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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EHD1-ADRBK2 (FusionGDB2 ID:25546)

Fusion Gene Summary for EHD1-ADRBK2

Fusion gene summary

Fusion gene information	Fusion gene name: EHD1-ADRBK2
	Fusion gene ID: 25546
		Hgene	Tgene
	Gene symbol	EHD1	ADRBK2
	Gene ID	10938	157
	Gene name	EH domain containing 1	G protein-coupled receptor kinase 3
	Synonyms	H-PAST\|HPAST1\|PAST\|PAST1	ADRBK2\|BARK2
	Cytomap	11q13.1	22q12.1
	Type of gene	protein-coding	protein-coding
	Description	EH domain-containing protein 1PAST homolog 1testilin	beta-adrenergic receptor kinase 2adrenergic, beta, receptor kinase 2beta-ARK-2
	Modification date	20200329	20200313
	UniProtAcc	Q9H4M9	.
	Ensembl transtripts involved in fusion gene	ENST00000359393, ENST00000320631, ENST00000488711,	ENST00000324198,
Fusion gene scores	* DoF score	6 X 7 X 6=252	3 X 2 X 3=18
	# samples	8	3
	** MAII score	log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EHD1 [Title/Abstract] AND ADRBK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EHD1(64627396)-ADRBK2(26057543), # samples:2
Anticipated loss of major functional domain due to fusion event.	EHD1-ADRBK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EHD1-ADRBK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ADRBK2	GO:0031623	receptor internalization	20074556

Fusion gene breakpoints across EHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADRBK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7686-01A	EHD1	chr11	64627396	-	ADRBK2	chr22	26057543	+
ChimerDB4	LGG	TCGA-HT-7686	EHD1	chr11	64627396	-	ADRBK2	chr22	26057543	+

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Fusion Gene ORF analysis for EHD1-ADRBK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000359393	ENST00000324198	EHD1	chr11	64627396	-	ADRBK2	chr22	26057543	+
In-frame	ENST00000320631	ENST00000324198	EHD1	chr11	64627396	-	ADRBK2	chr22	26057543	+
intron-3CDS	ENST00000488711	ENST00000324198	EHD1	chr11	64627396	-	ADRBK2	chr22	26057543	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000320631

EHD1

chr11

64627396

ENST00000324198

ADRBK2

chr22

26057543

9817

1170

123

2972

949

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000320631	ENST00000324198	EHD1	chr11	64627396	-	ADRBK2	chr22	26057543	+	0.000148637	0.99985135

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Fusion Genomic Features for EHD1-ADRBK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EHD1	chr11	64627395	-	ADRBK2	chr22	26057542	+	0.00012209	0.9998779
EHD1	chr11	64627395	-	ADRBK2	chr22	26057542	+	0.00012209	0.9998779
EHD1	chr11	64627395	-	ADRBK2	chr22	26057542	+	0.00012209	0.9998779
EHD1	chr11	64627395	-	ADRBK2	chr22	26057542	+	0.00012209	0.9998779

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EHD1-ADRBK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64627396/chr22:26057543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EHD1 Q9H4M9	.
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250\|UniProtKB:Q641Z6, ECO:0000250\|UniProtKB:Q9WVK4, ECO:0000269\|PubMed:15020713, ECO:0000269\|PubMed:17233914, ECO:0000269\|PubMed:20801876, ECO:0000269\|PubMed:24019528, ECO:0000269\|PubMed:25686250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

198_227

305

535.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

198_227

305

535.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

55_286

305

535.0

Domain

Dynamin-type G

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

55_286

305

535.0

Domain

Dynamin-type G

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

153_156

305

535.0

Region

G3 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

219_222

305

535.0

Region

G4 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

243_243

305

535.0

Region

G5 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

65_72

305

535.0

Region

G1 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

91_92

305

535.0

Region

G2 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

153_156

305

535.0

Region

G3 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

219_222

305

535.0

Region

G4 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

243_243

305

535.0

Region

G5 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

65_72

305

535.0

Region

G1 motif

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

91_92

305

535.0

Region

G2 motif

Tgene

ADRBK2

chr11:64627396

chr22:26057543

ENST00000324198

191_453

689.0

Domain

Protein kinase

Tgene

ADRBK2

chr11:64627396

chr22:26057543

ENST00000324198

454_521

689.0

Domain

AGC-kinase C-terminal

Tgene

ADRBK2

chr11:64627396

chr22:26057543

ENST00000324198

558_652

689.0

Domain

Tgene

ADRBK2

chr11:64627396

chr22:26057543

ENST00000324198

197_205

689.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

489_500

305

535.0

Calcium binding

Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

489_500

305

535.0

Calcium binding

Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

444_532

305

535.0

Domain

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000320631

476_511

305

535.0

Domain

EF-hand

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

444_532

305

535.0

Domain

Hgene

EHD1

chr11:64627396

chr22:26057543

ENST00000359393

476_511

305

535.0

Domain

EF-hand

Tgene

ADRBK2

chr11:64627396

chr22:26057543

ENST00000324198

54_175

689.0

Domain

RGS

Tgene

ADRBK2

chr11:64627396

chr22:26057543

ENST00000324198

1_190

689.0

Region

Note=N-terminal

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Fusion Gene Sequence for EHD1-ADRBK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>25546_25546_1_EHD1-ADRBK2_EHD1_chr11_64627396_ENST00000320631_ADRBK2_chr22_26057543_ENST00000324198_length(transcript)=9817nt_BP=1170nt
CCCTACCGCCCCCAATTCCGCCCTGCCCCCGCCGCGGCGGCGCTAGCCGCCACTGAGGGACCGACCCTATAAAGGCCGCTCCGCGAGGGG
TGCGCAGCATTCGGCAGAGGGCGCTTCGACGGGCTGGGCTGTGCGCCTGCGCAGTGTGGGTCGCTCCCGATTCCCTGCCCCGGCCGGCCC
CGCCTCGGCTCCGCACCCTCGCCCCGCTCTCAGCCGCCGCTCTGCCCCGCAGCAGCCAGCCCCGTGTCCGGCAGTATGTTCAGCTGGGTC
AGCAAGGATGCCCGCCGCAAGAAGGAGCCGGAGCTCTTCCAGACGGTGGCTGAGGGGCTGCGGCAGCTGTACGCGCAGAAGCTGCTACCC
CTGGAGGAGCACTACCGCTTCCACGAGTTCCACTCGCCCGCGCTGGAGGACGCTGACTTCGACAACAAGCCTATGGTGCTCCTCGTGGGG
CAGTACAGCACGGGCAAGACCACCTTCATCCGACACCTGATCGAGCAGGACTTCCCGGGGATGCGCATCGGGCCCGAGCCCACCACCGAC
TCCTTCATCGCCGTCATGCACGGCCCCACTGAGGGCGTGGTGCCGGGCAACGCGCTCGTGGTGGACCCGCGGCGCCCCTTCCGCAAGCTC
AACGCGTTTGGCAACGCTTTCCTCAACAGGTTCATGTGTGCCCAGCTGCCCAACCCCGTCCTGGACAGCATCAGCATCATCGACACCCCC
GGGATCCTGTCTGGAGAGAAGCAGCGGATCAGCAGAGGCTATGACTTTGCAGCCGTCCTGGAGTGGTTCGCGGAGCGTGTGGACCGCATC
ATCCTGCTCTTCGACGCCCACAAGCTGGACATCTCCGATGAGTTCTCGGAAGTGATCAAGGCTCTGAAGAACCATGAGGACAAGATCCGC
GTGGTGCTGAACAAGGCAGACCAGATCGAGACGCAGCAGCTGATGCGGGTGTACGGGGCCCTCATGTGGTCCCTGGGCAAGATCATCAAC
ACCCCCGAGGTGGTCAGGGTCTACATCGGCTCCTTCTGGTCCCACCCGCTCCTCATCCCCGACAACCGCAAGCTCTTTGAGGCCGAGGAG
CAGGACCTCTTCAAGGACATCCAGTCACTGCCCCGAAACGCCGCCCTCAGGAAGCTCAATGACCTGATCAAGCGGGCACGGCTGGCCAAG
ATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAACTTCTT
TCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTTCAGCCA
TACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAGTGGAAA
AACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTATGGTTGC
AGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCCTTAAAT
GAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAACTCTGC
TTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTTTATGCC
ACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGATGAACAT
GGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTTGGCACCCATGGGTACATGGCT
CCCGAGGTGCTGCAGAAGGGGACGGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCAC
AGCCCTTTCAGACAACATAAAACCAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCT
CCTGAACTGAAGTCCCTTTTGGAGGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAA
GAGCACAGCTTTTTCAAAGGTGTTGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAAT
GCTGCTGATGCCTTTGATATTGGCTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAAC
TTCCCTTTGGTCATCTCTGAACGCTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCC
AGGAAGAGAGCTAAAAATAAGCAACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTG
GGAAACCCATTTCTGACTCAGTGGCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAA
AATTTACTGACAATGGAACAGATTCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAA
CAATTTGTCTTGCAATGTGAGAGTGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTG
CGTCGTGCCCCGAAGTTCCTCAACAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTC
TAGCACCCAGAAACAGGGAGGGTCCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTC
GCTACCGGGACTCCTCCAGGCTCCCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCA
TTAGAAACTACTGAAGAAATAAAAGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATC
ACGTAAATTTTTATGTCTGATATCAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTA
AGCATTGCCACATATTCTGTCTAGTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCT
TTTGTGCACTTCGCAACTGACTTCTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACT
TGGGCCCTCCTCTGGGAGCCGCACCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGA
CACGTACTATCCAAGTGTATGGGATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACA
GGCCGTGGAGTTTTAGGTTTCAGGGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATG
CAGGAGCACTCATGGGTGAGTCCGTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAG
ACATATCAGTAATGGATGTACAAAAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGA
ATGTGTCAAAATGGGTTAACTGTGTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGA
CAGTGAGGACCTTAGGGCATGAAGCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCC
ACTGATACCCCCAAATAGATGCTGGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGT
ATTTGTCCCATTCTTGGAGTAGTTTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCC
TGTCCTTGATATTTTTAGCAGTTCCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTA
TTTTGAGAGTTTGGAAGATAATTACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGT
CTATCTCAACTACTAGTTGGGGTTTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACAT
GCATTCTCCTTATTTAAAAAGGAAGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGA
AGCAGAAAAGCCATTGTTCTTAAAGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCA
AGCTCATAGGTTCTCAGCATGTGCAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTC
CACCAGGGTCTGGGCTTAGCGTCTAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATAC
TTGTTCTAAAATTGAGCTGATCCGCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAA
AAGATATATGAATTGGAAAATGCTCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTG
TAATGATATGGTTGAGAAGTACATCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAG
TTGTGTTGGGGTCTGGTTTGAGTGCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCA
CCCGGTTGCCTGCATGGCCAGAGGAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTT
TGGGATAGGGCCTCGCTCTGTCACCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATC
CTCCCACGTCAGCCTCCTGAGTAGCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGA
ACTCTTAGGCTCAAGTGATCCTCCTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGA
TGTTTTAGAAGGTTTTCCAAGTATTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTAT
TTTTTTTCATTATTTTAGATTCCTGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCG
GTAATAAGTCTTGATTTCATGATTCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAA
TAAATTAAAAACCTTTGTGAATTCAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTC
ATTGGTTTTCCTTCTTTGTCATATTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGC
TCATGCCTCTGATTGGTCCATTCACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCC
TATAATCCCAGCACTTTGGGAGGCCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCT
CTACTAAAAATACAAATAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCAT
GAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAA
AAGGAGGGGGGCTAAATATCCAGTGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTG
TTGCAAACAAGATGTAGCTTGATTTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTA
CAAAGTAATGTTTACCAATTGACGACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCG
GAATTTGTAGCTGGGCCAATTCAACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAA
ACAACGTTCTCAAAGTCTGGCCTCTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGT
ATGATTTAATCATATGCAGTGTTGTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCA
CCCTGAGTGAGGGGTTGACTTGTTGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGA
ATAGTGGTAGAAATCGGGCGAAGGAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATA
GGTGAAGTTTCTTTTTTCCCCCCTGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAG
CTGCTGAACTCATTCAGAAGCCATTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCAT
GGAGGCACAGGGGACCCAGAGCTAAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGCACTTTGCAGCCCCCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTG
TTACAAATCCACTGAAGTCCTGGTAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCC
TGGGCAACACAGCAAGACCCCATCTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTT
TTCCCTCCTATGTAAAGTTTACTGGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACA
AAGTTTATTATGAAACAAATGAAATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCC
TTAAGGACTAAGATAGTTGTTTTATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTT
TCTGACCTGGCTGTGTTAGCACTGATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGG
TTAAGAGTATACGCATTTCATCAAACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAG
CGCTCCAGTATCTAACAATCTCAGAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTT
GATGTAAGGGTAGGGAATGGAGAAATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAA
ATGATGTATATATTATATGTGGTTTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTAT
AATAGATCTGGCTTTTTCTGGATAGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTT
ATATTATTTATTGAATCCATAAGTTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAA
GAAATGGCAGTCCTTCCTGTTCTTAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACT
GTTTTCAACAACAGTTGATCTTCTGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACT
GCTTTCATCTACCTCTTCAGAAGGCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTC
TGTAAGACTTTGCAGTGTCATTCCCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTA
GCTATCCCTCCCATGTCATTAGTAATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCAC
CATCAGCCTTGCCATTGCCTTAAGATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGG
CAAGCTGTGCTTAGAAACACTGCTTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATG
GGGTCTTAAAGGTAAGCGCCCTCATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAG
AATGAAGTCCTGTCTCTGTGAGAGAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACT
ATATTCTTGAATACCCTTGAAGAAAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCT
AGATATTGTACCTAGACAAAATATCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACA
CTCACTAGTGCACGTCTGAAATAGTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAG
CACCACCGTTTTTACAGTTACTTTGGAGCTGCTAGACTGGTTTTCTGTGTTGGTAAATTGCCTATATAAATCTGAATAAAAAGGATCTGT

>25546_25546_1_EHD1-ADRBK2_EHD1_chr11_64627396_ENST00000320631_ADRBK2_chr22_26057543_ENST00000324198_length(amino acids)=949AA_BP=349
MGCAPAQCGSLPIPCPGRPRLGSAPSPRSQPPLCPAAASPVSGSMFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFH
SPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRF
MCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIET
QQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKIKEYEKLDNEE
DRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMN
EFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDL
HYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYD
SSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQ
HVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGH
EEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPE

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Top

Fusion Gene PPI Analysis for EHD1-ADRBK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EHD1-ADRBK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EHD1-ADRBK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source