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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3D-IQCE (FusionGDB2 ID:25806)

Fusion Gene Summary for EIF3D-IQCE

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3D-IQCE
Fusion gene ID: 25806
HgeneTgene
Gene symbol

EIF3D

IQCE

Gene ID

8664

23288

Gene nameeukaryotic translation initiation factor 3 subunit DIQ motif containing E
SynonymsEIF3S7|eIF3-p66|eIF3-zeta1700028P05Rik|PAPA7
Cytomap

22q12.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunitIQ domain-containing protein E
Modification date2020031320200313
UniProtAcc

O15371

Q6IPM2

Ensembl transtripts involved in fusion geneENST00000216190, ENST00000478547, 
ENST00000541106, ENST00000405442, 
ENST00000497572, ENST00000325979, 
ENST00000402050, ENST00000404984, 
ENST00000438376, 
Fusion gene scores* DoF score12 X 14 X 6=100812 X 3 X 9=324
# samples 1512
** MAII scorelog2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3D [Title/Abstract] AND IQCE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3D(36906902)-IQCE(2641075), # samples:1
Anticipated loss of major functional domain due to fusion event.EIF3D-IQCE seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF3D-IQCE seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3D

GO:0002191

cap-dependent translational initiation

27462815

HgeneEIF3D

GO:0006413

translational initiation

17581632

HgeneEIF3D

GO:0075522

IRES-dependent viral translational initiation

9573242

HgeneEIF3D

GO:0075525

viral translational termination-reinitiation

21347434


check buttonFusion gene breakpoints across EIF3D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IQCE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A19H-06AEIF3Dchr22

36906902

-IQCEchr7

2641075

+


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Fusion Gene ORF analysis for EIF3D-IQCE

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216190ENST00000497572EIF3Dchr22

36906902

-IQCEchr7

2641075

+
5CDS-intronENST00000478547ENST00000497572EIF3Dchr22

36906902

-IQCEchr7

2641075

+
5CDS-intronENST00000541106ENST00000497572EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000216190ENST00000325979EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000216190ENST00000402050EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000216190ENST00000404984EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000216190ENST00000438376EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000478547ENST00000325979EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000478547ENST00000402050EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000478547ENST00000404984EIF3Dchr22

36906902

-IQCEchr7

2641075

+
Frame-shiftENST00000478547ENST00000438376EIF3Dchr22

36906902

-IQCEchr7

2641075

+
In-frameENST00000541106ENST00000325979EIF3Dchr22

36906902

-IQCEchr7

2641075

+
In-frameENST00000541106ENST00000402050EIF3Dchr22

36906902

-IQCEchr7

2641075

+
In-frameENST00000541106ENST00000404984EIF3Dchr22

36906902

-IQCEchr7

2641075

+
In-frameENST00000541106ENST00000438376EIF3Dchr22

36906902

-IQCEchr7

2641075

+
intron-3CDSENST00000405442ENST00000325979EIF3Dchr22

36906902

-IQCEchr7

2641075

+
intron-3CDSENST00000405442ENST00000402050EIF3Dchr22

36906902

-IQCEchr7

2641075

+
intron-3CDSENST00000405442ENST00000404984EIF3Dchr22

36906902

-IQCEchr7

2641075

+
intron-3CDSENST00000405442ENST00000438376EIF3Dchr22

36906902

-IQCEchr7

2641075

+
intron-intronENST00000405442ENST00000497572EIF3Dchr22

36906902

-IQCEchr7

2641075

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541106EIF3Dchr2236906902-ENST00000404984IQCEchr72641075+678217311011600499
ENST00000541106EIF3Dchr2236906902-ENST00000402050IQCEchr72641075+678317311011600499
ENST00000541106EIF3Dchr2236906902-ENST00000438376IQCEchr72641075+221117311011600499
ENST00000541106EIF3Dchr2236906902-ENST00000325979IQCEchr72641075+221117311011600499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541106ENST00000404984EIF3Dchr2236906902-IQCEchr72641075+0.0016560750.99834394
ENST00000541106ENST00000402050EIF3Dchr2236906902-IQCEchr72641075+0.0016593620.9983406
ENST00000541106ENST00000438376EIF3Dchr2236906902-IQCEchr72641075+0.0024548010.9975452
ENST00000541106ENST00000325979EIF3Dchr2236906902-IQCEchr72641075+0.0024548010.9975452

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Fusion Genomic Features for EIF3D-IQCE


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EIF3Dchr2236906903-IQCEchr72641074+0.0177312810.9822687
EIF3Dchr2236906903-IQCEchr72641074+0.0177312810.9822687

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EIF3D-IQCE


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:36906902/chr7:2641075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3D

O15371

IQCE

Q6IPM2

FUNCTION: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis (PubMed:28488682). {ECO:0000250|UniProtKB:Q6PCQ0, ECO:0000269|PubMed:28488682}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Dchr22:36906902chr7:2641075ENST00000216190-1515530_547594549.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneEIF3Dchr22:36906902chr7:2641075ENST00000216190-1515285_299594549.0RegionRNA gate
TgeneIQCEchr22:36906902chr7:2641075ENST000003259791420534_539471631.0Compositional biasNote=Poly-Lys
TgeneIQCEchr22:36906902chr7:2641075ENST000004020501622534_539536696.0Compositional biasNote=Poly-Lys
TgeneIQCEchr22:36906902chr7:2641075ENST000004049841521534_539485645.0Compositional biasNote=Poly-Lys
TgeneIQCEchr22:36906902chr7:2641075ENST000004383761521534_539520680.0Compositional biasNote=Poly-Lys
TgeneIQCEchr22:36906902chr7:2641075ENST000003259791420542_571471631.0DomainIQ 1
TgeneIQCEchr22:36906902chr7:2641075ENST000003259791420601_630471631.0DomainIQ 2
TgeneIQCEchr22:36906902chr7:2641075ENST000004020501622542_571536696.0DomainIQ 1
TgeneIQCEchr22:36906902chr7:2641075ENST000004020501622601_630536696.0DomainIQ 2
TgeneIQCEchr22:36906902chr7:2641075ENST000004049841521542_571485645.0DomainIQ 1
TgeneIQCEchr22:36906902chr7:2641075ENST000004049841521601_630485645.0DomainIQ 2
TgeneIQCEchr22:36906902chr7:2641075ENST000004383761521542_571520680.0DomainIQ 1
TgeneIQCEchr22:36906902chr7:2641075ENST000004383761521601_630520680.0DomainIQ 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Dchr22:36906902chr7:2641075ENST00000405442-115530_5470549.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneEIF3Dchr22:36906902chr7:2641075ENST00000405442-115285_2990549.0RegionRNA gate
TgeneIQCEchr22:36906902chr7:2641075ENST000003259791420157_264471631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000003259791420292_358471631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000003259791420387_477471631.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004020501622157_264536696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004020501622292_358536696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004020501622387_477536696.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004049841521157_264485645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004049841521292_358485645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004049841521387_477485645.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004383761521157_264520680.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004383761521292_358520680.0Coiled coilOntology_term=ECO:0000255
TgeneIQCEchr22:36906902chr7:2641075ENST000004383761521387_477520680.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for EIF3D-IQCE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25806_25806_1_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000325979_length(transcript)=2211nt_BP=1731nt
CTCTTTTCCTGGTTTCTCAAGAGTGCTGCTGCTAACGCGGTCCCCGGCACGCACCATCTGTTGCCATCCCGGCCGGCCGAGGCCATTGCA
GATTTTGGAAGATGGCAAAGTTCATGACACCCGTGATCCAGGACAACCCCTCAGGCTGGGGTCCCTGTGCGGTTCCCGAGCAGTTTCGGG
ATATGCCCTACCAGCCGTTCAGCAAAGGAGATCGGCTAGGAAAGGTTGCAGACTGGACAGGAGCCACATACCAAGATAAGAGGAACCTCC
GCAGAGACAAAGATCGTCGGAACATGTTGCAGTTCAACCTGCAGATCCTGCCTAAGAGTGCCAAACAGAAAGAGAGAGAACGCATTCGAC
TGCAGAAAAAGTTCCAGAAACAATTTGGGGTTAGGCAGAAATGGGATCAGAAATCACAGAAACCCCGAGACTCTTCAGTTGAAGTTCGTA
GTGATTGGGAAGTGAAAGAGGAAATGGATTTTCCTCAGTTGATGAAGATGCGCTACTTGGAAGTATCAGAGCCACAGGACATTGAGTGTT
GTGGGGCCCTAGAATACTACGACAAAGCCTTTGACCGCATCACCACGAGGAGTGAGAAGCCACTGCGGAGCATCAAGCGCATCTTCCACA
CTGTCACCACCACAGACGACCCTGTCATCCGCAAGCTGGCAAAAACTCAGGGGAATGTGTTTGCCACTGATGCCATCCTGGCCACGCTGA
TGAGCTGTACCCGCTCAGTGTATTCCTGGGATATTGTCGTCCAGAGAGTTGGGTCCAAACTCTTCTTTGACAAGAGAGACAACTCTGACT
TTGACCTCCTGACAGTGAGTGAGACTGCCAATGAGCCCCCTCAAGATGAAGGTAATTCCTTCAATTCACCCCGCAACCTGGCCATGGAGG
CAACCTACATCAACCACAATTTCTCCCAGCAGTGCTTGAGAATGGGGAAGGAAAGATACAACTTCCCCAACCCAAACCCGTTTGTGGAGG
ACGACATGGATAAGAATGAAATCGCCTCTGTTGCGTACCGTTACCGCAGGTGGAAGCTTGGAGATGATATTGACCTTATTGTCCGTTGTG
AGCACGATGGCGTCATGACTGGAGCCAACGGGGAAGTGTCCTTCATCAACATCAAGACACTCAATGAGTGGGATTCCAGGCACTGTAATG
GCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGA
CCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCC
TAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTG
ACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCA
CCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGG
AGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACATTTAGCAGATGAAATAA
AATATATATCTGTTTAGTCTTAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGG
ACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCG
AGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCC
AGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCA
CCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCC

>25806_25806_1_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000325979_length(amino acids)=499AA_BP=
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKK
FQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTT
TDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYI
NHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDW
RQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICM

--------------------------------------------------------------
>25806_25806_2_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000402050_length(transcript)=6783nt_BP=1731nt
CTCTTTTCCTGGTTTCTCAAGAGTGCTGCTGCTAACGCGGTCCCCGGCACGCACCATCTGTTGCCATCCCGGCCGGCCGAGGCCATTGCA
GATTTTGGAAGATGGCAAAGTTCATGACACCCGTGATCCAGGACAACCCCTCAGGCTGGGGTCCCTGTGCGGTTCCCGAGCAGTTTCGGG
ATATGCCCTACCAGCCGTTCAGCAAAGGAGATCGGCTAGGAAAGGTTGCAGACTGGACAGGAGCCACATACCAAGATAAGAGGAACCTCC
GCAGAGACAAAGATCGTCGGAACATGTTGCAGTTCAACCTGCAGATCCTGCCTAAGAGTGCCAAACAGAAAGAGAGAGAACGCATTCGAC
TGCAGAAAAAGTTCCAGAAACAATTTGGGGTTAGGCAGAAATGGGATCAGAAATCACAGAAACCCCGAGACTCTTCAGTTGAAGTTCGTA
GTGATTGGGAAGTGAAAGAGGAAATGGATTTTCCTCAGTTGATGAAGATGCGCTACTTGGAAGTATCAGAGCCACAGGACATTGAGTGTT
GTGGGGCCCTAGAATACTACGACAAAGCCTTTGACCGCATCACCACGAGGAGTGAGAAGCCACTGCGGAGCATCAAGCGCATCTTCCACA
CTGTCACCACCACAGACGACCCTGTCATCCGCAAGCTGGCAAAAACTCAGGGGAATGTGTTTGCCACTGATGCCATCCTGGCCACGCTGA
TGAGCTGTACCCGCTCAGTGTATTCCTGGGATATTGTCGTCCAGAGAGTTGGGTCCAAACTCTTCTTTGACAAGAGAGACAACTCTGACT
TTGACCTCCTGACAGTGAGTGAGACTGCCAATGAGCCCCCTCAAGATGAAGGTAATTCCTTCAATTCACCCCGCAACCTGGCCATGGAGG
CAACCTACATCAACCACAATTTCTCCCAGCAGTGCTTGAGAATGGGGAAGGAAAGATACAACTTCCCCAACCCAAACCCGTTTGTGGAGG
ACGACATGGATAAGAATGAAATCGCCTCTGTTGCGTACCGTTACCGCAGGTGGAAGCTTGGAGATGATATTGACCTTATTGTCCGTTGTG
AGCACGATGGCGTCATGACTGGAGCCAACGGGGAAGTGTCCTTCATCAACATCAAGACACTCAATGAGTGGGATTCCAGGCACTGTAATG
GCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGA
CCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCC
TAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTG
ACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCA
CCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGG
AGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACATTTAGCAGATGAAATAA
AATATATATCTGTTTAGTCTTAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGG
ACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCG
AGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCC
AGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCA
CCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCC
GACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAGTTTAGGTCCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGC
CGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGGAGAAGAACGATGATACCTACTTAACACCTCAGCATCTGCGTCGT
GTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTACTTTATTCTCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTC
CAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCTGCCGTGAACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTC
TCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGCTGCTATCCGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGT
GACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCCAGGCAGACACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGC
TTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAGGAGCTAAAGACACCCAGGTCCCCAAATGATCTTACTCCATGCCC
CACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGAGCACTGCCCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTG
GATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTACAAAAGCAGCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTC
TGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCCGGGGAAGAGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTC
CAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTCTGGGACAGTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCC
AAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGGCGTGCGGAGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGG
AGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTGTGTGTGAGATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTT
AGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCAGGCCTGGTGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTG
CCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCCCCTTTTTACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACG
GGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCTTCTGAGTCACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTC
AGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGGAGGCTCTGCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTG
TCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCACCCAAAGTGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGC
CCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGTCAGCGGGGGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCT
GTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAACTTGATGGACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGC
CTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAGCCATCCCTGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAG
TCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTGGGGGAGACCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTA
AACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGGCCTAGAGCTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTC
AGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGGTGCAGCTGGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGC
TCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTGATGCCCAGTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTA
CAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTTTTGTTCCATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCA
CGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTTAGGCAGGAGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGA
GCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGGCGAGCTGTGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAA
TGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCATGGGAAAGGTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGA
GCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGGCCTAGCCATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGG
GAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGCTGGCAGGGCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGT
AGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTGCCAAAGCAGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGC
AGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACATCACCTTGAACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCA
GAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTATCCCATGCCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCC
AGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTGACACTGCTGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAG
CCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTCCCCAACTCCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCT
CAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATACAGGAGGCTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTT
GTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGAGAAAGAGGAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGC
CGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGTCCCTTGGTTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCA
GGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGCAGAAGTGAGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGG
GGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATGCCAGAGAGGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGG
GTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCACCAAGACCACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGA
GACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCCGGTGTTGGACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTA
TTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTGGCTGTGGTCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAG
ACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCCTTCCTTGCAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCA
ACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCATTTTTGAGGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAA
GATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAATTCCTCCTTTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCG
GATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGTCCGAGCCAGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCA
AGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGTACAGACCACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGA
CGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGGAAGGAGTGGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTA
TTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATAAGGTTTTCATTCTTGTGCAACTCATTATTCTCATTATTGGCCTT

>25806_25806_2_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000402050_length(amino acids)=499AA_BP=
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKK
FQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTT
TDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYI
NHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDW
RQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICM

--------------------------------------------------------------
>25806_25806_3_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000404984_length(transcript)=6782nt_BP=1731nt
CTCTTTTCCTGGTTTCTCAAGAGTGCTGCTGCTAACGCGGTCCCCGGCACGCACCATCTGTTGCCATCCCGGCCGGCCGAGGCCATTGCA
GATTTTGGAAGATGGCAAAGTTCATGACACCCGTGATCCAGGACAACCCCTCAGGCTGGGGTCCCTGTGCGGTTCCCGAGCAGTTTCGGG
ATATGCCCTACCAGCCGTTCAGCAAAGGAGATCGGCTAGGAAAGGTTGCAGACTGGACAGGAGCCACATACCAAGATAAGAGGAACCTCC
GCAGAGACAAAGATCGTCGGAACATGTTGCAGTTCAACCTGCAGATCCTGCCTAAGAGTGCCAAACAGAAAGAGAGAGAACGCATTCGAC
TGCAGAAAAAGTTCCAGAAACAATTTGGGGTTAGGCAGAAATGGGATCAGAAATCACAGAAACCCCGAGACTCTTCAGTTGAAGTTCGTA
GTGATTGGGAAGTGAAAGAGGAAATGGATTTTCCTCAGTTGATGAAGATGCGCTACTTGGAAGTATCAGAGCCACAGGACATTGAGTGTT
GTGGGGCCCTAGAATACTACGACAAAGCCTTTGACCGCATCACCACGAGGAGTGAGAAGCCACTGCGGAGCATCAAGCGCATCTTCCACA
CTGTCACCACCACAGACGACCCTGTCATCCGCAAGCTGGCAAAAACTCAGGGGAATGTGTTTGCCACTGATGCCATCCTGGCCACGCTGA
TGAGCTGTACCCGCTCAGTGTATTCCTGGGATATTGTCGTCCAGAGAGTTGGGTCCAAACTCTTCTTTGACAAGAGAGACAACTCTGACT
TTGACCTCCTGACAGTGAGTGAGACTGCCAATGAGCCCCCTCAAGATGAAGGTAATTCCTTCAATTCACCCCGCAACCTGGCCATGGAGG
CAACCTACATCAACCACAATTTCTCCCAGCAGTGCTTGAGAATGGGGAAGGAAAGATACAACTTCCCCAACCCAAACCCGTTTGTGGAGG
ACGACATGGATAAGAATGAAATCGCCTCTGTTGCGTACCGTTACCGCAGGTGGAAGCTTGGAGATGATATTGACCTTATTGTCCGTTGTG
AGCACGATGGCGTCATGACTGGAGCCAACGGGGAAGTGTCCTTCATCAACATCAAGACACTCAATGAGTGGGATTCCAGGCACTGTAATG
GCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGA
CCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCC
TAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTG
ACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCA
CCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGG
AGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACATTTAGCAGATGAAATAA
AATATATATCTGTTTAGTCTTAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGG
ACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCG
AGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCC
AGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCA
CCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCC
GACGATATTGTCATTGCACCGTCTCTGCCCACGAAGAACTTTCCAGTTTAGGTCCCCGTCACTGTCTCCACGCCGTGATGGCAGCGCTGC
CGAGGACATAGGAACCACGACTGGAAAGATAATTTATCGTGTTAGGAGAAGAACGATGATACCTACTTAACACCTCAGCATCTGCGTCGT
GTCTCTTTGTGCTTTTGTTTGTGGAAGGAGACCCAAATGCCTTTACTTTATTCTCTGGGGAGGGCCAGCGGCTCGCATCCCCCTCATCTC
CAGCTGCAGCTCGGATGGTGGATTTTCAGTGCCAACAGACACATCTGCCGTGAACTCGCAGATGCCAGGGAGCCCTGTAGTGACACGTTC
TCTGACAGCACCTTGCCGCCTGCCCACGACCTTGACCGTGAGGAGCTGCTATCCGCAACCAGCGCCGACACCATGCCCCCTCTTCCTGGT
GACACCCTCAACAACCAGGATTTGCTCGATCTCAGCCCAGCAGGCCAGGCAGACACACCCCGCTGTGCCTTAGGAAGGTGTGAGACCGGC
TTCCCCCATCCCCACAGCAAAACACGGCCTGTCCCAAGCCAGTGAGGAGCTAAAGACACCCAGGTCCCCAAATGATCTTACTCCATGCCC
CACCCGCTCACACCGTCCTTTCCCGTCACCCTTGCTATCCCCTGGAGCACTGCCCTCCAGAGCTGCCCTTCCCAGGAAGGAATTTGGTTG
GATTCTGTCACTGTGGAGACCAAGATTTTTTAAAATTCCCAATTACAAAAGCAGCATCACACTTGCTTCTGAGAACAGCAGGGTGATGTC
TGTTCCCAAGCTGGTGGCGGGAGCCTTAGCCTGTGTGGGGCCACCCGGGGAAGAGGAGGAGAGGAGGGTGAGGAGGCAGGCTCGCCGTTC
CAAGGGACAGCATAGGCTCGTGGTGGGGCGTGTTGCATCTGGTGTCTGGGACAGTCCCCGTCACCCCATGTGTGCGGCCTCTGCACTCCC
AAGCTCCATGGCTGGGCTGGGCTGGGCTGGGCTGGGCTGGGCCGGGCGTGCGGAGCCTGTGGAGCCAGCAGCTGCAGAGGCCTAGGAGGG
AGTTCCTGGGGGAAGCGCACAGTGTCCAGTGCCCATCTCTTGCTTGTGTGTGAGATTAGCCCTTGCTGGGGCGTCAAGAGGAAGAGCCTT
AGACCTGGGCGGGCCTTCAGGGGCATCTAGACCCCTGCACAGCCCAGGCCTGGTGTCTGCATTTCCACAGCACCCCTGTGGGGACTCCTG
CCGGGGCTGGCCGCTGTCTCAGGAGAGACCCAATGGTTAGAAAGCCCCTTTTTACACAGCTGACAGCTTCTCCCAAGGCTTCCGTCCACG
GGGACAGGCTTAACCCCTGGGCGCCTTTTCTGCAGCATGGCGGCCTTCTGAGTCACCTAAGCTGAGCCTGGGTCATTCTCTGTGGCGGTC
AGAAGGCCGATGGCCCCAACACAGTGGCTTGTGAAAGGGAGAGAGGAGGCTCTGCATGTCCACCTGCTCTATGGGAGGAGGACACAGGTG
TCCCCAGCCCAGCCTGTTCTCTCCCAGTCACTCAGGGATGGGGCCACCCAAAGTGCAGGACCCGCCCCACCCTGCGGTTCGAAGCCTGGC
CCCTGTCTCCACTTAGCTTCTGTTTCTGCAGTGGGTGGAAGCGAGTCAGCGGGGGGCCTGGCTTGTGTACGTGTTTTCCTTATTTGGTCT
GTGGGTTGCCAAGTCCATTTTTTTTTCCACTGAACTGGCTGGTAACTTGATGGACTGTGTAACTGACACAGGCCCTCTTTAGACCCCTGC
CTTCACCCCACCCGCCCGGGTCCACTCCCTGGGGCGCTGTCCCAAGCCATCCCTGCTTGCCAGCTCAAAGCTTCAGGTCCTAGGAGCCAG
TCCACCTCGAAAGCCCTGAGAAAGTGAGACACCTGCACATTCGCTGGGGGAGACCCTCCGTTCTCTTGTGGCAGCTGCTCCCACTTGTTA
AACCAAGCTGTTTCTGCGGGACGTGCTCACTCTTGGGAACCAGTGGCCTAGAGCTTTGGGTTACAGGCATGGAGAGGGCTTTCCTGCCTC
AGGCTTGGAGGCCAATGTTCCATACATAAACCGCCATGTCCTCTGGTGCAGCTGGGCTGCTCTTTTAAAAGCCAGCATCCATCTTGAAGC
TCGCTGGGTAAATGGCAATGCATTCTCAAGCCAGTGTCTTCAGCTGATGCCCAGTGTCCAGTGCTGGTCACCAGTCCCCTTTGCTGGGTA
CAGCCTGCCTGGCTGTTCTGTGGTCCTGGAACGCTGCAGTGTGGTTTTGTTCCATGGAGACAGTACCAAGCGGAGAGGCCTCCTTGCCCA
CGGCCCCAGGGCCTGGGGGCCAGGGGTTCTGGCCCTGCGGGGACTTAGGCAGGAGGGGAAGAGAAGCCCATGGAGCCATGGGAGGGGTGA
GCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGGCGGGGCGAGCTGTGGGTGGGGCCTAGCCATGGGAGAGGTGAGCTGTGAA
TGGGGCTAGCTATGGGTGGGGTGAGCTGTGGACAGGGCCTAGCCATGGGAAAGGTGAGCTGTGGGCGGGGCCTAGTCACGGGAGAGGTGA
GCTGTGGGCGGGGCCTAGTCATGGGAGGGGTGAGCTGTGGATGGGGCCTAGCCATGGGAGGGGTGAGCTGTGAGTGGGGCTGAGCCATGG
GAGCAGCAAGCTGGTGGAGTGGGCTGGGCGGAGCTGTGGGGGCTGCTGGCAGGGCCTAGGAAAGTAGACAACTCCCGGGGGAGACGAAGT
AGAGAGTGAGTCCCCAAGAAAGGGACTCCTGCCCCAGCGTCAAGTGCCAAAGCAGGCCCCATCTACCACTTCAGGGTCGACGTTGGTGGC
AGGTGTTGTTCACGGTGTACTGATTGTCACTGCAACACCTCCACATCACCTTGAACTTCAAGAACAGCAGCAAAGCTGTATCTGCTATCA
GAGGCTGTTAGGTAGTCCAGCTTTAAAATAACACACTCTTTCTCTATCCCATGCCCTTTAAACAAGCAGCCACAGGAGATGTCAGTCTCC
AGGGCCTGGCCCCACTGTGTTGACAGCAGTCACGTCTGTTGAGCTGACACTGCTGAGGCTGAAGCTGGCCCCGTGCAGGTGGCTGGTGAG
CCACAGGTGCAGTACCCGGAGGTGTGCTCTCCCCTAGAGGCCTGTCCCCAACTCCTCCCCTAGAGGCCTATTCCCGCTGCTCACAGACCT
CAGCAGAGGCACCAGCTGGAGGGCTCCAGGGACATCCTTGGAGATACAGGAGGCTTTCCTGGCACAGGGCACAGCTCTTAGGAGGCCTTT
GTAGGACGCTGTCTCCCCAGCGTGTCCTGCTCATCCAGGATGGGGAGAAAGAGGAGGAGGCCCCAGGCTCAGAAGCCAGGGACAGACTGC
CGACGATTACCAAACTGAATCCAGGCAGTGCCATGACCCTGGGTGTCCCTTGGTTCACATCACCCACCAGACAGCTGCGGAGAGAGTGCA
GGGAGGGGCTGGGACCAAACAGGCCAGAAACCAGCAGAAAAGAGGCAGAAGTGAGGTGGGTGTGCCTGGGGCACGAAGCCAGCGCCGGGG
GGATTTCAGTGGAGCCTTACAGCCAGGCTCCGTGCGGACTGTGATGCCAGAGAGGCGTGCAGCCTCTGGGCAAGTCGGGAGAGGGCTTGG
GTGGTCCCCACAAGGCAGAAGAGGTGGAAGGGCCAGAGAAGACCACCAAGACCACCGTTCCCGCAGGCCTGGGGTGAGTGACCTGACTGA
GACTAGCGGGCAGAGCCAAGCAGGGCTAAACTCCAACCCAGGGCCCGGTGTTGGACAAAGTAGCTTTTTCTTTGCTCGTTTGTCTGTGTA
TTAAGAAGAGACTAAAATAGCCAAACGACGCTGGTCGCATGCGCTGGCTGTGGTCTGTCTGCTGAATGTCTATTTTTGTCTCCTGACGAG
ACGTGAGGACCATGCCCTTGATCCCTCCGATGGACCAGAAACCCCCTTCCTTGCAAAAAAAAGGCAATTGAATTAGGAAAAGATAGCCCA
ACCTAGCTCAGATCCACCAAGATAAGCACAGCAAAGCTTGGCTGCATTTTTGAGGAATAAAAACCTGCAGAAAGCACCGATAACCTTCAA
GATCTGAATGAGATTCTATTATAACCCGTCTAAACGATTGCAAAATTCCTCCTTTGGTTTTGGAAGCAGCGTTTGCTCTCCCGTGGCTCG
GATTCTCTGAGGACCAGGGAGTTGACACACAAACCCCGCCATGGGTCCGAGCCAGCTATTTCTCAAGGCTCCCACCTCGCCAAGCTCCCA
AGGGCCTGCTGGCAGTGCCTACGCTGTGCCAACTACCCTGTCTGGTACAGACCACGGCTGGGTAAGCACCCTTAAAAGCAACAGAAATGA
CGTCTGGAAGCTGAAATGTGAAACTGTCAAGATGGCTTAGGAGAGGAAGGAGTGGACCCGCTGGTCTTTGGCATTTTGTATTTAGAATTA
TTCTAACTTTATACATAATGTATAGGCCGATCTTTTGGAAGGGATAAGGTTTTCATTCTTGTGCAACTCATTATTCTCATTATTGGCCTT

>25806_25806_3_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000404984_length(amino acids)=499AA_BP=
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKK
FQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTT
TDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYI
NHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDW
RQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICM

--------------------------------------------------------------
>25806_25806_4_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000438376_length(transcript)=2211nt_BP=1731nt
CTCTTTTCCTGGTTTCTCAAGAGTGCTGCTGCTAACGCGGTCCCCGGCACGCACCATCTGTTGCCATCCCGGCCGGCCGAGGCCATTGCA
GATTTTGGAAGATGGCAAAGTTCATGACACCCGTGATCCAGGACAACCCCTCAGGCTGGGGTCCCTGTGCGGTTCCCGAGCAGTTTCGGG
ATATGCCCTACCAGCCGTTCAGCAAAGGAGATCGGCTAGGAAAGGTTGCAGACTGGACAGGAGCCACATACCAAGATAAGAGGAACCTCC
GCAGAGACAAAGATCGTCGGAACATGTTGCAGTTCAACCTGCAGATCCTGCCTAAGAGTGCCAAACAGAAAGAGAGAGAACGCATTCGAC
TGCAGAAAAAGTTCCAGAAACAATTTGGGGTTAGGCAGAAATGGGATCAGAAATCACAGAAACCCCGAGACTCTTCAGTTGAAGTTCGTA
GTGATTGGGAAGTGAAAGAGGAAATGGATTTTCCTCAGTTGATGAAGATGCGCTACTTGGAAGTATCAGAGCCACAGGACATTGAGTGTT
GTGGGGCCCTAGAATACTACGACAAAGCCTTTGACCGCATCACCACGAGGAGTGAGAAGCCACTGCGGAGCATCAAGCGCATCTTCCACA
CTGTCACCACCACAGACGACCCTGTCATCCGCAAGCTGGCAAAAACTCAGGGGAATGTGTTTGCCACTGATGCCATCCTGGCCACGCTGA
TGAGCTGTACCCGCTCAGTGTATTCCTGGGATATTGTCGTCCAGAGAGTTGGGTCCAAACTCTTCTTTGACAAGAGAGACAACTCTGACT
TTGACCTCCTGACAGTGAGTGAGACTGCCAATGAGCCCCCTCAAGATGAAGGTAATTCCTTCAATTCACCCCGCAACCTGGCCATGGAGG
CAACCTACATCAACCACAATTTCTCCCAGCAGTGCTTGAGAATGGGGAAGGAAAGATACAACTTCCCCAACCCAAACCCGTTTGTGGAGG
ACGACATGGATAAGAATGAAATCGCCTCTGTTGCGTACCGTTACCGCAGGTGGAAGCTTGGAGATGATATTGACCTTATTGTCCGTTGTG
AGCACGATGGCGTCATGACTGGAGCCAACGGGGAAGTGTCCTTCATCAACATCAAGACACTCAATGAGTGGGATTCCAGGCACTGTAATG
GCGTTGACTGGCGTCAGAAGCTGGACTCTCAGCGAGGGGCTGTCATTGCCACGGAGCTGAAGAACAACAGCTACAAGTTGGCCCGGTGGA
CCTGCTGTGCTTTGCTGGCTGGATCTGAGTACCTCAAGCTTGGTTATGTGTCTCGGTACCACGTGAAAGACTCCTCACGCCACGTCATCC
TAGGCACCCAGCAGTTCAAGCCTAATGAGTTTGCCAGCCAGATCAACCTGAGCGTGGAGAATGCCTGGGGCATTTTACGCTGCGTCATTG
ACATCTGCATGAAGCTGGAGGAGGGCAAATACCTCATCCTCAAGGACCCCAACAAGCAGGTCATCCGTGTCTACAGCCTCCCTGATGGCA
CCTTCAGCTCTGATGAAGATGAGGAGGAAGAGGAGGAGGAAGAAGAGGAAGAAGAAGAGGAAGAAACTTAAACCAGTGATGTGGAGCTGG
AGTTTGTCCTTCCACCGAGACTACGAGGGCCTTTGATGCTTAGTGGAATGTGTGTCTAACTTGCTCTCTGACATTTAGCAGATGAAATAA
AATATATATCTGTTTAGTCTTAAAAAAAAGGCTGTTCTGGATGAGGCGGCTGTGGTGCTTCAGGCAGCTTTCAGGGGACATCTCACGCGG
ACAAAGCTCTTAGCAAGCAAAGCACATGGCTCAGAGCCACCCAGCGTGCCAGGCCTCCCAGACCAGAGCTCTCCTGTGCCCCGCGTTCCG
AGCCCCATCGCCCAGGCCACGGGCAGCCCTGTGCAGGAGGAGGCCATCGTCATCATCCAGTCCGCTCTGCGGGCACACCTGGCCCGGGCC
AGGCACAGTGCTACCGGTAAAAGAACCACCACCGCAGCTTCTACCAGGAGGAGATCGGCTTCAGCCACACACGGGGACGCCTCCTCCCCA
CCCTTCCTCGCAGCTCTTCCTGACCCCTCTCCCTCAGGGCCACAGGCCTTGGCACCTCTACCTGGGGATGACGTCAACTCCGATGATTCC

>25806_25806_4_EIF3D-IQCE_EIF3D_chr22_36906902_ENST00000541106_IQCE_chr7_2641075_ENST00000438376_length(amino acids)=499AA_BP=
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKK
FQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTT
TDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYI
NHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDW
RQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EIF3D-IQCE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3D-IQCE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3D-IQCE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource