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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EHMT1-SPATA17 (FusionGDB2 ID:25589)

Fusion Gene Summary for EHMT1-SPATA17

check button Fusion gene summary
Fusion gene informationFusion gene name: EHMT1-SPATA17
Fusion gene ID: 25589
HgeneTgene
Gene symbol

EHMT1

SPATA17

Gene ID

79813

128153

Gene nameeuchromatic histone lysine methyltransferase 1spermatogenesis associated 17
SynonymsEHMT1-IT1|EUHMTASE1|Eu-HMTase1|FP13812|GLP|GLP1|KLEFS1|KMT1DCFAP305|FAP305|IQCH|MOT17|MSRG-11|MSRG11
Cytomap

9q34.3

1q41

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase EHMT1EHMT1 intronic transcript 1G9a-like protein 1H3-K9-HMTase 5euchromatic histone-lysine N-methyltransferase 1histone H3-K9 methyltransferase 5histone-lysine N-methyltransferase, H3 lysine-9 specific 5lysine N-mspermatogenesis-associated protein 17IQ motif containing Hspermatogenesis-related protein 11
Modification date2020031320200313
UniProtAcc

Q9H9B1

.
Ensembl transtripts involved in fusion geneENST00000371394, ENST00000460843, 
ENST00000462484, ENST00000334856, 
ENST00000366933, ENST00000471021, 
Fusion gene scores* DoF score15 X 9 X 8=10807 X 9 X 6=378
# samples 207
** MAII scorelog2(20/1080*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/378*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EHMT1 [Title/Abstract] AND SPATA17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEHMT1(140513501)-SPATA17(217856600), # samples:2
Anticipated loss of major functional domain due to fusion event.EHMT1-SPATA17 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EHMT1-SPATA17 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEHMT1

GO:0006325

chromatin organization

12004135

HgeneEHMT1

GO:0016571

histone methylation

12004135

HgeneEHMT1

GO:0018027

peptidyl-lysine dimethylation

20118233


check buttonFusion gene breakpoints across EHMT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPATA17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1924-01AEHMT1chr9

140513501

+SPATA17chr1

217856600

+
ChimerDB4OVTCGA-24-1924-01AEHMT1chr9

140513501

+SPATA17chr1

217915317

+


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Fusion Gene ORF analysis for EHMT1-SPATA17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000371394ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217856600

+
3UTR-3CDSENST00000371394ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217915317

+
3UTR-intronENST00000371394ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217856600

+
3UTR-intronENST00000371394ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217915317

+
5CDS-intronENST00000460843ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217856600

+
5CDS-intronENST00000460843ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217915317

+
5CDS-intronENST00000462484ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217856600

+
5CDS-intronENST00000462484ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217915317

+
5UTR-3CDSENST00000334856ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217856600

+
5UTR-3CDSENST00000334856ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217915317

+
5UTR-intronENST00000334856ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217856600

+
5UTR-intronENST00000334856ENST00000471021EHMT1chr9

140513501

+SPATA17chr1

217915317

+
Frame-shiftENST00000460843ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217915317

+
Frame-shiftENST00000462484ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217915317

+
In-frameENST00000460843ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217856600

+
In-frameENST00000462484ENST00000366933EHMT1chr9

140513501

+SPATA17chr1

217856600

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462484EHMT1chr9140513501+ENST00000366933SPATA17chr1217856600+55305822852276
ENST00000460843EHMT1chr9140513501+ENST00000366933SPATA17chr1217856600+55204812842276

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462484ENST00000366933EHMT1chr9140513501+SPATA17chr1217856600+0.0007153930.9992847
ENST00000460843ENST00000366933EHMT1chr9140513501+SPATA17chr1217856600+0.0007166660.9992834

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Fusion Genomic Features for EHMT1-SPATA17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EHMT1chr9140513501+SPATA17chr1217915316+2.52E-060.9999975
EHMT1chr9140513501+SPATA17chr1217856599+1.49E-081
EHMT1chr9140513501+SPATA17chr1217915316+2.52E-060.9999975
EHMT1chr9140513501+SPATA17chr1217856599+1.49E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EHMT1-SPATA17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:140513501/chr1:217856600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHMT1

Q9H9B1

.
FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity). {ECO:0000250|UniProtKB:Q5DW34, ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171292_12950826.0Compositional biasNote=Poly-Ala
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117406_4090826.0Compositional biasNote=Poly-Glu
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117442_4490826.0Compositional biasNote=Poly-Arg
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271292_129571299.0Compositional biasNote=Poly-Ala
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127406_40971299.0Compositional biasNote=Poly-Glu
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127442_44971299.0Compositional biasNote=Poly-Arg
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161292_12957809.0Compositional biasNote=Poly-Ala
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116406_4097809.0Compositional biasNote=Poly-Glu
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116442_4497809.0Compositional biasNote=Poly-Arg
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171060_11230826.0DomainPre-SET
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171126_12430826.0DomainSET
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271060_112371299.0DomainPre-SET
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271126_124371299.0DomainSET
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161060_11237809.0DomainPre-SET
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161126_12437809.0DomainSET
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171136_11380826.0RegionNote=S-adenosyl-L-methionine binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171200_12010826.0RegionNote=S-adenosyl-L-methionine binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117905_9070826.0RegionNote=Histone H3K9me binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271136_113871299.0RegionNote=S-adenosyl-L-methionine binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271200_120171299.0RegionNote=S-adenosyl-L-methionine binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127905_90771299.0RegionNote=Histone H3K9me binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161136_11387809.0RegionNote=S-adenosyl-L-methionine binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161200_12017809.0RegionNote=S-adenosyl-L-methionine binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116905_9077809.0RegionNote=Histone H3K9me binding
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117737_7660826.0RepeatNote=ANK 1
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117772_8010826.0RepeatNote=ANK 2
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117805_8340826.0RepeatNote=ANK 3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117838_8680826.0RepeatNote=ANK 4
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117872_9010826.0RepeatNote=ANK 5
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117905_9340826.0RepeatNote=ANK 6
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117938_9670826.0RepeatNote=ANK 7
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+117971_10040826.0RepeatNote=ANK 8
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127737_76671299.0RepeatNote=ANK 1
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127772_80171299.0RepeatNote=ANK 2
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127805_83471299.0RepeatNote=ANK 3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127838_86871299.0RepeatNote=ANK 4
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127872_90171299.0RepeatNote=ANK 5
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127905_93471299.0RepeatNote=ANK 6
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127938_96771299.0RepeatNote=ANK 7
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+127971_100471299.0RepeatNote=ANK 8
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116737_7667809.0RepeatNote=ANK 1
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116772_8017809.0RepeatNote=ANK 2
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116805_8347809.0RepeatNote=ANK 3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116838_8687809.0RepeatNote=ANK 4
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116872_9017809.0RepeatNote=ANK 5
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116905_9347809.0RepeatNote=ANK 6
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116938_9677809.0RepeatNote=ANK 7
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+116971_10047809.0RepeatNote=ANK 8
TgeneSPATA17chr9:140513501chr1:217856600ENST0000036693331132_61971879.3333333333333DomainIQ 1
TgeneSPATA17chr9:140513501chr1:217856600ENST0000036693331155_84971879.3333333333333DomainIQ 2
TgeneSPATA17chr9:140513501chr1:217856600ENST0000036693331191_120971879.3333333333333DomainIQ 3


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Fusion Gene Sequence for EHMT1-SPATA17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25589_25589_1_EHMT1-SPATA17_EHMT1_chr9_140513501_ENST00000460843_SPATA17_chr1_217856600_ENST00000366933_length(transcript)=5520nt_BP=48nt
GGCGGGGCCACGCTGCGGGCCCGGGCCATGGCCGCCGCCGATGCCGAGATTCAGAGACGATGGCGAGGCTATAGGGTTCGGAAGTACCTC
TTTAATTATTATTATTTGAAAGAGTACCTGAAAGTCGTTTCAGAGACCAATGATGCAATTAGGAAGGCACTGGAGGAGTTTGCAGAAATG
AAAGAAAGAGAAGAGAAGAAGGCTAACCTCGAAAGGGAAGAGAAGAAAAGAGATTACCAAGCCCGAAAGATGCATTACCTCCTCAGCACA
AAGCAGATTCCAGGAATATACAATTCACCCTTCAGAAAAGAGCCTGATCCATGGGAGCTGCAATTACAGAAGGCAAAGCCTTTAACACAC
CGAAGACCTAAAGTTAAGCAGAAGGACTCCACCAGCCTTACTGATTGGCTAGCTTGTACAAGCGCCCGTTCTTTTCCTCGGTCTGAAATT
CTACCACCTATTAATAGAAAGCAATGTCAGGGGCCCTTCCGAGATATCACCGAAGTATTAGAACAACGCTACAGGCCTTTGGAGCCAACG
TTGCGGGTGGCAGAACCAATCGATGAGTTAAAGTTGGCCAGAGAGGAGCTCAGAAGAGAGGAATGGCTGCAAAATGTAAATGACAATATG
TTTTTGCCATTTTCTTCATACCATAAAAATGAAAAGTACATCCCATCAATGCATTTATCAAGCAAGTATGGTCCTATTTCTTACAAAGAA
CAATTCCGAAGTGAAAATCCTAAGAAATGGATCTGTGACAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTCAAAGTATGGA
AAATTATATTCAAAAGCTGGACAGATTGTATAAAGGCGTCAGAAGAAGAAACTGAAGCCATCTGCATTTTAAAACTTAACAGTTCTGAAA
GGAAAACACAGATGAAGATCCTGTAGGAAATATACTTGCTATGATTCAATAAACTATAAAATTTTGTAGCTCTAGTCATGAATTAATTAT
TGTGTGTATGTATTTGAAATCTCTTAGACATATCTTTTCAAACAAATACTTAAACTTGAGTCTGTTACCTCTGAGAATGTCTGTCACAAT
CACAGCCCCTGGTGACCAACAGTGCCATAAATGGTTCCCCTGAAATACCCATATTCTGACCCCATCACCCGGGTCACAAATGATGACACC
AGTGCTGGGTACCCAAATTAAGGGCGACTAACATGTAAGTAGGATGATGAATGGTTTGAAGTGTAAATTGTGTGAAATAGTTCAGCATGA
AAGCTCTGCCCTGAGAAATAATGACTGATTATACCAGTTAGAAACCCTTCAGACTGTTGAACTTGAGACACACAGACACAACAGACACAG
ACTAGTGGGTGTGGGAGCAGAAGCATAGGCACTCTCAAATAGAGAAGACATTTGCAAGTCTCTGCTGCCAAGGGAGCAAAGAGATAATCT
CGATGCCAGGGCTGTGTCAGATCCTGCATGGCTCTGAACTACAGTTGGTTTCCAAAAAGCTGGGCTTTTGTGAGGTTTCTGTTTTTTATG
CGATGCTTAGATTTTCCTGGAATCCTTGGAAGTTAACTCAACATTTGAGGTTCCTATATCCTTTAATCCCATCCCATGTGTATCTTTACA
ATAAAACTTCCTGCTAGAGGTATCCTGAGGGAATCTTTGTTTCTTGCATCTGAAGAGAATAACACTAAACTTATTGCATATGATTTGGGG
GTTGGATCCAATGATAGCACAGAGGGACAGGAAATGTGATTTATTGACCATAAAAGCTTTAATTTAAAATTGCTGGCCAGCGAAATCCAG
ACTCTGGGAAATGTTATAGGCCAAATGATCTGTTTCTTCAACAAATAAATTACAAAACTGAGGGGAAAAAAAGGAACCTATTAAAAAGAC
ATTATCTATCAATCACTGTGTGTGTACAGTTTTGAGCTCCTGATTTAAATAAACAAATTGTAAAATAAAAGATCTTTTGAAACAATTGGA
AGTTTGAACACTGATTGGATATTGGTGGTATAAAAGAATTATTGGTTTTTTTTAGGTGTCATGGTATTGTTTTGGTTTACAAAGTTATAG
ATATAAATGTTGAAATATTTACAGATGCAGTGATATGTTGGCTGGGATTTAATTTGAAAGTCAAAGAAGTGAGTTAAAATACATATACTC
CTCCTCTTATAATCGGTTATGTGCCAATAAATCCATTGTAAATTGAAAATATCCTAAGTTGAAAATATTGTAAGTTAAAAATGCATTTAA
TACAGCTAACTTACCAGACAGCTTAGCTTAGCCTCACCTACCTTAAATATGCTCAGAACACATACGTTAGCCTATAGTTGGGCAAAATCA
TCTAACACAAAGCCTATTTTATAATATTGAACAGCCCATGTAATTTATTGAATATTGTACTAAAAGTGAAAAACTGAATAGTTGTATGCA
TACTCAAAGTATGGTTTCTACTGAATGCATTGTAAACCAGAAAGTATCTGAGACAATGTTTTTTTTTTTTTTTTTTTTTTTTTTAATTTC
TGAGACAGAGTCTCATTCTGTCACCCAGGTTGGAGTGCAGTGGCATGAACTCAGCTCACTGCAACCTTCACCTCCCAGGCTCAAGCAGTC
CTCCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGGGCCAACAAGCCTGGCTAAATATTTTGTACTTTTGGTAGACACGGGTTT
TTACCATGTTGTGCAGGCTGGTCTTGAACGCCTGAGCTCAAGTGATCTGCCTGCCTCGGCCTCCCAAAGTACTGGGATTACAGGCATGAG
TCACTGAACCCAGCCCTGAGACATGTCTCAATTAGTTTAGAAGTTTATTTGGCCAAGGTTAAGGACATGCCCTTGACACTGCACCTGTCA
GTACAGGTCCTGACAACATGTGTCCAAGGTGGTCAAGCTATACAACTTGGTTTTATACATTTTAAGGAGACATAAGACATCAATAAATAC
ATGGAAGATGTACATTGGTTCAGTCTGGAAAGGCAGGATGCCTCAAACTTGAAACAAGAGAATGGGGGGTGGGAGGATGTGGGAGATGCT
TCCAGGTCATAGTTGGAGTCAAAGACTTTCCAATTGGCAATTGGTTCAAAGAATTTATCTAAAGACCTGGAATCCATAGAAGGCTTTACC
TGGATTAAAATAAGGGGACCAAGGTTCTCATGCAGATGAAGCCTCCAGGTGGCAGACTTCAGAGAGCATAGATTGTAAATGTTTCTTATC
TGACTTAAAAAGGTGTCAGACTCTTAGTAAATTATCTCCTGGATCAGTGAAAAGATGTGAAAAAAGGTTCTCTACAGAATGTAGATTTTC
CCCATAAGAGATAGCTTCGCAGGGCCATTGCAAAATATGTCAAAAATATATATTTTAGGGTAAAATGCCTCAATTTATTTCAAGGCCTGA
TATTTGTCATGTGATGCTATACTACAGTCAGGCTGAAACTTGGCATCTTATTGCTATGAAAAATCTTAAGATCTCTATTTTAATGTTAAT
GCTGGTCACTGGTGCCTGAATTCCAAAGGGAGGAGGGTATAATGAAGCATGTCCAATTCCCCATGCCCCACCCCCACCCCCACATCCTAT
AATGGCCTGAACTAGTTTTTCAGGTTAACTTTGGAATACCCTTGGCCAAGAAGAGGGGTCCATGCAGATGTTTGGAGGGGGGGGTCTTAA
AGCTTTATTTTTAGATTACAGCATATTGCTTTTGCACTATCATAAAGTAAAAACATCATAAGTCAAGCCACCATAAATAGCGGACCATCT
GTATATCTGAAAGAAGATGAACCAAGACTTGGTTATTGTTAAAGCTGATGATTGGCTGTATGAAGATTTACTATACAATTTTGTGTACTT
TTGTAAGTTCTTGGTTGTTTCTAAACTTATAACAAAATAAATAATTGGCCATCTTCATTGGATTGTGAAGCCATTTCCTCCCACATGTTC
GTAAAAATGGTAGCCATGGCCCCTGACTGAACCCAGGTATGAATGGCCTTCATTGATTTTGTAGACCCTGACCTTCTCTGTTCTTCCAGA
GAAGGTGGTACTCAGATAAAAACTTTGAAGCATTTTATTGTTCAGAATATGACTTTGATCTTCTCATAAGACTCAAGTTTTTGAATGCTT
AAGGCTCTTTATCGCTAGTGTATGTAAGTAATATCATTGTCCTTAACCACCATCTGCCTCTCCCCCCAGACACACATAAGTTTATGATAA
CTACAGAGGTGTCCAGATGAGTAAAAACTGCCTTTGCATTAAGGTGAGAGAAGACCGAGATGAAATCTTATTAGAAAATATAACTGGGGA
AAGCAGTTTGTCTGTTTCTCCTGGAAAACTACTAGACTACATCAACTTATATACTACTTCTTTTCTATATTCTCAATATGAGCCACTTAA
GAAAATTAATGAGACTTTATGTTTGACCAAAGCTGGTAATTCCTTGATCTTATTCTCCAAACTTGATTCTGAATGACTACTGACCACTAA
AAACACTAAGAGTACCACTGTGGATGTTTAAAAACATACACCCTAAGAGCCTTCAGAATTAGACGCTTCAATTCTTCTGAAATCAAAAGT
CACACCAGCTTTGCTGTAGTTAATCAGGTAATACCTTTCTTCTCCACTACTCTCTAATTTCCTTGAGGGCAAATATTGTCTTTCTTGATA
AATGCCCTGGACCCAACATCTAACAGAATACCTGGCATAAAGTGAAATCCATCGAATGTGCTAATGATAAATAAAGAAGTTCAAAAAAAT
CTTTTAATAGAAGCTATAAAATAGCAGATAAGCTAAGTCATTCTCATAAAACACCATTTGTCATTTGAATGCGTGCATTGTGGCCTGTTA
CTTTTAACTAGTCTCACTAATTTATAGTTATATATGATGTAGATCTAGATTGTGATGTACACTAAGTGGGTTGATCCTGAGATCAAGCTA
TGATTGCTGCTTGCGTAAAGTGTTCCTTTTGGGAAATAAATAATCTTTCATATCTGTAAACTTTGGTATAATTGGTTATTTATGCAATGT
ATTGTTGTGGTTGTCAACTCAAGATTGTATTCTCATCTGGGGACATTATGAATCTTGTTATTTTATCCCCTTTTTTGCTCTGTTTTTTCA
CATTTATGGCCTACCTGTTACAGCTGCACGGTATCCATTTTCTGTGCTAAATTCATCTTTAATTTATTATTTTTTTTCAACCTCAGCTTT
TAACTTTGCCCTGATTTTCTCTTCCATTTTATTTTCACTTCCATTTTAAGCTGGCTCAAAGCCTTTTAGGAACAATAAGTTACTGAATTA
TATGAACCTATTTGAGGTAATGATGATGCCTGGGAAGGAGCAGTATTGCTGGATCAGAATTCACTTTTTCCAAGTTACAGATTTTAATAA
ACCACTGTGCAAAGCATTAGGATAAATTTTTATTGAAAATTGAGTGAATGACTGAACAAATCGCTGGGTAATGCTGTTTAGGTTGTTCTA

>25589_25589_1_EHMT1-SPATA17_EHMT1_chr9_140513501_ENST00000460843_SPATA17_chr1_217856600_ENST00000366933_length(amino acids)=276AA_BP=12
MRARAMAAADAEIQRRWRGYRVRKYLFNYYYLKEYLKVVSETNDAIRKALEEFAEMKEREEKKANLEREEKKRDYQARKMHYLLSTKQIP
GIYNSPFRKEPDPWELQLQKAKPLTHRRPKVKQKDSTSLTDWLACTSARSFPRSEILPPINRKQCQGPFRDITEVLEQRYRPLEPTLRVA
EPIDELKLAREELRREEWLQNVNDNMFLPFSSYHKNEKYIPSMHLSSKYGPISYKEQFRSENPKKWICDKDFQTVLPSFELFSKYGKLYS

--------------------------------------------------------------
>25589_25589_2_EHMT1-SPATA17_EHMT1_chr9_140513501_ENST00000462484_SPATA17_chr1_217856600_ENST00000366933_length(transcript)=5530nt_BP=58nt
GCGCGGGAGGGGCGGGGCCACGCTGCGGGCCCGGGCCATGGCCGCCGCCGATGCCGAGATTCAGAGACGATGGCGAGGCTATAGGGTTCG
GAAGTACCTCTTTAATTATTATTATTTGAAAGAGTACCTGAAAGTCGTTTCAGAGACCAATGATGCAATTAGGAAGGCACTGGAGGAGTT
TGCAGAAATGAAAGAAAGAGAAGAGAAGAAGGCTAACCTCGAAAGGGAAGAGAAGAAAAGAGATTACCAAGCCCGAAAGATGCATTACCT
CCTCAGCACAAAGCAGATTCCAGGAATATACAATTCACCCTTCAGAAAAGAGCCTGATCCATGGGAGCTGCAATTACAGAAGGCAAAGCC
TTTAACACACCGAAGACCTAAAGTTAAGCAGAAGGACTCCACCAGCCTTACTGATTGGCTAGCTTGTACAAGCGCCCGTTCTTTTCCTCG
GTCTGAAATTCTACCACCTATTAATAGAAAGCAATGTCAGGGGCCCTTCCGAGATATCACCGAAGTATTAGAACAACGCTACAGGCCTTT
GGAGCCAACGTTGCGGGTGGCAGAACCAATCGATGAGTTAAAGTTGGCCAGAGAGGAGCTCAGAAGAGAGGAATGGCTGCAAAATGTAAA
TGACAATATGTTTTTGCCATTTTCTTCATACCATAAAAATGAAAAGTACATCCCATCAATGCATTTATCAAGCAAGTATGGTCCTATTTC
TTACAAAGAACAATTCCGAAGTGAAAATCCTAAGAAATGGATCTGTGACAAGGATTTCCAGACTGTATTACCATCATTTGAGCTCTTCTC
AAAGTATGGAAAATTATATTCAAAAGCTGGACAGATTGTATAAAGGCGTCAGAAGAAGAAACTGAAGCCATCTGCATTTTAAAACTTAAC
AGTTCTGAAAGGAAAACACAGATGAAGATCCTGTAGGAAATATACTTGCTATGATTCAATAAACTATAAAATTTTGTAGCTCTAGTCATG
AATTAATTATTGTGTGTATGTATTTGAAATCTCTTAGACATATCTTTTCAAACAAATACTTAAACTTGAGTCTGTTACCTCTGAGAATGT
CTGTCACAATCACAGCCCCTGGTGACCAACAGTGCCATAAATGGTTCCCCTGAAATACCCATATTCTGACCCCATCACCCGGGTCACAAA
TGATGACACCAGTGCTGGGTACCCAAATTAAGGGCGACTAACATGTAAGTAGGATGATGAATGGTTTGAAGTGTAAATTGTGTGAAATAG
TTCAGCATGAAAGCTCTGCCCTGAGAAATAATGACTGATTATACCAGTTAGAAACCCTTCAGACTGTTGAACTTGAGACACACAGACACA
ACAGACACAGACTAGTGGGTGTGGGAGCAGAAGCATAGGCACTCTCAAATAGAGAAGACATTTGCAAGTCTCTGCTGCCAAGGGAGCAAA
GAGATAATCTCGATGCCAGGGCTGTGTCAGATCCTGCATGGCTCTGAACTACAGTTGGTTTCCAAAAAGCTGGGCTTTTGTGAGGTTTCT
GTTTTTTATGCGATGCTTAGATTTTCCTGGAATCCTTGGAAGTTAACTCAACATTTGAGGTTCCTATATCCTTTAATCCCATCCCATGTG
TATCTTTACAATAAAACTTCCTGCTAGAGGTATCCTGAGGGAATCTTTGTTTCTTGCATCTGAAGAGAATAACACTAAACTTATTGCATA
TGATTTGGGGGTTGGATCCAATGATAGCACAGAGGGACAGGAAATGTGATTTATTGACCATAAAAGCTTTAATTTAAAATTGCTGGCCAG
CGAAATCCAGACTCTGGGAAATGTTATAGGCCAAATGATCTGTTTCTTCAACAAATAAATTACAAAACTGAGGGGAAAAAAAGGAACCTA
TTAAAAAGACATTATCTATCAATCACTGTGTGTGTACAGTTTTGAGCTCCTGATTTAAATAAACAAATTGTAAAATAAAAGATCTTTTGA
AACAATTGGAAGTTTGAACACTGATTGGATATTGGTGGTATAAAAGAATTATTGGTTTTTTTTAGGTGTCATGGTATTGTTTTGGTTTAC
AAAGTTATAGATATAAATGTTGAAATATTTACAGATGCAGTGATATGTTGGCTGGGATTTAATTTGAAAGTCAAAGAAGTGAGTTAAAAT
ACATATACTCCTCCTCTTATAATCGGTTATGTGCCAATAAATCCATTGTAAATTGAAAATATCCTAAGTTGAAAATATTGTAAGTTAAAA
ATGCATTTAATACAGCTAACTTACCAGACAGCTTAGCTTAGCCTCACCTACCTTAAATATGCTCAGAACACATACGTTAGCCTATAGTTG
GGCAAAATCATCTAACACAAAGCCTATTTTATAATATTGAACAGCCCATGTAATTTATTGAATATTGTACTAAAAGTGAAAAACTGAATA
GTTGTATGCATACTCAAAGTATGGTTTCTACTGAATGCATTGTAAACCAGAAAGTATCTGAGACAATGTTTTTTTTTTTTTTTTTTTTTT
TTTTAATTTCTGAGACAGAGTCTCATTCTGTCACCCAGGTTGGAGTGCAGTGGCATGAACTCAGCTCACTGCAACCTTCACCTCCCAGGC
TCAAGCAGTCCTCCCATCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGGGCCAACAAGCCTGGCTAAATATTTTGTACTTTTGGTAG
ACACGGGTTTTTACCATGTTGTGCAGGCTGGTCTTGAACGCCTGAGCTCAAGTGATCTGCCTGCCTCGGCCTCCCAAAGTACTGGGATTA
CAGGCATGAGTCACTGAACCCAGCCCTGAGACATGTCTCAATTAGTTTAGAAGTTTATTTGGCCAAGGTTAAGGACATGCCCTTGACACT
GCACCTGTCAGTACAGGTCCTGACAACATGTGTCCAAGGTGGTCAAGCTATACAACTTGGTTTTATACATTTTAAGGAGACATAAGACAT
CAATAAATACATGGAAGATGTACATTGGTTCAGTCTGGAAAGGCAGGATGCCTCAAACTTGAAACAAGAGAATGGGGGGTGGGAGGATGT
GGGAGATGCTTCCAGGTCATAGTTGGAGTCAAAGACTTTCCAATTGGCAATTGGTTCAAAGAATTTATCTAAAGACCTGGAATCCATAGA
AGGCTTTACCTGGATTAAAATAAGGGGACCAAGGTTCTCATGCAGATGAAGCCTCCAGGTGGCAGACTTCAGAGAGCATAGATTGTAAAT
GTTTCTTATCTGACTTAAAAAGGTGTCAGACTCTTAGTAAATTATCTCCTGGATCAGTGAAAAGATGTGAAAAAAGGTTCTCTACAGAAT
GTAGATTTTCCCCATAAGAGATAGCTTCGCAGGGCCATTGCAAAATATGTCAAAAATATATATTTTAGGGTAAAATGCCTCAATTTATTT
CAAGGCCTGATATTTGTCATGTGATGCTATACTACAGTCAGGCTGAAACTTGGCATCTTATTGCTATGAAAAATCTTAAGATCTCTATTT
TAATGTTAATGCTGGTCACTGGTGCCTGAATTCCAAAGGGAGGAGGGTATAATGAAGCATGTCCAATTCCCCATGCCCCACCCCCACCCC
CACATCCTATAATGGCCTGAACTAGTTTTTCAGGTTAACTTTGGAATACCCTTGGCCAAGAAGAGGGGTCCATGCAGATGTTTGGAGGGG
GGGGTCTTAAAGCTTTATTTTTAGATTACAGCATATTGCTTTTGCACTATCATAAAGTAAAAACATCATAAGTCAAGCCACCATAAATAG
CGGACCATCTGTATATCTGAAAGAAGATGAACCAAGACTTGGTTATTGTTAAAGCTGATGATTGGCTGTATGAAGATTTACTATACAATT
TTGTGTACTTTTGTAAGTTCTTGGTTGTTTCTAAACTTATAACAAAATAAATAATTGGCCATCTTCATTGGATTGTGAAGCCATTTCCTC
CCACATGTTCGTAAAAATGGTAGCCATGGCCCCTGACTGAACCCAGGTATGAATGGCCTTCATTGATTTTGTAGACCCTGACCTTCTCTG
TTCTTCCAGAGAAGGTGGTACTCAGATAAAAACTTTGAAGCATTTTATTGTTCAGAATATGACTTTGATCTTCTCATAAGACTCAAGTTT
TTGAATGCTTAAGGCTCTTTATCGCTAGTGTATGTAAGTAATATCATTGTCCTTAACCACCATCTGCCTCTCCCCCCAGACACACATAAG
TTTATGATAACTACAGAGGTGTCCAGATGAGTAAAAACTGCCTTTGCATTAAGGTGAGAGAAGACCGAGATGAAATCTTATTAGAAAATA
TAACTGGGGAAAGCAGTTTGTCTGTTTCTCCTGGAAAACTACTAGACTACATCAACTTATATACTACTTCTTTTCTATATTCTCAATATG
AGCCACTTAAGAAAATTAATGAGACTTTATGTTTGACCAAAGCTGGTAATTCCTTGATCTTATTCTCCAAACTTGATTCTGAATGACTAC
TGACCACTAAAAACACTAAGAGTACCACTGTGGATGTTTAAAAACATACACCCTAAGAGCCTTCAGAATTAGACGCTTCAATTCTTCTGA
AATCAAAAGTCACACCAGCTTTGCTGTAGTTAATCAGGTAATACCTTTCTTCTCCACTACTCTCTAATTTCCTTGAGGGCAAATATTGTC
TTTCTTGATAAATGCCCTGGACCCAACATCTAACAGAATACCTGGCATAAAGTGAAATCCATCGAATGTGCTAATGATAAATAAAGAAGT
TCAAAAAAATCTTTTAATAGAAGCTATAAAATAGCAGATAAGCTAAGTCATTCTCATAAAACACCATTTGTCATTTGAATGCGTGCATTG
TGGCCTGTTACTTTTAACTAGTCTCACTAATTTATAGTTATATATGATGTAGATCTAGATTGTGATGTACACTAAGTGGGTTGATCCTGA
GATCAAGCTATGATTGCTGCTTGCGTAAAGTGTTCCTTTTGGGAAATAAATAATCTTTCATATCTGTAAACTTTGGTATAATTGGTTATT
TATGCAATGTATTGTTGTGGTTGTCAACTCAAGATTGTATTCTCATCTGGGGACATTATGAATCTTGTTATTTTATCCCCTTTTTTGCTC
TGTTTTTTCACATTTATGGCCTACCTGTTACAGCTGCACGGTATCCATTTTCTGTGCTAAATTCATCTTTAATTTATTATTTTTTTTCAA
CCTCAGCTTTTAACTTTGCCCTGATTTTCTCTTCCATTTTATTTTCACTTCCATTTTAAGCTGGCTCAAAGCCTTTTAGGAACAATAAGT
TACTGAATTATATGAACCTATTTGAGGTAATGATGATGCCTGGGAAGGAGCAGTATTGCTGGATCAGAATTCACTTTTTCCAAGTTACAG
ATTTTAATAAACCACTGTGCAAAGCATTAGGATAAATTTTTATTGAAAATTGAGTGAATGACTGAACAAATCGCTGGGTAATGCTGTTTA

>25589_25589_2_EHMT1-SPATA17_EHMT1_chr9_140513501_ENST00000462484_SPATA17_chr1_217856600_ENST00000366933_length(amino acids)=276AA_BP=12
MRARAMAAADAEIQRRWRGYRVRKYLFNYYYLKEYLKVVSETNDAIRKALEEFAEMKEREEKKANLEREEKKRDYQARKMHYLLSTKQIP
GIYNSPFRKEPDPWELQLQKAKPLTHRRPKVKQKDSTSLTDWLACTSARSFPRSEILPPINRKQCQGPFRDITEVLEQRYRPLEPTLRVA
EPIDELKLAREELRREEWLQNVNDNMFLPFSSYHKNEKYIPSMHLSSKYGPISYKEQFRSENPKKWICDKDFQTVLPSFELFSKYGKLYS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EHMT1-SPATA17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171162_11810826.0histone H3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000334856+1171242_12450826.0histone H3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271162_11817.01299.0histone H3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000460843+1271242_12457.01299.0histone H3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161162_11817.0809.0histone H3
HgeneEHMT1chr9:140513501chr1:217856600ENST00000462484+1161242_12457.0809.0histone H3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EHMT1-SPATA17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EHMT1-SPATA17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource