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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EFR3B-NCOA1 (FusionGDB2 ID:25408)

Fusion Gene Summary for EFR3B-NCOA1

check button Fusion gene summary
Fusion gene informationFusion gene name: EFR3B-NCOA1
Fusion gene ID: 25408
HgeneTgene
Gene symbol

EFR3B

NCOA1

Gene ID

22979

8648

Gene nameEFR3 homolog Bnuclear receptor coactivator 1
SynonymsKIAA0953F-SRC-1|KAT13A|RIP160|SRC1|bHLHe42|bHLHe74
Cytomap

2p23.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein EFR3 homolog Bnuclear receptor coactivator 1Hin-2 proteinclass E basic helix-loop-helix protein 74renal carcinoma antigen NY-REN-52steroid receptor coactivator-1
Modification date2020031320200313
UniProtAcc

Q9Y2G0

Q15788

Ensembl transtripts involved in fusion geneENST00000401432, ENST00000402191, 
ENST00000403714, ENST00000405108, 
ENST00000288599, ENST00000348332, 
ENST00000395856, ENST00000405141, 
ENST00000407230, ENST00000469850, 
ENST00000538539, ENST00000406961, 
Fusion gene scores* DoF score3 X 3 X 3=2711 X 13 X 7=1001
# samples 313
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EFR3B [Title/Abstract] AND NCOA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFR3B(25367920)-NCOA1(24962301), # samples:1
Anticipated loss of major functional domain due to fusion event.EFR3B-NCOA1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EFR3B-NCOA1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
EFR3B-NCOA1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EFR3B-NCOA1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
EFR3B-NCOA1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEFR3B

GO:0046854

phosphatidylinositol phosphorylation

23229899

HgeneEFR3B

GO:0072659

protein localization to plasma membrane

23229899

TgeneNCOA1

GO:0000435

positive regulation of transcription from RNA polymerase II promoter by galactose

10207113

TgeneNCOA1

GO:0006351

transcription, DNA-templated

9223431

TgeneNCOA1

GO:0045893

positive regulation of transcription, DNA-templated

11891224|15367689

TgeneNCOA1

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check buttonFusion gene breakpoints across EFR3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCOA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A8OQ-01AEFR3Bchr2

25367920

+NCOA1chr2

24962301

+


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Fusion Gene ORF analysis for EFR3B-NCOA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000401432ENST00000288599EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000401432ENST00000348332EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000401432ENST00000395856EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000401432ENST00000405141EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000401432ENST00000407230EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000401432ENST00000469850EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000401432ENST00000538539EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000288599EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000348332EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000395856EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000405141EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000407230EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000469850EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000402191ENST00000538539EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000288599EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000348332EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000395856EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000405141EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000407230EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000469850EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000403714ENST00000538539EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000288599EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000348332EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000395856EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000405141EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000407230EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000469850EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
5CDS-intronENST00000405108ENST00000538539EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
Frame-shiftENST00000401432ENST00000406961EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
In-frameENST00000402191ENST00000406961EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
In-frameENST00000403714ENST00000406961EFR3Bchr2

25367920

+NCOA1chr2

24962301

+
In-frameENST00000405108ENST00000406961EFR3Bchr2

25367920

+NCOA1chr2

24962301

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000403714EFR3Bchr225367920+ENST00000406961NCOA1chr224962301+576123254534491134
ENST00000402191EFR3Bchr225367920+ENST00000406961NCOA1chr224962301+577523391734631148
ENST00000405108EFR3Bchr225367920+ENST00000406961NCOA1chr224962301+533118951973019940

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000403714ENST00000406961EFR3Bchr225367920+NCOA1chr224962301+0.0014485830.9985514
ENST00000402191ENST00000406961EFR3Bchr225367920+NCOA1chr224962301+0.0015656980.99843425
ENST00000405108ENST00000406961EFR3Bchr225367920+NCOA1chr224962301+0.0018985780.9981014

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Fusion Genomic Features for EFR3B-NCOA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EFR3Bchr225367920+NCOA1chr224962300+1.97E-050.99998033
EFR3Bchr225367920+NCOA1chr224962300+1.97E-050.99998033

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EFR3B-NCOA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:25367920/chr2:24962301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFR3B

Q9Y2G0

NCOA1

Q15788

FUNCTION: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:25608530, PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3B probably acts as the membrane-anchoring component (PubMed:23229899). Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect (PubMed:25380825). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25380825, ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:26571211, ECO:0000305}.FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:10449719, ECO:0000269|PubMed:12954634, ECO:0000269|PubMed:7481822, ECO:0000269|PubMed:9223281, ECO:0000269|PubMed:9223431, ECO:0000269|PubMed:9296499, ECO:0000269|PubMed:9427757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCOA1chr2:25367920chr2:24962301ENST0000028859914221435_143910672199.3333333333335MotifNote=LXXLL motif 7
TgeneNCOA1chr2:25367920chr2:24962301ENST0000034833214211435_143910671442.0MotifNote=LXXLL motif 7
TgeneNCOA1chr2:25367920chr2:24962301ENST0000039585614211435_143910671441.0MotifNote=LXXLL motif 7
TgeneNCOA1chr2:25367920chr2:24962301ENST0000040514117251435_143910672183.6666666666665MotifNote=LXXLL motif 7
TgeneNCOA1chr2:25367920chr2:24962301ENST0000040696116231435_143910671442.0MotifNote=LXXLL motif 7
TgeneNCOA1chr2:25367920chr2:24962301ENST0000053853915231435_143910671422.6666666666667MotifNote=LXXLL motif 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNCOA1chr2:25367920chr2:24962301ENST0000028859914221053_113810672199.3333333333335Compositional biasNote=Gln-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422389_68210672199.3333333333335Compositional biasNote=Ser-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST0000034833214211053_113810671442.0Compositional biasNote=Gln-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421389_68210671442.0Compositional biasNote=Ser-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST0000039585614211053_113810671441.0Compositional biasNote=Gln-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421389_68210671441.0Compositional biasNote=Ser-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST0000040514117251053_113810672183.6666666666665Compositional biasNote=Gln-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725389_68210672183.6666666666665Compositional biasNote=Ser-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST0000040696116231053_113810671442.0Compositional biasNote=Gln-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623389_68210671442.0Compositional biasNote=Ser-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST0000053853915231053_113810671422.6666666666667Compositional biasNote=Gln-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523389_68210671422.6666666666667Compositional biasNote=Ser-rich
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422109_18010672199.3333333333335DomainPAS
TgeneNCOA1chr2:25367920chr2:24962301ENST00000288599142223_8010672199.3333333333335DomainbHLH
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421109_18010671442.0DomainPAS
TgeneNCOA1chr2:25367920chr2:24962301ENST00000348332142123_8010671442.0DomainbHLH
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421109_18010671441.0DomainPAS
TgeneNCOA1chr2:25367920chr2:24962301ENST00000395856142123_8010671441.0DomainbHLH
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725109_18010672183.6666666666665DomainPAS
TgeneNCOA1chr2:25367920chr2:24962301ENST00000405141172523_8010672183.6666666666665DomainbHLH
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623109_18010671442.0DomainPAS
TgeneNCOA1chr2:25367920chr2:24962301ENST00000406961162323_8010671442.0DomainbHLH
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523109_18010671422.6666666666667DomainPAS
TgeneNCOA1chr2:25367920chr2:24962301ENST00000538539152323_8010671422.6666666666667DomainbHLH
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422112_11610672199.3333333333335MotifNote=LXXLL motif 2
TgeneNCOA1chr2:25367920chr2:24962301ENST00000288599142246_5010672199.3333333333335MotifNote=LXXLL motif 1
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422633_63710672199.3333333333335MotifNote=LXXLL motif 3
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422690_69410672199.3333333333335MotifNote=LXXLL motif 4
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422749_75310672199.3333333333335MotifNote=LXXLL motif 5
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422913_91710672199.3333333333335MotifNote=LXXLL motif 6
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421112_11610671442.0MotifNote=LXXLL motif 2
TgeneNCOA1chr2:25367920chr2:24962301ENST00000348332142146_5010671442.0MotifNote=LXXLL motif 1
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421633_63710671442.0MotifNote=LXXLL motif 3
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421690_69410671442.0MotifNote=LXXLL motif 4
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421749_75310671442.0MotifNote=LXXLL motif 5
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421913_91710671442.0MotifNote=LXXLL motif 6
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421112_11610671441.0MotifNote=LXXLL motif 2
TgeneNCOA1chr2:25367920chr2:24962301ENST00000395856142146_5010671441.0MotifNote=LXXLL motif 1
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421633_63710671441.0MotifNote=LXXLL motif 3
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421690_69410671441.0MotifNote=LXXLL motif 4
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421749_75310671441.0MotifNote=LXXLL motif 5
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421913_91710671441.0MotifNote=LXXLL motif 6
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725112_11610672183.6666666666665MotifNote=LXXLL motif 2
TgeneNCOA1chr2:25367920chr2:24962301ENST00000405141172546_5010672183.6666666666665MotifNote=LXXLL motif 1
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725633_63710672183.6666666666665MotifNote=LXXLL motif 3
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725690_69410672183.6666666666665MotifNote=LXXLL motif 4
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725749_75310672183.6666666666665MotifNote=LXXLL motif 5
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725913_91710672183.6666666666665MotifNote=LXXLL motif 6
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623112_11610671442.0MotifNote=LXXLL motif 2
TgeneNCOA1chr2:25367920chr2:24962301ENST00000406961162346_5010671442.0MotifNote=LXXLL motif 1
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623633_63710671442.0MotifNote=LXXLL motif 3
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623690_69410671442.0MotifNote=LXXLL motif 4
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623749_75310671442.0MotifNote=LXXLL motif 5
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623913_91710671442.0MotifNote=LXXLL motif 6
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523112_11610671422.6666666666667MotifNote=LXXLL motif 2
TgeneNCOA1chr2:25367920chr2:24962301ENST00000538539152346_5010671422.6666666666667MotifNote=LXXLL motif 1
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523633_63710671422.6666666666667MotifNote=LXXLL motif 3
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523690_69410671422.6666666666667MotifNote=LXXLL motif 4
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523749_75310671422.6666666666667MotifNote=LXXLL motif 5
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523913_91710671422.6666666666667MotifNote=LXXLL motif 6


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Fusion Gene Sequence for EFR3B-NCOA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25408_25408_1_EFR3B-NCOA1_EFR3B_chr2_25367920_ENST00000402191_NCOA1_chr2_24962301_ENST00000406961_length(transcript)=5775nt_BP=2339nt
GTGCGCGCGCGTCTGCGCTGCGAGGACAAAGATGCCTCGGGCCGGGGACCCTGGGGTCCTCTCCAGGCCCGGCGCGTGCCGGTGCTGGGC
GGTGGTCCTTCGGGGGGCGGAGGCTCAGGGGAAAGCGGGTCTCCCGGAGCCGAGCAGACCGGGAGTGCTGGAGGAGGTGGTCGTGTGGCA
GCATTTGCGGAATTAACAAAAGCGGTGTGTGTGGCTGCTGTGGTGCCCTACGCCCCAGGTACAAAAGGCTGGTTGACAACATCTTCCCTG
AGGATCCCGAGGATGGTCTGGTGAAGACCAACATGGAGAAGCTGACCTTCTATGCCCTCTCAGCTCCAGAAAAACTTGATCGTATTGGCG
CCTACCTCTCTGAGAGGCTCATCCGTGACGTGGGTCGCCATCGATATGGGTACGTGTGCATTGCTATGGAGGCTTTGGACCAGCTGCTCA
TGGCCTGCCACTGCCAGAGCATCAACCTCTTCGTGGAGAGCTTCCTCAAGATGGTGGCCAAGCTGCTGGAGTCAGAGAAACCCAACCTGC
AGATCCTCGGCACCAACTCGTTTGTGAAGTTTGCCAACATCGAGGAGGACACCCCGTCCTATCACCGGAGCTATGACTTCTTTGTGTCCC
GATTCAGTGAAATGTGCCACTCGAGCCATGATGACTTAGAAATCAAGACCAAAATTCGAATGTCAGGCATCAAAGGCCTGCAAGGGGTGG
TGAGGAAGACGGTGAATGATGAACTGCAGGCCAATATCTGGGACCCACAGCACATGGATAAGATCGTTCCATCACTGCTTTTCAATCTAC
AGCATGTAGAGGAGGCAGAGAGCCGGTCTCCCTCACCCCTCCAAGCACCTGAGAAGGAGAAAGAGAGCCCCGCGGAGCTGGCTGAGAGGT
GTCTTCGGGAGCTGCTGGGCCGGGCTGCCTTTGGCAACATCAAAAACGCCATCAAGCCTGTTCTCATCCATCTGGATAACCATTCTCTTT
GGGAACCCAAGGTGTTTGCCATCCGTTGCTTTAAAATCATCATGTACTCAATTCAGCCGCAGCACTCACACCTGGTCATCCAGCAGCTCC
TGGGCCACCTGGACGCCAACAGCCGCAGCGCTGCGACGGTGCGCGCGGGCATCGTGGAAGTCTTGTCGGAAGCCGCGGTCATCGCTGCCA
CCGGCTCTGTGGGGCCCACAGTACTGGAGATGTTCAACACGCTGCTGAGGCAGCTGCGGCTCAGCATCGACTACGCGCTGACCGGGAGCT
ACGACGGGGCGGTCAGCCTCGGCACCAAGATCATCAAGGAGCACGAGGAGCGCATGTTCCAGGAGGCCGTCATCAAGACCGTGGGCTCCT
TTGCCAGCACGCTGCCCACCTACCAGCGCTCCGAGGTGATCCTCTTCATCATGAGCAAGGTCCCGCGGCCATCCCTGCACCAGGCGGTGG
ACACAGGCAGGACGGGGGAGAATAGGAACCGTCTGACCCAGATTATGCTGCTAAAATCCCTCCTGCAGGTATCCACAGGTTTCCAGTGCA
ACAACATGATGTCAGCCCTGCCTAGCAACTTCCTGGACCGCCTTCTCTCCACCGCCCTCATGGAGGATGCAGAAATTCGACTCTTTGTTC
TAGAGATTCTCATCAGTTTCATTGATCGTCATGGCAACCGCCACAAGTTCTCTACCATCAGTACCCTCAGTGACATCTCTGTCCTGAAGC
TGAAAGTGGACAAGTGCTCTCGACAGGACACCGTCTTCATGAAGAAGCACTCCCAGCAGCTCTACAGACACATCTACCTGAGCTGCAAGG
AGGAAACAAACGTGCAGAAACACTACGAGGCGCTCTATGGCTTGCTGGCCCTCATCAGCATCGAGCTGGCTAACGAGGAGGTGGTGGTGG
ACCTCATCCGTCTGGTGCTGGCTGTTCAGGACGTGGCCCAAGTCAATGAGGAGAACTTGCCTGTCTACAACCGCTGTGCCCTCTATGCTC
TGGGCGCAGCCTACCTGAACCTCATCAGTCAGCTCACAACAGTGCCTGCCTTCTGCCAGCACATCCATGAGGTGATAGAGACCAGGAAGA
AAGAGGCTCCATACATGCTCCCCGAGGATGTGTTTGTGGAGAGGCCCAGGCTGTCTCAGAATCTTGATGGGGTGGTCATTGAGCTCCTCT
TCCGCCAGAGCAAGATCAGTGAAGTCCTGGGAGGCAGTGGCTACAACTCGGACCGGCTCTGCCTGCCCTACATTCCTCAGCTGACAGATG
AGGATCGTTTATCCAAGAGGAGGAGCATTGGAGAGACCATCTCCCTGCAGGTGGAGGTAGAATCGAGGAACAGTCCGGAGAAGGAGGAGT
TGATACACCAAAATCGGCAAGCTATCTTAAACCAGTTTGCAGCAACTGCTCCTGTTGGCATCAATATGAGATCAGGCATGCAACAGCAAA
TTACACCTCAGCCACCCCTGAATGCTCAAATGTTGGCACAACGTCAGCGGGAACTGTACAGTCAACAGCACCGACAGAGGCAGCTAATAC
AGCAGCAAAGAGCCATGCTTATGAGGCAGCAAAGCTTTGGGAACAACCTCCCTCCCTCATCTGGACTACCAGTTCAAATGGGGAACCCCC
GTCTTCCTCAGGGTGCTCCACAGCAATTCCCCTATCCACCAAACTATGGTACAAATCCAGGAACCCCACCTGCTTCTACCAGCCCGTTTT
CACAACTAGCAGCAAATCCTGAAGCATCCTTGGCCAACCGCAACAGCATGGTGAGCAGAGGCATGACAGGAAACATAGGAGGACAGTTTG
GCACTGGAATCAATCCTCAGATGCAGCAGAATGTCTTCCAGTATCCAGGAGCAGGAATGGTTCCCCAAGGTGAGGCCAACTTTGCTCCAT
CTCTAAGCCCTGGGAGCTCCATGGTGCCGATGCCAATCCCTCCTCCTCAGAGTTCTCTTCTCCAGCAAACTCCACCTGCCTCCGGGTATC
AGTCACCAGACATGAAGGCCTGGCAGCAAGGAGCGATAGGAAACAACAATGTGTTCAGTCAAGCTGTCCAGAACCAGCCCACGCCTGCAC
AGCCAGGAGTATACAACAACATGAGCATCACCGTTTCCATGGCAGGTGGAAATACGAATGTTCAGAACATGAACCCAATGATGGCCCAGA
TGCAGATGAGCTCTTTGCAGATGCCAGGAATGAACACTGTGTGCCCTGAGCAGATAAATGATCCCGCACTGAGACACACAGGCCTCTACT
GCAACCAGCTCTCATCCACTGACCTTCTCAAAACAGAAGCAGATGGAACCCAGCAGGTGCAACAGGTTCAGGTGTTTGCTGACGTCCAGT
GTACAGTGAATCTGGTAGGCGGGGACCCTTACCTGAACCAGCCTGGTCCACTGGGAACTCAAAAGCCCACGTCAGGACCACAGACCCCCC
AGGCCCAGCAGAAGAGCCTCCTTCAGCAGCTACTGACTGAATAACCACTTTTAAAGGAATGTGAAATTTAAATAATAGACATACAGAGAT
ATACAAATATATTATATATTTTTCTGAGATTTTTGATATCTCAATCTGCAGCCATTCTTCAGGTCGTAGCATTTGGAGCAAAAAAAAAAA
AAAAAAAAAAAAAAGGAGTTTGCTTTTGTCGGGAGATTGAAAGATGTTTTTGTTTCTTTCTTTGTAAAGGCCTTGGATATTGAAAAAATA
CCAAGGCAGAACAGTTGGACAATCTATTTCTTGAGCCAAATTTAATTATTCTTATTTTTGTAATCAGTCATTGGCTTCTTATCTGGATGA
AGGCTTTTGGAGGAGAACCAAAACGACAAGTTCCAAGAAGAAGATGAAGCTCCGCCTCCGCCGCTTAGTCCCAACCCTGCCCAGGAAGAA
GGGCCCGTGGGGCTTTGCCTGTGCCCGTCCACCAAAGGCTGTCATGTGTCTCGAAATCAGCAGCCCTCCCCATCCCAATCCCAGGCAGCT
TGTGTGTACAATCAGCTTCTCTAGCAACTCTGTATCTGTTGGCTTCAAGAGAATATTTTGCCTCCACATATGTACCCCTTCTCCTTTTTT
TAAAGATGGATTTAAACCAAGATGCCTCCAGGAAAGAGGACGAAATGAGTATATTCACAGAGGAATCCAAAAAATACAGTTTGGGGGAAA
ATGCAATAATTTTTGATGAGATGGGTGAAGGACAAGAAGTGAGTTGTGTCAATTATTGTAGATACAATTTTCTGATTAAATCTGGAAAAA
TAAAAGGCAGCCTGTTTTTTCTGCTTTTATTGTATTAACAGCTGAGGTAGCTAAAGTTATTTAAAATAAAATTAAATTTATGATCCAAGT
AGCTTATTTTTCCCTTTAAATCTCATTGTAAATATATTTGATTTCTTGTAGAAATTGATTTCCTTCTGTTTAATTTTATGCTTTTATTAT
ACTCTTGATTTTTCTAAATTTGTGTGTGAAATATAACATTGATTGAATTGCAGTTACATTTGGTTAGTAATATTTCATTATTTTAATAAC
TGTGATGTCATGTATGGATTTACTTTGGGGTTCAAATCAAAATGTCACTGCCAGAAAGAGCTGTTCCAGCTGATCTAGAGCATACTGCCC
TAGAGTGTCCCTGGGATCATCTGAACAGAAGTGCACAGGCTACTTGTACAGAGAAAAAATTAATACTCAAAGGAAATCTTCATTTTTTAG
ATTGACTTTGGGAATTTGAATTTTCATCAGTGCAAATATAAATTTCTCTATCCTGCTCTGAGGCTAATTGGTACCATATTTTCCCTTTGT
GTCTTGTGACTCTGCCACATCCCATCTCATCCTGGCCTCTGAGTCAAGAACCCAGTGAACTGACTTTCTAGTTCTAGAAGTTCCGCTGCA
AGGCCAGGAAAGCTTGAGAAAGGTATTGTGGAAGAAGCAAAGGTAGACCCCCATCACTCACCTTTGTCTGCATCCCTGGGCCTGTGAATG
ATGACAGCACCTGACATTCTGCACCAGCTACCTCTGCCTCCATGGCAGAGAAAAGGCCATAAGAACAGTGGAAGAGGAGCATGGACTCAG
ACTTCAAGGAAGAAGCCATTTCCCCAGGTCCTTCCTTCTGCATCTCACCACCCCTAGTTACAAATAACTCCATTGAACAGCATCTATTCA
GAAACTATGCCGAATAAAAAGATTGGTGGAAGGGCTCATGTGGTTAGCAACTATGAAACAGAAATAGGACACTCAGTTACAAACATTATC
TCCTTTAGTTTTTCAGAAAATGCATCCCTGATTTCATTCATTTCCAGCTTGAAAGCCAGCCATATTACTCTAGTCCCTACCAAACTGCTC
TAGAAGGTCATTTCCATTTTGTTTGTGATATTTAGACGCGCAGACTTCAGGAAGTTCACCTTTAACTTCAGCATTCCAGATGAAGTTTCC
TGACTCAGTGCTTTTGCATAAGGAACTAGAAAAAAAAAGTAAGGAAAATTGGAGATGCTAACATCCTCCCCCATCCCAACTGCACCTTAA
AATATGCATGTCACCTTCAAGGTTTTATAATTGCACTGTTTGTTTTATGTATGTACAGATTAAAATTATTGCTACATTTGAGGAAAATAA
AATTGCTTGCTTCTATGTAATTCCTGTCATTCCACAGGAAATTCACTTTTCCAGCTACTGAATAGAATTTGTTTAACAACCTCATGGGTT
GCCTCTTCATTTACAGGGAAGAAATGAAATGTACATCTGCAGAAATTGCCAAAGCCCAAATTAACGAGTATTATAAAAGGATAATAAAGC

>25408_25408_1_EFR3B-NCOA1_EFR3B_chr2_25367920_ENST00000402191_NCOA1_chr2_24962301_ENST00000406961_length(amino acids)=1148AA_BP=774
MRGQRCLGPGTLGSSPGPARAGAGRWSFGGRRLRGKRVSRSRADRECWRRWSCGSICGINKSGVCGCCGALRPRYKRLVDNIFPEDPEDG
LVKTNMEKLTFYALSAPEKLDRIGAYLSERLIRDVGRHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVAKLLESEKPNLQILGTN
SFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEA
ESRSPSPLQAPEKEKESPAELAERCLRELLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDA
NSRSAATVRAGIVEVLSEAAVIAATGSVGPTVLEMFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLP
TYQRSEVILFIMSKVPRPSLHQAVDTGRTGENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILIS
FIDRHGNRHKFSTISTLSDISVLKLKVDKCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDLIRLV
LAVQDVAQVNEENLPVYNRCALYALGAAYLNLISQLTTVPAFCQHIHEVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKI
SEVLGGSGYNSDRLCLPYIPQLTDEDRLSKRRSIGETISLQVEVESRNSPEKEELIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPP
LNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAAN
PEASLANRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMK
AWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSS

--------------------------------------------------------------
>25408_25408_2_EFR3B-NCOA1_EFR3B_chr2_25367920_ENST00000403714_NCOA1_chr2_24962301_ENST00000406961_length(transcript)=5761nt_BP=2325nt
GCTGGCGGCGCCCGGCTCCGTCCTGCCCGCGGCCGGCCCCCGCGTCTGCTCCCTCCCCGCCCGGGCCCCTGTCGGCCGCCGCCAGTCCCC
GCCCCGACTGTGAATGAAAGGCGGGCGCCGCCGAGGGCTGGCTGGGAACGCCGCAGCGACGCCGGCCTCTCGAGAGGCGCGCGCCCCGCC
GAGATGTACGGTGTGTGTGGCTGCTGTGGTGCCCTACGCCCCAGGTACAAAAGGCTGGTTGACAACATCTTCCCTGAGGATCCCGAGGAT
GGTCTGGTGAAGACCAACATGGAGAAGCTGACCTTCTATGCCCTCTCAGCTCCAGAAAAACTTGATCGTATTGGCGCCTACCTCTCTGAG
AGGCTCATCCGTGACGTGGGTCGCCATCGATATGGGTACGTGTGCATTGCTATGGAGGCTTTGGACCAGCTGCTCATGGCCTGCCACTGC
CAGAGCATCAACCTCTTCGTGGAGAGCTTCCTCAAGATGGTGGCCAAGCTGCTGGAGTCAGAGAAACCCAACCTGCAGATCCTCGGCACC
AACTCGTTTGTGAAGTTTGCCAACATCGAGGAGGACACCCCGTCCTATCACCGGAGCTATGACTTCTTTGTGTCCCGATTCAGTGAAATG
TGCCACTCGAGCCATGATGACTTAGAAATCAAGACCAAAATTCGAATGTCAGGCATCAAAGGCCTGCAAGGGGTGGTGAGGAAGACGGTG
AATGATGAACTGCAGGCCAATATCTGGGACCCACAGCACATGGATAAGATCGTTCCATCACTGCTTTTCAATCTACAGCATGTAGAGGAG
GCAGAGAGCCGGTCTCCCTCACCCCTCCAAGCACCTGAGAAGGAGAAAGAGAGCCCCGCGGAGCTGGCTGAGAGGTGTCTTCGGGAGCTG
CTGGGCCGGGCTGCCTTTGGCAACATCAAAAACGCCATCAAGCCTGTTCTCATCCATCTGGATAACCATTCTCTTTGGGAACCCAAGGTG
TTTGCCATCCGTTGCTTTAAAATCATCATGTACTCAATTCAGCCGCAGCACTCACACCTGGTCATCCAGCAGCTCCTGGGCCACCTGGAC
GCCAACAGCCGCAGCGCTGCGACGGTGCGCGCGGGCATCGTGGAAGTCTTGTCGGAAGCCGCGGTCATCGCTGCCACCGGCTCTGTGGGG
CCCACAGTACTGGAGATGTTCAACACGCTGCTGAGGCAGCTGCGGCTCAGCATCGACTACGCGCTGACCGGGAGCTACGACGGGGCGGTC
AGCCTCGGCACCAAGATCATCAAGGAGCACGAGGAGCGCATGTTCCAGGAGGCCGTCATCAAGACCGTGGGCTCCTTTGCCAGCACGCTG
CCCACCTACCAGCGCTCCGAGGTGATCCTCTTCATCATGAGCAAGGTCCCGCGGCCATCCCTGCACCAGGCGGTGGACACAGGCAGGACG
GGGGAGAATAGGAACCGTCTGACCCAGATTATGCTGCTAAAATCCCTCCTGCAGGTATCCACAGGTTTCCAGTGCAACAACATGATGTCA
GCCCTGCCTAGCAACTTCCTGGACCGCCTTCTCTCCACCGCCCTCATGGAGGATGCAGAAATTCGACTCTTTGTTCTAGAGATTCTCATC
AGTTTCATTGATCGTCATGGCAACCGCCACAAGTTCTCTACCATCAGTACCCTCAGTGACATCTCTGTCCTGAAGCTGAAAGTGGACAAG
TGCTCTCGACAGGACACCGTCTTCATGAAGAAGCACTCCCAGCAGCTCTACAGACACATCTACCTGAGCTGCAAGGAGGAAACAAACGTG
CAGAAACACTACGAGGCGCTCTATGGCTTGCTGGCCCTCATCAGCATCGAGCTGGCTAACGAGGAGGTGGTGGTGGACCTCATCCGTCTG
GTGCTGGCTGTTCAGGACGTGGCCCAAGTCAATGAGGAGAACTTGCCTGTCTACAACCGCTGTGCCCTCTATGCTCTGGGCGCAGCCTAC
CTGAACCTCATCAGTCAGCTCACAACAGTGCCTGCCTTCTGCCAGCACATCCATGAGGTGATAGAGACCAGGAAGAAAGAGGCTCCATAC
ATGCTCCCCGAGGATGTGTTTGTGGAGAGGCCCAGGCTGTCTCAGAATCTTGATGGGGTGGTCATTGAGCTCCTCTTCCGCCAGAGCAAG
ATCAGTGAAGTCCTGGGAGGCAGTGGCTACAACTCGGACCGGCTCTGCCTGCCCTACATTCCTCAGCTGACAGATGAGGATCGTTTATCC
AAGAGGAGGAGCATTGGAGAGACCATCTCCCTGCAGGTGGAGGTAGAATCGAGGAACAGTCCGGAGAAGGAGGAGTTGATACACCAAAAT
CGGCAAGCTATCTTAAACCAGTTTGCAGCAACTGCTCCTGTTGGCATCAATATGAGATCAGGCATGCAACAGCAAATTACACCTCAGCCA
CCCCTGAATGCTCAAATGTTGGCACAACGTCAGCGGGAACTGTACAGTCAACAGCACCGACAGAGGCAGCTAATACAGCAGCAAAGAGCC
ATGCTTATGAGGCAGCAAAGCTTTGGGAACAACCTCCCTCCCTCATCTGGACTACCAGTTCAAATGGGGAACCCCCGTCTTCCTCAGGGT
GCTCCACAGCAATTCCCCTATCCACCAAACTATGGTACAAATCCAGGAACCCCACCTGCTTCTACCAGCCCGTTTTCACAACTAGCAGCA
AATCCTGAAGCATCCTTGGCCAACCGCAACAGCATGGTGAGCAGAGGCATGACAGGAAACATAGGAGGACAGTTTGGCACTGGAATCAAT
CCTCAGATGCAGCAGAATGTCTTCCAGTATCCAGGAGCAGGAATGGTTCCCCAAGGTGAGGCCAACTTTGCTCCATCTCTAAGCCCTGGG
AGCTCCATGGTGCCGATGCCAATCCCTCCTCCTCAGAGTTCTCTTCTCCAGCAAACTCCACCTGCCTCCGGGTATCAGTCACCAGACATG
AAGGCCTGGCAGCAAGGAGCGATAGGAAACAACAATGTGTTCAGTCAAGCTGTCCAGAACCAGCCCACGCCTGCACAGCCAGGAGTATAC
AACAACATGAGCATCACCGTTTCCATGGCAGGTGGAAATACGAATGTTCAGAACATGAACCCAATGATGGCCCAGATGCAGATGAGCTCT
TTGCAGATGCCAGGAATGAACACTGTGTGCCCTGAGCAGATAAATGATCCCGCACTGAGACACACAGGCCTCTACTGCAACCAGCTCTCA
TCCACTGACCTTCTCAAAACAGAAGCAGATGGAACCCAGCAGGTGCAACAGGTTCAGGTGTTTGCTGACGTCCAGTGTACAGTGAATCTG
GTAGGCGGGGACCCTTACCTGAACCAGCCTGGTCCACTGGGAACTCAAAAGCCCACGTCAGGACCACAGACCCCCCAGGCCCAGCAGAAG
AGCCTCCTTCAGCAGCTACTGACTGAATAACCACTTTTAAAGGAATGTGAAATTTAAATAATAGACATACAGAGATATACAAATATATTA
TATATTTTTCTGAGATTTTTGATATCTCAATCTGCAGCCATTCTTCAGGTCGTAGCATTTGGAGCAAAAAAAAAAAAAAAAAAAAAAAAA
GGAGTTTGCTTTTGTCGGGAGATTGAAAGATGTTTTTGTTTCTTTCTTTGTAAAGGCCTTGGATATTGAAAAAATACCAAGGCAGAACAG
TTGGACAATCTATTTCTTGAGCCAAATTTAATTATTCTTATTTTTGTAATCAGTCATTGGCTTCTTATCTGGATGAAGGCTTTTGGAGGA
GAACCAAAACGACAAGTTCCAAGAAGAAGATGAAGCTCCGCCTCCGCCGCTTAGTCCCAACCCTGCCCAGGAAGAAGGGCCCGTGGGGCT
TTGCCTGTGCCCGTCCACCAAAGGCTGTCATGTGTCTCGAAATCAGCAGCCCTCCCCATCCCAATCCCAGGCAGCTTGTGTGTACAATCA
GCTTCTCTAGCAACTCTGTATCTGTTGGCTTCAAGAGAATATTTTGCCTCCACATATGTACCCCTTCTCCTTTTTTTAAAGATGGATTTA
AACCAAGATGCCTCCAGGAAAGAGGACGAAATGAGTATATTCACAGAGGAATCCAAAAAATACAGTTTGGGGGAAAATGCAATAATTTTT
GATGAGATGGGTGAAGGACAAGAAGTGAGTTGTGTCAATTATTGTAGATACAATTTTCTGATTAAATCTGGAAAAATAAAAGGCAGCCTG
TTTTTTCTGCTTTTATTGTATTAACAGCTGAGGTAGCTAAAGTTATTTAAAATAAAATTAAATTTATGATCCAAGTAGCTTATTTTTCCC
TTTAAATCTCATTGTAAATATATTTGATTTCTTGTAGAAATTGATTTCCTTCTGTTTAATTTTATGCTTTTATTATACTCTTGATTTTTC
TAAATTTGTGTGTGAAATATAACATTGATTGAATTGCAGTTACATTTGGTTAGTAATATTTCATTATTTTAATAACTGTGATGTCATGTA
TGGATTTACTTTGGGGTTCAAATCAAAATGTCACTGCCAGAAAGAGCTGTTCCAGCTGATCTAGAGCATACTGCCCTAGAGTGTCCCTGG
GATCATCTGAACAGAAGTGCACAGGCTACTTGTACAGAGAAAAAATTAATACTCAAAGGAAATCTTCATTTTTTAGATTGACTTTGGGAA
TTTGAATTTTCATCAGTGCAAATATAAATTTCTCTATCCTGCTCTGAGGCTAATTGGTACCATATTTTCCCTTTGTGTCTTGTGACTCTG
CCACATCCCATCTCATCCTGGCCTCTGAGTCAAGAACCCAGTGAACTGACTTTCTAGTTCTAGAAGTTCCGCTGCAAGGCCAGGAAAGCT
TGAGAAAGGTATTGTGGAAGAAGCAAAGGTAGACCCCCATCACTCACCTTTGTCTGCATCCCTGGGCCTGTGAATGATGACAGCACCTGA
CATTCTGCACCAGCTACCTCTGCCTCCATGGCAGAGAAAAGGCCATAAGAACAGTGGAAGAGGAGCATGGACTCAGACTTCAAGGAAGAA
GCCATTTCCCCAGGTCCTTCCTTCTGCATCTCACCACCCCTAGTTACAAATAACTCCATTGAACAGCATCTATTCAGAAACTATGCCGAA
TAAAAAGATTGGTGGAAGGGCTCATGTGGTTAGCAACTATGAAACAGAAATAGGACACTCAGTTACAAACATTATCTCCTTTAGTTTTTC
AGAAAATGCATCCCTGATTTCATTCATTTCCAGCTTGAAAGCCAGCCATATTACTCTAGTCCCTACCAAACTGCTCTAGAAGGTCATTTC
CATTTTGTTTGTGATATTTAGACGCGCAGACTTCAGGAAGTTCACCTTTAACTTCAGCATTCCAGATGAAGTTTCCTGACTCAGTGCTTT
TGCATAAGGAACTAGAAAAAAAAAGTAAGGAAAATTGGAGATGCTAACATCCTCCCCCATCCCAACTGCACCTTAAAATATGCATGTCAC
CTTCAAGGTTTTATAATTGCACTGTTTGTTTTATGTATGTACAGATTAAAATTATTGCTACATTTGAGGAAAATAAAATTGCTTGCTTCT
ATGTAATTCCTGTCATTCCACAGGAAATTCACTTTTCCAGCTACTGAATAGAATTTGTTTAACAACCTCATGGGTTGCCTCTTCATTTAC
AGGGAAGAAATGAAATGTACATCTGCAGAAATTGCCAAAGCCCAAATTAACGAGTATTATAAAAGGATAATAAAGCATCCCTGAAGCCAA

>25408_25408_2_EFR3B-NCOA1_EFR3B_chr2_25367920_ENST00000403714_NCOA1_chr2_24962301_ENST00000406961_length(amino acids)=1134AA_BP=760
MLPPRPGPCRPPPVPAPTVNERRAPPRAGWERRSDAGLSRGARPAEMYGVCGCCGALRPRYKRLVDNIFPEDPEDGLVKTNMEKLTFYAL
SAPEKLDRIGAYLSERLIRDVGRHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKMVAKLLESEKPNLQILGTNSFVKFANIEEDTPS
YHRSYDFFVSRFSEMCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPLQAPEKE
KESPAELAERCLRELLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDANSRSAATVRAGIVE
VLSEAAVIAATGSVGPTVLEMFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLPTYQRSEVILFIMSK
VPRPSLHQAVDTGRTGENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILISFIDRHGNRHKFSTI
STLSDISVLKLKVDKCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDLIRLVLAVQDVAQVNEENL
PVYNRCALYALGAAYLNLISQLTTVPAFCQHIHEVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKISEVLGGSGYNSDRL
CLPYIPQLTDEDRLSKRRSIGETISLQVEVESRNSPEKEELIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELY
SQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSR
GMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFS
QAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQV

--------------------------------------------------------------
>25408_25408_3_EFR3B-NCOA1_EFR3B_chr2_25367920_ENST00000405108_NCOA1_chr2_24962301_ENST00000406961_length(transcript)=5331nt_BP=1895nt
GCAAATAAGCTTTACTACAACCATATCTGAAATGTGTTTTCCTGATCAAGTGGGATGGGAAAGAACAGTGAGTGGAGTCCCAGGCATGTT
AAGAATGGCGTGCTGTTTTTTAAGTGTTTGTGAAGTTTGCCAACATCGAGGAGGACACCCCGTCCTATCACCGGAGCTATGACTTCTTTG
TGTCCCGATTCAGTGAAATGTGCCACTCGAGCCATGATGACTTAGAAATCAAGACCAAAATTCGAATGTCAGGCATCAAAGGCCTGCAAG
GGGTGGTGAGGAAGACGGTGAATGATGAACTGCAGGCCAATATCTGGGACCCACAGCACATGGATAAGATCGTTCCATCACTGCTTTTCA
ATCTACAGCATGTAGAGGAGGCAGAGAGCCGGTCTCCCTCACCCCTCCAAGCACCTGAGAAGGAGAAAGAGAGCCCCGCGGAGCTGGCTG
AGAGGTGTCTTCGGGAGCTGCTGGGCCGGGCTGCCTTTGGCAACATCAAAAACGCCATCAAGCCTGTTCTCATCCATCTGGATAACCATT
CTCTTTGGGAACCCAAGGTGTTTGCCATCCGTTGCTTTAAAATCATCATGTACTCAATTCAGCCGCAGCACTCACACCTGGTCATCCAGC
AGCTCCTGGGCCACCTGGACGCCAACAGCCGCAGCGCTGCGACGGTGCGCGCGGGCATCGTGGAAGTCTTGTCGGAAGCCGCGGTCATCG
CTGCCACCGGCTCTGTGGGGCCCACAGTACTGGAGATGTTCAACACGCTGCTGAGGCAGCTGCGGCTCAGCATCGACTACGCGCTGACCG
GGAGCTACGACGGGGCGGTCAGCCTCGGCACCAAGATCATCAAGGAGCACGAGGAGCGCATGTTCCAGGAGGCCGTCATCAAGACCGTGG
GCTCCTTTGCCAGCACGCTGCCCACCTACCAGCGCTCCGAGGTGATCCTCTTCATCATGAGCAAGGTCCCGCGGCCATCCCTGCACCAGG
CGGTGGACACAGGCAGGACGGGGGAGAATAGGAACCGTCTGACCCAGATTATGCTGCTAAAATCCCTCCTGCAGGTATCCACAGGTTTCC
AGTGCAACAACATGATGTCAGCCCTGCCTAGCAACTTCCTGGACCGCCTTCTCTCCACCGCCCTCATGGAGGATGCAGAAATTCGACTCT
TTGTTCTAGAGATTCTCATCAGTTTCATTGATCGTCATGGCAACCGCCACAAGTTCTCTACCATCAGTACCCTCAGTGACATCTCTGTCC
TGAAGCTGAAAGTGGACAAGTGCTCTCGACAGGACACCGTCTTCATGAAGAAGCACTCCCAGCAGCTCTACAGACACATCTACCTGAGCT
GCAAGGAGGAAACAAACGTGCAGAAACACTACGAGGCGCTCTATGGCTTGCTGGCCCTCATCAGCATCGAGCTGGCTAACGAGGAGGTGG
TGGTGGACCTCATCCGTCTGGTGCTGGCTGTTCAGGACGTGGCCCAAGTCAATGAGGAGAACTTGCCTGTCTACAACCGCTGTGCCCTCT
ATGCTCTGGGCGCAGCCTACCTGAACCTCATCAGTCAGCTCACAACAGTGCCTGCCTTCTGCCAGCACATCCATGAGGTGATAGAGACCA
GGAAGAAAGAGGCTCCATACATGCTCCCCGAGGATGTGTTTGTGGAGAGGCCCAGGCTGTCTCAGAATCTTGATGGGGTGGTCATTGAGC
TCCTCTTCCGCCAGAGCAAGATCAGTGAAGTCCTGGGAGGCAGTGGCTACAACTCGGACCGGCTCTGCCTGCCCTACATTCCTCAGCTGA
CAGATGAGGATCGTTTATCCAAGAGGAGGAGCATTGGAGAGACCATCTCCCTGCAGGTGGAGGTAGAATCGAGGAACAGTCCGGAGAAGG
AGGAGTTGATACACCAAAATCGGCAAGCTATCTTAAACCAGTTTGCAGCAACTGCTCCTGTTGGCATCAATATGAGATCAGGCATGCAAC
AGCAAATTACACCTCAGCCACCCCTGAATGCTCAAATGTTGGCACAACGTCAGCGGGAACTGTACAGTCAACAGCACCGACAGAGGCAGC
TAATACAGCAGCAAAGAGCCATGCTTATGAGGCAGCAAAGCTTTGGGAACAACCTCCCTCCCTCATCTGGACTACCAGTTCAAATGGGGA
ACCCCCGTCTTCCTCAGGGTGCTCCACAGCAATTCCCCTATCCACCAAACTATGGTACAAATCCAGGAACCCCACCTGCTTCTACCAGCC
CGTTTTCACAACTAGCAGCAAATCCTGAAGCATCCTTGGCCAACCGCAACAGCATGGTGAGCAGAGGCATGACAGGAAACATAGGAGGAC
AGTTTGGCACTGGAATCAATCCTCAGATGCAGCAGAATGTCTTCCAGTATCCAGGAGCAGGAATGGTTCCCCAAGGTGAGGCCAACTTTG
CTCCATCTCTAAGCCCTGGGAGCTCCATGGTGCCGATGCCAATCCCTCCTCCTCAGAGTTCTCTTCTCCAGCAAACTCCACCTGCCTCCG
GGTATCAGTCACCAGACATGAAGGCCTGGCAGCAAGGAGCGATAGGAAACAACAATGTGTTCAGTCAAGCTGTCCAGAACCAGCCCACGC
CTGCACAGCCAGGAGTATACAACAACATGAGCATCACCGTTTCCATGGCAGGTGGAAATACGAATGTTCAGAACATGAACCCAATGATGG
CCCAGATGCAGATGAGCTCTTTGCAGATGCCAGGAATGAACACTGTGTGCCCTGAGCAGATAAATGATCCCGCACTGAGACACACAGGCC
TCTACTGCAACCAGCTCTCATCCACTGACCTTCTCAAAACAGAAGCAGATGGAACCCAGCAGGTGCAACAGGTTCAGGTGTTTGCTGACG
TCCAGTGTACAGTGAATCTGGTAGGCGGGGACCCTTACCTGAACCAGCCTGGTCCACTGGGAACTCAAAAGCCCACGTCAGGACCACAGA
CCCCCCAGGCCCAGCAGAAGAGCCTCCTTCAGCAGCTACTGACTGAATAACCACTTTTAAAGGAATGTGAAATTTAAATAATAGACATAC
AGAGATATACAAATATATTATATATTTTTCTGAGATTTTTGATATCTCAATCTGCAGCCATTCTTCAGGTCGTAGCATTTGGAGCAAAAA
AAAAAAAAAAAAAAAAAAAAGGAGTTTGCTTTTGTCGGGAGATTGAAAGATGTTTTTGTTTCTTTCTTTGTAAAGGCCTTGGATATTGAA
AAAATACCAAGGCAGAACAGTTGGACAATCTATTTCTTGAGCCAAATTTAATTATTCTTATTTTTGTAATCAGTCATTGGCTTCTTATCT
GGATGAAGGCTTTTGGAGGAGAACCAAAACGACAAGTTCCAAGAAGAAGATGAAGCTCCGCCTCCGCCGCTTAGTCCCAACCCTGCCCAG
GAAGAAGGGCCCGTGGGGCTTTGCCTGTGCCCGTCCACCAAAGGCTGTCATGTGTCTCGAAATCAGCAGCCCTCCCCATCCCAATCCCAG
GCAGCTTGTGTGTACAATCAGCTTCTCTAGCAACTCTGTATCTGTTGGCTTCAAGAGAATATTTTGCCTCCACATATGTACCCCTTCTCC
TTTTTTTAAAGATGGATTTAAACCAAGATGCCTCCAGGAAAGAGGACGAAATGAGTATATTCACAGAGGAATCCAAAAAATACAGTTTGG
GGGAAAATGCAATAATTTTTGATGAGATGGGTGAAGGACAAGAAGTGAGTTGTGTCAATTATTGTAGATACAATTTTCTGATTAAATCTG
GAAAAATAAAAGGCAGCCTGTTTTTTCTGCTTTTATTGTATTAACAGCTGAGGTAGCTAAAGTTATTTAAAATAAAATTAAATTTATGAT
CCAAGTAGCTTATTTTTCCCTTTAAATCTCATTGTAAATATATTTGATTTCTTGTAGAAATTGATTTCCTTCTGTTTAATTTTATGCTTT
TATTATACTCTTGATTTTTCTAAATTTGTGTGTGAAATATAACATTGATTGAATTGCAGTTACATTTGGTTAGTAATATTTCATTATTTT
AATAACTGTGATGTCATGTATGGATTTACTTTGGGGTTCAAATCAAAATGTCACTGCCAGAAAGAGCTGTTCCAGCTGATCTAGAGCATA
CTGCCCTAGAGTGTCCCTGGGATCATCTGAACAGAAGTGCACAGGCTACTTGTACAGAGAAAAAATTAATACTCAAAGGAAATCTTCATT
TTTTAGATTGACTTTGGGAATTTGAATTTTCATCAGTGCAAATATAAATTTCTCTATCCTGCTCTGAGGCTAATTGGTACCATATTTTCC
CTTTGTGTCTTGTGACTCTGCCACATCCCATCTCATCCTGGCCTCTGAGTCAAGAACCCAGTGAACTGACTTTCTAGTTCTAGAAGTTCC
GCTGCAAGGCCAGGAAAGCTTGAGAAAGGTATTGTGGAAGAAGCAAAGGTAGACCCCCATCACTCACCTTTGTCTGCATCCCTGGGCCTG
TGAATGATGACAGCACCTGACATTCTGCACCAGCTACCTCTGCCTCCATGGCAGAGAAAAGGCCATAAGAACAGTGGAAGAGGAGCATGG
ACTCAGACTTCAAGGAAGAAGCCATTTCCCCAGGTCCTTCCTTCTGCATCTCACCACCCCTAGTTACAAATAACTCCATTGAACAGCATC
TATTCAGAAACTATGCCGAATAAAAAGATTGGTGGAAGGGCTCATGTGGTTAGCAACTATGAAACAGAAATAGGACACTCAGTTACAAAC
ATTATCTCCTTTAGTTTTTCAGAAAATGCATCCCTGATTTCATTCATTTCCAGCTTGAAAGCCAGCCATATTACTCTAGTCCCTACCAAA
CTGCTCTAGAAGGTCATTTCCATTTTGTTTGTGATATTTAGACGCGCAGACTTCAGGAAGTTCACCTTTAACTTCAGCATTCCAGATGAA
GTTTCCTGACTCAGTGCTTTTGCATAAGGAACTAGAAAAAAAAAGTAAGGAAAATTGGAGATGCTAACATCCTCCCCCATCCCAACTGCA
CCTTAAAATATGCATGTCACCTTCAAGGTTTTATAATTGCACTGTTTGTTTTATGTATGTACAGATTAAAATTATTGCTACATTTGAGGA
AAATAAAATTGCTTGCTTCTATGTAATTCCTGTCATTCCACAGGAAATTCACTTTTCCAGCTACTGAATAGAATTTGTTTAACAACCTCA
TGGGTTGCCTCTTCATTTACAGGGAAGAAATGAAATGTACATCTGCAGAAATTGCCAAAGCCCAAATTAACGAGTATTATAAAAGGATAA

>25408_25408_3_EFR3B-NCOA1_EFR3B_chr2_25367920_ENST00000405108_NCOA1_chr2_24962301_ENST00000406961_length(amino acids)=940AA_BP=566
MCHSSHDDLEIKTKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPLQAPEKEKESPAELAERCLRE
LLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFKIIMYSIQPQHSHLVIQQLLGHLDANSRSAATVRAGIVEVLSEAAVIAATGSV
GPTVLEMFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLPTYQRSEVILFIMSKVPRPSLHQAVDTGR
TGENRNRLTQIMLLKSLLQVSTGFQCNNMMSALPSNFLDRLLSTALMEDAEIRLFVLEILISFIDRHGNRHKFSTISTLSDISVLKLKVD
KCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDLIRLVLAVQDVAQVNEENLPVYNRCALYALGAA
YLNLISQLTTVPAFCQHIHEVIETRKKEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKISEVLGGSGYNSDRLCLPYIPQLTDEDRL
SKRRSIGETISLQVEVESRNSPEKEELIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQR
AMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGNIGGQFGTGI
NPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGV
YNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQVQQVQVFADVQCTVN

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Fusion Gene PPI Analysis for EFR3B-NCOA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422781_9881067.02199.3333333333335CREBBP
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421781_9881067.01442.0CREBBP
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421781_9881067.01441.0CREBBP
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725781_9881067.02183.6666666666665CREBBP
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623781_9881067.01442.0CREBBP
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523781_9881067.01422.6666666666667CREBBP
TgeneNCOA1chr2:25367920chr2:24962301ENST000002885991422361_5671067.02199.3333333333335STAT3
TgeneNCOA1chr2:25367920chr2:24962301ENST000003483321421361_5671067.01442.0STAT3
TgeneNCOA1chr2:25367920chr2:24962301ENST000003958561421361_5671067.01441.0STAT3
TgeneNCOA1chr2:25367920chr2:24962301ENST000004051411725361_5671067.02183.6666666666665STAT3
TgeneNCOA1chr2:25367920chr2:24962301ENST000004069611623361_5671067.01442.0STAT3
TgeneNCOA1chr2:25367920chr2:24962301ENST000005385391523361_5671067.01422.6666666666667STAT3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EFR3B-NCOA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EFR3B-NCOA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource