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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3C-FERMT3 (FusionGDB2 ID:25791)

Fusion Gene Summary for EIF3C-FERMT3

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3C-FERMT3
Fusion gene ID: 25791
HgeneTgene
Gene symbol

EIF3C

FERMT3

Gene ID

8663

83706

Gene nameeukaryotic translation initiation factor 3 subunit Cfermitin family member 3
SynonymsEIF3CL|EIF3S8|eIF3-p110KIND3|MIG-2|MIG2B|UNC112C|URP2|URP2SF
Cytomap

16p11.2

11q13.1

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit Ccell migration-inducing protein 17eIF3 p110eukaryotic translation initiation factor 3 subunit 8eukaryotic translation initiation factor 3, subunit 8 (110kD)eukaryotic translation initiation factor 3fermitin family homolog 3MIG2-like proteinUNC-112 related protein 2kindlin 3unc-112-related protein 2
Modification date2020032220200313
UniProtAcc

Q99613

Q86UX7

Ensembl transtripts involved in fusion geneENST00000331666, ENST00000395587, 
ENST00000564243, ENST00000566501, 
ENST00000566866, ENST00000565099, 
ENST00000279227, ENST00000345728, 
Fusion gene scores* DoF score12 X 9 X 10=10805 X 5 X 3=75
# samples 125
** MAII scorelog2(12/1080*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3C [Title/Abstract] AND FERMT3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3C(28734872)-FERMT3(63990519), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3C

GO:0006413

translational initiation

17581632

TgeneFERMT3

GO:0030335

positive regulation of cell migration

19234463

TgeneFERMT3

GO:0033622

integrin activation

19234463

TgeneFERMT3

GO:0033632

regulation of cell-cell adhesion mediated by integrin

19234463


check buttonFusion gene breakpoints across EIF3C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FERMT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A2MYEIF3Cchr16

28734872

+FERMT3chr11

63990519

+


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Fusion Gene ORF analysis for EIF3C-FERMT3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000331666ENST00000279227EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000331666ENST00000345728EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000395587ENST00000279227EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000395587ENST00000345728EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000564243ENST00000279227EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000564243ENST00000345728EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000566501ENST00000279227EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000566501ENST00000345728EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000566866ENST00000279227EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
In-frameENST00000566866ENST00000345728EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
intron-3CDSENST00000565099ENST00000279227EIF3Cchr16

28734872

+FERMT3chr11

63990519

+
intron-3CDSENST00000565099ENST00000345728EIF3Cchr16

28734872

+FERMT3chr11

63990519

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566501EIF3Cchr1628734872+ENST00000279227FERMT3chr1163990519+205313413011662453
ENST00000566501EIF3Cchr1628734872+ENST00000345728FERMT3chr1163990519+205313413011662453
ENST00000331666EIF3Cchr1628734872+ENST00000279227FERMT3chr1163990519+193812261861547453
ENST00000331666EIF3Cchr1628734872+ENST00000345728FERMT3chr1163990519+193812261861547453
ENST00000395587EIF3Cchr1628734872+ENST00000279227FERMT3chr1163990519+188911771371498453
ENST00000395587EIF3Cchr1628734872+ENST00000345728FERMT3chr1163990519+188911771371498453
ENST00000564243EIF3Cchr1628734872+ENST00000279227FERMT3chr1163990519+17971085751406443
ENST00000564243EIF3Cchr1628734872+ENST00000345728FERMT3chr1163990519+17971085751406443
ENST00000566866EIF3Cchr1628734872+ENST00000279227FERMT3chr1163990519+191212001601521453
ENST00000566866EIF3Cchr1628734872+ENST00000345728FERMT3chr1163990519+191212001601521453

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566501ENST00000279227EIF3Cchr1628734872+FERMT3chr1163990519+0.0027201590.99727976
ENST00000566501ENST00000345728EIF3Cchr1628734872+FERMT3chr1163990519+0.0027201590.99727976
ENST00000331666ENST00000279227EIF3Cchr1628734872+FERMT3chr1163990519+0.0021110960.99788886
ENST00000331666ENST00000345728EIF3Cchr1628734872+FERMT3chr1163990519+0.0021110960.99788886
ENST00000395587ENST00000279227EIF3Cchr1628734872+FERMT3chr1163990519+0.0021493850.99785066
ENST00000395587ENST00000345728EIF3Cchr1628734872+FERMT3chr1163990519+0.0021493850.99785066
ENST00000564243ENST00000279227EIF3Cchr1628734872+FERMT3chr1163990519+0.0024184560.9975815
ENST00000564243ENST00000345728EIF3Cchr1628734872+FERMT3chr1163990519+0.0024184560.9975815
ENST00000566866ENST00000279227EIF3Cchr1628734872+FERMT3chr1163990519+0.0019732350.9980268
ENST00000566866ENST00000345728EIF3Cchr1628734872+FERMT3chr1163990519+0.0019732350.9980268

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Fusion Genomic Features for EIF3C-FERMT3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EIF3Cchr1628734872+FERMT3chr1163990519+6.31E-121
EIF3Cchr1628734872+FERMT3chr1163990519+6.31E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EIF3C-FERMT3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:28734872/chr11:63990519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3C

Q99613

FERMT3

Q86UX7

FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03002, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.FUNCTION: Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000331666+1021164_189346914.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000331666+1021243_246346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000331666+1021291_294346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000395587+1021164_189346914.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000395587+1021243_246346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000395587+1021291_294346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566501+1021164_189346914.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566501+1021243_246346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566501+1021291_294346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566866+920164_189346914.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566866+920243_246346914.0Compositional biasNote=Poly-Glu
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566866+920291_294346914.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000331666+1021673_849346914.0DomainPCI
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000395587+1021673_849346914.0DomainPCI
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566501+1021673_849346914.0DomainPCI
HgeneEIF3Cchr16:28734872chr11:63990519ENST00000566866+920673_849346914.0DomainPCI
TgeneFERMT3chr16:28734872chr11:63990519ENST000002792271215147_155560668.0Compositional biasNote=Poly-Lys
TgeneFERMT3chr16:28734872chr11:63990519ENST000003457281215147_155556664.0Compositional biasNote=Poly-Lys
TgeneFERMT3chr16:28734872chr11:63990519ENST000002792271215229_558560668.0DomainNote=FERM
TgeneFERMT3chr16:28734872chr11:63990519ENST000002792271215354_457560668.0DomainPH
TgeneFERMT3chr16:28734872chr11:63990519ENST000003457281215229_558556664.0DomainNote=FERM
TgeneFERMT3chr16:28734872chr11:63990519ENST000003457281215354_457556664.0DomainPH


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Fusion Gene Sequence for EIF3C-FERMT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25791_25791_1_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000331666_FERMT3_chr11_63990519_ENST00000279227_length(transcript)=1938nt_BP=1226nt
AGGCTTGTCCCCGCCCCCTTATGGCGCGAAGGCCACTGGGAGTTGTAGTCTCCCAGTGTAGTTAGTCGGCGCTTCCCGGAAGTGACGCGA
GGACCCGCCTTCTCTCTCGGCGTTTCCGCTGTCAGGGCCCTGCGGTGTGACTCGCGGGCTCAGCTGGTCCGGCCGTAGCACCTCCGCGCC
GTCGCCATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGA
GGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAG
GAGCTGACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAA
GCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAAT
GAGCTTTGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATAC
AACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGCAGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCA
GAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGT
CGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATTCCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCC
GATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAG
GCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGAAATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGC
GGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTT
GTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAACTGATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGC
ATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTC
AACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACAC
GAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGG
GGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCT
CACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCC
AGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCT
GATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGATGAAACATGGTTTCAAACGAGTTCTT

>25791_25791_1_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000331666_FERMT3_chr11_63990519_ENST00000279227_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

--------------------------------------------------------------
>25791_25791_2_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000331666_FERMT3_chr11_63990519_ENST00000345728_length(transcript)=1938nt_BP=1226nt
AGGCTTGTCCCCGCCCCCTTATGGCGCGAAGGCCACTGGGAGTTGTAGTCTCCCAGTGTAGTTAGTCGGCGCTTCCCGGAAGTGACGCGA
GGACCCGCCTTCTCTCTCGGCGTTTCCGCTGTCAGGGCCCTGCGGTGTGACTCGCGGGCTCAGCTGGTCCGGCCGTAGCACCTCCGCGCC
GTCGCCATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGA
GGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAG
GAGCTGACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAA
GCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAAT
GAGCTTTGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATAC
AACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGCAGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCA
GAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGT
CGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATTCCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCC
GATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAG
GCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGAAATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGC
GGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTT
GTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAACTGATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGC
ATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTC
AACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACAC
GAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGG
GGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCT
CACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCC
AGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCT
GATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGATGAAACATGGTTTCAAACGAGTTCTT

>25791_25791_2_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000331666_FERMT3_chr11_63990519_ENST00000345728_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

--------------------------------------------------------------
>25791_25791_3_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000395587_FERMT3_chr11_63990519_ENST00000279227_length(transcript)=1889nt_BP=1177nt
CTTCTCTCTCGGCGTTTCCGCTGTCAGGGCCCTGCGGTGTGACTCGCGGGCTCAGCTGGTTGGTATTTTTTGGGCCTCGTGCTTCGTGGT
GGGAGACCCAGGTCGAGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGT
CGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAGGATGAAGAAGATA
CCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTG
ATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCCCCCGGT
TCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATG
CCAAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGC
AGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAA
CTTTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATT
CCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAA
GATTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGA
AATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGC
CAAAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAA
CTGATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGG
TCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATG
TGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTG
GGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACC
ACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCT
GCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAG
CTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGAT

>25791_25791_3_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000395587_FERMT3_chr11_63990519_ENST00000279227_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

--------------------------------------------------------------
>25791_25791_4_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000395587_FERMT3_chr11_63990519_ENST00000345728_length(transcript)=1889nt_BP=1177nt
CTTCTCTCTCGGCGTTTCCGCTGTCAGGGCCCTGCGGTGTGACTCGCGGGCTCAGCTGGTTGGTATTTTTTGGGCCTCGTGCTTCGTGGT
GGGAGACCCAGGTCGAGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGT
CGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAGGATGAAGAAGATA
CCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTG
ATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCCCCCGGT
TCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATG
CCAAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGC
AGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAA
CTTTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATT
CCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAA
GATTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGA
AATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGC
CAAAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAA
CTGATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGG
TCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATG
TGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTG
GGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACC
ACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCT
GCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAG
CTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGAT

>25791_25791_4_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000395587_FERMT3_chr11_63990519_ENST00000345728_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

--------------------------------------------------------------
>25791_25791_5_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000564243_FERMT3_chr11_63990519_ENST00000279227_length(transcript)=1797nt_BP=1085nt
GTTTCCGCTGTCAGGGCCCTGCGGTGTGACTCGCGGGCTCAGCTGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTC
ACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCA
TTGTTGCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGG
ACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGC
ATTGTGGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGATGAACAAGAACAATGCC
AAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGCAG
TCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACT
TTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATTCC
GAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGA
TTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGAAA
TCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCA
AAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAACT
GATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTC
AAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTG
GCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGG
GAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCAC
CCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGC
TGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCT
CATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGT

>25791_25791_5_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000564243_FERMT3_chr11_63990519_ENST00000279227_length(amino acids)=443AA_BP=336
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNEMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDG
VSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKK
KHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIANNRLIRIDLA

--------------------------------------------------------------
>25791_25791_6_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000564243_FERMT3_chr11_63990519_ENST00000345728_length(transcript)=1797nt_BP=1085nt
GTTTCCGCTGTCAGGGCCCTGCGGTGTGACTCGCGGGCTCAGCTGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTC
ACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCA
TTGTTGCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGG
ACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGC
ATTGTGGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGATGAACAAGAACAATGCC
AAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGCAG
TCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACT
TTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATTCC
GAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGA
TTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGAAA
TCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCA
AAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAACT
GATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTC
AAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTG
GCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGG
GAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCAC
CCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGC
TGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCT
CATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGT

>25791_25791_6_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000564243_FERMT3_chr11_63990519_ENST00000345728_length(amino acids)=443AA_BP=336
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNEMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDG
VSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKK
KHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIANNRLIRIDLA

--------------------------------------------------------------
>25791_25791_7_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566501_FERMT3_chr11_63990519_ENST00000279227_length(transcript)=2053nt_BP=1341nt
GTGGCAGGCAGCCCTGCACCGGACACACAGTGGCATTCAACTTCCTGCCTGCCAGCCCCAGTGTGTGGTTCCCAGCCTGACAACCTTGGC
ACCCCAGCACCCCAGCAGGAGGGGTTTCTGCTTGTGGTCCCCTGGCCACCAGCCTCGGCCAGCTGGTTGTGGACCAGCCGTGACCTGGGG
CAACCCAGCCAACCTCACCGTCCAATGGGCTGCAGCCACCTCTCTCCAGTGAGGTCTGAGACCCAGCCTTAACGAGGCTACCCCCTTCCA
GGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGA
GGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCG
CAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCT
GGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCT
GGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCAC
CTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGCAGTCTGCGGATGAAGA
TGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAA
ATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATTCCGAAGATGATGAAGA
CTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGC
ACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGAAATCCAAGCGCCTGGA
TGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAA
GGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAACTGATCGGTTCAAGGG
CAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTT
CAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGT
GTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGA
AGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCAC
TCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTG
TGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCC
TTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGAT

>25791_25791_7_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566501_FERMT3_chr11_63990519_ENST00000279227_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

--------------------------------------------------------------
>25791_25791_8_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566501_FERMT3_chr11_63990519_ENST00000345728_length(transcript)=2053nt_BP=1341nt
GTGGCAGGCAGCCCTGCACCGGACACACAGTGGCATTCAACTTCCTGCCTGCCAGCCCCAGTGTGTGGTTCCCAGCCTGACAACCTTGGC
ACCCCAGCACCCCAGCAGGAGGGGTTTCTGCTTGTGGTCCCCTGGCCACCAGCCTCGGCCAGCTGGTTGTGGACCAGCCGTGACCTGGGG
CAACCCAGCCAACCTCACCGTCCAATGGGCTGCAGCCACCTCTCTCCAGTGAGGTCTGAGACCCAGCCTTAACGAGGCTACCCCCTTCCA
GGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGA
GGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCG
CAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCT
GGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCT
GGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCAC
CTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACCCCGAGCAGTCTGCGGATGAAGA
TGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAA
ATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAGGACTCAGAAGATTCCGAAGATGATGAAGA
CTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGC
ACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAGAAGCACGACAGGAAATCCAAGCGCCTGGA
TGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAA
GGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGAGGCAAGAAGGGAACTGATCGGTTCAAGGG
CAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCATCGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTT
CAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCATCGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGT
GTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCTGTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGA
AGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTCTGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCAC
TCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAGGCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTG
TGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAGGGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCC
TTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCCCCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGAT

>25791_25791_8_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566501_FERMT3_chr11_63990519_ENST00000345728_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

--------------------------------------------------------------
>25791_25791_9_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566866_FERMT3_chr11_63990519_ENST00000279227_length(transcript)=1912nt_BP=1200nt
TTTTTGGGCCTCGTGCTTCGTGGTGGGAGACCCAGGTCGAGGTCCGGGTGGGGCCGGTGAGGGGTTGGGCGTCGGGAGGTGTTGGCTCGG
GCCTCTTCGCGTGGCCGGTGACGCCTTGGCTCCCCCGCAGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTCACCAC
CGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTT
GCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGGACCAT
CCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGT
GGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAGATAAGGAAGGGAA
GAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCAC
AAGCTACAAGCAGAACCCCGAGCAGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGA
TGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGA
TGAAGATGAGGACTCAGAAGATTCCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGG
GAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAA
AGCTAAGAAGAAGCACGACAGGAAATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGG
AGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCT
ACAGGCACGAGGCAAGAAGGGAACTGATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCAT
CGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCAT
CGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCT
GTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTC
TGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAG
GCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAG
GGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCC
CCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGATGAAACATGGTTTCAAACGAGTTCTTTCTTGTTACTTTTTAAAATTTCTTTT

>25791_25791_9_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566866_FERMT3_chr11_63990519_ENST00000279227_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

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>25791_25791_10_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566866_FERMT3_chr11_63990519_ENST00000345728_length(transcript)=1912nt_BP=1200nt
TTTTTGGGCCTCGTGCTTCGTGGTGGGAGACCCAGGTCGAGGTCCGGGTGGGGCCGGTGAGGGGTTGGGCGTCGGGAGGTGTTGGCTCGG
GCCTCTTCGCGTGGCCGGTGACGCCTTGGCTCCCCCGCAGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCGCGGTTTTTCACCAC
CGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTT
GCTGAGCGAGGATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACCTTATCCGGACCAT
CCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGT
GGACAAAGAAGGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAGATAAGGAAGGGAA
GAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCACCTTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCAC
AAGCTACAAGCAGAACCCCGAGCAGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAGATGAGGATGAGGA
TGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAAATCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGA
TGAAGATGAGGACTCAGAAGATTCCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCCGACTCAGAGGAGGAAGAAGG
GAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGCACCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAA
AGCTAAGAAGAAGCACGACAGGAAATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAGTGGGAAAGGGTCCGGGGCGG
AGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAAGGGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCT
ACAGGCACGAGGCAAGAAGGGAACTGATCGGTTCAAGGGCAGCAGGAAAGACGAGATCCTGGGCATCGCCAACAACCGACTGATCCGCAT
CGACTTGGCCGTGGGCGACGTGGTCAAGACCTGGCGTTTCAGCAACATGCGCCAGTGGAATGTCAACTGGGACATCCGGCAGGTGGCCAT
CGAGTTTGATGAACACATCAATGTGGCCTTCAGCTGCGTGTCTGCCAGCTGCCGAATTGTACACGAGTATATCGGGGGCTACATTTTCCT
GTCGACGCGGGAGCGGGCCCGTGGGGAGGAGCTGGATGAAGACCTCTTCCTGCAGCTCACCGGGGGCCATGAGGCCTTCTGAGGGCTGTC
TGATTGCCCCTGCCCTGCTCACCACCCTGTCACAGCCACTCCCAAGCCCACACCCACAGGGGCTCACTGCCCCACACCCGCTCCAGGCAG
GCACCCAGCTGGGCATTTCACCTGCTGTCACTGACTTTGTGCAGGCCAAGGACCTGGCAGGGCCAGACGCTGTACCATCACCCAGGCCAG
GGATGGGGGTGGGGGTCCCTGAGCTCATGTGGTGCCCCCTTTCCTTGTCTGAGTGGCTGAGGCTGATACCCCTGACCTATCTGCAGTCCC
CCAGCACACAAGGAAGACCAGATGTAGCTACAGGATGATGAAACATGGTTTCAAACGAGTTCTTTCTTGTTACTTTTTAAAATTTCTTTT

>25791_25791_10_EIF3C-FERMT3_EIF3C_chr16_28734872_ENST00000566866_FERMT3_chr11_63990519_ENST00000345728_length(amino acids)=453AA_BP=346
MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAY
GKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEG
SSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAA
EKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRFKGSRKDEILGIA
NNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGH

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Fusion Gene PPI Analysis for EIF3C-FERMT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3C-FERMT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3C-FERMT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource