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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ADRBK2-NOTCH2 (FusionGDB2 ID:2546)

Fusion Gene Summary for ADRBK2-NOTCH2

Fusion gene summary

Fusion gene information	Fusion gene name: ADRBK2-NOTCH2
	Fusion gene ID: 2546
		Hgene	Tgene
	Gene symbol	ADRBK2	NOTCH2
	Gene ID	157	4853
	Gene name	G protein-coupled receptor kinase 3	notch receptor 2
	Synonyms	ADRBK2\|BARK2	AGS2\|HJCYS\|hN2
	Cytomap	22q12.1	1p12
	Type of gene	protein-coding	protein-coding
	Description	beta-adrenergic receptor kinase 2adrenergic, beta, receptor kinase 2beta-ARK-2	neurogenic locus notch homolog protein 2Notch homolog 2notch 2
	Modification date	20200313	20200329
	UniProtAcc	.	P0DPK3
	Ensembl transtripts involved in fusion gene	ENST00000324198,	ENST00000602566, ENST00000493703, ENST00000256646,
Fusion gene scores	* DoF score	9 X 4 X 7=252	13 X 10 X 6=780
	# samples	10	14
	** MAII score	log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/780*10)=-2.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADRBK2 [Title/Abstract] AND NOTCH2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADRBK2(26000420)-NOTCH2(120572610), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADRBK2	GO:0031623	receptor internalization	20074556
Tgene	NOTCH2	GO:0007050	cell cycle arrest	11306509
Tgene	NOTCH2	GO:0007219	Notch signaling pathway	11306509\|25985737
Tgene	NOTCH2	GO:0010629	negative regulation of gene expression	11306509
Tgene	NOTCH2	GO:0010838	positive regulation of keratinocyte proliferation	18469519
Tgene	NOTCH2	GO:0045967	negative regulation of growth rate	11306509
Tgene	NOTCH2	GO:0046579	positive regulation of Ras protein signal transduction	11306509
Tgene	NOTCH2	GO:0070374	positive regulation of ERK1 and ERK2 cascade	11306509
Tgene	NOTCH2	GO:2000249	regulation of actin cytoskeleton reorganization	18469519

Fusion gene breakpoints across ADRBK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NOTCH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-29-1691-01A	ADRBK2	chr22	26000420	+	NOTCH2	chr1	120572610	-

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Fusion Gene ORF analysis for ADRBK2-NOTCH2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000324198	ENST00000602566	ADRBK2	chr22	26000420	+	NOTCH2	chr1	120572610	-
5CDS-intron	ENST00000324198	ENST00000493703	ADRBK2	chr22	26000420	+	NOTCH2	chr1	120572610	-
In-frame	ENST00000324198	ENST00000256646	ADRBK2	chr22	26000420	+	NOTCH2	chr1	120572610	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000324198

ADRBK2

chr22

26000420

ENST00000256646

NOTCH2

chr1

120572610

11478

382

192

7724

2510

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000324198	ENST00000256646	ADRBK2	chr22	26000420	+	NOTCH2	chr1	120572610	-	0.00088761	0.9991124

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Fusion Genomic Features for ADRBK2-NOTCH2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADRBK2-NOTCH2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:26000420/chr1:120572610)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NOTCH2 P0DPK3
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955). {ECO:0000269\|PubMed:29561261, ECO:0000269\|PubMed:29856954, ECO:0000269\|PubMed:29856955}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1645_1648

2472.0

Compositional bias

Note=Poly-Ala

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1994_1997

2472.0

Compositional bias

Note=Poly-Leu

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

2426_2429

2472.0

Compositional bias

Note=Poly-Ser

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1025_1061

2472.0

Domain

EGF-like 27%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

105_143

2472.0

Domain

EGF-like 3

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1063_1099

2472.0

Domain

EGF-like 28

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1101_1147

2472.0

Domain

EGF-like 29

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1149_1185

2472.0

Domain

EGF-like 30%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1187_1223

2472.0

Domain

EGF-like 31%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1225_1262

2472.0

Domain

EGF-like 32%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1264_1302

2472.0

Domain

EGF-like 33

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1304_1343

2472.0

Domain

EGF-like 34

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1374_1412

2472.0

Domain

EGF-like 35

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

144_180

2472.0

Domain

EGF-like 4

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

182_219

2472.0

Domain

EGF-like 5%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

221_258

2472.0

Domain

EGF-like 6

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

260_296

2472.0

Domain

EGF-like 7%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

26_63

2472.0

Domain

EGF-like 1

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

298_336

2472.0

Domain

EGF-like 8%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

338_374

2472.0

Domain

EGF-like 9%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

375_413

2472.0

Domain

EGF-like 10

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

415_454

2472.0

Domain

EGF-like 11%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

456_492

2472.0

Domain

EGF-like 12%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

494_530

2472.0

Domain

EGF-like 13%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

532_568

2472.0

Domain

EGF-like 14%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

570_605

2472.0

Domain

EGF-like 15%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

607_643

2472.0

Domain

EGF-like 16%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

645_680

2472.0

Domain

EGF-like 17%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

64_102

2472.0

Domain

EGF-like 2

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

682_718

2472.0

Domain

EGF-like 18%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

720_755

2472.0

Domain

EGF-like 19

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

757_793

2472.0

Domain

EGF-like 20%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

795_831

2472.0

Domain

EGF-like 21%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

833_871

2472.0

Domain

EGF-like 22

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

873_909

2472.0

Domain

EGF-like 23%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

911_947

2472.0

Domain

EGF-like 24%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

949_985

2472.0

Domain

EGF-like 25%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

987_1023

2472.0

Domain

EGF-like 26%3B calcium-binding

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1425_1677

2472.0

Region

Note=Negative regulatory region (NRR)

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1425_1465

2472.0

Repeat

Note=LNR 1

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1466_1502

2472.0

Repeat

Note=LNR 2

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1503_1544

2472.0

Repeat

Note=LNR 3

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1827_1871

2472.0

Repeat

Note=ANK 1

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1876_1905

2472.0

Repeat

Note=ANK 2

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1909_1939

2472.0

Repeat

Note=ANK 3

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1943_1972

2472.0

Repeat

Note=ANK 4

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1976_2005

2472.0

Repeat

Note=ANK 5

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

2009_2038

2472.0

Repeat

Note=ANK 6

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1699_2471

2472.0

Topological domain

Cytoplasmic

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

26_1677

2472.0

Topological domain

Extracellular

Tgene

NOTCH2

chr22:26000420

chr1:120572610

ENST00000256646

1678_1698

2472.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADRBK2

chr22:26000420

chr1:120572610

ENST00000324198

191_453

689.0

Domain

Protein kinase

Hgene

ADRBK2

chr22:26000420

chr1:120572610

ENST00000324198

454_521

689.0

Domain

AGC-kinase C-terminal

Hgene

ADRBK2

chr22:26000420

chr1:120572610

ENST00000324198

54_175

689.0

Domain

RGS

Hgene

ADRBK2

chr22:26000420

chr1:120572610

ENST00000324198

558_652

689.0

Domain

Hgene

ADRBK2

chr22:26000420

chr1:120572610

ENST00000324198

197_205

689.0

Nucleotide binding

ATP

Hgene

ADRBK2

chr22:26000420

chr1:120572610

ENST00000324198

1_190

689.0

Region

Note=N-terminal

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Fusion Gene Sequence for ADRBK2-NOTCH2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2546_2546_1_ADRBK2-NOTCH2_ADRBK2_chr22_26000420_ENST00000324198_NOTCH2_chr1_120572610_ENST00000256646_length(transcript)=11478nt_BP=382nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGCATTGCAGTGTCGAGATGGCTATGAACCCTGTGTAAATGAAGGAATGTGTGTTACCTACCACAATGGC
ACAGGATACTGCAAATGTCCAGAAGGCTTCTTGGGGGAATATTGTCAACATCGAGACCCCTGTGAGAAGAACCGCTGCCAGAATGGTGGG
ACTTGTGTGGCCCAGGCCATGCTGGGGAAAGCCACGTGCCGATGTGCCTCAGGGTTTACAGGAGAGGACTGCCAGTACTCAACATCTCAT
CCATGCTTTGTGTCTCGACCCTGCCTGAATGGCGGCACATGCCATATGCTCAGCCGGGATACCTATGAGTGCACCTGTCAAGTCGGGTTT
ACAGGTAAGGAGTGCCAATGGACGGATGCCTGCCTGTCTCATCCCTGTGCAAATGGAAGTACCTGTACCACTGTGGCCAACCAGTTCTCC
TGCAAATGCCTCACAGGCTTCACAGGGCAGAAATGTGAGACTGATGTCAATGAGTGTGACATTCCAGGACACTGCCAGCATGGTGGCACC
TGCCTCAACCTGCCTGGTTCCTACCAGTGCCAGTGCCCTCAGGGCTTCACAGGCCAGTACTGTGACAGCCTGTATGTGCCCTGTGCACCC
TCACCTTGTGTCAATGGAGGCACCTGTCGGCAGACTGGTGACTTCACTTTTGAGTGCAACTGCCTTCCAGGTTTTGAAGGGAGCACCTGT
GAGAGGAATATTGATGACTGCCCTAACCACAGGTGTCAGAATGGAGGGGTTTGTGTGGATGGGGTCAACACTTACAACTGCCGCTGTCCC
CCACAATGGACAGGACAGTTCTGCACAGAGGATGTGGATGAATGCCTGCTGCAGCCCAATGCCTGTCAAAATGGGGGCACCTGTGCCAAC
CGCAATGGAGGCTATGGCTGTGTATGTGTCAACGGCTGGAGTGGAGATGACTGCAGTGAGAACATTGATGATTGTGCCTTCGCCTCCTGT
ACTCCAGGCTCCACCTGCATCGACCGTGTGGCCTCCTTCTCTTGCATGTGCCCAGAGGGGAAGGCAGGTCTCCTGTGTCATCTGGATGAT
GCATGCATCAGCAATCCTTGCCACAAGGGGGCACTGTGTGACACCAACCCCCTAAATGGGCAATATATTTGCACCTGCCCACAAGGCTAC
AAAGGGGCTGACTGCACAGAAGATGTGGATGAATGTGCCATGGCCAATAGCAATCCTTGTGAGCATGCAGGAAAATGTGTGAACACGGAT
GGCGCCTTCCACTGTGAGTGTCTGAAGGGTTATGCAGGACCTCGTTGTGAGATGGACATCAATGAGTGCCATTCAGACCCCTGCCAGAAT
GATGCTACCTGTCTGGATAAGATTGGAGGCTTCACATGTCTGTGCATGCCAGGTTTCAAAGGTGTGCATTGTGAATTAGAAATAAATGAA
TGTCAGAGCAACCCTTGTGTGAACAATGGGCAGTGTGTGGATAAAGTCAATCGTTTCCAGTGCCTGTGTCCTCCTGGTTTCACTGGGCCA
GTTTGCCAGATTGATATTGATGACTGTTCCAGTACTCCGTGTCTGAATGGGGCAAAGTGTATCGATCACCCGAATGGCTATGAATGCCAG
TGTGCCACAGGTTTCACTGGTGTGTTGTGTGAGGAGAACATTGACAACTGTGACCCCGATCCTTGCCACCATGGTCAGTGTCAGGATGGT
ATTGATTCCTACACCTGCATCTGCAATCCCGGGTACATGGGCGCCATCTGCAGTGACCAGATTGATGAATGTTACAGCAGCCCTTGCCTG
AACGATGGTCGCTGCATTGACCTGGTCAATGGCTACCAGTGCAACTGCCAGCCAGGCACGTCAGGGGTTAATTGTGAAATTAATTTTGAT
GACTGTGCAAGTAACCCTTGTATCCATGGAATCTGTATGGATGGCATTAATCGCTACAGTTGTGTCTGCTCACCAGGATTCACAGGGCAG
AGATGTAACATTGACATTGATGAGTGTGCCTCCAATCCCTGTCGCAAGGGTGCAACATGTATCAACGGTGTGAATGGTTTCCGCTGTATA
TGCCCCGAGGGACCCCATCACCCCAGCTGCTACTCACAGGTGAACGAATGCCTGAGCAATCCCTGCATCCATGGAAACTGTACTGGAGGT
CTCAGTGGATATAAGTGTCTCTGTGATGCAGGCTGGGTTGGCATCAACTGTGAAGTGGACAAAAATGAATGCCTTTCGAATCCATGCCAG
AATGGAGGAACTTGTGACAATCTGGTGAATGGATACAGGTGTACTTGCAAGAAGGGCTTTAAAGGCTATAACTGCCAGGTGAATATTGAT
GAATGTGCCTCAAATCCATGCCTGAACCAAGGAACCTGCTTTGATGACATAAGTGGCTACACTTGCCACTGTGTGCTGCCATACACAGGC
AAGAATTGTCAGACAGTATTGGCTCCCTGTTCCCCAAACCCTTGTGAGAATGCTGCTGTTTGCAAAGAGTCACCAAATTTTGAGAGTTAT
ACTTGCTTGTGTGCTCCTGGCTGGCAAGGTCAGCGGTGTACCATTGACATTGACGAGTGTATCTCCAAGCCCTGCATGAACCATGGTCTC
TGCCATAACACCCAGGGCAGCTACATGTGTGAATGTCCACCAGGCTTCAGTGGTATGGACTGTGAGGAGGACATTGATGACTGCCTTGCC
AATCCTTGCCAGAATGGAGGTTCCTGTATGGATGGAGTGAATACTTTCTCCTGCCTCTGCCTTCCGGGTTTCACTGGGGATAAGTGCCAG
ACAGACATGAATGAGTGTCTGAGTGAACCCTGTAAGAATGGAGGGACCTGCTCTGACTACGTCAACAGTTACACTTGCAAGTGCCAGGCA
GGATTTGATGGAGTCCATTGTGAGAACAACATCAATGAGTGCACTGAGAGCTCCTGTTTCAATGGTGGCACATGTGTTGATGGGATTAAC
TCCTTCTCTTGCTTGTGCCCTGTGGGTTTCACTGGATCCTTCTGCCTCCATGAGATCAATGAATGCAGCTCTCATCCATGCCTGAATGAG
GGAACGTGTGTTGATGGCCTGGGTACCTACCGCTGCAGCTGCCCCCTGGGCTACACTGGGAAAAACTGTCAGACCCTGGTGAATCTCTGC
AGTCGGTCTCCATGTAAAAACAAAGGTACTTGCGTTCAGAAAAAAGCAGAGTCCCAGTGCCTATGTCCATCTGGATGGGCTGGTGCCTAT
TGTGACGTGCCCAATGTCTCTTGTGACATAGCAGCCTCCAGGAGAGGTGTGCTTGTTGAACACTTGTGCCAGCACTCAGGTGTCTGCATC
AATGCTGGCAACACGCATTACTGTCAGTGCCCCCTGGGCTATACTGGGAGCTACTGTGAGGAGCAACTCGATGAGTGTGCGTCCAACCCC
TGCCAGCACGGGGCAACATGCAGTGACTTCATTGGTGGATACAGATGCGAGTGTGTCCCAGGCTATCAGGGTGTCAACTGTGAGTATGAA
GTGGATGAGTGCCAGAATCAGCCCTGCCAGAATGGAGGCACCTGTATTGACCTTGTGAACCATTTCAAGTGCTCTTGCCCACCAGGCACT
CGGGGCCTACTCTGTGAAGAGAACATTGATGACTGTGCCCGGGGTCCCCATTGCCTTAATGGTGGTCAGTGCATGGATAGGATTGGAGGC
TACAGTTGTCGCTGCTTGCCTGGCTTTGCTGGGGAGCGTTGTGAGGGAGACATCAACGAGTGCCTCTCCAACCCCTGCAGCTCTGAGGGC
AGCCTGGACTGTATACAGCTCACCAATGACTACCTGTGTGTTTGCCGTAGTGCCTTTACTGGCCGGCACTGTGAAACCTTCGTCGATGTG
TGTCCCCAGATGCCCTGCCTGAATGGAGGGACTTGTGCTGTGGCCAGTAACATGCCTGATGGTTTCATTTGCCGTTGTCCCCCGGGATTT
TCCGGGGCAAGGTGCCAGAGCAGCTGTGGACAAGTGAAATGTAGGAAGGGGGAGCAGTGTGTGCACACCGCCTCTGGACCCCGCTGCTTC
TGCCCCAGTCCCCGGGACTGCGAGTCAGGCTGTGCCAGTAGCCCCTGCCAGCACGGGGGCAGCTGCCACCCTCAGCGCCAGCCTCCTTAT
TACTCCTGCCAGTGTGCCCCACCATTCTCGGGTAGCCGCTGTGAACTCTACACGGCACCCCCCAGCACCCCTCCTGCCACCTGTCTGAGC
CAGTATTGTGCCGACAAAGCTCGGGATGGCGTCTGTGATGAGGCCTGCAACAGCCATGCCTGCCAGTGGGATGGGGGTGACTGTTCTCTC
ACCATGGAGAACCCCTGGGCCAACTGCTCCTCCCCACTTCCCTGCTGGGATTATATCAACAACCAGTGTGATGAGCTGTGCAACACGGTC
GAGTGCCTGTTTGACAACTTTGAATGCCAGGGGAACAGCAAGACATGCAAGTATGACAAATACTGTGCAGACCACTTCAAAGACAACCAC
TGTGACCAGGGGTGCAACAGTGAGGAGTGTGGTTGGGATGGGCTGGACTGTGCTGCTGACCAACCTGAGAACCTGGCAGAAGGTACCCTG
GTTATTGTGGTATTGATGCCACCTGAACAACTGCTCCAGGATGCTCGCAGCTTCTTGCGGGCACTGGGTACCCTGCTCCACACCAACCTG
CGCATTAAGCGGGACTCCCAGGGGGAACTCATGGTGTACCCCTATTATGGTGAGAAGTCAGCTGCTATGAAGAAACAGAGGATGACACGC
AGATCCCTTCCTGGTGAACAAGAACAGGAGGTGGCTGGCTCTAAAGTCTTTCTGGAAATTGACAACCGCCAGTGTGTTCAAGACTCAGAC
CACTGCTTCAAGAACACGGATGCAGCAGCAGCTCTCCTGGCCTCTCACGCCATACAGGGGACCCTGTCATACCCTCTTGTGTCTGTCGTC
AGTGAATCCCTGACTCCAGAACGCACTCAGCTCCTCTATCTCCTTGCTGTTGCTGTTGTCATCATTCTGTTTATTATTCTGCTGGGGGTA
ATCATGGCAAAACGAAAGCGTAAGCATGGCTCTCTCTGGCTGCCTGAAGGTTTCACTCTTCGCCGAGATGCAAGCAATCACAAGCGTCGT
GAGCCAGTGGGACAGGATGCTGTGGGGCTGAAAAATCTCTCAGTGCAAGTCTCAGAAGCTAACCTAATTGGTACTGGAACAAGTGAACAC
TGGGTCGATGATGAAGGGCCCCAGCCAAAGAAAGTAAAGGCTGAAGATGAGGCCTTACTCTCAGAAGAAGATGACCCCATTGATCGACGG
CCATGGACACAGCAGCACCTTGAAGCTGCAGACATCCGTAGGACACCATCGCTGGCTCTCACCCCTCCTCAGGCAGAGCAGGAGGTGGAT
GTGTTAGATGTGAATGTCCGTGGCCCAGATGGCTGCACCCCATTGATGTTGGCTTCTCTCCGAGGAGGCAGCTCAGATTTGAGTGATGAA
GATGAAGATGCAGAGGACTCTTCTGCTAACATCATCACAGACTTGGTCTACCAGGGTGCCAGCCTCCAGGCCCAGACAGACCGGACTGGT
GAGATGGCCCTGCACCTTGCAGCCCGCTACTCACGGGCTGATGCTGCCAAGCGTCTCCTGGATGCAGGTGCAGATGCCAATGCCCAGGAC
AACATGGGCCGCTGTCCACTCCATGCTGCAGTGGCAGCTGATGCCCAAGGTGTCTTCCAGATTCTGATTCGCAACCGAGTAACTGATCTA
GATGCCAGGATGAATGATGGTACTACACCCCTGATCCTGGCTGCCCGCCTGGCTGTGGAGGGAATGGTGGCAGAACTGATCAACTGCCAA
GCGGATGTGAATGCAGTGGATGACCATGGAAAATCTGCTCTTCACTGGGCAGCTGCTGTCAATAATGTGGAGGCAACTCTTTTGTTGTTG
AAAAATGGGGCCAACCGAGACATGCAGGACAACAAGGAAGAGACACCTCTGTTTCTTGCTGCCCGGGAGGGGAGCTATGAAGCAGCCAAG
ATCCTGTTAGACCATTTTGCCAATCGAGACATCACAGACCATATGGATCGTCTTCCCCGGGATGTGGCTCGGGATCGCATGCACCATGAC
ATTGTGCGCCTTCTGGATGAATACAATGTGACCCCAAGCCCTCCAGGCACCGTGTTGACTTCTGCTCTCTCACCTGTCATCTGTGGGCCC
AACAGATCTTTCCTCAGCCTGAAGCACACCCCAATGGGCAAGAAGTCTAGACGGCCCAGTGCCAAGAGTACCATGCCTACTAGCCTCCCT
AACCTTGCCAAGGAGGCAAAGGATGCCAAGGGTAGTAGGAGGAAGAAGTCTCTGAGTGAGAAGGTCCAACTGTCTGAGAGTTCAGTAACT
TTATCCCCTGTTGATTCCCTAGAATCTCCTCACACGTATGTTTCCGACACCACATCCTCTCCAATGATTACATCCCCTGGGATCTTACAG
GCCTCACCCAACCCTATGTTGGCCACTGCCGCCCCTCCTGCCCCAGTCCATGCCCAGCATGCACTATCTTTTTCTAACCTTCATGAAATG
CAGCCTTTGGCACATGGGGCCAGCACTGTGCTTCCCTCAGTGAGCCAGTTGCTATCCCACCACCACATTGTGTCTCCAGGCAGTGGCAGT
GCTGGAAGCTTGAGTAGGCTCCATCCAGTCCCAGTCCCAGCAGATTGGATGAACCGCATGGAGGTGAATGAGACCCAGTACAATGAGATG
TTTGGTATGGTCCTGGCTCCAGCTGAGGGCACCCATCCTGGCATAGCTCCCCAGAGCAGGCCACCTGAAGGGAAGCACATAACCACCCCT
CGGGAGCCCTTGCCCCCCATTGTGACTTTCCAGCTCATCCCTAAAGGCAGTATTGCCCAACCAGCGGGGGCTCCCCAGCCTCAGTCCACC
TGCCCTCCAGCTGTTGCGGGCCCCCTGCCCACCATGTACCAGATTCCAGAAATGGCCCGTTTGCCCAGTGTGGCTTTCCCCACTGCCATG
ATGCCCCAGCAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCCAGCCTCTGTGGGCAAGTACCCCACACCCCCT
TCACAGCACAGTTATGCTTCCTCAAATGCTGCTGAGCGAACACCCAGTCACAGTGGTCACCTCCAGGGTGAGCATCCCTACCTGACACCA
TCCCCAGAGTCTCCTGACCAGTGGTCAAGTTCATCACCCCACTCTGCTTCTGACTGGTCAGATGTGACCACCAGCCCTACCCCTGGGGGT
GCTGGAGGAGGTCAGCGGGGACCTGGGACACACATGTCTGAGCCACCACACAACAACATGCAGGTTTATGCGTGAGAGAGTCCACCTCCA
GTGTAGAGACATAACTGACTTTTGTAAATGCTGCTGAGGAACAAATGAAGGTCATCCGGGAGAGAAATGAAGAAATCTCTGGAGCCAGCT
TCTAGAGGTAGGAAAGAGAAGATGTTCTTATTCAGATAATGCAAGAGAAGCAATTCGTCAGTTTCACTGGGTATCTGCAAGGCTTATTGA
TTATTCTAATCTAATAAGACAAGTTTGTGGAAATGCAAGATGAATACAAGCCTTGGGTCCATGTTTACTCTCTTCTATTTGGAGAATAAG
ATGGATGCTTATTGAAGCCCAGACATTCTTGCAGCTTGGACTGCATTTTAAGCCCTGCAGGCTTCTGCCATATCCATGAGAAGATTCTAC
ACTAGCGTCCTGTTGGGAATTATGCCCTGGAATTCTGCCTGAATTGACCTACGCATCTCCTCCTCCTTGGACATTCTTTTGTCTTCATTT
GGTGCTTTTGGTTTTGCACCTCTCCGTGATTGTAGCCCTACCAGCATGTTATAGGGCAAGACCTTTGTGCTTTTGATCATTCTGGCCCAT
GAAAGCAACTTTGGTCTCCTTTCCCCTCCTGTCTTCCCGGTATCCCTTGGAGTCTCACAAGGTTTACTTTGGTATGGTTCTCAGCACAAA
CCTTTCAAGTATGTTGTTTCTTTGGAAAATGGACATACTGTATTGTGTTCTCCTGCATATATCATTCCTGGAGAGAGAAGGGGAGAAGAA
TACTTTTCTTCAACAAATTTTGGGGGCAGGAGATCCCTTCAAGAGGCTGCACCTTAATTTTTCTTGTCTGTGTGCAGGTCTTCATATAAA
CTTTACCAGGAAGAAGGGTGTGAGTTTGTTGTTTTTCTGTGTATGGGCCTGGTCAGTGTAAAGTTTTATCCTTGATAGTCTAGTTACTAT
GACCCTCCCCACTTTTTTAAAACCAGAAAAAGGTTTGGAATGTTGGAATGACCAAGAGACAAGTTAACTCGTGCAAGAGCCAGTTACCCA
CCCACAGGTCCCCCTACTTCCTGCCAAGCATTCCATTGACTGCCTGTATGGAACACATTTGTCCCAGATCTGAGCATTCTAGGCCTGTTT
CACTCACTCACCCAGCATATGAAACTAGTCTTAACTGTTGAGCCTTTCCTTTCATATCCACAGAAGACACTGTCTCAAATGTTGTACCCT
TGCCATTTAGGACTGAACTTTCCTTAGCCCAAGGGACCCAGTGACAGTTGTCTTCCGTTTGTCAGATGATCAGTCTCTACTGATTATCTT
GCTGCTTAAAGGCCTGCTCACCAATCTTTCTTTCACACCGTGTGGTCCGTGTTACTGGTATACCCAGTATGTTCTCACTGAAGACATGGA
CTTTATATGTTCAAGTGCAGGAATTGGAAAGTTGGACTTGTTTTCTATGATCCAAAACAGCCCTATAAGAAGGTTGGAAAAGGAGGAACT
ATATAGCAGCCTTTGCTATTTTCTGCTACCATTTCTTTTCCTCTGAAGCGGCCATGACATTCCCTTTGGCAACTAACGTAGAAACTCAAC
AGAACATTTTCCTTTCCTAGAGTCACCTTTTAGATGATAATGGACAACTATAGACTTGCTCATTGTTCAGACTGATTGCCCCTCACCTGA
ATCCACTCTCTGTATTCATGCTCTTGGCAATTTCTTTGACTTTCTTTTAAGGGCAGAAGCATTTTAGTTAATTGTAGATAAAGAATAGTT
TTCTTCCTCTTCTCCTTGGGCCAGTTAATAATTGGTCCATGGCTACACTGCAACTTCCGTCCAGTGCTGTGATGCCCATGACACCTGCAA
AATAAGTTCTGCCTGGGCATTTTGTAGATATTAACAGGTGAATTCCCGACTCTTTTGGTTTGAATGACAGTTCTCATTCCTTCTATGGCT
GCAAGTATGCATCAGTGCTTCCCACTTACCTGATTTGTCTGTCGGTGGCCCCATATGGAAACCCTGCGTGTCTGTTGGCATAATAGTTTA
CAAATGGTTTTTTCAGTCCTATCCAAATTTATTGAACCAACAAAAATAATTACTTCTGCCCTGAGATAAGCAGATTAAGTTTGTTCATTC
TCTGCTTTATTCTCTCCATGTGGCAACATTCTGTCAGCCTCTTTCATAGTGTGCAAACATTTTATCATTCTAAATGGTGACTCTCTGCCC
TTGGACCCATTTATTATTCACAGATGGGGAGAACCTATCTGCATGGACCTCTGTGGACCACAGCGTACCTGCCCCTTTCTGCCCTCCTGC
TCCAGCCCCACTTCTGAAAGTATCAGCTACTGATCCAGCCACTGGATATTTTATATCCTCCCTTTTCCTTAAGCACAATGTCAGACCAAA
TTGCTTGTTTCTTTTTCTTGGACTACTTTAATTTGGATCCTTTGGGTTTGGAGAAAGGGAATGTGAAAGCTGTCATTACAGACAACAGGT
TTCAGTGATGAGGAGGACAACACTGCCTTTCAAACTTTTTACTGATCTCTTAGATTTTAAGAACTCTTGAATTGTGTGGTATCTAATAAA
AGGGAAGGTAAGATGGATAATCACTTTCTCATTTGGGTTCTGAATTGGAGACTCAGTTTTTATGAGACACATCTTTTATGCCATGTATAG
ATCCTCCCCTGCTATTTTTGGTTTATTTTTATTGTTATAAATGCTTTCTTTCTTTGACTCCTCTTCTGCCTGCCTTTGGGGATAGGTTTT
TTTGTTTGTTTATTTGCTTCCTCTGTTTTGTTTTAAGCATCATTTTCTTATGTGAGGTGGGGAAGGGAAAGGTATGAGGGAAAGAGAGTC
TGAGAATTAAAATATTTTAGTATAAGCAATTGGCTGTGATGCTCAAATCCATTGCATCCTCTTATTGAATTTGCCAATTTGTAATTTTTG
CATAATAAAGAACCAAAGGTGTAATGTTTTGTTGAGAGGTGGTTTAGGGATTTTGGCCCTAACCAATACATTGAATGTATGATGACTATT
TGGGAGGACACATTTATGTACCCAGAGGCCCCCACTAATAAGTGGTACTATGGTTACTTCCTTGTGTACATTTCTCTTAAAAGTGATATT
ATATCTGTTTGTATGAGAAACCCAGTAACCAATAAAATGACCGCATATTCCTGACTAAACGTAGTAAGGAAAATGCACACTTTGTTTTTA
CTTTTCCGTTTCATTCTAAAGGTAGTTAAGATGAAATTTATATGAAAGCATTTTTATCACAAAATAAAAAAGGTTTGCCAAGCTCAGTGG
TGTTGTATTTTTTATTTTCCAATACTGCATCCATGGCCTGGCAGTGTTACCTCATGATGTCATAATTTGCTGAGAGAGCAAATTTTCTTT
TCTTTCTGAATCCCACAAAGCCTAGCACCAAACTTCTTTTTTTCTTCCTTTAATTAGATCATAAATAAATGATCCTGGGGAAAAAGCATC
TGTCAAATAGGAAACATCACAAAACTGAGCACTCTTCTGTGCACTAGCCATAGCTGGTGACAAACAGATGGTTGCTCAGGGACAAGGTGC
CTTCCAATGGAAATGCGAAGTAGTTGCTATAGCAAGAATTGGGAACTGGGATATAAGTCATAATATTAATTATGCTGTTATGTAAATGAT
TGGTTTGTAACATTCCTTAAGTGAAATTTGTGTAGAACTTAATATACAGGATTATAAAATAATATTTTGTGTATAAATTTGTTATAAGTT

>2546_2546_1_ADRBK2-NOTCH2_ADRBK2_chr22_26000420_ENST00000324198_NOTCH2_chr1_120572610_ENST00000256646_length(amino acids)=2510AA_BP=63
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIALQCRDGYEPCVNEGMCVTYHNGTGYC
KCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKE
CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV
NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGG
YGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGAD
CTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSN
PCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSY
TCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNI
DIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGT
CDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLC
APGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMN
ECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCV
DGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGN
THYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLL
CEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQM
PCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQ
CAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLF
DNFECQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKR
DSQGELMVYPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESL
TPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDD
EGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDA
EDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARM
NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLD
HFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTSALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAK
EAKDAKGSRRKKSLSEKVQLSESSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLA
HGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGKHITTPREPL
PPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHS

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Fusion Gene PPI Analysis for ADRBK2-NOTCH2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ADRBK2-NOTCH2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ADRBK2-NOTCH2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source