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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3E-PHF20L1 (FusionGDB2 ID:25831)

Fusion Gene Summary for EIF3E-PHF20L1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3E-PHF20L1
Fusion gene ID: 25831
HgeneTgene
Gene symbol

EIF3E

PHF20L1

Gene ID

3646

51105

Gene nameeukaryotic translation initiation factor 3 subunit EPHD finger protein 20 like 1
SynonymsEIF3-P48|EIF3S6|INT6|eIF3-p46CGI-72|TDRD20B|URLC1
Cytomap

8q23.1

8q24.22

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit EeIF-3 p48eukaryotic translation initiation factor 3 subunit 6eukaryotic translation initiation factor 3 subunit E isoform 2 transcripteukaryotic translation initiation factor 3, subunit 6 (48kD)eukaPHD finger protein 20-like protein 1tudor domain containing 20Btudor domain-containing protein PHF20L1up-regulated in lung cancer 1
Modification date2020031320200320
UniProtAcc

P60228

.
Ensembl transtripts involved in fusion geneENST00000220849, ENST00000519030, 
ENST00000519517, 		ENST00000220847, 
ENST00000395379, ENST00000395390, 
ENST00000337920, ENST00000395376, 
ENST00000395386, 
Fusion gene scores* DoF score13 X 12 X 7=10928 X 9 X 7=504
# samples 1610
** MAII scorelog2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3E [Title/Abstract] AND PHF20L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3E(109240496)-PHF20L1(133806656), # samples:2
Anticipated loss of major functional domain due to fusion event.EIF3E-PHF20L1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF3E-PHF20L1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
EIF3E-PHF20L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF3E-PHF20L1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
EIF3E-PHF20L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3E

GO:0006413

translational initiation

17581632


check buttonFusion gene breakpoints across EIF3E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHF20L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8SH-01BEIF3Echr8

109240496

-PHF20L1chr8

133806656

+
ChimerDB4PRADTCGA-YL-A8SHEIF3Echr8

109240496

-PHF20L1chr8

133806656

+


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Fusion Gene ORF analysis for EIF3E-PHF20L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000220849ENST00000220847EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5CDS-5UTRENST00000220849ENST00000395379EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5CDS-5UTRENST00000220849ENST00000395390EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5CDS-5UTRENST00000519030ENST00000220847EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5CDS-5UTRENST00000519030ENST00000395379EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5CDS-5UTRENST00000519030ENST00000395390EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5UTR-3CDSENST00000519517ENST00000337920EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5UTR-3CDSENST00000519517ENST00000395376EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5UTR-3CDSENST00000519517ENST00000395386EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5UTR-5UTRENST00000519517ENST00000220847EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5UTR-5UTRENST00000519517ENST00000395379EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
5UTR-5UTRENST00000519517ENST00000395390EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
Frame-shiftENST00000519030ENST00000337920EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
Frame-shiftENST00000519030ENST00000395376EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
Frame-shiftENST00000519030ENST00000395386EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
In-frameENST00000220849ENST00000337920EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
In-frameENST00000220849ENST00000395376EIF3Echr8

109240496

-PHF20L1chr8

133806656

+
In-frameENST00000220849ENST00000395386EIF3Echr8

109240496

-PHF20L1chr8

133806656

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000220849EIF3Echr8109240496-ENST00000395386PHF20L1chr8133806656+66407856337551230
ENST00000220849EIF3Echr8109240496-ENST00000337920PHF20L1chr8133806656+2742785631559498
ENST00000220849EIF3Echr8109240496-ENST00000395376PHF20L1chr8133806656+2835785631652529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220849ENST00000395386EIF3Echr8109240496-PHF20L1chr8133806656+0.0001612410.9998387
ENST00000220849ENST00000337920EIF3Echr8109240496-PHF20L1chr8133806656+0.0001562090.9998437
ENST00000220849ENST00000395376EIF3Echr8109240496-PHF20L1chr8133806656+0.0001360580.999864

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Fusion Genomic Features for EIF3E-PHF20L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EIF3Echr8109240495-PHF20L1chr8133806655+0.0037383330.99626166
EIF3Echr8109240495-PHF20L1chr8133806655+0.0037383330.99626166
EIF3Echr8109240495-PHF20L1chr8133806655+0.0037383330.99626166
EIF3Echr8109240495-PHF20L1chr8133806655+0.0037383330.99626166

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EIF3E-PHF20L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:109240496/chr8:133806656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3E

P60228

.
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHF20L1chr8:109240496chr8:133806656ENST00000220847120530_5790405.0Compositional biasNote=Lys-rich
TgenePHF20L1chr8:109240496chr8:133806656ENST0000033792018530_57927286.0Compositional biasNote=Lys-rich
TgenePHF20L1chr8:109240496chr8:133806656ENST00000395386121530_579271018.0Compositional biasNote=Lys-rich
TgenePHF20L1chr8:109240496chr8:133806656ENST0000022084712011_710405.0DomainNote=Tudor 1
TgenePHF20L1chr8:109240496chr8:133806656ENST0000022084712085_1410405.0DomainNote=Tudor 2
TgenePHF20L1chr8:109240496chr8:133806656ENST000003379201885_14127286.0DomainNote=Tudor 2
TgenePHF20L1chr8:109240496chr8:133806656ENST0000039538612185_141271018.0DomainNote=Tudor 2
TgenePHF20L1chr8:109240496chr8:133806656ENST00000220847120681_7290405.0Zinc fingerNote=PHD-type
TgenePHF20L1chr8:109240496chr8:133806656ENST0000033792018681_72927286.0Zinc fingerNote=PHD-type
TgenePHF20L1chr8:109240496chr8:133806656ENST00000395386121681_729271018.0Zinc fingerNote=PHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Echr8:109240496chr8:133806656ENST00000220849-713221_398240446.0DomainPCI
TgenePHF20L1chr8:109240496chr8:133806656ENST000003379201811_7127286.0DomainNote=Tudor 1
TgenePHF20L1chr8:109240496chr8:133806656ENST0000039538612111_71271018.0DomainNote=Tudor 1


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Fusion Gene Sequence for EIF3E-PHF20L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25831_25831_1_EIF3E-PHF20L1_EIF3E_chr8_109240496_ENST00000220849_PHF20L1_chr8_133806656_ENST00000337920_length(transcript)=2742nt_BP=785nt
TGTTCGTTTGTCGGCGCTACCAATAAAGTTTTAGTGAGCACAGACTCCCTTTTCTTTGGCAAGATGGCGGAGTACGACTTGACTACTCGC
ATCGCGCACTTTTTGGATCGGCATCTAGTCTTTCCGCTTCTTGAATTTCTCTCTGTAAAGGAGATATATAATGAAAAGGAATTATTACAA
GGTAAATTGGACCTTCTTAGTGATACCAACATGGTAGACTTTGCTATGGATGTATACAAAAACCTTTATTCTGATGATATTCCTCATGCT
TTGAGAGAGAAAAGAACCACAGTGGTTGCACAACTGAAACAGCTTCAGGCAGAAACAGAACCAATTGTGAAGATGTTTGAAGATCCAGAA
ACTACAAGGCAAATGCAGTCAACCAGGGATGGTAGGATGCTCTTTGACTACCTGGCGGACAAGCATGGTTTTAGGCAGGAATATTTAGAT
ACACTCTACAGATATGCAAAATTCCAGTACGAATGTGGGAATTACTCAGGAGCAGCAGAATATCTTTATTTTTTTAGAGTGCTGGTTCCA
GCAACAGATAGAAATGCTTTAAGTTCACTCTGGGGAAAGCTGGCCTCTGAAATCTTAATGCAGAATTGGGATGCAGCCATGGAAGACCTT
ACACGGTTAAAAGAGACCATAGATAATAATTCTGTGAGTTCTCCACTTCAGTCTCTTCAGCAGAGAACATGGCTCATTCACTGGTCTCTG
TTTGTTTTCTTCAATCACCCCAAAGGTCGCGATAATATTATTGACCTCTTCCTTTATCAGCCACAGTATCCATCACGAATTGAAAAAATT
GACTATGAGGAGGGCAAGATGTTGGTCCATTTTGAGCGCTGGAGTCATCGTTATGATGAGTGGATTTACTGGGATAGCAATAGATTGCGA
CCCCTTGAGAGACCAGCACTAAGAAAAGAAGGGCTAAAAGATGAGGAAGATTTCTTTGATTTTAAAGCTGGAGAAGAAGTTCTGGCTCGT
TGGACAGACTGTCGCTATTACCCTGCCAAGATTGAAGCAATTAACAAAGAAGGAACATTTACAGTTCAGTTTTATGATGGAGTAATTCGT
TGTTTAAAAAGAATGCACATTAAAGCCATGCCCGAGGATGCTAAGGGGCAGGATTGGATAGCTTTAGTCAAAGCAGCTGCTGCAGCTGCA
GCCAAGAACAAAACAGGGAGTAAACCTCGAACCAGCGCTAACAGCAATAAAGATAAGGATAAAGATGAGAGAAAGTGGTTTAAAGTACCT
TCAAAGAAGGAGGAAACTTCAACTTGTATAGCCACACCAGACGTAGAGAAGAAGGAAGATCTGCCTACATCTAGTGAAACATTTGGACTT
CATGTAGAGAACGTTCCAAAGATGGTCTTTCCACAGCCAGAGAGCACATTATCAAACAAGAGGAAAAATAATCAAGGCAACTCGTTTCAG
GCAAAGAGAGCTCGACTTAACAAGATTACTGGTTTGTTGGCATCCAAAGCTGTTGGGGTTGATGGTGCTGAAAAAAAGGAAGACTACAAT
GAAACAGCTCCAATGCTGGAGCAGGTATGAAATGGTAGCATTTGATTTTTTTCAAGGTTCCCACTGGAATGATCACGGAGCTCTAGTATC
TACGTAATTGAAATTCCCCTTTTGATCAGATATGGGAATAGGAAGCTAATTAATTGATGATATATTTTTAACTCTGCCTTCTCCAAGGTA
TACAGATAACTACAGACTTCATTAGTGTTTGATTTCATAGACTGGCATTAAAGCCTTTGTCTCCAAAATTTGAAGGCCTGGAGACAGGCA
TCCCAGGGTATAAGCTTCCAGCTGGATCACCTTTAACTAGCTTACAAAAAGACCCTTACACAAATACTTTCCATTTGTGAGTTAAAACAG
GGTTTTTTGACATCGAATAAAGCTTCTTTTGTAAGAAGTTTCTTTTATATTGTAACAATTGGTGTTGTTAGACTGACTATGTGTTTTATG
AATTGATCAATGAGCCATACATTTTTGCTAGGATGTATATTTTAATAACTACAAAAAAAGAGAGTTTAAAAAACTATTAAGGGTCTGTCT
TTAAACCACCTAATAGAGGAATTTAAAAGTGAAGGTTGCAGTTGCTAGATTTTGCCTTGGCTACCTTCAGATTCCCACAATACTTGTACA
TAATGAACTGTGCATGCTTTTACATTCTCTAAGGGCTTAACTTCTTAGGCACTGTAAGACTATAAGAACGCAGTAATAGCCATAACTGGA
TTTCCTTGGTTCTCCTGTTTTAAAATCTGAGCCTTAATGTAGTTTTAATATATCCTTTTTGTATTACTTTTCTTTATTAGTAGCCTAATA
AAGAAGACTTTGAGTATCTTTTGCTCTCCTCTAGATGCGTTTTAAAAACTATTCCAAATTTAATTGATATTGTATTGAGTTTTTCAGGGT
TATTTTAGGCCTGATTTGATAACAATGCGTTGTTTTGGTGCCTCCATTAATGTTGTATTAAATCAATGGGTCTTTTAAATTGATTAATAT
GTCATTGAATCATACCTTCTGATTTTCTGTGATCATCCAACGGTTAAGTCTTTGCCGTTATTGTCAATATATCAACCAAATTTTAAATAA
CTTTTTTTACTGTGTATTACTATATTCAACGTCCCAGATATAACAATATTTTGTATTTTCACCACTGTTTATGGTATTCTCAGAATGCGA

>25831_25831_1_EIF3E-PHF20L1_EIF3E_chr8_109240496_ENST00000220849_PHF20L1_chr8_133806656_ENST00000337920_length(amino acids)=498AA_BP=241
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEP
IVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQ
NWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYPSRIEKIDYEEGKMLVHFERWSHRYDEW
IYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQDWIA
LVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATPDVEKKEDLPTSSETFGLHVENVPKMVFPQPESTLSNKR

--------------------------------------------------------------
>25831_25831_2_EIF3E-PHF20L1_EIF3E_chr8_109240496_ENST00000220849_PHF20L1_chr8_133806656_ENST00000395376_length(transcript)=2835nt_BP=785nt
TGTTCGTTTGTCGGCGCTACCAATAAAGTTTTAGTGAGCACAGACTCCCTTTTCTTTGGCAAGATGGCGGAGTACGACTTGACTACTCGC
ATCGCGCACTTTTTGGATCGGCATCTAGTCTTTCCGCTTCTTGAATTTCTCTCTGTAAAGGAGATATATAATGAAAAGGAATTATTACAA
GGTAAATTGGACCTTCTTAGTGATACCAACATGGTAGACTTTGCTATGGATGTATACAAAAACCTTTATTCTGATGATATTCCTCATGCT
TTGAGAGAGAAAAGAACCACAGTGGTTGCACAACTGAAACAGCTTCAGGCAGAAACAGAACCAATTGTGAAGATGTTTGAAGATCCAGAA
ACTACAAGGCAAATGCAGTCAACCAGGGATGGTAGGATGCTCTTTGACTACCTGGCGGACAAGCATGGTTTTAGGCAGGAATATTTAGAT
ACACTCTACAGATATGCAAAATTCCAGTACGAATGTGGGAATTACTCAGGAGCAGCAGAATATCTTTATTTTTTTAGAGTGCTGGTTCCA
GCAACAGATAGAAATGCTTTAAGTTCACTCTGGGGAAAGCTGGCCTCTGAAATCTTAATGCAGAATTGGGATGCAGCCATGGAAGACCTT
ACACGGTTAAAAGAGACCATAGATAATAATTCTGTGAGTTCTCCACTTCAGTCTCTTCAGCAGAGAACATGGCTCATTCACTGGTCTCTG
TTTGTTTTCTTCAATCACCCCAAAGGTCGCGATAATATTATTGACCTCTTCCTTTATCAGCCACAGTATCCATCACGAATTGAAAAAATT
GACTATGAGGAGGGCAAGATGTTGGTCCATTTTGAGCGCTGGAGTCATCGTTATGATGAGTGGATTTACTGGGATAGCAATAGATTGCGA
CCCCTTGAGAGACCAGCACTAAGAAAAGAAGGGCTAAAAGATGAGGAAGATTTCTTTGATTTTAAAGCTGGAGAAGAAGTTCTGGCTCGT
TGGACAGACTGTCGCTATTACCCTGCCAAGATTGAAGCAATTAACAAAGAAGGAACATTTACAGTTCAGTTTTATGATGGAGTAATTCGT
TGTTTAAAAAGAATGCACATTAAAGCCATGCCCGAGGATGCTAAGGGGCAGTTTCTGTTCCAGGTGAAATCCCAGCATCCACTAAGCTGG
TGTTGTCCTATCGACCCAGCTGGATCGTGTAACCAGTCTATGGGAAGTGAGGATTGGATAGCTTTAGTCAAAGCAGCTGCTGCAGCTGCA
GCCAAGAACAAAACAGGGAGTAAACCTCGAACCAGCGCTAACAGCAATAAAGATAAGGATAAAGATGAGAGAAAGTGGTTTAAAGTACCT
TCAAAGAAGGAGGAAACTTCAACTTGTATAGCCACACCAGACGTAGAGAAGAAGGAAGATCTGCCTACATCTAGTGAAACATTTGTAGGA
CTTCATGTAGAGAACGTTCCAAAGATGGTCTTTCCACAGCCAGAGAGCACATTATCAAACAAGAGGAAAAATAATCAAGGCAACTCGTTT
CAGGCAAAGAGAGCTCGACTTAACAAGATTACTGGTTTGTTGGCATCCAAAGCTGTTGGGGTTGATGGTGCTGAAAAAAAGGAAGACTAC
AATGAAACAGCTCCAATGCTGGAGCAGGTATGAAATGGTAGCATTTGATTTTTTTCAAGGTTCCCACTGGAATGATCACGGAGCTCTAGT
ATCTACGTAATTGAAATTCCCCTTTTGATCAGATATGGGAATAGGAAGCTAATTAATTGATGATATATTTTTAACTCTGCCTTCTCCAAG
GTATACAGATAACTACAGACTTCATTAGTGTTTGATTTCATAGACTGGCATTAAAGCCTTTGTCTCCAAAATTTGAAGGCCTGGAGACAG
GCATCCCAGGGTATAAGCTTCCAGCTGGATCACCTTTAACTAGCTTACAAAAAGACCCTTACACAAATACTTTCCATTTGTGAGTTAAAA
CAGGGTTTTTTGACATCGAATAAAGCTTCTTTTGTAAGAAGTTTCTTTTATATTGTAACAATTGGTGTTGTTAGACTGACTATGTGTTTT
ATGAATTGATCAATGAGCCATACATTTTTGCTAGGATGTATATTTTAATAACTACAAAAAAAGAGAGTTTAAAAAACTATTAAGGGTCTG
TCTTTAAACCACCTAATAGAGGAATTTAAAAGTGAAGGTTGCAGTTGCTAGATTTTGCCTTGGCTACCTTCAGATTCCCACAATACTTGT
ACATAATGAACTGTGCATGCTTTTACATTCTCTAAGGGCTTAACTTCTTAGGCACTGTAAGACTATAAGAACGCAGTAATAGCCATAACT
GGATTTCCTTGGTTCTCCTGTTTTAAAATCTGAGCCTTAATGTAGTTTTAATATATCCTTTTTGTATTACTTTTCTTTATTAGTAGCCTA
ATAAAGAAGACTTTGAGTATCTTTTGCTCTCCTCTAGATGCGTTTTAAAAACTATTCCAAATTTAATTGATATTGTATTGAGTTTTTCAG
GGTTATTTTAGGCCTGATTTGATAACAATGCGTTGTTTTGGTGCCTCCATTAATGTTGTATTAAATCAATGGGTCTTTTAAATTGATTAA
TATGTCATTGAATCATACCTTCTGATTTTCTGTGATCATCCAACGGTTAAGTCTTTGCCGTTATTGTCAATATATCAACCAAATTTTAAA
TAACTTTTTTTACTGTGTATTACTATATTCAACGTCCCAGATATAACAATATTTTGTATTTTCACCACTGTTTATGGTATTCTCAGAATG

>25831_25831_2_EIF3E-PHF20L1_EIF3E_chr8_109240496_ENST00000220849_PHF20L1_chr8_133806656_ENST00000395376_length(amino acids)=529AA_BP=241
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEP
IVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQ
NWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYPSRIEKIDYEEGKMLVHFERWSHRYDEW
IYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQFLFQ
VKSQHPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATPDVEKKEDL

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>25831_25831_3_EIF3E-PHF20L1_EIF3E_chr8_109240496_ENST00000220849_PHF20L1_chr8_133806656_ENST00000395386_length(transcript)=6640nt_BP=785nt
TGTTCGTTTGTCGGCGCTACCAATAAAGTTTTAGTGAGCACAGACTCCCTTTTCTTTGGCAAGATGGCGGAGTACGACTTGACTACTCGC
ATCGCGCACTTTTTGGATCGGCATCTAGTCTTTCCGCTTCTTGAATTTCTCTCTGTAAAGGAGATATATAATGAAAAGGAATTATTACAA
GGTAAATTGGACCTTCTTAGTGATACCAACATGGTAGACTTTGCTATGGATGTATACAAAAACCTTTATTCTGATGATATTCCTCATGCT
TTGAGAGAGAAAAGAACCACAGTGGTTGCACAACTGAAACAGCTTCAGGCAGAAACAGAACCAATTGTGAAGATGTTTGAAGATCCAGAA
ACTACAAGGCAAATGCAGTCAACCAGGGATGGTAGGATGCTCTTTGACTACCTGGCGGACAAGCATGGTTTTAGGCAGGAATATTTAGAT
ACACTCTACAGATATGCAAAATTCCAGTACGAATGTGGGAATTACTCAGGAGCAGCAGAATATCTTTATTTTTTTAGAGTGCTGGTTCCA
GCAACAGATAGAAATGCTTTAAGTTCACTCTGGGGAAAGCTGGCCTCTGAAATCTTAATGCAGAATTGGGATGCAGCCATGGAAGACCTT
ACACGGTTAAAAGAGACCATAGATAATAATTCTGTGAGTTCTCCACTTCAGTCTCTTCAGCAGAGAACATGGCTCATTCACTGGTCTCTG
TTTGTTTTCTTCAATCACCCCAAAGGTCGCGATAATATTATTGACCTCTTCCTTTATCAGCCACAGTATCCATCACGAATTGAAAAAATT
GACTATGAGGAGGGCAAGATGTTGGTCCATTTTGAGCGCTGGAGTCATCGTTATGATGAGTGGATTTACTGGGATAGCAATAGATTGCGA
CCCCTTGAGAGACCAGCACTAAGAAAAGAAGGGCTAAAAGATGAGGAAGATTTCTTTGATTTTAAAGCTGGAGAAGAAGTTCTGGCTCGT
TGGACAGACTGTCGCTATTACCCTGCCAAGATTGAAGCAATTAACAAAGAAGGAACATTTACAGTTCAGTTTTATGATGGAGTAATTCGT
TGTTTAAAAAGAATGCACATTAAAGCCATGCCCGAGGATGCTAAGGGGCAGGTGAAATCCCAGCATCCACTAAGCTGGTGTTGTCCTATC
GACCCAGCTGGATCGTGTAACCAGTCTATGGGAAGTGAGGATTGGATAGCTTTAGTCAAAGCAGCTGCTGCAGCTGCAGCCAAGAACAAA
ACAGGGAGTAAACCTCGAACCAGCGCTAACAGCAATAAAGATAAGGATAAAGATGAGAGAAAGTGGTTTAAAGTACCTTCAAAGAAGGAG
GAAACTTCAACTTGTATAGCCACACCAGACGTAGAGAAGAAGGAAGATCTGCCTACATCTAGTGAAACATTTGGACTTCATGTAGAGAAC
GTTCCAAAGATGGTCTTTCCACAGCCAGAGAGCACATTATCAAACAAGAGGAAAAATAATCAAGGCAACTCGTTTCAGGCAAAGAGAGCT
CGACTTAACAAGATTACTGGTTTGTTGGCATCCAAAGCTGTTGGGGTTGATGGTGCTGAAAAAAAGGAAGACTACAATGAAACAGCTCCA
ATGCTGGAGCAGGCGATTTCACCTAAACCTCAAAGTCAGAAAAAAAATGAAGCTGACATTAGCAGTTCTGCCAACACTCAGAAACCTGCA
CTGTTATCCTCAACTTTGTCTTCAGGGAAGGCTCGCAGCAAGAAATGCAAACATGAATCTGGAGATTCTTCTGGGTGTATAAAACCCCCT
AAATCACCACTTTCCCCAGAATTAATACAAGTCGAGGATTTGACGCTTGTATCTCAGCTTTCTTCTTCAGTGATAAATAAAACTAGTCCT
CCACAGCCTGTGAATCCCCCTAGACCTTTCAAGCATAGTGAGCGGAGAAGAAGATCTCAGCGTTTAGCCACCTTACCCATGCCTGATGAT
TCTGTAGAAAAGGTTTCTTCTCCCTCTCCAGCCACTGATGGGAAAGTATTCTCCATCAGTTCTCAAAATCAGCAAGAATCTTCAGTACCA
GAGGTGCCTGATGTTGCACATTTGCCACTTGAGAAGCTGGGACCCTGTCTCCCTCTTGACTTAAGTCGTGGTTCAGAAGTTACAGCACCG
GTAGCCTCAGATTCCTCTTACCGTAATGAATGTCCCAGGGCAGAAAAAGAGGATACACAGATGCTTCCAAATCCTTCTTCCAAAGCAATA
GCTGATGGAAGAGGAGCTCCAGCAGCAGCAGGAATATCGAAAACAGAAAAAAAAGTGAAATTGGAAGACAAAAGCTCAACAGCATTTGGT
AAGAGAAAAGAAAAAGATAAGGAAAGAAGAGAGAAGAGAGACAAAGATCACTACAGACCAAAACAGAAGAAGAAGAAAAAAAAGAAAAAG
AAATCTAAGCAACATGACTATTCAGACTATGAAGACAGTTCCCTCGAATTTTTGGAAAGGTGCTCTTCTCCACTAACTCGATCTTCTGGG
AGTTCTCTGGCTTCACGAAGCATGTTTACGGAGAAAACTACAACCTATCAGTACCCAAGGGCAATTCTATCCGTTGATCTTAGTGGTGAA
AACTTATCAGATGTAGACTTCCTAGATGATTCTTCAACGGAGAGTTTGCTTCTGAGTGGGGATGAATACAATCAGGACTTTGATTCAACC
AATTTTGAGGAATCTCAGGATGAGGATGATGCTCTTAATGAAATTGTGCGATGTATTTGTGAGATGGATGAGGAGAATGGCTTCATGATC
CAGTGTGAAGAGTGCTTGTGTTGGCAACACAGCGTGTGCATGGGGCTGCTGGAGGAGAGCATTCCAGAGCAGTACATCTGCTATATCTGC
CGGGACCCACCAGGTCAGAGGTGGAGTGCAAAATATCGTTATGATAAGGAGTGGTTGAATAATGGGAGAATGTGCGGGTTATCATTTTTC
AAAGAAAATTATTCTCATCTCAATGCCAAAAAGATAGTTTCTACACATCACCTGCTTGCTGATGTCTATGGTGTTACAGAAGTGCTACAC
GGGCTACAGCTGAAGATTGGAATACTAAAGAATAAACATCATCCTGACCTTCATCTCTGGGCTTGTTCCGGGAAGCGAAAAGACCAAGAT
CAAATAATAGCTGGGGTGGAGAAAAAAATAGCTCAAGACACAGTTAATCGAGAAGAAAAGAAATATGTACAGAACCATAAAGAACCACCT
CGTTTGCCCCTAAAAATGGAAGGAACTTATATAACAAGTGAGCATAGCTATCAAAAGCCACAAAGTTTTGGTCAGGACTGTAAATCTCTC
GCAGACCCTGGGAGCTCAGATGATGATGATGTTAGTAGTTTGGAAGAAGAACAAGAATTCCACATGAGAAGTAAAAACAGTTTACAGTAC
TCAGCAAAAGAACATGGAATGCCTGAAAAGAATCCAGCTGAAGGGAATACAGTATTTGTTTATAATGATAAAAAGGGCACCGAAGACCCA
GGAGACTCACATCTTCAGTGGCAGCTCAATCTCCTTACACACATAGAAAATGTGCAGAACGAAGTTACCAGCAGGATGGACCTAATAGAA
AAAGAAGTCGATGTTCTGGAAAGCTGGCTTGATTTCACAGGGGAGTTGGAGCCACCAGATCCTCTTGCAAGATTGCCCCAACTTAAACGC
CACATAAAACAGCTCCTAATTGACATGGGCAAAGTACAGCAGATAGCAACTCTTTGCTCTGTATGACAACAGTGAACACTTAATGAAAGA
ATGTGGCTTTCTTCAGTCAAAGCATTTTTATTATCCACGTGATGGCTAAGTGGATAATTTAAAAGCTTAGTAATGTCTGGTCATTCACTG
ATTTGTGATGTCAATAGGATGGCACCTTGGAAAGAAAAATGAAGAACAACTTTATCAAGGAAGCTAGTATTTAAAAACAAATTCATGAGC
AAGCTGCAAATGAGAATGTGTTATATGCCAAGGAACAATGAAGTAGAATATAATGTATACTAAGGGATTTCAAGTTCTCAGAATTTTTGA
GTAGTTGCTTACGTGAAGCTCAAGATACCTGTAGAAAGAAATATGGTATATTTGTATAGTTTTTAATAGAAAGATCTATGTTTATAAACC
AGCACTTGGCCAAAAACAAAATTGTAAAGGAAATTTAAATTCTGGAGAATTCTACAGGGTTGCTCTAAGAACTGTCTTCTCAGCAGTTGA
TCCAGCTGTACGGAAATTTAGGGTATTTAAACTTTTAAAGGATCATGAGCTGTTTCTTGGGCGATGAATGTTCTCAATCAGAAAACTGAC
AGTAGAAATCTCACTTCTGGGGAAAACAGTTGTGGAATTCTTACTTCATTATGAATGTATTTAAAAAACAAACACCAAATAATTGGAATA
TATTGCAGGCATTAAGCTCATTAAAAACAAACTGGCTTGCAGAAGGGTCCGATGTGCCAAGTGATCATGATTCTGCTGGAAAGAGGATTT
TAAATATTGTGGGAGTTCTCCCACCCTAAGTCTTACATAATGCCACCAGTCCATCCAAAACCTATATATCACCTATACTATATATATCAT
ATATATAGTTGAATGGCAGTATTCAGGCTCAACGTACAGTTTGATCCTGAGTATGCTTGGTGTTTGCCTTCAGAAAAAAAAAAATACATT
GTAAATAACCTCAGCTGGGATGAGGAGTGACAGAATATCAAAATAATTTGTGGCTGTGGATTTTTTTAACTGCTAGTAGTGGAATACTGG
AAAAGCTTCATTTCTGAAGATGAATTTTATTTTTAAAAAATACATGCACACTCAAAACTTTTAGCTTTGATCACAAGTGGACAAATTTCT
GAAACCAAAGGCAACTAAGTTGCTGTGTTAGCTCTTGCTGGATTTTGAGCCTAGGTCCTACTGTCTGCCAGTACTCATGTGAGTTGTATG
TGCCCCCAGTGCTACATACGCAGGTATGCGTAAGTGTGTATGCTTGTTTTAAACAAACACTCAACGTACATATGTACATAATCTACACAT
ATTTATATCACATATCTAGTTTTATTACTATAGACTATACGAATTGGTGGTTAACATGAAATGTTACCTTTTAACAGACTGTTTTTAAAA
ATTAAAAATGTATGTATAGGTTTTGAAATTTTTTTAAAAGGGGAGAAAGACTGTTAAGAGGAGGCTATTTGATGACATAACACTTGAATA
TTTTATGCCTCATTCTGTTTATCAGTTCTCGCAATCTGTATAAATGCATTTTAGAACTGATAGACAGTAAACTTGAATTTATCTTTGATA
AGAATACATGCCACTGTACATTCAGATATTATTTAAATTTGCAAACACATTGTTCTATATGTAAGGGTACTGTATGTAAAACTCTGTATT
AAAACTATTCCACATATCCTAAAATTTCAGCTTGCCTTTTTGCGGCCTTATATTTTGATGTAAAGATTAAAAGAATGTGCAAAACAGTCA
GAAATTTTTATTGCCTTTTGAGATTCTCCAACTTGACAAATGTGCCAAAGATCAACAGACAGAAAATATCATCCTGTGTATTTACTTGTC
ATACTTTAACTTTGTGAAAGATCTTACTGATAAATGAAAAGCTTTAGCAGAGGTGGTATTGTGGGGTAATTGCTTAAATTTACATATCAA
AGTAAAAAAGTAGTGCCTGTATTCCATGTGTGGAGTAAATTTGCTAATGTCTATATTTTATGATTGATACTATTATTTTTCCTTTGCATT
TTAAAATAGTGGCTCTAATATTTTCCCTGTCATGGCTACATTCTAGACATTGAATTTATATCTTCTTTTTTTCAGATACGGAGCAAATAG
CATCCTTAACCTATGAATAATGGTGTTGCCTAGATTCTTGTCACACACACAGAAGACCCTTTGTACCTAGTAACATTCATCCTCTTGATT
CCTGGTGAACACGGTTAAATTCATGCACATTTGTTCTTGTAGTTTCTAAAAATTAGATCAATTTATTTGTTAGCCAGCAAATTGAAAATT
CCATTATTAGATTAATGAAATTTTTGCTCTGCTTATATGTATACGAACTGGAAATCTGAATTTTTAAATTTAGATCTTTAAATCAAATTA
TTTTTATGCATATTTTCATTTAATATAGAGTATACCAATCGATTGAAGCCTTTCACAAGTAGTGCGCTGAGCTTTTCTTATTGAAGAGAG
TGAATTAGTTTCTGAGAAGTCAGTCTATTGTGAAAAGTTTCAGATGAGATTATTTTCTTTTAGTCTTTTTAAATATCACTATATGTATTT
AAATAGAAGCAATAAACTAGAGAGAGTGTTTCTTGAAAAGACAATGTTTTATTTGCCACCAGGCAGAACAGAATGAGCATTGGTAGAGAA
GGCTCCCTCTTGGTATGTTACTGATAAACTTGTACTTCCTCATACTTGTTTGTGGTTCTACTGACTTATTTCCAAACTTAAGAGTAATGT
ACTTCGAAAACAACTTGGTTATTCTTTAAATTTCAGGTAAAACCCCTTTTCCTAACACTCATCTTATTTCCACTGTCTTATTTCCTCTCA

>25831_25831_3_EIF3E-PHF20L1_EIF3E_chr8_109240496_ENST00000220849_PHF20L1_chr8_133806656_ENST00000395386_length(amino acids)=1230AA_BP=241
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEP
IVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQ
NWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYPSRIEKIDYEEGKMLVHFERWSHRYDEW
IYWDSNRLRPLERPALRKEGLKDEEDFFDFKAGEEVLARWTDCRYYPAKIEAINKEGTFTVQFYDGVIRCLKRMHIKAMPEDAKGQVKSQ
HPLSWCCPIDPAGSCNQSMGSEDWIALVKAAAAAAAKNKTGSKPRTSANSNKDKDKDERKWFKVPSKKEETSTCIATPDVEKKEDLPTSS
ETFGLHVENVPKMVFPQPESTLSNKRKNNQGNSFQAKRARLNKITGLLASKAVGVDGAEKKEDYNETAPMLEQAISPKPQSQKKNEADIS
SSANTQKPALLSSTLSSGKARSKKCKHESGDSSGCIKPPKSPLSPELIQVEDLTLVSQLSSSVINKTSPPQPVNPPRPFKHSERRRRSQR
LATLPMPDDSVEKVSSPSPATDGKVFSISSQNQQESSVPEVPDVAHLPLEKLGPCLPLDLSRGSEVTAPVASDSSYRNECPRAEKEDTQM
LPNPSSKAIADGRGAPAAAGISKTEKKVKLEDKSSTAFGKRKEKDKERREKRDKDHYRPKQKKKKKKKKKSKQHDYSDYEDSSLEFLERC
SSPLTRSSGSSLASRSMFTEKTTTYQYPRAILSVDLSGENLSDVDFLDDSSTESLLLSGDEYNQDFDSTNFEESQDEDDALNEIVRCICE
MDEENGFMIQCEECLCWQHSVCMGLLEESIPEQYICYICRDPPGQRWSAKYRYDKEWLNNGRMCGLSFFKENYSHLNAKKIVSTHHLLAD
VYGVTEVLHGLQLKIGILKNKHHPDLHLWACSGKRKDQDQIIAGVEKKIAQDTVNREEKKYVQNHKEPPRLPLKMEGTYITSEHSYQKPQ
SFGQDCKSLADPGSSDDDDVSSLEEEQEFHMRSKNSLQYSAKEHGMPEKNPAEGNTVFVYNDKKGTEDPGDSHLQWQLNLLTHIENVQNE

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Fusion Gene PPI Analysis for EIF3E-PHF20L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3E-PHF20L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3E-PHF20L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource