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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EFNA1-ADAM15 (FusionGDB2 ID:25367)

Fusion Gene Summary for EFNA1-ADAM15

check button Fusion gene summary
Fusion gene informationFusion gene name: EFNA1-ADAM15
Fusion gene ID: 25367
HgeneTgene
Gene symbol

EFNA1

ADAM15

Gene ID

1942

8751

Gene nameephrin A1ADAM metallopeptidase domain 15
SynonymsB61|ECKLG|EFL1|EPLG1|GMAN|LERK-1|LERK1|TNFAIP4MDC15
Cytomap

1q22

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionephrin-A1TNF alpha-induced protein 4eph-related receptor tyrosine kinase ligand 1epididymis secretory sperm binding proteingastric cancer metastasis associated long noncoding RNAimmediate early response protein B61ligand of eph-related kinase 1tumodisintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Modification date2020031320200320
UniProtAcc

P20827

Q13444

Ensembl transtripts involved in fusion geneENST00000469878, ENST00000368406, 
ENST00000368407, 		ENST00000449910, 
ENST00000271836, ENST00000355956, 
ENST00000356955, ENST00000359280, 
ENST00000360674, ENST00000368410, 
ENST00000368412, ENST00000368413, 
ENST00000472434, ENST00000531455, 
ENST00000447332, 
Fusion gene scores* DoF score7 X 6 X 5=2103 X 3 X 3=27
# samples 83
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EFNA1 [Title/Abstract] AND ADAM15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFNA1(155104110)-ADAM15(155034936), # samples:3
Anticipated loss of major functional domain due to fusion event.EFNA1-ADAM15 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEFNA1

GO:0016477

cell migration

10655584

HgeneEFNA1

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgeneEFNA1

GO:0034446

substrate adhesion-dependent cell spreading

10655584

HgeneEFNA1

GO:0048013

ephrin receptor signaling pathway

10655584

HgeneEFNA1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10655584

HgeneEFNA1

GO:1902004

positive regulation of amyloid-beta formation

24217950

TgeneADAM15

GO:0002418

immune response to tumor cell

22505472

TgeneADAM15

GO:0006915

apoptotic process

22505472

TgeneADAM15

GO:0045087

innate immune response

22505472

TgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check buttonFusion gene breakpoints across EFNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADAM15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-ZS-A9CF-01AEFNA1chr1

155104110

-ADAM15chr1

155034936

+
ChimerDB4LIHCTCGA-ZS-A9CF-01AEFNA1chr1

155104110

+ADAM15chr1

155034936

+


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Fusion Gene ORF analysis for EFNA1-ADAM15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469878ENST00000449910EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000271836EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000355956EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000356955EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000359280EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000360674EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000368410EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000368412EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000368413EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000472434EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000531455EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-intronENST00000469878ENST00000447332EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000271836EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000355956EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000356955EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000359280EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000360674EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000368410EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000368412EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000368413EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000472434EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000531455EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000271836EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000355956EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000356955EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000359280EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000360674EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000368410EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000368412EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000368413EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000472434EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000531455EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-intronENST00000368406ENST00000447332EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-intronENST00000368407ENST00000447332EFNA1chr1

155104110

+ADAM15chr1

155034936

+
Frame-shiftENST00000368406ENST00000449910EFNA1chr1

155104110

+ADAM15chr1

155034936

+
Frame-shiftENST00000368407ENST00000449910EFNA1chr1

155104110

+ADAM15chr1

155034936

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EFNA1-ADAM15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EFNA1chr1155104110+ADAM15chr1155034935+0.0014502630.99854976
EFNA1chr1155104110+ADAM15chr1155034935+0.0014502630.99854976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EFNA1-ADAM15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:155104110/:155034936)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFNA1

P20827

ADAM15

Q13444

FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EFNA1-ADAM15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EFNA1-ADAM15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EFNA1-ADAM15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EFNA1-ADAM15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource