

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 1-betaEF-1-betaeukaryotic translation elongation factor 1 beta 1ATP-binding cassette sub-family F member 2ABC-type transport proteinATP-binding cassette, sub-family F (GCN20), member 2iron-inhibited ABC transporter 2
Modification date2020031320200313
UniProtAcc

P24534

Q9UG63

Ensembl transtripts involved in fusion geneENST00000236957, ENST00000392221, 
ENST00000392222, 		ENST00000473874, 
ENST00000222388, ENST00000287844, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 4 X 3=60
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/60*10)=0
Context

PubMed: EEF1B2 [Title/Abstract] AND ABCF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEEF1B2(207026196)-ABCF2(150913115), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EEF1B2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01AEEF1B2chr2

207026196

+ABCF2chr7

150913115

-


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Fusion Gene ORF analysis for EEF1B2-ABCF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000236957ENST00000473874EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
5CDS-intronENST00000392221ENST00000473874EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
5CDS-intronENST00000392222ENST00000473874EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
In-frameENST00000236957ENST00000222388EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
In-frameENST00000236957ENST00000287844EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
In-frameENST00000392221ENST00000222388EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
In-frameENST00000392221ENST00000287844EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
In-frameENST00000392222ENST00000222388EEF1B2chr2

207026196

+ABCF2chr7

150913115

-
In-frameENST00000392222ENST00000287844EEF1B2chr2

207026196

+ABCF2chr7

150913115

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000236957EEF1B2chr2207026196+ENST00000222388ABCF2chr7150913115-12524511211017298
ENST00000236957EEF1B2chr2207026196+ENST00000287844ABCF2chr7150913115-2549451121984287
ENST00000392221EEF1B2chr2207026196+ENST00000222388ABCF2chr7150913115-12894881581054298
ENST00000392221EEF1B2chr2207026196+ENST00000287844ABCF2chr7150913115-25864881581021287
ENST00000392222EEF1B2chr2207026196+ENST00000222388ABCF2chr7150913115-15067053751271298
ENST00000392222EEF1B2chr2207026196+ENST00000287844ABCF2chr7150913115-28037053751238287

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000236957ENST00000222388EEF1B2chr2207026196+ABCF2chr7150913115-0.002356390.99764353
ENST00000236957ENST00000287844EEF1B2chr2207026196+ABCF2chr7150913115-0.0017439110.998256
ENST00000392221ENST00000222388EEF1B2chr2207026196+ABCF2chr7150913115-0.0025499590.99745005
ENST00000392221ENST00000287844EEF1B2chr2207026196+ABCF2chr7150913115-0.0017316720.99826825
ENST00000392222ENST00000222388EEF1B2chr2207026196+ABCF2chr7150913115-0.0017483880.9982516
ENST00000392222ENST00000287844EEF1B2chr2207026196+ABCF2chr7150913115-0.0011547650.9988452

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Fusion Genomic Features for EEF1B2-ABCF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EEF1B2-ABCF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:207026196/chr7:150913115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1B2

P24534

ABCF2

Q9UG63

FUNCTION: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEEF1B2chr2:207026196chr7:150913115ENST00000236957+472_84110226.0DomainNote=GST C-terminal
HgeneEEF1B2chr2:207026196chr7:150913115ENST00000392221+472_84110226.0DomainNote=GST C-terminal
HgeneEEF1B2chr2:207026196chr7:150913115ENST00000392222+362_84110226.0DomainNote=GST C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCF2chr2:207026196chr7:150913115ENST000002878441015396_613446624.0DomainABC transporter 2
TgeneABCF2chr2:207026196chr7:150913115ENST00000287844101586_325446624.0DomainABC transporter 1
TgeneABCF2chr2:207026196chr7:150913115ENST000002878441015118_125446624.0Nucleotide bindingATP 1
TgeneABCF2chr2:207026196chr7:150913115ENST000002878441015430_437446624.0Nucleotide bindingATP 2


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Fusion Gene Sequence for EEF1B2-ABCF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25158_25158_1_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000236957_ABCF2_chr7_150913115_ENST00000222388_length(transcript)=1252nt_BP=451nt
CGCAGTTCCGCCGGAAGTGGCCCCAGCCTCGAGGCCGGGCGTCTTCGGTCATCTCCGGCGCTTCTAGGGCTGGTTCCCGTCATCTTCGGG
AGCCGTGGAGCTCTCGGATACAGCCGACACCATGGGTTTCGGAGACCTGAAAAGCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGC
GGACAAGAGCTACATCGAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTATTTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTG
TCATGCCCTACGTTGGTATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGG
TCCTGCCGATGTGGAAGACACTACAGGAAGTGGAGCTACAGATAGTAAAGATGATGATGACATTGACCTCTTTGGATCTGATGATGAGGA
GCTACTACCCACAGATGGCATGATCCGAAAACACTCTCATGTCAAGATAGGGCGTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGA
TCTCTCACCTTTGGAGTACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGGAAGAAATGAGGAAGATCATTGGGCGATACGGTCTCAC
TGGGAAACAACAGGTGAGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCCGAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCA
CATGCTCTTCCTGGATGAACCCACCAATCACCTGGATATCGAGACCATCGACGCCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTAT
GATGCTGGTCAGCCATGACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTTGGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGG
AGACATCCTGGCTTACAAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGCCCCAGCTCACCAAGAGGACCCACAACGTGTGCACCCT
GACATTGGCATCTCTGCCAAGGCCATGAGCATCATGAACTCGTTTGTAAACGACGTGTTTGAGCAGCTGGCGTGTGAGGCTGCCCGGCTG
GCCCAGTACTCGGGCCGGACCACCCTGACATCCCGAGAAGTCCAGACGGCTGTGCGTCTGCTGCTGCCTGGGGAGCTGGCCAAGCACGCT

>25158_25158_1_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000236957_ABCF2_chr7_150913115_ENST00000222388_length(amino acids)=298AA_BP=110
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGS
GATDSKDDDDIDLFGSDDEELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRN
LSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLK

--------------------------------------------------------------
>25158_25158_2_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000236957_ABCF2_chr7_150913115_ENST00000287844_length(transcript)=2549nt_BP=451nt
CGCAGTTCCGCCGGAAGTGGCCCCAGCCTCGAGGCCGGGCGTCTTCGGTCATCTCCGGCGCTTCTAGGGCTGGTTCCCGTCATCTTCGGG
AGCCGTGGAGCTCTCGGATACAGCCGACACCATGGGTTTCGGAGACCTGAAAAGCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGC
GGACAAGAGCTACATCGAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTATTTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTG
TCATGCCCTACGTTGGTATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGG
TCCTGCCGATGTGGAAGACACTACAGGAAGTGGAGCTACAGATAGTAAAGATGATGATGACATTGACCTCTTTGGATCTGATGATGAGGA
GCTACTACCCACAGATGGCATGATCCGAAAACACTCTCATGTCAAGATAGGGCGTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGA
TCTCTCACCTTTGGAGTACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGGAAGAAATGAGGAAGATCATTGGGCGATACGGTCTCAC
TGGGAAACAACAGGTGAGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCCGAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCA
CATGCTCTTCCTGGATGAACCCACCAATCACCTGGATATCGAGACCATCGACGCCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTAT
GATGCTGGTCAGCCATGACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTTGGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGG
AGACATCCTGGCTTACAAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGCCCCAGCTCACCAAGAGGACCCACAACGTGTGAGCCCT
CTACCTGGGTTCGGGTCAGGAGCTCCATCTGGGAACTAACAGCTGCTAACCTGACCAGCCGCTCAGGACAGGACCCTGGGGCTACACTCC
TGCATTGCTGCAATACTGCTCCCCCAGCCTCTCCCCTGCCCCTCAACCTGCCTTAGCTGCACTCTCTTACCTACAGCTGGACAGTACCTG
TCTGTTTCCTGTCCTCCTTCCAGTTACATCTGTCCATGTCTGGACTCGGCTGGCCGTTCCCTCCAGCCCCTTGCTGGTTATCTTACTCTG
AGTGTGATGCAGTCAGAGGCACCTGCGGGTTAGCCCAGGGGCCCAAGCCCTGGATTTGGCCTGCGGAGGAGCTTAGGATCCTCGTTTTCT
GGGTTTTGGTGATGTTGGAGGAGTACCCCCCAGCCCACCGCCCCGATTCCTTTTTGCTTCTGGTTTGGAGCTCCGGACCAGGACCTTCGT
CCTGGTCAGTTTTTAAATAATTATTTAGCAGTGTAACTTTTAGACCTGCGTGACATCTACAAAGCGCCCAATAAAGAAAGAGGAAGCCAC
GGTCCCTACCTTCCTTCTCGGGTCTCTGGGGCCTTCTCCTCCCTGCAGTGCCAACATGCACTGCCCACAGCAGGAGCTGGATCCAGCGTC
AGTGTGTCGATGGGAACTGAAGACTAGTCCATAGGAGCTGGAAGAACTTTGTCCCTTTACTTCTGATTTGAAATTGTACCTTTTCTCAGG
CCTGTGATTCACAGACTTTAACATGAATCAGAATCACCTGGAGGGCTCATGCAATCAGATTGCCAGATCTCGCCTCAGCGTTTCTGGTTC
AATAGGTTTTGGGGGAGACCAAGAACGTTAACATTTCTAGCAAGTTTCCAGGTGATGCTGTTGTTGCTGGTCTAGAGACTATTTTGAGAA
CCACTGTCCAGGAGCGTGGTTTTCTGATTGTGATCTGAGGTTCTGCCCCAACTGCACAGCAGTTGGGCTGCTTGTTAAAAATGCAGGCCA
GGTGCGGTGGCTCACACCTGTAATCCCAGCGCTTTGGGAGGCTGAGGCAGGTGGATCACTTGAGCTCAGGAGTTCAAGACCAGCTTGGGA
AACATGGCAAAACCCGTCTTTATGTGCCTGGAATCCCACCTGCTCAGGTGGCTAGGGTGGATGGATCGCTTGAGCCCAGGAGGTGGAGGT
TGCAGTGAGCTGAGATTGCACCACTGCATTCCAGCCTGGATGACAGAGCAAAACCCTGTCTCAAAAAAATGCAGACTGGCCAGGCACAGT
GGCTCACACCTGTAATCCGACTGTAAGCTCATCACCTTGGGAGGCCACTGTAGGAGGATCAATTGAGCCTAGAAGTTCAAGACCAGCCTG
GGCAAAGTAGGGAGACCCCTTCTCTACAAATAGTAATAAAATGAACCGGGCATAGTAGCATGTGCCTGCGGTCCCAGCTGCTCTGATAAG
AGGAGGCTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCAGAGCGTGCCGCTACACTCCAGCCTGATGACAGACCGAGACACTGTCT

>25158_25158_2_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000236957_ABCF2_chr7_150913115_ENST00000287844_length(amino acids)=287AA_BP=110
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGS
GATDSKDDDDIDLFGSDDEELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRN
LSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLK

--------------------------------------------------------------
>25158_25158_3_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392221_ABCF2_chr7_150913115_ENST00000222388_length(transcript)=1289nt_BP=488nt
GCCGGAAGTGGCCCCAGCCTCGAGGCCGGGCGTCTTCGGTCATCTCCGGCGCTTCTAGGGCTGGTTCCCGTCATCTTCGGGAGCCGTGGA
GCGTGGGGCGCCCACAATTTGCGCGCTCTCTTTCTGCTGCTCCCCAGCTCTCGGATACAGCCGACACCATGGGTTTCGGAGACCTGAAAA
GCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGCGGACAAGAGCTACATCGAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTAT
TTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTGTCATGCCCTACGTTGGTATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCA
GCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGGTCCTGCCGATGTGGAAGACACTACAGGAAGTGGAGCTACAGATAGTAAAGATG
ATGATGACATTGACCTCTTTGGATCTGATGATGAGGAGCTACTACCCACAGATGGCATGATCCGAAAACACTCTCATGTCAAGATAGGGC
GTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGATCTCTCACCTTTGGAGTACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGG
AAGAAATGAGGAAGATCATTGGGCGATACGGTCTCACTGGGAAACAACAGGTGAGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCC
GAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCACATGCTCTTCCTGGATGAACCCACCAATCACCTGGATATCGAGACCATCGACG
CCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTATGATGCTGGTCAGCCATGACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTT
GGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGGAGACATCCTGGCTTACAAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGC
CCCAGCTCACCAAGAGGACCCACAACGTGTGCACCCTGACATTGGCATCTCTGCCAAGGCCATGAGCATCATGAACTCGTTTGTAAACGA
CGTGTTTGAGCAGCTGGCGTGTGAGGCTGCCCGGCTGGCCCAGTACTCGGGCCGGACCACCCTGACATCCCGAGAAGTCCAGACGGCTGT
GCGTCTGCTGCTGCCTGGGGAGCTGGCCAAGCACGCTGTGTCTGAGGGCACCAAGGCTGTCACCAAGTACACCAGCTCCAAGTGACCCAG

>25158_25158_3_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392221_ABCF2_chr7_150913115_ENST00000222388_length(amino acids)=298AA_BP=110
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGS
GATDSKDDDDIDLFGSDDEELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRN
LSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLK

--------------------------------------------------------------
>25158_25158_4_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392221_ABCF2_chr7_150913115_ENST00000287844_length(transcript)=2586nt_BP=488nt
GCCGGAAGTGGCCCCAGCCTCGAGGCCGGGCGTCTTCGGTCATCTCCGGCGCTTCTAGGGCTGGTTCCCGTCATCTTCGGGAGCCGTGGA
GCGTGGGGCGCCCACAATTTGCGCGCTCTCTTTCTGCTGCTCCCCAGCTCTCGGATACAGCCGACACCATGGGTTTCGGAGACCTGAAAA
GCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGCGGACAAGAGCTACATCGAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTAT
TTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTGTCATGCCCTACGTTGGTATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCA
GCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGGTCCTGCCGATGTGGAAGACACTACAGGAAGTGGAGCTACAGATAGTAAAGATG
ATGATGACATTGACCTCTTTGGATCTGATGATGAGGAGCTACTACCCACAGATGGCATGATCCGAAAACACTCTCATGTCAAGATAGGGC
GTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGATCTCTCACCTTTGGAGTACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGG
AAGAAATGAGGAAGATCATTGGGCGATACGGTCTCACTGGGAAACAACAGGTGAGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCC
GAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCACATGCTCTTCCTGGATGAACCCACCAATCACCTGGATATCGAGACCATCGACG
CCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTATGATGCTGGTCAGCCATGACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTT
GGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGGAGACATCCTGGCTTACAAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGC
CCCAGCTCACCAAGAGGACCCACAACGTGTGAGCCCTCTACCTGGGTTCGGGTCAGGAGCTCCATCTGGGAACTAACAGCTGCTAACCTG
ACCAGCCGCTCAGGACAGGACCCTGGGGCTACACTCCTGCATTGCTGCAATACTGCTCCCCCAGCCTCTCCCCTGCCCCTCAACCTGCCT
TAGCTGCACTCTCTTACCTACAGCTGGACAGTACCTGTCTGTTTCCTGTCCTCCTTCCAGTTACATCTGTCCATGTCTGGACTCGGCTGG
CCGTTCCCTCCAGCCCCTTGCTGGTTATCTTACTCTGAGTGTGATGCAGTCAGAGGCACCTGCGGGTTAGCCCAGGGGCCCAAGCCCTGG
ATTTGGCCTGCGGAGGAGCTTAGGATCCTCGTTTTCTGGGTTTTGGTGATGTTGGAGGAGTACCCCCCAGCCCACCGCCCCGATTCCTTT
TTGCTTCTGGTTTGGAGCTCCGGACCAGGACCTTCGTCCTGGTCAGTTTTTAAATAATTATTTAGCAGTGTAACTTTTAGACCTGCGTGA
CATCTACAAAGCGCCCAATAAAGAAAGAGGAAGCCACGGTCCCTACCTTCCTTCTCGGGTCTCTGGGGCCTTCTCCTCCCTGCAGTGCCA
ACATGCACTGCCCACAGCAGGAGCTGGATCCAGCGTCAGTGTGTCGATGGGAACTGAAGACTAGTCCATAGGAGCTGGAAGAACTTTGTC
CCTTTACTTCTGATTTGAAATTGTACCTTTTCTCAGGCCTGTGATTCACAGACTTTAACATGAATCAGAATCACCTGGAGGGCTCATGCA
ATCAGATTGCCAGATCTCGCCTCAGCGTTTCTGGTTCAATAGGTTTTGGGGGAGACCAAGAACGTTAACATTTCTAGCAAGTTTCCAGGT
GATGCTGTTGTTGCTGGTCTAGAGACTATTTTGAGAACCACTGTCCAGGAGCGTGGTTTTCTGATTGTGATCTGAGGTTCTGCCCCAACT
GCACAGCAGTTGGGCTGCTTGTTAAAAATGCAGGCCAGGTGCGGTGGCTCACACCTGTAATCCCAGCGCTTTGGGAGGCTGAGGCAGGTG
GATCACTTGAGCTCAGGAGTTCAAGACCAGCTTGGGAAACATGGCAAAACCCGTCTTTATGTGCCTGGAATCCCACCTGCTCAGGTGGCT
AGGGTGGATGGATCGCTTGAGCCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATTGCACCACTGCATTCCAGCCTGGATGACAGAGCAAAA
CCCTGTCTCAAAAAAATGCAGACTGGCCAGGCACAGTGGCTCACACCTGTAATCCGACTGTAAGCTCATCACCTTGGGAGGCCACTGTAG
GAGGATCAATTGAGCCTAGAAGTTCAAGACCAGCCTGGGCAAAGTAGGGAGACCCCTTCTCTACAAATAGTAATAAAATGAACCGGGCAT
AGTAGCATGTGCCTGCGGTCCCAGCTGCTCTGATAAGAGGAGGCTCACTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCAGAGCGTGCCG

>25158_25158_4_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392221_ABCF2_chr7_150913115_ENST00000287844_length(amino acids)=287AA_BP=110
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGS
GATDSKDDDDIDLFGSDDEELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRN
LSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLK

--------------------------------------------------------------
>25158_25158_5_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392222_ABCF2_chr7_150913115_ENST00000222388_length(transcript)=1506nt_BP=705nt
CCCCAGCCTCGAGGCCGGGCGTCTTCGGTCATCTCCGGCGCTTCTAGGGCTGGTTCCCGTCATCTTCGGGAGCCGTGGAGGTACGAACTT
AAGACATGCCTATTTTATTAATTTACTTCCAAACGCAACGAAAGGTCCATGGACAATTTGTGGGCCATTTAATTCAGGGCCCCCAATTCG
TACGTGGAGAAGTGGGAATGCAAAAGTACTTTGACCTTTAACCTTCGGTCCGGCGCGGTGGAGGGAAACGCCTCCGTCTCTATATAAGGA
ATTTTCCGGTCTCTTCGGGTCCTTTTTCCTCTCTTCAGCGTGGGGCGCCCACAATTTGCGCGCTCTCTTTCTGCTGCTCCCCAGCTCTCG
GATACAGCCGACACCATGGGTTTCGGAGACCTGAAAAGCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGCGGACAAGAGCTACATC
GAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTATTTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTGTCATGCCCTACGTTGG
TATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGGTCCTGCCGATGTGGAA
GACACTACAGGAAGTGGAGCTACAGATAGTAAAGATGATGATGACATTGACCTCTTTGGATCTGATGATGAGGAGCTACTACCCACAGAT
GGCATGATCCGAAAACACTCTCATGTCAAGATAGGGCGTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGATCTCTCACCTTTGGAG
TACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGGAAGAAATGAGGAAGATCATTGGGCGATACGGTCTCACTGGGAAACAACAGGTG
AGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCCGAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCACATGCTCTTCCTGGAT
GAACCCACCAATCACCTGGATATCGAGACCATCGACGCCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTATGATGCTGGTCAGCCAT
GACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTTGGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGGAGACATCCTGGCTTAC
AAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGCCCCAGCTCACCAAGAGGACCCACAACGTGTGCACCCTGACATTGGCATCTCTG
CCAAGGCCATGAGCATCATGAACTCGTTTGTAAACGACGTGTTTGAGCAGCTGGCGTGTGAGGCTGCCCGGCTGGCCCAGTACTCGGGCC
GGACCACCCTGACATCCCGAGAAGTCCAGACGGCTGTGCGTCTGCTGCTGCCTGGGGAGCTGGCCAAGCACGCTGTGTCTGAGGGCACCA

>25158_25158_5_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392222_ABCF2_chr7_150913115_ENST00000222388_length(amino acids)=298AA_BP=110
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGS
GATDSKDDDDIDLFGSDDEELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRN
LSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLK

--------------------------------------------------------------
>25158_25158_6_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392222_ABCF2_chr7_150913115_ENST00000287844_length(transcript)=2803nt_BP=705nt
CCCCAGCCTCGAGGCCGGGCGTCTTCGGTCATCTCCGGCGCTTCTAGGGCTGGTTCCCGTCATCTTCGGGAGCCGTGGAGGTACGAACTT
AAGACATGCCTATTTTATTAATTTACTTCCAAACGCAACGAAAGGTCCATGGACAATTTGTGGGCCATTTAATTCAGGGCCCCCAATTCG
TACGTGGAGAAGTGGGAATGCAAAAGTACTTTGACCTTTAACCTTCGGTCCGGCGCGGTGGAGGGAAACGCCTCCGTCTCTATATAAGGA
ATTTTCCGGTCTCTTCGGGTCCTTTTTCCTCTCTTCAGCGTGGGGCGCCCACAATTTGCGCGCTCTCTTTCTGCTGCTCCCCAGCTCTCG
GATACAGCCGACACCATGGGTTTCGGAGACCTGAAAAGCCCTGCCGGCCTCCAGGTGCTCAACGATTACCTGGCGGACAAGAGCTACATC
GAGGGGTATGTGCCATCACAAGCAGATGTGGCAGTATTTGAAGCCGTGTCCAGCCCACCGCCTGCCGACTTGTGTCATGCCCTACGTTGG
TATAATCACATCAAGTCTTACGAAAAGGAAAAGGCCAGCCTGCCAGGAGTGAAGAAAGCTTTGGGCAAATATGGTCCTGCCGATGTGGAA
GACACTACAGGAAGTGGAGCTACAGATAGTAAAGATGATGATGACATTGACCTCTTTGGATCTGATGATGAGGAGCTACTACCCACAGAT
GGCATGATCCGAAAACACTCTCATGTCAAGATAGGGCGTTACCATCAGCATTTACAAGAGCAGCTGGACTTAGATCTCTCACCTTTGGAG
TACATGATGAAGTGCTACCCAGAGATCAAGGAGAAGGAAGAAATGAGGAAGATCATTGGGCGATACGGTCTCACTGGGAAACAACAGGTG
AGCCCAATCCGGAACTTGTCAGACGGGCAGAAGTGCCGAGTGTGTCTGGCCTGGCTGGCCTGGCAGAACCCCCACATGCTCTTCCTGGAT
GAACCCACCAATCACCTGGATATCGAGACCATCGACGCCCTGGCAGATGCCATCAATGAGTTTGAGGGTGGTATGATGCTGGTCAGCCAT
GACTTCAGACTCATTCAGCAGGTTGCACAGGAAATTTGGGTCTGTGAGAAGCAGACAATCACCAAGTGGCCTGGAGACATCCTGGCTTAC
AAGGAGCACCTCAAGTCCAAGCTGGTGGATGAGGAGCCCCAGCTCACCAAGAGGACCCACAACGTGTGAGCCCTCTACCTGGGTTCGGGT
CAGGAGCTCCATCTGGGAACTAACAGCTGCTAACCTGACCAGCCGCTCAGGACAGGACCCTGGGGCTACACTCCTGCATTGCTGCAATAC
TGCTCCCCCAGCCTCTCCCCTGCCCCTCAACCTGCCTTAGCTGCACTCTCTTACCTACAGCTGGACAGTACCTGTCTGTTTCCTGTCCTC
CTTCCAGTTACATCTGTCCATGTCTGGACTCGGCTGGCCGTTCCCTCCAGCCCCTTGCTGGTTATCTTACTCTGAGTGTGATGCAGTCAG
AGGCACCTGCGGGTTAGCCCAGGGGCCCAAGCCCTGGATTTGGCCTGCGGAGGAGCTTAGGATCCTCGTTTTCTGGGTTTTGGTGATGTT
GGAGGAGTACCCCCCAGCCCACCGCCCCGATTCCTTTTTGCTTCTGGTTTGGAGCTCCGGACCAGGACCTTCGTCCTGGTCAGTTTTTAA
ATAATTATTTAGCAGTGTAACTTTTAGACCTGCGTGACATCTACAAAGCGCCCAATAAAGAAAGAGGAAGCCACGGTCCCTACCTTCCTT
CTCGGGTCTCTGGGGCCTTCTCCTCCCTGCAGTGCCAACATGCACTGCCCACAGCAGGAGCTGGATCCAGCGTCAGTGTGTCGATGGGAA
CTGAAGACTAGTCCATAGGAGCTGGAAGAACTTTGTCCCTTTACTTCTGATTTGAAATTGTACCTTTTCTCAGGCCTGTGATTCACAGAC
TTTAACATGAATCAGAATCACCTGGAGGGCTCATGCAATCAGATTGCCAGATCTCGCCTCAGCGTTTCTGGTTCAATAGGTTTTGGGGGA
GACCAAGAACGTTAACATTTCTAGCAAGTTTCCAGGTGATGCTGTTGTTGCTGGTCTAGAGACTATTTTGAGAACCACTGTCCAGGAGCG
TGGTTTTCTGATTGTGATCTGAGGTTCTGCCCCAACTGCACAGCAGTTGGGCTGCTTGTTAAAAATGCAGGCCAGGTGCGGTGGCTCACA
CCTGTAATCCCAGCGCTTTGGGAGGCTGAGGCAGGTGGATCACTTGAGCTCAGGAGTTCAAGACCAGCTTGGGAAACATGGCAAAACCCG
TCTTTATGTGCCTGGAATCCCACCTGCTCAGGTGGCTAGGGTGGATGGATCGCTTGAGCCCAGGAGGTGGAGGTTGCAGTGAGCTGAGAT
TGCACCACTGCATTCCAGCCTGGATGACAGAGCAAAACCCTGTCTCAAAAAAATGCAGACTGGCCAGGCACAGTGGCTCACACCTGTAAT
CCGACTGTAAGCTCATCACCTTGGGAGGCCACTGTAGGAGGATCAATTGAGCCTAGAAGTTCAAGACCAGCCTGGGCAAAGTAGGGAGAC
CCCTTCTCTACAAATAGTAATAAAATGAACCGGGCATAGTAGCATGTGCCTGCGGTCCCAGCTGCTCTGATAAGAGGAGGCTCACTTGAG
CCCAGGAGGTTGAGGCTGCAGTGAGCAGAGCGTGCCGCTACACTCCAGCCTGATGACAGACCGAGACACTGTCTCAAAAAAATAAAAAAA

>25158_25158_6_EEF1B2-ABCF2_EEF1B2_chr2_207026196_ENST00000392222_ABCF2_chr7_150913115_ENST00000287844_length(amino acids)=287AA_BP=110
MGFGDLKSPAGLQVLNDYLADKSYIEGYVPSQADVAVFEAVSSPPPADLCHALRWYNHIKSYEKEKASLPGVKKALGKYGPADVEDTTGS
GATDSKDDDDIDLFGSDDEELLPTDGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSPIRN
LSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EEF1B2-ABCF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EEF1B2-ABCF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EEF1B2-ABCF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource