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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EFCAB4B-SOX5 (FusionGDB2 ID:25304)

Fusion Gene Summary for EFCAB4B-SOX5

check button Fusion gene summary
Fusion gene informationFusion gene name: EFCAB4B-SOX5
Fusion gene ID: 25304
HgeneTgene
Gene symbol

EFCAB4B

SOX5

Gene ID

84766

6660

Gene namecalcium release activated channel regulator 2ASRY-box transcription factor 5
SynonymsEFCAB4BL-SOX5|L-SOX5B|L-SOX5F|LAMSHF
Cytomap

12p13.32

12p12.1

Type of geneprotein-codingprotein-coding
DescriptionEF-hand calcium-binding domain-containing protein 4BCRAC channel regulator 2ACRAC regulator 2ACa2+ release-activated Ca2+ (CRAC) channel regulator 2AEF-hand calcium binding domain 4Bcalcium release-activated calcium channel regulator 2Atranscription factor SOX-5SRY (sex determining region Y)-box 5SRY-box 5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000252322, ENST00000440314, 
ENST00000444507, ENST00000514026, 
ENST00000309359, ENST00000381381, 
ENST00000451604, ENST00000537393, 
ENST00000541536, ENST00000546136, 
ENST00000396007, ENST00000441133, 
ENST00000536850, ENST00000541847, 
ENST00000545921, 
Fusion gene scores* DoF score4 X 4 X 4=6416 X 19 X 9=2736
# samples 518
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2736*10)=-3.92599941855622
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EFCAB4B [Title/Abstract] AND SOX5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFCAB4B(3822402)-SOX5(23818498), # samples:1
EFCAB4B(3822403)-SOX5(23818498), # samples:1
EFCAB4B(3822403)-SOX5(23818501), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSOX5

GO:0032332

positive regulation of chondrocyte differentiation

21401405

TgeneSOX5

GO:0061036

positive regulation of cartilage development

21401405

TgeneSOX5

GO:0071560

cellular response to transforming growth factor beta stimulus

21401405

TgeneSOX5

GO:2000741

positive regulation of mesenchymal stem cell differentiation

21401405


check buttonFusion gene breakpoints across EFCAB4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SOX5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1870-01AEFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
ChimerDB4OVTCGA-25-1870-01AEFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
ChimerDB4OVTCGA-25-1870EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-


Top

Fusion Gene ORF analysis for EFCAB4B-SOX5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000252322ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000252322ENST00000309359EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000252322ENST00000381381EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000252322ENST00000451604EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000252322ENST00000537393EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000252322ENST00000541536EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000252322ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000252322ENST00000546136EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000440314ENST00000309359EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000440314ENST00000381381EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000440314ENST00000451604EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000440314ENST00000537393EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000440314ENST00000541536EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000440314ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000440314ENST00000546136EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000444507ENST00000309359EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000444507ENST00000381381EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000444507ENST00000451604EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000444507ENST00000537393EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000444507ENST00000541536EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-3CDSENST00000444507ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-3CDSENST00000444507ENST00000546136EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000252322ENST00000396007EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000252322ENST00000441133EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000252322ENST00000536850EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000252322ENST00000541847EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000252322ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000252322ENST00000545921EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000440314ENST00000396007EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000440314ENST00000441133EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000440314ENST00000536850EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000440314ENST00000541847EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000440314ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000440314ENST00000545921EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000444507ENST00000396007EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000444507ENST00000441133EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000444507ENST00000536850EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000444507ENST00000541847EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
5UTR-intronENST00000444507ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
5UTR-intronENST00000444507ENST00000545921EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000309359EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-3CDSENST00000514026ENST00000309359EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000381381EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-3CDSENST00000514026ENST00000381381EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000451604EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-3CDSENST00000514026ENST00000451604EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000537393EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-3CDSENST00000514026ENST00000537393EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000541536EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-3CDSENST00000514026ENST00000541536EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-3CDSENST00000514026ENST00000546136EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-3CDSENST00000514026ENST00000546136EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000396007EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-intronENST00000514026ENST00000396007EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000441133EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-intronENST00000514026ENST00000441133EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000536850EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-intronENST00000514026ENST00000536850EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000541847EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-intronENST00000514026ENST00000541847EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818498

-
intron-intronENST00000514026ENST00000545921EFCAB4Bchr12

3822403

-SOX5chr12

23818501

-
intron-intronENST00000514026ENST00000545921EFCAB4Bchr12

3822402

-SOX5chr12

23818498

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EFCAB4B-SOX5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EFCAB4B-SOX5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3822402/:23818498)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EFCAB4B-SOX5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EFCAB4B-SOX5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EFCAB4B-SOX5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EFCAB4B-SOX5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource