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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADRBK2-AP1B1 (FusionGDB2 ID:2543)

Fusion Gene Summary for ADRBK2-AP1B1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADRBK2-AP1B1
Fusion gene ID: 2543
HgeneTgene
Gene symbol

ADRBK2

AP1B1

Gene ID

157

162

Gene nameG protein-coupled receptor kinase 3adaptor related protein complex 1 subunit beta 1
SynonymsADRBK2|BARK2ADTB1|AP105A|BAM22|CLAPB2|KIDAR
Cytomap

22q12.1

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionbeta-adrenergic receptor kinase 2adrenergic, beta, receptor kinase 2beta-ARK-2AP-1 complex subunit beta-1ADTB1, CLAPB2Golgi adaptor HA1/AP1 adaptin beta subunitadapter-related protein complex 1 subunit beta-1adaptor protein complex AP-1 subunit beta-1adaptor related protein complex 1 beta 1 subunitbeta-1-adaptinbeta-adaptin
Modification date2020031320200313
UniProtAcc.

Q10567

Ensembl transtripts involved in fusion geneENST00000324198, ENST00000472057, 
ENST00000317368, ENST00000356015, 
ENST00000357586, ENST00000402502, 
ENST00000405198, ENST00000415447, 
ENST00000432560, 
Fusion gene scores* DoF score9 X 4 X 7=2528 X 9 X 4=288
# samples 109
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADRBK2 [Title/Abstract] AND AP1B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAP1B1(29750639)-ADRBK2(26091074), # samples:2
ADRBK2(26086250)-AP1B1(29747814), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADRBK2

GO:0031623

receptor internalization

20074556


check buttonFusion gene breakpoints across ADRBK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP1B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-C4-A0F7-01AADRBK2chr22

26086250

-AP1B1chr22

29747814

-
ChimerDB4BLCATCGA-C4-A0F7-01AADRBK2chr22

26086250

+AP1B1chr22

29747814

-


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Fusion Gene ORF analysis for ADRBK2-AP1B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000324198ENST00000472057ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000317368ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000356015ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000357586ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000402502ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000405198ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000415447ADRBK2chr22

26086250

+AP1B1chr22

29747814

-
In-frameENST00000324198ENST00000432560ADRBK2chr22

26086250

+AP1B1chr22

29747814

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324198ADRBK2chr2226086250+ENST00000356015AP1B1chr2229747814-427412441923134980
ENST00000324198ADRBK2chr2226086250+ENST00000432560AP1B1chr2229747814-426512441923125977
ENST00000324198ADRBK2chr2226086250+ENST00000357586AP1B1chr2229747814-429512441923155987
ENST00000324198ADRBK2chr2226086250+ENST00000405198AP1B1chr2229747814-411212441923155987
ENST00000324198ADRBK2chr2226086250+ENST00000317368AP1B1chr2229747814-402212441923065957
ENST00000324198ADRBK2chr2226086250+ENST00000402502AP1B1chr2229747814-320912441923125977
ENST00000324198ADRBK2chr2226086250+ENST00000415447AP1B1chr2229747814-312612441923125977

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324198ENST00000356015ADRBK2chr2226086250+AP1B1chr2229747814-0.001391470.9986085
ENST00000324198ENST00000432560ADRBK2chr2226086250+AP1B1chr2229747814-0.0013465190.9986534
ENST00000324198ENST00000357586ADRBK2chr2226086250+AP1B1chr2229747814-0.0013633750.99863666
ENST00000324198ENST00000405198ADRBK2chr2226086250+AP1B1chr2229747814-0.0016489710.9983511
ENST00000324198ENST00000317368ADRBK2chr2226086250+AP1B1chr2229747814-0.0015357320.99846435
ENST00000324198ENST00000402502ADRBK2chr2226086250+AP1B1chr2229747814-0.002546570.9974534
ENST00000324198ENST00000415447ADRBK2chr2226086250+AP1B1chr2229747814-0.0024533240.9975466

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Fusion Genomic Features for ADRBK2-AP1B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADRBK2-AP1B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29750639/chr22:26091074)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AP1B1

Q10567

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:31630791}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADRBK2chr22:26086250chr22:29747814ENST00000324198+122154_175350689.0DomainRGS
HgeneADRBK2chr22:26086250chr22:29747814ENST00000324198+1221197_205350689.0Nucleotide bindingATP
HgeneADRBK2chr22:26086250chr22:29747814ENST00000324198+12211_190350689.0RegionNote=N-terminal
TgeneAP1B1chr22:26086250chr22:29747814ENST00000317368621576_725312920.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr22:26086250chr22:29747814ENST00000356015622576_725312943.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr22:26086250chr22:29747814ENST00000357586623576_725312950.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr22:26086250chr22:29747814ENST00000402502520576_725312940.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr22:26086250chr22:29747814ENST00000405198522576_725312950.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr22:26086250chr22:29747814ENST00000415447520576_725312940.0Compositional biasNote=Pro-rich (stalk region)
TgeneAP1B1chr22:26086250chr22:29747814ENST00000432560621576_725312940.0Compositional biasNote=Pro-rich (stalk region)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADRBK2chr22:26086250chr22:29747814ENST00000324198+1221191_453350689.0DomainProtein kinase
HgeneADRBK2chr22:26086250chr22:29747814ENST00000324198+1221454_521350689.0DomainAGC-kinase C-terminal
HgeneADRBK2chr22:26086250chr22:29747814ENST00000324198+1221558_652350689.0DomainPH


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Fusion Gene Sequence for ADRBK2-AP1B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2543_2543_1_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000317368_length(transcript)=4022nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCA
GCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCA
TATGTGGCCCCCAAAGCAGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAG
TTCAACCGCAACAGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTG
CCTCTCAGCACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTC
AGCACCTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAAT
GAGAATGAGGCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTC
GCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAG
CCGGGCAACCCCAGCTGCACGCTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTCAAG
AACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCAGGA
GGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCCCTC
CTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAAAGG
AAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGGCTC
CTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGAGGG
GTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGGGAG
GAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGACCC
ACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACTTCT
GCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGATGGG
GCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTCAGT

>2543_2543_1_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000317368_length(amino acids)=957AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPA
NLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQVHAPLSPNQTVEISLPLST
VGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRN

--------------------------------------------------------------
>2543_2543_2_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000356015_length(transcript)=4274nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCA
GCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCA
TATGTGGCCCCCAAAGCAGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATC
TCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGCTTTGGCCTGGCCCCC
GCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAG
ATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTT
GTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAGAC
TGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATG
CTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGGACTTAGAG
CTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTCAAGAACTGAGACCCCGGCCAGCGC
CCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCAGGAGGGACCAGGCGGGGCTCCAGG
CCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCCCTCCTGGGGTGAGAGCGCAGTGCA
CTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAAAGGAAACAGAGCCAGAGCAGCCAC
AGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGGCTCCTTGGTCTCTCCGGTTGGTGT
TAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGAGGGGTTCCCCTTGGTACCAGGAGA
GCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGGGAGGAGCCCAGGGCCTGCACCACC
CACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGACCCACATGGTCAAGACCAGGCAGA
AGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACTTCTGCCCCAAGGGTGGTCACTGCC
TGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGATGGGGCTGGGTAAGCGGGTGCGCCT
CCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTCAGTTGTGTCTGACAGAGCATTAGG
TTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTTCCCCTCCACCGAATGTCAGGATTG
AAAGCTGCCTCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAACTAGATCTAATATATATCATCAGAAAATATATATTGTATGTTT

>2543_2543_2_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000356015_length(amino acids)=980AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPA
NLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPL
QVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLN

--------------------------------------------------------------
>2543_2543_3_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000357586_length(transcript)=4295nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATGGGGGATGAGCCTGAAGGGATTGGGGGCACCAAC
TTCGTGGCACCTCCAACAGCAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGC
GTGGGCACCCTGTCAGGATCATATGTGGCCCCCAAAGCAGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTC
ACCCGCCAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGC
AACAGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGC
ACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTG
TACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAG
GCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGG
AACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAAC
CCCAGCTGCACGGACTTAGAGCTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTCAAG
AACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCAGGA
GGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCCCTC
CTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAAAGG
AAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGGCTC
CTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGAGGG
GTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGGGAG
GAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGACCC
ACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACTTCT
GCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGATGGG
GCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTCAGT
TGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTGTGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTTCCC
CTCCACCGAATGTCAGGATTGAAAGCTGCCTCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAACTAGATCTAATATATATCATCA

>2543_2543_3_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000357586_length(amino acids)=987AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAP
PTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG
LAPATPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQ

--------------------------------------------------------------
>2543_2543_4_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000402502_length(transcript)=3209nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCA
GCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCA
TATGTGGCCCCCAAAGCAGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATC
TCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGCTTTGGCCTGGCCCCC
GCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAG
ATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTT
GTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAGAC
TGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATG
CTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGCTGTCCCTG
AAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTCAAGAACTGAGACCCCGGCCAGCGCCCACCCCAG

>2543_2543_4_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000402502_length(amino acids)=977AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPA
NLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPL
QVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLN

--------------------------------------------------------------
>2543_2543_5_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000405198_length(transcript)=4112nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATGGGGGATGAGCCTGAAGGGATTGGGGGCACCAAC
TTCGTGGCACCTCCAACAGCAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGC
GTGGGCACCCTGTCAGGATCATATGTGGCCCCCAAAGCAGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTC
ACCCGCCAGGTGGGCTCCATCTCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGC
AACAGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGC
ACGGTGGGCTCGGTCATGAAGATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTG
TACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAG
GCCCAGTTCCAGATCAGAGACTGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGG
AACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAAC
CCCAGCTGCACGGACTTAGAGCTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTCAAG
AACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCAGGA
GGGACCAGGCGGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCCCTC
CTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAAAGG
AAACAGAGCCAGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGGCTC
CTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGAGGG
GTTCCCCTTGGTACCAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGGGAG
GAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGACCC
ACATGGTCAAGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACTTCT
GCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGATGGG
GCTGGGTAAGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTCAGT

>2543_2543_5_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000405198_length(amino acids)=987AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLMGDEPEGIGGTNFVAP
PTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFG
LAPATPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQ

--------------------------------------------------------------
>2543_2543_6_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000415447_length(transcript)=3126nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCA
GCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCA
TATGTGGCCCCCAAAGCAGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATC
TCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGCTTTGGCCTGGCCCCC
GCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAG
ATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTT
GTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAGAC
TGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATG
CTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGCTGTCCCTG

>2543_2543_6_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000415447_length(amino acids)=977AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPA
NLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPL
QVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLN

--------------------------------------------------------------
>2543_2543_7_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000432560_length(transcript)=4265nt_BP=1244nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAA
CTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTT
CAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAG
TGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTAT
GGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCC
TTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAA
CTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTT
TATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGAT
GAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTGCCTGAGATCCTGAAG
CATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAAGCTGGACATCATGATCCGCCTGGCCTCTCAG
GCCAACATCGCCCAGGTGTTGGCAGAGCTGAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGGC
CGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCTCATCCAGACCAAGGTCAACTATGTGGTCCAG
GAGGCCATCGTGGTCATCAAGGACATCTTCCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTCC
CTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACGGATCGACAACGCAGATGAGCTGCTGGAGAGC
TTCCTCGAGGGCTTCCATGACGAGAGCACACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGAG
ACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGACCTGCGGGACCGTGGCTACATCTACTGGCGC
CTGCTGTCCACGGACCCGGTGGCAGCCAAGGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTCATCGAGCCCACA
CTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTCCCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTC
GTGCACAAGAGCCTGCCACCTCGCACGGCCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGCAG
CCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCGGCCCCCCAGTGAGCGGCCCACCCCTGGCCACC
TCCTCGGTGCAGATGGGAGCTGTGGACCTTCTTGGCGGTGGCCTTGACAGCCTGATTGGGGGCACCAACTTCGTGGCACCTCCAACAGCA
GCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACCTGACCAGTGGCGTGGGCACCCTGTCAGGATCA
TATGTGGCCCCCAAAGCAGTCTGGCTCCCAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCATC
TCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCCAGTTCAACCGCAACAGCTTTGGCCTGGCCCCC
GCCACCCCCCTCCAGGTCCACGCGCCACTCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGAAG
ATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACTTCAGCACCTTGTACCCACTGCACATCCTCTTT
GTGGAGGACGGGAAGATGGACCGGCAGATGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAGAC
TGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTGTCGCCAAGAGGAACGTGGAGGGCCAGGACATG
CTCTACCAGTCCCTGAAGCTGACCAACGGCATCTGGGTGCTGGCGGAGCTGCGGATCCAGCCGGGCAACCCCAGCTGCACGCTGTCCCTG
AAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTACGAGACCATCCTCAAGAACTGAGACCCCGGCCAGCGCCCACCCCAG
CCTTCTGCCCGCCCCATCGAGGAGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCAGGAGGGACCAGGCGGGGCTCCAGGCCACTCAGT
GGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTGGGGTAGGGCACCACCCCCTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGC
TCTGGGACACCCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAAAGGAAACAGAGCCAGAGCAGCCACAGAAGCTGT
GCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACAGCCCCGGCAGCCCCTGGCTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCC
CTCCACTGCCACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGAGGGGTTCCCCTTGGTACCAGGAGAGCTGCTCAC
TTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGAGGGGCAGAGCTAGGCTGGGAGGAGCCCAGGGCCTGCACCACCCACTTGCAA
CCACCAGGCTGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGACCCACATGGTCAAGACCAGGCAGAAGCTCCCAG
AGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCACTATCCCCAACTCCCCACTTCTGCCCCAAGGGTGGTCACTGCCTGTGATACA
TTCCTCAGTGTCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGATGGGGCTGGGTAAGCGGGTGCGCCTCCTGTTTGG
GTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCCTCCTGGCCTCCCAGGTTTCAGTTGTGTCTGACAGAGCATTAGGTTTTCCTGT
TACTGCTGTGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTTCCCCTCCACCGAATGTCAGGATTGAAAGCTGCC
TCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAACTAGATCTAATATATATCATCAGAAAATATATATTGTATGTTTACTCTTATT

>2543_2543_7_ADRBK2-AP1B1_ADRBK2_chr22_26086250_ENST00000324198_AP1B1_chr22_29747814_ENST00000432560_length(amino acids)=977AA_BP=351
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIK
EYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFI
LDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVPEILKHEMK
VFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIV
VIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQEL
VQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKS
LPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPA
NLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPL
QVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADRBK2-AP1B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADRBK2-AP1B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADRBK2-AP1B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource