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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EHF-CAT (FusionGDB2 ID:25568)

Fusion Gene Summary for EHF-CAT

check button Fusion gene summary
Fusion gene informationFusion gene name: EHF-CAT
Fusion gene ID: 25568
HgeneTgene
Gene symbol

EHF

CAT

Gene ID

26298

10249

Gene nameETS homologous factorglycine-N-acyltransferase
SynonymsESE3|ESE3B|ESEJACGNAT|CAT|GAT
Cytomap

11p13

11q12.1

Type of geneprotein-codingprotein-coding
DescriptionETS homologous factorESE3 transcription factorETS domain-containing transcription factorepithelium-specific Ets transcription factor 3hEHFglycine N-acyltransferaseAAcHRP-1(CLP)acyl-CoA:glycine N-acyltransferasearalkyl acyl-CoA N-acyltransferasearalkyl acyl-CoA:amino acid N-acyltransferasearalkyl-CoA N-acyltransferasebenzoyl-coenzyme A:glycine N-acyltransferaseepididymis secretory sp
Modification date2020032920200313
UniProtAcc

Q9NZC4

Q6ZRH7

Ensembl transtripts involved in fusion geneENST00000257831, ENST00000450654, 
ENST00000527935, ENST00000530286, 
ENST00000531728, ENST00000531794, 
ENST00000533754, ENST00000527001, 
ENST00000534710, ENST00000241052, 
Fusion gene scores* DoF score9 X 13 X 4=46814 X 11 X 8=1232
# samples 1218
** MAII scorelog2(12/468*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1232*10)=-2.77493344436523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EHF [Title/Abstract] AND CAT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEHF(34668231)-CAT(34485652), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEHF

GO:0045893

positive regulation of transcription, DNA-templated

10644770

HgeneEHF

GO:0045944

positive regulation of transcription by RNA polymerase II

17027647

TgeneCAT

GO:0006544

glycine metabolic process

22475485

TgeneCAT

GO:1901787

benzoyl-CoA metabolic process

22475485


check buttonFusion gene breakpoints across EHF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0B9-01AEHFchr11

34668231

+CATchr11

34485652

+


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Fusion Gene ORF analysis for EHF-CAT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000257831ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
5CDS-intronENST00000450654ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
5CDS-intronENST00000527935ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
5CDS-intronENST00000530286ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
5CDS-intronENST00000531728ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
5CDS-intronENST00000531794ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
5CDS-intronENST00000533754ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000257831ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000450654ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000527935ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000530286ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000531728ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000531794ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
In-frameENST00000533754ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
intron-3CDSENST00000527001ENST00000241052EHFchr11

34668231

+CATchr11

34485652

+
intron-intronENST00000527001ENST00000534710EHFchr11

34668231

+CATchr11

34485652

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000257831EHFchr1134668231+ENST00000241052CATchr1134485652+1482464121852243
ENST00000450654EHFchr1134668231+ENST00000241052CATchr1134485652+145844097828243
ENST00000530286EHFchr1134668231+ENST00000241052CATchr1134485652+1501483140871243
ENST00000533754EHFchr1134668231+ENST00000241052CATchr1134485652+1578560208948246
ENST00000531728EHFchr1134668231+ENST00000241052CATchr1134485652+1257239214627137
ENST00000531794EHFchr1134668231+ENST00000241052CATchr1134485652+15535356923305
ENST00000527935EHFchr1134668231+ENST00000241052CATchr1134485652+1329311370699109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000257831ENST00000241052EHFchr1134668231+CATchr1134485652+0.0025487170.99745125
ENST00000450654ENST00000241052EHFchr1134668231+CATchr1134485652+0.0025792090.9974208
ENST00000530286ENST00000241052EHFchr1134668231+CATchr1134485652+0.0025321260.9974679
ENST00000533754ENST00000241052EHFchr1134668231+CATchr1134485652+0.0016309960.99836904
ENST00000531728ENST00000241052EHFchr1134668231+CATchr1134485652+0.004902050.99509794
ENST00000531794ENST00000241052EHFchr1134668231+CATchr1134485652+0.0013807370.9986193
ENST00000527935ENST00000241052EHFchr1134668231+CATchr1134485652+0.78681890.21318108

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Fusion Genomic Features for EHF-CAT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EHFchr1134668231+CATchr1134485651+0.0012704430.9987295
EHFchr1134668231+CATchr1134485651+0.0012704430.9987295

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EHF-CAT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:34668231/chr11:34485652)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHF

Q9NZC4

CAT

Q6ZRH7

FUNCTION: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. {ECO:0000269|PubMed:10527851, ECO:0000269|PubMed:10644770, ECO:0000269|PubMed:11259407, ECO:0000269|PubMed:12444029, ECO:0000269|PubMed:17027647}.FUNCTION: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000250|UniProtKB:C6KI89}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHFchr11:34668231chr11:34485652ENST00000257831+3929_115114301.0DomainPNT
HgeneEHFchr11:34668231chr11:34485652ENST00000450654+3829_115114278.0DomainPNT
HgeneEHFchr11:34668231chr11:34485652ENST00000530286+3929_115114301.0DomainPNT
HgeneEHFchr11:34668231chr11:34485652ENST00000531794+3929_115136323.0DomainPNT
HgeneEHFchr11:34668231chr11:34485652ENST00000533754+3929_115114301.0DomainPNT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHFchr11:34668231chr11:34485652ENST00000257831+39207_289114301.0DNA bindingETS
HgeneEHFchr11:34668231chr11:34485652ENST00000450654+38207_289114278.0DNA bindingETS
HgeneEHFchr11:34668231chr11:34485652ENST00000530286+39207_289114301.0DNA bindingETS
HgeneEHFchr11:34668231chr11:34485652ENST00000531794+39207_289136323.0DNA bindingETS
HgeneEHFchr11:34668231chr11:34485652ENST00000533754+39207_289114301.0DNA bindingETS


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Fusion Gene Sequence for EHF-CAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25568_25568_1_EHF-CAT_EHF_chr11_34668231_ENST00000257831_CAT_chr11_34485652_ENST00000241052_length(transcript)=1482nt_BP=464nt
ACTTGATAACACCCGTGGTGCCCCATCCCTATAGGAGCTGGTGAGATTGCAGCCTGCTGCCTCCCCTCCAACAGCCACAGCTATTGGATT
TCCCACCCAGAATCTTTAGGTAAATGAGATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAACCCCGGCAACAACCTCCTTCACCA
GCCGCCAGCCTGGACAGACAGCTACTCCACGTGCAATGTTTCCAGTGGGTTTTTTGGAGGCCAGTGGCATGAAATTCATCCTCAGTACTG
GACCAAGTACCAGGTGTGGGAGTGGCTCCAGCACCTCCTGGACACCAACCAGCTGGATGCCAATTGTATCCCTTTCCAAGAGTTCGACAT
CAACGGCGAGCACCTCTGCAGCATGAGTTTGCAGGAGTTCACCCGGGCGGCAGGGACGGCGGGGCAGCTCCTCTACAGCAACTTGCAGCA
TCTGAAGTGGAACGGTGGTGCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAGCACAGCATCCA
ATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTTACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGA
ACAGAGGAAACGTCTGTGTGAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAGAACTTCACTGA
GGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTACAATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCA
GTCCGGATCTCACTTGGCGGCAAGGGAGAAGGCAAATCTGTGAGGCCGGGGCCCTGCACCTGTGCAGCGAAGCTTAGCGTTCATCCGTGT
AACCCGCTCATCACTGGATGAAGATTCTCCTGTGCTAGATGTGCAAATGCAAGCTAGTGGCTTCAAAATAGAGAATCCCACTTTCTATAG
CAGATTGTGTAACAATTTTAATGCTATTTCCCCAGGGGAAAATGAAGGTTAGGATTTAACAGTCATTTAAAAAAAAAATTTGTTTTGACG
GATGATTGGATTATTCATTTAAAATGATTAGAAGGCAAGTTTCTAGCTAGAAATATGATTTTATTTGACAAAATTTGTTGAAATTATGTA
TGTTTACATATCACCTCATGGCCTATTATATTAAAATATGGCTATAAATATATAAAAAGAAAAGATAAAGATGATCTACTCAGAAATTTT
TATTTTTCTAAGGTTCTCATAGGAAAAGTACATTTAATACAGCAGTGTCATCAGAAGATAACTTGAGCACCGTCATGGCTTAATGTTTAT
TCCTGATAATAATTGATCAAATTCATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCACTGATTTCACAACAGATCAATTTGTAAT

>25568_25568_1_EHF-CAT_EHF_chr11_34668231_ENST00000257831_CAT_chr11_34485652_ENST00000241052_length(amino acids)=243AA_BP=114
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSL
QEFTRAAGTAGQLLYSNLQHLKWNGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIA

--------------------------------------------------------------
>25568_25568_2_EHF-CAT_EHF_chr11_34668231_ENST00000450654_CAT_chr11_34485652_ENST00000241052_length(transcript)=1458nt_BP=440nt
ATCCCTATAGGAGCTGGTGAGATTGCAGCCTGCTGCCTCCCCTCCAACAGCCACAGCTATTGGATTTCCCACCCAGAATCTTTAGGTAAA
TGAGATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAACCCCGGCAACAACCTCCTTCACCAGCCGCCAGCCTGGACAGACAGCTA
CTCCACGTGCAATGTTTCCAGTGGGTTTTTTGGAGGCCAGTGGCATGAAATTCATCCTCAGTACTGGACCAAGTACCAGGTGTGGGAGTG
GCTCCAGCACCTCCTGGACACCAACCAGCTGGATGCCAATTGTATCCCTTTCCAAGAGTTCGACATCAACGGCGAGCACCTCTGCAGCAT
GAGTTTGCAGGAGTTCACCCGGGCGGCAGGGACGGCGGGGCAGCTCCTCTACAGCAACTTGCAGCATCTGAAGTGGAACGGTGGTGCTCC
AAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAGCACAGCATCCAATATTCTGGAGAAGTGCGGAGATT
CAACACTGCCAATGATGATAACGTTACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGTGAGAA
CATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAGAACTTCACTGAGGTCCACCCTGACTACGGGAGCCA
CATCCAGGCTCTTCTGGACAAGTACAATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCGGCAAG
GGAGAAGGCAAATCTGTGAGGCCGGGGCCCTGCACCTGTGCAGCGAAGCTTAGCGTTCATCCGTGTAACCCGCTCATCACTGGATGAAGA
TTCTCCTGTGCTAGATGTGCAAATGCAAGCTAGTGGCTTCAAAATAGAGAATCCCACTTTCTATAGCAGATTGTGTAACAATTTTAATGC
TATTTCCCCAGGGGAAAATGAAGGTTAGGATTTAACAGTCATTTAAAAAAAAAATTTGTTTTGACGGATGATTGGATTATTCATTTAAAA
TGATTAGAAGGCAAGTTTCTAGCTAGAAATATGATTTTATTTGACAAAATTTGTTGAAATTATGTATGTTTACATATCACCTCATGGCCT
ATTATATTAAAATATGGCTATAAATATATAAAAAGAAAAGATAAAGATGATCTACTCAGAAATTTTTATTTTTCTAAGGTTCTCATAGGA
AAAGTACATTTAATACAGCAGTGTCATCAGAAGATAACTTGAGCACCGTCATGGCTTAATGTTTATTCCTGATAATAATTGATCAAATTC
ATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCACTGATTTCACAACAGATCAATTTGTAATTGCTTACATTTTTACAATAAATAA

>25568_25568_2_EHF-CAT_EHF_chr11_34668231_ENST00000450654_CAT_chr11_34485652_ENST00000241052_length(amino acids)=243AA_BP=114
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSL
QEFTRAAGTAGQLLYSNLQHLKWNGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIA

--------------------------------------------------------------
>25568_25568_3_EHF-CAT_EHF_chr11_34668231_ENST00000527935_CAT_chr11_34485652_ENST00000241052_length(transcript)=1329nt_BP=311nt
GATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAACCCCGGCAACAACCTCCTTCACCAGCCGCCAGCCTGGACAGACAGCTACTC
CACGTGCAATGGTGACTCTCTCTTTCTGTGTCTCTCCCTACCCTGCTAGGAGCCAGCTGGAAGAATAGAGATTCTGCAGATGACAGGATT
CTTTGTCAGGGACAAGAAAGAGTGGTCTCACCTCCAAATTACCATGTCCCAAGACAGAGAAATGGAAGGAAGATGAAAGGACAGGATTGA
AGCATAGGGTACCTGGTGTGCCTAATCCCTTATAAATGCCAGTGGTGCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACA
GCCTTCTGCCCTGGAGCACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTTACTCAGGTGCGGGC
ATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGTGAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCA
GAAGAAAGCGGTCAAGAACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTACAATGCTGAGAAGCC
TAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCGGCAAGGGAGAAGGCAAATCTGTGAGGCCGGGGCCCTGCACCTGT
GCAGCGAAGCTTAGCGTTCATCCGTGTAACCCGCTCATCACTGGATGAAGATTCTCCTGTGCTAGATGTGCAAATGCAAGCTAGTGGCTT
CAAAATAGAGAATCCCACTTTCTATAGCAGATTGTGTAACAATTTTAATGCTATTTCCCCAGGGGAAAATGAAGGTTAGGATTTAACAGT
CATTTAAAAAAAAAATTTGTTTTGACGGATGATTGGATTATTCATTTAAAATGATTAGAAGGCAAGTTTCTAGCTAGAAATATGATTTTA
TTTGACAAAATTTGTTGAAATTATGTATGTTTACATATCACCTCATGGCCTATTATATTAAAATATGGCTATAAATATATAAAAAGAAAA
GATAAAGATGATCTACTCAGAAATTTTTATTTTTCTAAGGTTCTCATAGGAAAAGTACATTTAATACAGCAGTGTCATCAGAAGATAACT
TGAGCACCGTCATGGCTTAATGTTTATTCCTGATAATAATTGATCAAATTCATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCAC

>25568_25568_3_EHF-CAT_EHF_chr11_34668231_ENST00000527935_CAT_chr11_34485652_ENST00000241052_length(amino acids)=109AA_BP=
MEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNA

--------------------------------------------------------------
>25568_25568_4_EHF-CAT_EHF_chr11_34668231_ENST00000530286_CAT_chr11_34485652_ENST00000241052_length(transcript)=1501nt_BP=483nt
CTCAGCAGCAACAAATGCCTTCTGAGACAGGGATTCTTTTGATTTTGCTTGGACATTGTGGAGAAGTGTTAGCCCCAATGTGGACTGATC
TGGGAACAGTGGGAAATTAACTTCTTGTTGGTAAATATCAGGCTGAGATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAACCCCG
GCAACAACCTCCTTCACCAGCCGCCAGCCTGGACAGACAGCTACTCCACGTGCAATGTTTCCAGTGGGTTTTTTGGAGGCCAGTGGCATG
AAATTCATCCTCAGTACTGGACCAAGTACCAGGTGTGGGAGTGGCTCCAGCACCTCCTGGACACCAACCAGCTGGATGCCAATTGTATCC
CTTTCCAAGAGTTCGACATCAACGGCGAGCACCTCTGCAGCATGAGTTTGCAGGAGTTCACCCGGGCGGCAGGGACGGCGGGGCAGCTCC
TCTACAGCAACTTGCAGCATCTGAAGTGGAACGGTGGTGCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTG
CCCTGGAGCACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTTACTCAGGTGCGGGCATTCTATG
TGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGTGAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAG
CGGTCAAGAACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTACAATGCTGAGAAGCCTAAGAATG
CGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCGGCAAGGGAGAAGGCAAATCTGTGAGGCCGGGGCCCTGCACCTGTGCAGCGAA
GCTTAGCGTTCATCCGTGTAACCCGCTCATCACTGGATGAAGATTCTCCTGTGCTAGATGTGCAAATGCAAGCTAGTGGCTTCAAAATAG
AGAATCCCACTTTCTATAGCAGATTGTGTAACAATTTTAATGCTATTTCCCCAGGGGAAAATGAAGGTTAGGATTTAACAGTCATTTAAA
AAAAAAATTTGTTTTGACGGATGATTGGATTATTCATTTAAAATGATTAGAAGGCAAGTTTCTAGCTAGAAATATGATTTTATTTGACAA
AATTTGTTGAAATTATGTATGTTTACATATCACCTCATGGCCTATTATATTAAAATATGGCTATAAATATATAAAAAGAAAAGATAAAGA
TGATCTACTCAGAAATTTTTATTTTTCTAAGGTTCTCATAGGAAAAGTACATTTAATACAGCAGTGTCATCAGAAGATAACTTGAGCACC
GTCATGGCTTAATGTTTATTCCTGATAATAATTGATCAAATTCATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCACTGATTTCA

>25568_25568_4_EHF-CAT_EHF_chr11_34668231_ENST00000530286_CAT_chr11_34485652_ENST00000241052_length(amino acids)=243AA_BP=114
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSL
QEFTRAAGTAGQLLYSNLQHLKWNGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIA

--------------------------------------------------------------
>25568_25568_5_EHF-CAT_EHF_chr11_34668231_ENST00000531728_CAT_chr11_34485652_ENST00000241052_length(transcript)=1257nt_BP=239nt
CCCTGCCTTTGTTACTGGGAAACCGAACGCGGCGCTGTGGCTTTCAGCTTGGATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAA
CCCCGGCAACAACCTCCTTCACCAGCCGCCAGCCTGGACAGACAGCTACTCCACGTGCAATGGTGACTCTCTCTTTCTGTGTCTCTCCCT
ACCCTGCTAGGAGCCAGCTGGAAGAATAGAGATTCTGCAGATGACAGGATTCTTTGTCAGTGGTGCTCCAAATTACTACCCCAACAGCTT
TGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAGCACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAA
CGTTACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGTGAGAACATTGCCGGCCACCTGAAGGA
TGCACAAATTTTCATCCAGAAGAAAGCGGTCAAGAACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAA
GTACAATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCGGCAAGGGAGAAGGCAAATCTGTGAGG
CCGGGGCCCTGCACCTGTGCAGCGAAGCTTAGCGTTCATCCGTGTAACCCGCTCATCACTGGATGAAGATTCTCCTGTGCTAGATGTGCA
AATGCAAGCTAGTGGCTTCAAAATAGAGAATCCCACTTTCTATAGCAGATTGTGTAACAATTTTAATGCTATTTCCCCAGGGGAAAATGA
AGGTTAGGATTTAACAGTCATTTAAAAAAAAAATTTGTTTTGACGGATGATTGGATTATTCATTTAAAATGATTAGAAGGCAAGTTTCTA
GCTAGAAATATGATTTTATTTGACAAAATTTGTTGAAATTATGTATGTTTACATATCACCTCATGGCCTATTATATTAAAATATGGCTAT
AAATATATAAAAAGAAAAGATAAAGATGATCTACTCAGAAATTTTTATTTTTCTAAGGTTCTCATAGGAAAAGTACATTTAATACAGCAG
TGTCATCAGAAGATAACTTGAGCACCGTCATGGCTTAATGTTTATTCCTGATAATAATTGATCAAATTCATTTTTTTCACTGGAGTTACA

>25568_25568_5_EHF-CAT_EHF_chr11_34668231_ENST00000531728_CAT_chr11_34485652_ENST00000241052_length(amino acids)=137AA_BP=9
MQMTGFFVSGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK

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>25568_25568_6_EHF-CAT_EHF_chr11_34668231_ENST00000531794_CAT_chr11_34485652_ENST00000241052_length(transcript)=1553nt_BP=535nt
AACCCACTGCTTTATTCTGCCCTGAGTGGAGATTGGTTTTGGCTCAGGCTGCTTTGTGAAACTCAGAAGCATTATCCTCTCTGCCAACTC
CACGTCCTAGTCAGAGTTTTCTGTGAAGGCAAGGGCATGGGGTTGCCGGAGAGAAGAGGATTGGTCCTGCTTTTAAGCCTAGCTGAAATT
CTTTTCAAGATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAACCCCGGCAACAACCTCCTTCACCAGCCGCCAGCCTGGACAGAC
AGCTACTCCACGTGCAATGTTTCCAGTGGGTTTTTTGGAGGCCAGTGGCATGAAATTCATCCTCAGTACTGGACCAAGTACCAGGTGTGG
GAGTGGCTCCAGCACCTCCTGGACACCAACCAGCTGGATGCCAATTGTATCCCTTTCCAAGAGTTCGACATCAACGGCGAGCACCTCTGC
AGCATGAGTTTGCAGGAGTTCACCCGGGCGGCAGGGACGGCGGGGCAGCTCCTCTACAGCAACTTGCAGCATCTGAAGTGGAACGGTGGT
GCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAGCACAGCATCCAATATTCTGGAGAAGTGCGG
AGATTCAACACTGCCAATGATGATAACGTTACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGT
GAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAGAACTTCACTGAGGTCCACCCTGACTACGGG
AGCCACATCCAGGCTCTTCTGGACAAGTACAATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCG
GCAAGGGAGAAGGCAAATCTGTGAGGCCGGGGCCCTGCACCTGTGCAGCGAAGCTTAGCGTTCATCCGTGTAACCCGCTCATCACTGGAT
GAAGATTCTCCTGTGCTAGATGTGCAAATGCAAGCTAGTGGCTTCAAAATAGAGAATCCCACTTTCTATAGCAGATTGTGTAACAATTTT
AATGCTATTTCCCCAGGGGAAAATGAAGGTTAGGATTTAACAGTCATTTAAAAAAAAAATTTGTTTTGACGGATGATTGGATTATTCATT
TAAAATGATTAGAAGGCAAGTTTCTAGCTAGAAATATGATTTTATTTGACAAAATTTGTTGAAATTATGTATGTTTACATATCACCTCAT
GGCCTATTATATTAAAATATGGCTATAAATATATAAAAAGAAAAGATAAAGATGATCTACTCAGAAATTTTTATTTTTCTAAGGTTCTCA
TAGGAAAAGTACATTTAATACAGCAGTGTCATCAGAAGATAACTTGAGCACCGTCATGGCTTAATGTTTATTCCTGATAATAATTGATCA
AATTCATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCACTGATTTCACAACAGATCAATTTGTAATTGCTTACATTTTTACAATA

>25568_25568_6_EHF-CAT_EHF_chr11_34668231_ENST00000531794_CAT_chr11_34485652_ENST00000241052_length(amino acids)=305AA_BP=176
MLYSALSGDWFWLRLLCETQKHYPLCQLHVLVRVFCEGKGMGLPERRGLVLLLSLAEILFKIMILEGGGVMNLNPGNNLLHQPPAWTDSY
STCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGGAP
NYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSH

--------------------------------------------------------------
>25568_25568_7_EHF-CAT_EHF_chr11_34668231_ENST00000533754_CAT_chr11_34485652_ENST00000241052_length(transcript)=1578nt_BP=560nt
ATTTTCACCGTCCATCTTTGCTGATTTACCATGCTCCCAGGATGGTGGGAGTGTGTGTTTTTAAGATGGAGAGTGTATGCTTCTGGGTTC
AAGTTCACAGGTGTCTCTGCTGGTTATCTGCACTCACCTTGGTAACAGGGAGAAAGTGAGTGAATGGATTCCAAGAACTTACTGATGGAA
GTCTAATTCAGGAGTTGGTTCTGCAGCCATGGAGATCATGATTCTGGAAGGAGGTGGTGTAATGAATCTCAACCCCGGCAACAACCTCCT
TCACCAGCCGCCAGCCTGGACAGACAGCTACTCCACGTGCAATGTTTCCAGTGGGTTTTTTGGAGGCCAGTGGCATGAAATTCATCCTCA
GTACTGGACCAAGTACCAGGTGTGGGAGTGGCTCCAGCACCTCCTGGACACCAACCAGCTGGATGCCAATTGTATCCCTTTCCAAGAGTT
CGACATCAACGGCGAGCACCTCTGCAGCATGAGTTTGCAGGAGTTCACCCGGGCGGCAGGGACGGCGGGGCAGCTCCTCTACAGCAACTT
GCAGCATCTGAAGTGGAACGGTGGTGCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAGCACAG
CATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTTACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAA
TGAGGAACAGAGGAAACGTCTGTGTGAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAGAACTT
CACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTACAATGCTGAGAAGCCTAAGAATGCGATTCACACCTT
TGTGCAGTCCGGATCTCACTTGGCGGCAAGGGAGAAGGCAAATCTGTGAGGCCGGGGCCCTGCACCTGTGCAGCGAAGCTTAGCGTTCAT
CCGTGTAACCCGCTCATCACTGGATGAAGATTCTCCTGTGCTAGATGTGCAAATGCAAGCTAGTGGCTTCAAAATAGAGAATCCCACTTT
CTATAGCAGATTGTGTAACAATTTTAATGCTATTTCCCCAGGGGAAAATGAAGGTTAGGATTTAACAGTCATTTAAAAAAAAAATTTGTT
TTGACGGATGATTGGATTATTCATTTAAAATGATTAGAAGGCAAGTTTCTAGCTAGAAATATGATTTTATTTGACAAAATTTGTTGAAAT
TATGTATGTTTACATATCACCTCATGGCCTATTATATTAAAATATGGCTATAAATATATAAAAAGAAAAGATAAAGATGATCTACTCAGA
AATTTTTATTTTTCTAAGGTTCTCATAGGAAAAGTACATTTAATACAGCAGTGTCATCAGAAGATAACTTGAGCACCGTCATGGCTTAAT
GTTTATTCCTGATAATAATTGATCAAATTCATTTTTTTCACTGGAGTTACATTAATGTTAATTCAGCACTGATTTCACAACAGATCAATT

>25568_25568_7_EHF-CAT_EHF_chr11_34668231_ENST00000533754_CAT_chr11_34485652_ENST00000241052_length(amino acids)=246AA_BP=117
MEIMILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCS
MSLQEFTRAAGTAGQLLYSNLQHLKWNGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EHF-CAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EHF-CAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EHF-CAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource