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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADRBK2-SF3A1 (FusionGDB2 ID:2549)

Fusion Gene Summary for ADRBK2-SF3A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADRBK2-SF3A1
Fusion gene ID: 2549
HgeneTgene
Gene symbol

ADRBK2

SF3A1

Gene ID

157

10291

Gene nameG protein-coupled receptor kinase 3splicing factor 3a subunit 1
SynonymsADRBK2|BARK2PRP21|PRPF21|SAP114|SF3A120
Cytomap

22q12.1

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionbeta-adrenergic receptor kinase 2adrenergic, beta, receptor kinase 2beta-ARK-2splicing factor 3A subunit 1SAP 114pre-mRNA processing 21pre-mRNA splicing factor SF3a (120 kDa subunit)spliceosome-associated protein 114splicing factor 3 subunit 1splicing factor 3a, subunit 1, 120kDsplicing factor 3a, subunit 1, 120kDa
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000324198, ENST00000215793, 
ENST00000439242, 
Fusion gene scores* DoF score9 X 4 X 7=2527 X 6 X 4=168
# samples 107
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADRBK2 [Title/Abstract] AND SF3A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADRBK2(26040632)-SF3A1(30749061), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADRBK2

GO:0031623

receptor internalization

20074556

TgeneSF3A1

GO:0000398

mRNA splicing, via spliceosome

10882114|29360106

TgeneSF3A1

GO:1903241

U2-type prespliceosome assembly

10882114|11533230


check buttonFusion gene breakpoints across ADRBK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SF3A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0T3-01AADRBK2chr22

26040632

-SF3A1chr22

30749061

-
ChimerDB4BRCATCGA-A2-A0T3-01AADRBK2chr22

26040632

+SF3A1chr22

30749061

-
ChimerDB4BRCATCGA-A2-A0T3ADRBK2chr22

26040632

+SF3A1chr22

30749061

-


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Fusion Gene ORF analysis for ADRBK2-SF3A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324198ENST00000215793ADRBK2chr22

26040632

+SF3A1chr22

30749061

-
In-frameENST00000324198ENST00000439242ADRBK2chr22

26040632

+SF3A1chr22

30749061

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324198ADRBK2chr2226040632+ENST00000215793SF3A1chr2230749061-53814561922774860
ENST00000324198ADRBK2chr2226040632+ENST00000439242SF3A1chr2230749061-51844561922579795

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324198ENST00000215793ADRBK2chr2226040632+SF3A1chr2230749061-0.0012409670.99875903
ENST00000324198ENST00000439242ADRBK2chr2226040632+SF3A1chr2230749061-0.0012620170.998738

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Fusion Genomic Features for ADRBK2-SF3A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADRBK2-SF3A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:26040632/chr22:30749061)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016118_12221794.0Compositional biasNote=Poly-Gln
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016260_26721794.0Compositional biasNote=Poly-Glu
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016369_37221794.0Compositional biasNote=Poly-Pro
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016557_56021794.0Compositional biasNote=Poly-Pro
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016672_67521794.0Compositional biasNote=Poly-Pro
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016707_79321794.0DomainUbiquitin-like
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016680_70221794.0RegionRequired and sufficient for nuclear import
TgeneSF3A1chr22:26040632chr22:30749061ENST00000215793016166_20821794.0RepeatNote=SURP motif 2
TgeneSF3A1chr22:26040632chr22:30749061ENST0000021579301652_9421794.0RepeatNote=SURP motif 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADRBK2chr22:26040632chr22:30749061ENST00000324198+321191_45388689.0DomainProtein kinase
HgeneADRBK2chr22:26040632chr22:30749061ENST00000324198+321454_52188689.0DomainAGC-kinase C-terminal
HgeneADRBK2chr22:26040632chr22:30749061ENST00000324198+32154_17588689.0DomainRGS
HgeneADRBK2chr22:26040632chr22:30749061ENST00000324198+321558_65288689.0DomainPH
HgeneADRBK2chr22:26040632chr22:30749061ENST00000324198+321197_20588689.0Nucleotide bindingATP
HgeneADRBK2chr22:26040632chr22:30749061ENST00000324198+3211_19088689.0RegionNote=N-terminal
TgeneSF3A1chr22:26040632chr22:30749061ENST0000021579301610_1621794.0Compositional biasNote=Poly-Pro


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Fusion Gene Sequence for ADRBK2-SF3A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2549_2549_1_ADRBK2-SF3A1_ADRBK2_chr22_26040632_ENST00000324198_SF3A1_chr22_30749061_ENST00000215793_length(transcript)=5381nt_BP=456nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAGTTGTGGGGATTATTTACCCTCCTCCAGAGGTC
AGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAGCTAGGATCCGACAGAACGAGATCAACAACCCC
AAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCAGCGAGTTCAAGGAAGGGAAGGCTCAGGAGCCG
TCCGCCGCCATCCCCAAGGTCATGCAGCAGCAGCAGCAGACCACCCAGCAGCAGCTGCCCCAGAAGGTCCAAGCCCAAGTAATCCAAGAG
ACCATCGTGCCCAAAGAGCCTCCTCCTGAGTTTGAGTTCATTGCTGATCCTCCCTCTATCTCAGCCTTCGACTTGGATGTGGTGAAGCTG
ACGGCTCAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAGAGCAGCGCAACTACCAGTTTGACTTTCTCCGC
CCACAGCACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCTTGATTCCACCCAAAGGTTTATTTTCAAAGCTC
AAGAAAGAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAATGGGCCAAATTCCAGGAACGTGAGAGGAAGAAG
GAAGAAGAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATTTTGTGGTGGTGGAAACAGTGGACTTCCAACCC
AATGAGCAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCCTCATTCAGGAGCGCTATGAAAAGTTTGGGGAG
AGTGAGGAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGGCGGAGGAGCCTCCTTCCCAGCTGGACCAGGAC
ACCCAAGTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGCCCCCACCCCCAGAGACACCCATGCCTCCACCT
CTGCCCCCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCAAGCCCTTGCCTCCAGCCCCTGCTCCAGATGAG
TATCTTGTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACATGCGCATTGGACTTCTTGACCCTCGCTGGCTG
GAGCAGCGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAGGTCTGGATATTGAGAGCAGCTTGAAGCAGTTG
GCTGAGCGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCGGTGAGGAGGAGATCCAGAAGCCAGAGGAAAAG
GTGACCTGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCAACATCACCCTCCAGGAGCAGATTGAGGCCATT
CACAAGGCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCAAGCCCAATGAAATCCCTCAACAGCCACCGCCA
CCATCTTCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGACCACCCACAATGCCACCTCCAGTTCGTACTACA
GTTGTCTCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGCCCCCAGGCTCAGTGATCGCCCCCATGCCGCCC
ATCATCCACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTATGGCCCCCCGCCCACCCCCCATGATTGTGCCA
ACAGCCTTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCCCTGTGCATCCCCCACCTCCCATGGAAGATGAG
CCCACCTCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGCGCAGAAACAAGGGTCCAGTGTCCATCAAAGTC
CAGGTGCCCAACATGCAGGATAAGACGGAATGGAAACTGAATGGGCAGGTGCTGGTCTTCACCCTCCCACTCACGGACCAGGTCTCTGTC
ATTAAGGTGAAGATTCATGAAGCCACAGGCATGCCTGCAGGGAAACAGAAGCTACAGTATGAGGGTATCTTCATCAAAGATTCCAACTCA
CTGGCTTACTACAACATGGCCAATGGCGCAGTCATCCACCTGGCCCTCAAGGAGAGAGGCGGGAGGAAGAAGTAGACAAGAGGAACCTGC
TGTCAAGTCCCTGCCATTTTGCCTCTCCTGTCTCCCACCCCCTGCCCCAGACCCAGGAGCCCCCCTGAGGCTTTGCCTTGCCTGCATATT
TGTTTCGCTCTTACTCAGTTTGGGAATTCAAATTGTCCTGCAGAGGTTCATTCCCCTGACCCTTTCCCCACATTGGTAAGAGTAGCTGGG
TTTTCTAAGCCACTCTCTGGAATCTCTTTGTGTTAGGGTCTCGATTTGAGGACATTCATTTCTTCAGCAGCCCATTAGCAACTGAGAGCC
CAGGGATGTCCTACAGGATAGTTTCATAGTGACAGGTGGCACTTGGCTAATAGAATATGGCTGATATTGTCATTAATCATTTTGTACCTT
GACATGGGTTGTCTAATAAAACTCGGACCCTTCTTGTGAAATCAGTTAAATAAGACTTGTCTCGGTCACCTGTGCCCTGTCCAGACTCGA
GGCAGTGGTAACACTGCACAGTGCTATGTGGCTTCTCTTTGAGGATTTTTGGGTTTTGTAACTAAATTCTTGCTGCCCTCATACTTTTTA
TGTATTAGAATCATATTCGTATTGCCCTTTTAAAACATTGGGATCCTCCAAAGGCCTGCCCCATGTATTTAACAGTAATACAGGAAGCAT
GGCAGGCACCATGCAAACCAAGGATGGATGGTGCAGTCCCTGTGTCAGTGGGCGGTGGTTTCCTGCTGGCCTGGAATCACTCATCACCTG
ATTGATTGGCTCTGTGGTCCTGGGCAGGTGCCTCATAGGTGTGTGGATATGATGACGTTTCTTTAAAATGTATGTATTTAACAAATACTT
AATTGTATTAAGGTCATGTACCAAGGATTTGATAAAGTTTAAATAATTTACTCTCTACTTTTATCCATTTTATCCATTTTAACTCATGTA
ATCCTCATGTGAGTATTCCTGTTTAACACTTGAGTAAACTGAGGCACAGAGAACATAAGTTGCATGCCATAGTCACACACTGTGAAAGTG
AAAAGAGAATGTGTGCAAAACACGTCACAGTCCTGGTTTCTGAGTAAAGGCAGGCTGTTATCTTTAGAATCAAGCTATCACAGGGAGATA
GGCAATGCTGTGGGTGTTGGAGGAAGGTGAGAGCCTGTTGCTAACAATTTCCTGGTTTTAAAGCTAAGGCTGATTTTATTGGGAAGATCT
CACATGTGTGTGGCCCCTGAGAGTTCCCAGTGCCTTTTATTTGCAGTCCTTCCATTTGGACCTCCTAGCTGCCCCATCAGGTCATCTCCA
GGGCTCAGAGGGGTGAGACCATTTCCCAAGGTCACAGAACCAGCTCTCTAGTCACCACCCTGCCTCTCCCTCTCACCCAGAGTCAGTACC
AGTTTTATGGCTTTATTACAAACTGCTGGGTCCCTCCCATTTTCAACTTGATTGATGGGATGTCATCCCTTATCCTGTCTGACATTTGCC
TCTGGCCTGGTTGCTAGAAGTTTGCCCCAGGGGCAAGAGTTGAAATTTGGCTTCCTGAGGTGGGCTTTGTGGTTTGCGTCCCTAAAGTGA
GCCCACTACTGGTTGCTTGTCCATGGCCAACACCAGAAATCCCCTGAGCACTACCTGGGTCTCATTCCAAGAAGGAAGAGGGTCAGGAGA
CCTGGGGAGTCTCATATTCCAAGTTCTTCTTTCTTTCTGGGAGCAGTGGGCAGTTCATGGTGTTAGGGCACTCACCCCCACAGACTGGCA
AACCCTGCAGGACTTCCGTGGCTGAGGCTGTGACCGGAGGCCAGGAATGCCGTTGGGTGGATTGTGAGTGAATGGGCCCTTTGAGCTGCC
CTCTAGAGAGCAAATCCAGTTTCCTGGAGCTCCTGAATGAATATCTGTACTGGCTCGCTCAGATGCAGAAGCTCCATTGACCATGAGGCC
TTGTGAACATCAGTGGCCACAGGCCCAGTGTGCTGCTTGGCACTGCACTAGTTTAGGACCTGCAGCATGTAGGTAGCGTCCTAGTGTTTA
TAATACAAAGCTGCTCTGCACAGCTTTTCTGATTCTTCTTGCAATCTCCTGAGGATTATCTGCCCCATTTTTAAAACGAGGTGGAATACC
CAAGGTCATGTAGCCAGTGAGTGCTCTGGAAAGCCAAAGCAGCTCATCCCTTCCTGGGGACCACACTGCTCTGCTCCACCAGACCACACT
ATGAAATAGGAATAAGTGCTCCTGTTGCAGGACTGCTGGGAAAACAGGTGGTGTGGGACTTAAGTCACCATAATTTTGAAGACTTGCATG
CAGAGGGCTCCAGGAATTGTAGACATTAAGGAATTTCACTTTCAGTTCTACCCACTACTTAAGTACTTGTCATGTACTCTTAGAGGAGGC
CAGTAATGATCAGAACCATTTTACTTTAAAATTAATAATATTGTATTAGAGAATATATTAAATGGTTATATTGGGTTATGTTAGGATATA
TACTTGAATGGAAATACATGTACTATTAGCAATCATATTTCATTTATCCCTGTAATTAGACAAGAAAGCATAATATAGCTCTACTCATGG

>2549_2549_1_ADRBK2-SF3A1_ADRBK2_chr22_26040632_ENST00000324198_SF3A1_chr22_30749061_ENST00000215793_length(amino acids)=860AA_BP=88
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEPT
EEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGKAQEPSAAI
PKVMQQQQQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHS
LFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQG
NFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPT
PDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERR
TDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSA
TNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFV
PAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKTEWKLNGQVLVFTLPLTDQVSVIKVK

--------------------------------------------------------------
>2549_2549_2_ADRBK2-SF3A1_ADRBK2_chr22_26040632_ENST00000324198_SF3A1_chr22_30749061_ENST00000439242_length(transcript)=5184nt_BP=456nt
GGCCGGCTACAGCCTGCGGCGCGCGCAGAGCGCTAGTGGGGCGCGCGGCGCGCGCGCGGGGCGGGGGCGCGCGGAGGGGGGGGCTGCCCC
GGGGCGGCCCCCCCAGGTCGGGGCGCGGCGGGCGGCGGCGGCGGGCGCGCGTCCCGTCCAGGTCCGGAGTAACCGCCGCCGCCGCCGCCA
AAGCTCGCCAACATGGCGGACCTGGAGGCTGTGCTGGCCGATGTCAGTTACCTGATGGCCATGGAGAAGAGCAAGGCGACCCCGGCCGCC
CGCGCCAGCAAGAGGATCGTCCTGCCGGAGCCCAGTATCCGGAGTGTGATGCAGAAGTACCTTGCAGAGAGAAATGAAATAACCTTTGAC
AAGATTTTCAATCAGAAAATTGGTTTCTTGCTATTTAAAGATTTTTGTTTGAATGAAATTAATGAAGCTGTACCTCAGGTGAAGTTTTAT
GAAGAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAGTTGTGGGGATTATTTACCCTCCTCCAGAGGTC
AGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAGCTAGGATCCGACAGAACGAGATCAACAACCCC
AAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCAGCGAGTTCAAGGAAGGGAAGGCTCAGTTTGTG
GCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAGAGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAGCACAGCCTC
TTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCTTGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAAGAGGCTGAA
AACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAATGGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAAGAGGAGAAG
GAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATTTTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAGCAAGGGAAC
TTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCCTCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAGGAAGTTGAG
ATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGGCGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAAGTACAAGAT
ATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGCCCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCCCCAACTCCA
GACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCAAGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTTGTGTCCCCC
ATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACATGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAGCGGGATCGC
TCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAGGTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAGCGGCGTACT
GACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCGGTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACCTGGGATGGC
CACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCAACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAGGCCAAAGGC
CTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCAAGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCTTCAGCCACC
AACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGACCACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTCTCCGCAGTA
CCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGCCCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATCCACGCGCCC
AGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTATGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCCTTTGTGCCT
GCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCCCTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACCTCCAAAAAA
CTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGCGCAGAAACAAGGGTCCAGTGTCCATCAAAGTCCAGGTGCCCAACATG
CAGGATAAGACGGAATGGAAACTGAATGGGCAGGTGCTGGTCTTCACCCTCCCACTCACGGACCAGGTCTCTGTCATTAAGGTGAAGATT
CATGAAGCCACAGGCATGCCTGCAGGGAAACAGAAGCTACAGTATGAGGGTATCTTCATCAAAGATTCCAACTCACTGGCTTACTACAAC
ATGGCCAATGGCGCAGTCATCCACCTGGCCCTCAAGGAGAGAGGCGGGAGGAAGAAGTAGACAAGAGGAACCTGCTGTCAAGTCCCTGCC
ATTTTGCCTCTCCTGTCTCCCACCCCCTGCCCCAGACCCAGGAGCCCCCCTGAGGCTTTGCCTTGCCTGCATATTTGTTTCGCTCTTACT
CAGTTTGGGAATTCAAATTGTCCTGCAGAGGTTCATTCCCCTGACCCTTTCCCCACATTGGTAAGAGTAGCTGGGTTTTCTAAGCCACTC
TCTGGAATCTCTTTGTGTTAGGGTCTCGATTTGAGGACATTCATTTCTTCAGCAGCCCATTAGCAACTGAGAGCCCAGGGATGTCCTACA
GGATAGTTTCATAGTGACAGGTGGCACTTGGCTAATAGAATATGGCTGATATTGTCATTAATCATTTTGTACCTTGACATGGGTTGTCTA
ATAAAACTCGGACCCTTCTTGTGAAATCAGTTAAATAAGACTTGTCTCGGTCACCTGTGCCCTGTCCAGACTCGAGGCAGTGGTAACACT
GCACAGTGCTATGTGGCTTCTCTTTGAGGATTTTTGGGTTTTGTAACTAAATTCTTGCTGCCCTCATACTTTTTATGTATTAGAATCATA
TTCGTATTGCCCTTTTAAAACATTGGGATCCTCCAAAGGCCTGCCCCATGTATTTAACAGTAATACAGGAAGCATGGCAGGCACCATGCA
AACCAAGGATGGATGGTGCAGTCCCTGTGTCAGTGGGCGGTGGTTTCCTGCTGGCCTGGAATCACTCATCACCTGATTGATTGGCTCTGT
GGTCCTGGGCAGGTGCCTCATAGGTGTGTGGATATGATGACGTTTCTTTAAAATGTATGTATTTAACAAATACTTAATTGTATTAAGGTC
ATGTACCAAGGATTTGATAAAGTTTAAATAATTTACTCTCTACTTTTATCCATTTTATCCATTTTAACTCATGTAATCCTCATGTGAGTA
TTCCTGTTTAACACTTGAGTAAACTGAGGCACAGAGAACATAAGTTGCATGCCATAGTCACACACTGTGAAAGTGAAAAGAGAATGTGTG
CAAAACACGTCACAGTCCTGGTTTCTGAGTAAAGGCAGGCTGTTATCTTTAGAATCAAGCTATCACAGGGAGATAGGCAATGCTGTGGGT
GTTGGAGGAAGGTGAGAGCCTGTTGCTAACAATTTCCTGGTTTTAAAGCTAAGGCTGATTTTATTGGGAAGATCTCACATGTGTGTGGCC
CCTGAGAGTTCCCAGTGCCTTTTATTTGCAGTCCTTCCATTTGGACCTCCTAGCTGCCCCATCAGGTCATCTCCAGGGCTCAGAGGGGTG
AGACCATTTCCCAAGGTCACAGAACCAGCTCTCTAGTCACCACCCTGCCTCTCCCTCTCACCCAGAGTCAGTACCAGTTTTATGGCTTTA
TTACAAACTGCTGGGTCCCTCCCATTTTCAACTTGATTGATGGGATGTCATCCCTTATCCTGTCTGACATTTGCCTCTGGCCTGGTTGCT
AGAAGTTTGCCCCAGGGGCAAGAGTTGAAATTTGGCTTCCTGAGGTGGGCTTTGTGGTTTGCGTCCCTAAAGTGAGCCCACTACTGGTTG
CTTGTCCATGGCCAACACCAGAAATCCCCTGAGCACTACCTGGGTCTCATTCCAAGAAGGAAGAGGGTCAGGAGACCTGGGGAGTCTCAT
ATTCCAAGTTCTTCTTTCTTTCTGGGAGCAGTGGGCAGTTCATGGTGTTAGGGCACTCACCCCCACAGACTGGCAAACCCTGCAGGACTT
CCGTGGCTGAGGCTGTGACCGGAGGCCAGGAATGCCGTTGGGTGGATTGTGAGTGAATGGGCCCTTTGAGCTGCCCTCTAGAGAGCAAAT
CCAGTTTCCTGGAGCTCCTGAATGAATATCTGTACTGGCTCGCTCAGATGCAGAAGCTCCATTGACCATGAGGCCTTGTGAACATCAGTG
GCCACAGGCCCAGTGTGCTGCTTGGCACTGCACTAGTTTAGGACCTGCAGCATGTAGGTAGCGTCCTAGTGTTTATAATACAAAGCTGCT
CTGCACAGCTTTTCTGATTCTTCTTGCAATCTCCTGAGGATTATCTGCCCCATTTTTAAAACGAGGTGGAATACCCAAGGTCATGTAGCC
AGTGAGTGCTCTGGAAAGCCAAAGCAGCTCATCCCTTCCTGGGGACCACACTGCTCTGCTCCACCAGACCACACTATGAAATAGGAATAA
GTGCTCCTGTTGCAGGACTGCTGGGAAAACAGGTGGTGTGGGACTTAAGTCACCATAATTTTGAAGACTTGCATGCAGAGGGCTCCAGGA
ATTGTAGACATTAAGGAATTTCACTTTCAGTTCTACCCACTACTTAAGTACTTGTCATGTACTCTTAGAGGAGGCCAGTAATGATCAGAA
CCATTTTACTTTAAAATTAATAATATTGTATTAGAGAATATATTAAATGGTTATATTGGGTTATGTTAGGATATATACTTGAATGGAAAT
ACATGTACTATTAGCAATCATATTTCATTTATCCCTGTAATTAGACAAGAAAGCATAATATAGCTCTACTCATGGGTACACATACCAGTG

>2549_2549_2_ADRBK2-SF3A1_ADRBK2_chr22_26040632_ENST00000324198_SF3A1_chr22_30749061_ENST00000439242_length(amino acids)=795AA_BP=88
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEPT
EEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKEGKAQFVARNG
RQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKER
VAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQVQDMDEG
SDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIRE
KQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPE
DDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIHAPRINV
VPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKGPVSIKVQVPNMQDKT

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Fusion Gene PPI Analysis for ADRBK2-SF3A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADRBK2-SF3A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADRBK2-SF3A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource