FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ADTRP-APOC1 (FusionGDB2 ID:2568)

Fusion Gene Summary for ADTRP-APOC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADTRP-APOC1
Fusion gene ID: 2568
HgeneTgene
Gene symbol

ADTRP

APOC1

Gene ID

84830

341

Gene nameandrogen dependent TFPI regulating proteinapolipoprotein C1
SynonymsAIG1L|C6orf105|dJ413H6.1Apo-CI|ApoC-I|apo-CIB|apoC-IB
Cytomap

6p24.1

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionandrogen-dependent TFPI-regulating proteinFAHFA hydrolase ADTRPandrogen-dependent TPF1-regulating proteinfatty acid esters of hydroxy fatty acids hydrolase ADTRPapolipoprotein C-I
Modification date2020031320200313
UniProtAcc

Q96IZ2

P02654

Ensembl transtripts involved in fusion geneENST00000229583, ENST00000379413, 
ENST00000414691, ENST00000514824, 
ENST00000252491, ENST00000588750, 
ENST00000588802, ENST00000592885, 
ENST00000586638, ENST00000589781, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 5 X 3=60
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADTRP [Title/Abstract] AND APOC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADTRP(11789982)-APOC1(45419445), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAPOC1

GO:0010900

negative regulation of phosphatidylcholine catabolic process

2302419

TgeneAPOC1

GO:0010916

negative regulation of very-low-density lipoprotein particle clearance

1917954

TgeneAPOC1

GO:0032375

negative regulation of cholesterol transport

10978346

TgeneAPOC1

GO:0033344

cholesterol efflux

11162594

TgeneAPOC1

GO:0033700

phospholipid efflux

11162594

TgeneAPOC1

GO:0034369

plasma lipoprotein particle remodeling

10978346

TgeneAPOC1

GO:0034382

chylomicron remnant clearance

4020294

TgeneAPOC1

GO:0045717

negative regulation of fatty acid biosynthetic process

15576844

TgeneAPOC1

GO:0045833

negative regulation of lipid metabolic process

182536

TgeneAPOC1

GO:0048261

negative regulation of receptor-mediated endocytosis

1917954

TgeneAPOC1

GO:0050995

negative regulation of lipid catabolic process

15576844

TgeneAPOC1

GO:0051005

negative regulation of lipoprotein lipase activity

15576844


check buttonFusion gene breakpoints across ADTRP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across APOC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP389649ADTRPchr6

11789982

+APOC1chr19

45419445

+


Top

Fusion Gene ORF analysis for ADTRP-APOC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000229583ENST00000252491ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000229583ENST00000588750ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000229583ENST00000588802ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000229583ENST00000592885ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000379413ENST00000252491ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000379413ENST00000588750ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000379413ENST00000588802ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000379413ENST00000592885ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000414691ENST00000252491ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000414691ENST00000588750ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000414691ENST00000588802ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000414691ENST00000592885ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000514824ENST00000252491ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000514824ENST00000588750ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000514824ENST00000588802ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-3CDSENST00000514824ENST00000592885ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000229583ENST00000586638ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000229583ENST00000589781ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000379413ENST00000586638ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000379413ENST00000589781ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000414691ENST00000586638ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000414691ENST00000589781ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000514824ENST00000586638ADTRPchr6

11789982

+APOC1chr19

45419445

+
intron-intronENST00000514824ENST00000589781ADTRPchr6

11789982

+APOC1chr19

45419445

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ADTRP-APOC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ADTRP-APOC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11789982/:45419445)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADTRP

Q96IZ2

APOC1

P02654

FUNCTION: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574). {ECO:0000269|PubMed:21868574, ECO:0000269|PubMed:27018888}.FUNCTION: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ADTRP-APOC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ADTRP-APOC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ADTRP-APOC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ADTRP-APOC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource