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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EIF2S3-MAPK10 (FusionGDB2 ID:25755) |
Fusion Gene Summary for EIF2S3-MAPK10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF2S3-MAPK10 | Fusion gene ID: 25755 | Hgene | Tgene | Gene symbol | EIF2S3 | MAPK10 | Gene ID | 1968 | 5602 |
| Gene name | eukaryotic translation initiation factor 2 subunit gamma | mitogen-activated protein kinase 10 | |
| Synonyms | EIF2|EIF2G|EIF2gamma|MEHMO|MRXSBRK|eIF-2gA | JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK | |
| Cytomap | Xp22.11 | 4q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 2 subunit 3eIF-2-gamma XeIF-2gXeukaryotic translation initiation factor 2 subunit gamma Xeukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaeukaryotic translation initiation factor 2G | mitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P41091 | P53779 | |
| Ensembl transtripts involved in fusion gene | ENST00000253039, ENST00000460032, | ENST00000359221, ENST00000361569, ENST00000395157, ENST00000395160, ENST00000395161, ENST00000395166, ENST00000395169, ENST00000449047, ENST00000513839, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 9 X 9 X 7=567 |
| # samples | 6 | 13 | |
| ** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/567*10)=-2.12483711191377 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EIF2S3 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | EIF2S3(24093514)-MAPK10(87354057), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF2S3 | GO:0006413 | translational initiation | 10900014 |
| Fusion gene breakpoints across EIF2S3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MAPK10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BQ371816 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
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Fusion Gene ORF analysis for EIF2S3-MAPK10 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000253039 | ENST00000359221 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000361569 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000395157 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000395160 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000395161 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000395166 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000395169 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000449047 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000253039 | ENST00000513839 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000359221 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000361569 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000395157 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000395160 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000395161 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000395166 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000395169 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000449047 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| intron-intron | ENST00000460032 | ENST00000513839 | EIF2S3 | chrX | 24093514 | + | MAPK10 | chr4 | 87354057 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for EIF2S3-MAPK10 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EIF2S3-MAPK10 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24093514/:87354057) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF2S3 | MAPK10 |
| FUNCTION: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). {ECO:0000250|UniProtKB:P32481, ECO:0000250|UniProtKB:Q9Z0N1}. | FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for EIF2S3-MAPK10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for EIF2S3-MAPK10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EIF2S3-MAPK10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EIF2S3-MAPK10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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