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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EHBP1-COMMD1 (FusionGDB2 ID:25526)

Fusion Gene Summary for EHBP1-COMMD1

Fusion gene summary

Fusion gene information	Fusion gene name: EHBP1-COMMD1
	Fusion gene ID: 25526
		Hgene	Tgene
	Gene symbol	EHBP1	COMMD1
	Gene ID	23301	150684
	Gene name	EH domain binding protein 1	copper metabolism domain containing 1
	Synonyms	HPC12\|NACSIN	C2orf5\|MURR1
	Cytomap	2p15	2p15
	Type of gene	protein-coding	protein-coding
	Description	EH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50e	COMM domain-containing protein 1copper metabolism (Murr1) domain containing 1copper metabolism gene MURR1protein Murr1
	Modification date	20200313	20200313
	UniProtAcc	Q8NDI1	Q9Y6G5
	Ensembl transtripts involved in fusion gene	ENST00000496857, ENST00000263991, ENST00000354487, ENST00000405015, ENST00000405289, ENST00000431489,	ENST00000311832, ENST00000472729, ENST00000538736,
Fusion gene scores	* DoF score	8 X 12 X 8=768	12 X 10 X 9=1080
	# samples	20	24
	** MAII score	log2(20/768*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/1080*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EHBP1 [Title/Abstract] AND COMMD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EHBP1(62998527)-COMMD1(62227836), # samples:2 EHBP1(62998527)-COMMD1(62362966), # samples:2 EHBP1(63223901)-COMMD1(62362966), # samples:2 EHBP1(62991496)-COMMD1(62362966), # samples:2 EHBP1(62974587)-COMMD1(62227836), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	COMMD1	GO:0031398	positive regulation of protein ubiquitination	17183367\|21741370
Tgene	COMMD1	GO:0032088	negative regulation of NF-kappaB transcription factor activity	15799966\|16573520
Tgene	COMMD1	GO:0048227	plasma membrane to endosome transport	21741370
Tgene	COMMD1	GO:0055070	copper ion homeostasis	14685266
Tgene	COMMD1	GO:1902306	negative regulation of sodium ion transmembrane transport	14645214
Tgene	COMMD1	GO:2000009	negative regulation of protein localization to cell surface	21741370

Fusion gene breakpoints across EHBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COMMD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GV-A40E-01A	EHBP1	chr2	62998527	-	COMMD1	chr2	62227836	+
ChimerDB4	BLCA	TCGA-GV-A40E-01A	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
ChimerDB4	BRCA	TCGA-AR-A1AO-01A	EHBP1	chr2	62998527	-	COMMD1	chr2	62362966	+
ChimerDB4	BRCA	TCGA-AR-A1AO-01A	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
ChimerDB4	BRCA	TCGA-AR-A1AO	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
ChimerDB4	LIHC	TCGA-DD-A3A5-01A	EHBP1	chr2	63223901	-	COMMD1	chr2	62362966	+
ChimerDB4	LIHC	TCGA-DD-A3A5-01A	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
ChimerDB4	LIHC	TCGA-DD-A3A5	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
ChimerDB4	LUAD	TCGA-44-7660-01A	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
ChimerDB4	LUSC	TCGA-63-A5MR-01A	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
ChimerDB4	LUSC	TCGA-63-A5MR-01A	EHBP1	chr2	62991496	-	COMMD1	chr2	62362966	+
ChimerDB4	LUSC	TCGA-63-A5MR	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
ChimerDB4	LUSC	TCGA-63-A5MR	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
ChimerDB4	STAD	TCGA-BR-8590-01A	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
ChimerDB4	STAD	TCGA-VQ-A925-01A	EHBP1	chr2	62974587	-	COMMD1	chr2	62227836	+
ChimerDB4	STAD	TCGA-VQ-A925-01A	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
ChimerDB4	STAD	TCGA-VQ-A925	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+

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Fusion Gene ORF analysis for EHBP1-COMMD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
3UTR-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
3UTR-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
3UTR-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
3UTR-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
3UTR-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	63182795	-	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	63086426	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62991495	+	COMMD1	chr2	62362965	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for EHBP1-COMMD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+	5.96E-07	0.9999994
EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+	5.96E-07	0.9999994
EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+	2.04E-07	0.99999976
EHBP1	chr2	62998527	+	COMMD1	chr2	62227835	+	2.43E-07	0.99999976
EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+	2.04E-07	0.99999976
EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+	4.12E-09	1
EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+	1.40E-09	1
EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+	4.12E-09	1
EHBP1	chr2	63086426	+	COMMD1	chr2	62227835	+	1.00E-09	1
EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+	1.40E-09	1
EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+	5.96E-07	0.9999994
EHBP1	chr2	62998527	+	COMMD1	chr2	62362965	+	5.96E-07	0.9999994
EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+	2.04E-07	0.99999976
EHBP1	chr2	62998527	+	COMMD1	chr2	62227835	+	2.43E-07	0.99999976
EHBP1	chr2	62991496	+	COMMD1	chr2	62362965	+	2.04E-07	0.99999976
EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+	4.12E-09	1
EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+	1.40E-09	1
EHBP1	chr2	63223901	+	COMMD1	chr2	62362965	+	4.12E-09	1
EHBP1	chr2	63086426	+	COMMD1	chr2	62227835	+	1.00E-09	1
EHBP1	chr2	62974587	+	COMMD1	chr2	62227835	+	1.40E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EHBP1-COMMD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:62998527/:62227836)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EHBP1 Q8NDI1	COMMD1 Q9Y6G5
FUNCTION: May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250\|UniProtKB:Q69ZW3, ECO:0000269\|PubMed:14676205, ECO:0000305\|PubMed:27552051}.	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269\|PubMed:15799966, ECO:0000305\|PubMed:21778237}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for EHBP1-COMMD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EHBP1-COMMD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EHBP1-COMMD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EHBP1-COMMD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source