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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3C-DCN (FusionGDB2 ID:25790)

Fusion Gene Summary for EIF3C-DCN

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3C-DCN
Fusion gene ID: 25790
HgeneTgene
Gene symbol

EIF3C

DCN

Gene ID

8663

1634

Gene nameeukaryotic translation initiation factor 3 subunit Cdecorin
SynonymsEIF3CL|EIF3S8|eIF3-p110CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B
Cytomap

16p11.2

12q21.33

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit Ccell migration-inducing protein 17eIF3 p110eukaryotic translation initiation factor 3 subunit 8eukaryotic translation initiation factor 3, subunit 8 (110kD)eukaryotic translation initiation factor 3decorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B
Modification date2020032220200313
UniProtAcc

Q99613

P07585

Ensembl transtripts involved in fusion geneENST00000331666, ENST00000395587, 
ENST00000564243, ENST00000565099, 
ENST00000566501, ENST00000566866, 
ENST00000052754, ENST00000228329, 
ENST00000303320, ENST00000393155, 
ENST00000425043, ENST00000552962, 
ENST00000420120, ENST00000441303, 
ENST00000456569, ENST00000546370, 
ENST00000546745, ENST00000547568, 
ENST00000548768, ENST00000550099, 
ENST00000551354, 
Fusion gene scores* DoF score12 X 9 X 10=108012 X 9 X 6=648
# samples 1212
** MAII scorelog2(12/1080*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3C [Title/Abstract] AND DCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3C(28727458)-DCN(91539778), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3C

GO:0006413

translational initiation

17581632

TgeneDCN

GO:0010508

positive regulation of autophagy

23798385

TgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

TgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

TgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

TgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

TgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across EIF3C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI494896EIF3Cchr16

28727458

-DCNchr12

91539778

-


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Fusion Gene ORF analysis for EIF3C-DCN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000331666ENST00000052754EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000331666ENST00000228329EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000331666ENST00000303320EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000331666ENST00000393155EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000331666ENST00000425043EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000331666ENST00000552962EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000395587ENST00000052754EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000395587ENST00000228329EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000395587ENST00000303320EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000395587ENST00000393155EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000395587ENST00000425043EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000395587ENST00000552962EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000564243ENST00000052754EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000564243ENST00000228329EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000564243ENST00000303320EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000564243ENST00000393155EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000564243ENST00000425043EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000564243ENST00000552962EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000565099ENST00000052754EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000565099ENST00000228329EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000565099ENST00000303320EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000565099ENST00000393155EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000565099ENST00000425043EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000565099ENST00000552962EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566501ENST00000052754EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566501ENST00000228329EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566501ENST00000303320EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566501ENST00000393155EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566501ENST00000425043EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566501ENST00000552962EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566866ENST00000052754EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566866ENST00000228329EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566866ENST00000303320EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566866ENST00000393155EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566866ENST00000425043EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-3UTRENST00000566866ENST00000552962EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000420120EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000441303EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000456569EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000546370EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000546745EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000547568EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000548768EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000550099EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000331666ENST00000551354EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000420120EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000441303EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000456569EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000546370EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000546745EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000547568EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000548768EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000550099EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000395587ENST00000551354EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000420120EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000441303EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000456569EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000546370EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000546745EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000547568EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000548768EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000550099EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000564243ENST00000551354EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000420120EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000441303EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000456569EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000546370EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000546745EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000547568EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000548768EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000550099EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000565099ENST00000551354EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000420120EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000441303EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000456569EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000546370EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000546745EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000547568EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000548768EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000550099EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566501ENST00000551354EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000420120EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000441303EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000456569EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000546370EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000546745EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000547568EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000548768EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000550099EIF3Cchr16

28727458

-DCNchr12

91539778

-
intron-intronENST00000566866ENST00000551354EIF3Cchr16

28727458

-DCNchr12

91539778

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EIF3C-DCN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF3C-DCN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:28727458/:91539778)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3C

Q99613

DCN

P07585

FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.FUNCTION: May affect the rate of fibrils formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EIF3C-DCN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EIF3C-DCN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3C-DCN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3C-DCN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource