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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EGFR-GRB10 (FusionGDB2 ID:25458)

Fusion Gene Summary for EGFR-GRB10

check button Fusion gene summary
Fusion gene informationFusion gene name: EGFR-GRB10
Fusion gene ID: 25458
HgeneTgene
Gene symbol

EGFR

GRB10

Gene ID

1956

2887

Gene nameepidermal growth factor receptorgrowth factor receptor bound protein 10
SynonymsERBB|ERBB1|HER1|NISBD2|PIG61|mENAGRB-IR|Grb-10|IRBP|MEG1|RSS
Cytomap

7p11.2

7p12.1

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinasgrowth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1
Modification date2020032920200327
UniProtAcc

P00533

Q13322

Ensembl transtripts involved in fusion geneENST00000463948, ENST00000275493, 
ENST00000342916, ENST00000344576, 
ENST00000420316, ENST00000442591, 
ENST00000455089, ENST00000454757, 
ENST00000335866, ENST00000357271, 
ENST00000398810, ENST00000398812, 
ENST00000401949, ENST00000402497, 
ENST00000402578, ENST00000403097, 
ENST00000406641, ENST00000407526, 
ENST00000439599, ENST00000483819, 
Fusion gene scores* DoF score41 X 25 X 14=143504 X 4 X 4=64
# samples 534
** MAII scorelog2(53/14350*10)=-4.75891456699985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EGFR [Title/Abstract] AND GRB10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEGFR(55087058)-GRB10(50742355), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEGFR

GO:0001934

positive regulation of protein phosphorylation

20551055

HgeneEGFR

GO:0007165

signal transduction

10572067

HgeneEGFR

GO:0007166

cell surface receptor signaling pathway

7736574

HgeneEGFR

GO:0007173

epidermal growth factor receptor signaling pathway

7736574|12435727

HgeneEGFR

GO:0008283

cell proliferation

17115032

HgeneEGFR

GO:0008284

positive regulation of cell proliferation

7736574

HgeneEGFR

GO:0010750

positive regulation of nitric oxide mediated signal transduction

12828935

HgeneEGFR

GO:0018108

peptidyl-tyrosine phosphorylation

22732145

HgeneEGFR

GO:0030307

positive regulation of cell growth

15467833

HgeneEGFR

GO:0042177

negative regulation of protein catabolic process

17115032

HgeneEGFR

GO:0042327

positive regulation of phosphorylation

15082764

HgeneEGFR

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneEGFR

GO:0045739

positive regulation of DNA repair

17115032

HgeneEGFR

GO:0045740

positive regulation of DNA replication

17115032

HgeneEGFR

GO:0045944

positive regulation of transcription by RNA polymerase II

20551055

HgeneEGFR

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneEGFR

GO:0050999

regulation of nitric-oxide synthase activity

12828935

HgeneEGFR

GO:0070141

response to UV-A

18483258

HgeneEGFR

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20551055

HgeneEGFR

GO:0071392

cellular response to estradiol stimulus

20551055

HgeneEGFR

GO:1900020

positive regulation of protein kinase C activity

22732145

HgeneEGFR

GO:1903078

positive regulation of protein localization to plasma membrane

22732145

TgeneGRB10

GO:0030178

negative regulation of Wnt signaling pathway

17376403

TgeneGRB10

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

15060076


check buttonFusion gene breakpoints across EGFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GRB10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A6I3-01AEGFRchr7

55087058

-GRB10chr7

50742355

-
ChimerDB4BLCATCGA-GC-A6I3-01AEGFRchr7

55087058

+GRB10chr7

50742355

-


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Fusion Gene ORF analysis for EGFR-GRB10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000463948ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-5UTRENST00000463948ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
3UTR-intronENST00000463948ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000275493ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000342916ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000344576ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000420316ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000442591ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-5UTRENST00000455089ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-intronENST00000275493ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-intronENST00000342916ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-intronENST00000344576ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-intronENST00000420316ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-intronENST00000442591ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
5CDS-intronENST00000455089ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000335866EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000357271EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000398810EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000398812EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000401949EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000402497EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000402578EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000403097EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000406641EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000407526EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-5UTRENST00000454757ENST00000439599EGFRchr7

55087058

+GRB10chr7

50742355

-
intron-intronENST00000454757ENST00000483819EGFRchr7

55087058

+GRB10chr7

50742355

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EGFR-GRB10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EGFR-GRB10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55087058/:50742355)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EGFR

P00533

GRB10

Q13322

FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EGFR-GRB10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EGFR-GRB10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EGFR-GRB10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EGFR-GRB10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource