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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3K-CYP39A1 (FusionGDB2 ID:25883)

Fusion Gene Summary for EIF3K-CYP39A1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3K-CYP39A1
Fusion gene ID: 25883
HgeneTgene
Gene symbol

EIF3K

CYP39A1

Gene ID

27335

51302

Gene nameeukaryotic translation initiation factor 3 subunit Kcytochrome P450 family 39 subfamily A member 1
SynonymsARG134|EIF3-p28|EIF3S12|HSPC029|M9|MSTP001|PLAC-24|PLAC24|PRO1474|PTD001-
Cytomap

19q13.2

6p12.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit KeIF-3 p28eukaryotic translation initiation factor 3, subunit 12muscle specificmuscle-specific gene M9 protein24-hydroxycholesterol 7-alpha-hydroxylasecytochrome P450, family 39, subfamily A, polypeptide 1cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1
Modification date2020032220200313
UniProtAcc

Q9UBQ5

Q9NYL5

Ensembl transtripts involved in fusion geneENST00000248342, ENST00000538434, 
ENST00000545173, ENST00000593149, 
ENST00000588934, ENST00000592558, 
ENST00000593062, 		ENST00000489657, 
ENST00000275016, 
Fusion gene scores* DoF score9 X 9 X 4=3244 X 4 X 4=64
# samples 124
** MAII scorelog2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3K [Title/Abstract] AND CYP39A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3K

GO:0006413

translational initiation

17581632

TgeneCYP39A1

GO:0006699

bile acid biosynthetic process

10748047


check buttonFusion gene breakpoints across EIF3K (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CYP39A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-


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Fusion Gene ORF analysis for EIF3K-CYP39A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000248342ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
5CDS-intronENST00000538434ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
5CDS-intronENST00000545173ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
5CDS-intronENST00000593149ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
In-frameENST00000248342ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
In-frameENST00000538434ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
In-frameENST00000545173ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
In-frameENST00000593149ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
intron-3CDSENST00000588934ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
intron-3CDSENST00000592558ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
intron-3CDSENST00000593062ENST00000275016EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
intron-intronENST00000588934ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
intron-intronENST00000592558ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-
intron-intronENST00000593062ENST00000489657EIF3Kchr19

39123318

+CYP39A1chr6

46607405

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000593149EIF3Kchr1939123318+ENST00000275016CYP39A1chr646607405-22285691451665506
ENST00000248342EIF3Kchr1939123318+ENST00000275016CYP39A1chr646607405-2330671521767571
ENST00000538434EIF3Kchr1939123318+ENST00000275016CYP39A1chr646607405-21324731811569462
ENST00000545173EIF3Kchr1939123318+ENST00000275016CYP39A1chr646607405-223457511671556

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EIF3K-CYP39A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF3K-CYP39A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:/chr6:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3K

Q9UBQ5

CYP39A1

Q9NYL5

FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.FUNCTION: A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis (PubMed:25201972, PubMed:10748047). Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver (PubMed:25201972, PubMed:10748047). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:25201972, PubMed:10748047). {ECO:0000269|PubMed:10748047, ECO:0000269|PubMed:25201972}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EIF3K-CYP39A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25883_25883_1_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000248342_CYP39A1_chr6_46607405_ENST00000275016_length(transcript)=2330nt_BP=671nt
GGAAAGCGTGGCGGCTGCTGCTAGAGCCTTTCCCTTTACCGCACCCAAGGAGCTGGAGCGACAACAACGACGTCGTTTCCGTTTCCACCA
CCTCTTCCTGTTCCCGTCCTTGAGGACGCCGTGCCGGGTCAGTGTTAGCCTCCAGCCCTGGTTGTGGAAGGCGACAGAAGTCATGGCGAT
GTTTGAGCAGATGAGAGCCAACGTGGGCAAGTTGCTCAAGGGTATCGACAGGTACAATCCTGAGAACCTGGCCACCCTGGAGCGCTATGT
AGAGACGCAGGCCAAGGAAAATGCCTATGATCTGGAAGCCAACCTGGCTGTCCTGAAGCTGTACCAGTTCAACCCAGCCTTCTTTCAGAC
CACGGTCACCGCCCAGATCCTGCTGAAGGCCCTCACCAACTTGCCGCACACAGACTTCACCCTGTGCAAGTGCATGATCGACCAGGCACA
TCAAGAAGAACGGCCAATCCGACAGATTTTGTACCTCGGGGACCTGCTGGAGACCTGCCATTTCCAGGCCTTCTGGCAAGCCCTGGATGA
AAACATGGACCTCTTGGAAGGTATAACTGGCTTTGAAGACTCTGTCCGAAAGTTTATCTGCCATGTTGTGGGTATCACTTACCAGCACAT
TGACCGCTGGCTGCTGGCCGAGATGCTCGGGGATCTGTCGGCATCAATTCCAAAGAATGTCTTTTTAGCACTGCATGAAAAACTCTATAT
TATGTTGAAAGGGAAAATGGGGACTGTCAATCTCCATCAGTTTACTGGGCAACTGACTGAAGAATTACATGAACAACTGGAGAATTTAGG
CACTCATGGGACAATGGACCTGAACAACTTAGTAAGACATCTCCTTTATCCAGTCACAGTGAATATGCTCTTTAATAAAAGTTTGTTTTC
CACAAACAAGAAAAAAATCAAGGAGTTCCATCAGTATTTTCAAGTTTATGATGAAGATTTTGAGTATGGGTCCCAGTTGCCAGAGTGTCT
TCTAAGAAACTGGTCAAAATCCAAAAAGTGGTTCCTGGAACTGTTTGAGAAAAACATTCCAGATATAAAAGCATGTAAATCTGCAAAAGA
TAATTCCATGACATTATTGCAAGCTACGCTGGATATTGTAGAGACGGAAACAAGTAAGGAAAACTCACCCAATTATGGGCTCTTACTGCT
TTGGGCTTCTCTGTCTAATGCTGTTCCTGTTGCATTTTGGACACTTGCATACGTCCTTTCTCATCCTGATATCCACAAGGCCATTATGGA
AGGCATATCTTCTGTGTTTGGCAAAGCAGGCAAAGATAAGATTAAAGTGTCTGAGGATGACCTGGAGAATCTCCTTCTAATTAAATGGTG
TGTTTTGGAAACCATTCGTTTAAAAGCTCCTGGTGTCATTACTAGAAAAGTGGTGAAGCCTGTGGAAATTTTGAATTACATCATTCCTTC
TGGTGACTTGTTGATGTTGTCTCCATTTTGGCTGCATAGAAATCCAAAGTATTTTCCTGAGCCTGAATTGTTCAAACCTGAACGTTGGAA
AAAGGCAAATTTAGAGAAGCACTCTTTCTTGGACTGCTTCATGGCATTTGGAAGCGGGAAGTTCCAGTGTCCTGCAAGGTGGTTTGCTCT
GTTAGAGGTTCAGATGTGTATTATTTTAATACTTTATAAATATGACTGTAGTCTTCTGGACCCATTACCCAAACAGAGTTATCTCCATTT
GGTGGGTGTCCCCCAGCCGGAAGGGCAATGCCGAATTGAATATAAACAAAGAATATGACATCTGTTGGGCCTCACAAGGACCAGGGCCTT
CTGGAGGAGTGGCACTACCCCACCTGGCAGCACCTAGACCTGAGCTCTACAAAAACACACTGCTTCACTTTGTTTTAGGACTTAGTTCAA
GAACACATTCAAATGGTGCATGTGTTTGGTATCTTCAACAGTAGACCAAGAATCTAACATCACTCTCAGTAATATAGAGACCGGAATACA
TGGTTTATAGGAAATGATCAAATGATCCAAAAAAACTCCACATTTTTTAAGAAGTTGGAATTTGATTTCATGCATAACTGTATTAAAACA
TTAAATAGAAATAATGTCATTTGAATGAAAATCTTATCACATTAAATTCACTGTGAAGGCAGCATACTTAAATTTTTATTTTGAAAAGTC
TAAAAGGCTTAGATTTTTAAAATTTAATAATTATTTCTACAAATTTTCTATTTTTCTTGAGGTGATTCTCAACTAGCAATTGGAACTCCT

>25883_25883_1_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000248342_CYP39A1_chr6_46607405_ENST00000275016_length(amino acids)=571AA_BP=206
MERQQRRRFRFHHLFLFPSLRTPCRVSVSLQPWLWKATEVMAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAV
LKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRK
FICHVVGITYQHIDRWLLAEMLGDLSASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYP
VTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETET
SKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKV
VKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCS

--------------------------------------------------------------
>25883_25883_2_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000538434_CYP39A1_chr6_46607405_ENST00000275016_length(transcript)=2132nt_BP=473nt
ACCTCTTCCTGTTCCCGTCCTTGAGGACGCCGTGCCGGGTCAGTGTTAGCCTCCAGCCCTGGTTGTGGAAGGCGACAGAAGTCATGGCGA
TGTTTGAGCAGATGAGAGCCAACGTGGGCAAGTTGCTCAAGGGTACCAGTTCAACCCAGCCTTCTTTCAGACCACGGTCACCGCCCAGAT
CCTGCTGAAGGCCCTCACCAACTTGCCGCACACAGACTTCACCCTGTGCAAGTGCATGATCGACCAGGCACATCAAGAAGAACGGCCAAT
CCGACAGATTTTGTACCTCGGGGACCTGCTGGAGACCTGCCATTTCCAGGCCTTCTGGCAAGCCCTGGATGAAAACATGGACCTCTTGGA
AGGTATAACTGGCTTTGAAGACTCTGTCCGAAAGTTTATCTGCCATGTTGTGGGTATCACTTACCAGCACATTGACCGCTGGCTGCTGGC
CGAGATGCTCGGGGATCTGTCGGCATCAATTCCAAAGAATGTCTTTTTAGCACTGCATGAAAAACTCTATATTATGTTGAAAGGGAAAAT
GGGGACTGTCAATCTCCATCAGTTTACTGGGCAACTGACTGAAGAATTACATGAACAACTGGAGAATTTAGGCACTCATGGGACAATGGA
CCTGAACAACTTAGTAAGACATCTCCTTTATCCAGTCACAGTGAATATGCTCTTTAATAAAAGTTTGTTTTCCACAAACAAGAAAAAAAT
CAAGGAGTTCCATCAGTATTTTCAAGTTTATGATGAAGATTTTGAGTATGGGTCCCAGTTGCCAGAGTGTCTTCTAAGAAACTGGTCAAA
ATCCAAAAAGTGGTTCCTGGAACTGTTTGAGAAAAACATTCCAGATATAAAAGCATGTAAATCTGCAAAAGATAATTCCATGACATTATT
GCAAGCTACGCTGGATATTGTAGAGACGGAAACAAGTAAGGAAAACTCACCCAATTATGGGCTCTTACTGCTTTGGGCTTCTCTGTCTAA
TGCTGTTCCTGTTGCATTTTGGACACTTGCATACGTCCTTTCTCATCCTGATATCCACAAGGCCATTATGGAAGGCATATCTTCTGTGTT
TGGCAAAGCAGGCAAAGATAAGATTAAAGTGTCTGAGGATGACCTGGAGAATCTCCTTCTAATTAAATGGTGTGTTTTGGAAACCATTCG
TTTAAAAGCTCCTGGTGTCATTACTAGAAAAGTGGTGAAGCCTGTGGAAATTTTGAATTACATCATTCCTTCTGGTGACTTGTTGATGTT
GTCTCCATTTTGGCTGCATAGAAATCCAAAGTATTTTCCTGAGCCTGAATTGTTCAAACCTGAACGTTGGAAAAAGGCAAATTTAGAGAA
GCACTCTTTCTTGGACTGCTTCATGGCATTTGGAAGCGGGAAGTTCCAGTGTCCTGCAAGGTGGTTTGCTCTGTTAGAGGTTCAGATGTG
TATTATTTTAATACTTTATAAATATGACTGTAGTCTTCTGGACCCATTACCCAAACAGAGTTATCTCCATTTGGTGGGTGTCCCCCAGCC
GGAAGGGCAATGCCGAATTGAATATAAACAAAGAATATGACATCTGTTGGGCCTCACAAGGACCAGGGCCTTCTGGAGGAGTGGCACTAC
CCCACCTGGCAGCACCTAGACCTGAGCTCTACAAAAACACACTGCTTCACTTTGTTTTAGGACTTAGTTCAAGAACACATTCAAATGGTG
CATGTGTTTGGTATCTTCAACAGTAGACCAAGAATCTAACATCACTCTCAGTAATATAGAGACCGGAATACATGGTTTATAGGAAATGAT
CAAATGATCCAAAAAAACTCCACATTTTTTAAGAAGTTGGAATTTGATTTCATGCATAACTGTATTAAAACATTAAATAGAAATAATGTC
ATTTGAATGAAAATCTTATCACATTAAATTCACTGTGAAGGCAGCATACTTAAATTTTTATTTTGAAAAGTCTAAAAGGCTTAGATTTTT
AAAATTTAATAATTATTTCTACAAATTTTCTATTTTTCTTGAGGTGATTCTCAACTAGCAATTGGAACTCCTAGGCTCTATTAACATAAT

>25883_25883_2_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000538434_CYP39A1_chr6_46607405_ENST00000275016_length(amino acids)=462AA_BP=97
MLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLA
EMLGDLSASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKI
KEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSN
AVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLML
SPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQP

--------------------------------------------------------------
>25883_25883_3_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000545173_CYP39A1_chr6_46607405_ENST00000275016_length(transcript)=2234nt_BP=575nt
CCTGTTCCCGTCCTTGAGGACGCCGTGCCGGGTCAGTGTTAGCCTCCAGCCCTGGTTGTGGAAGGCGACAGAAGTCATGGCGATGTTTGA
GCAGATGAGAGCCAACGTGGGCAAGTTGCTCAAGGGTATCGACAGGTACAATCCTGAGAACCTGGCCACCCTGGAGCGCTATGTAGAGAC
GCAGGCCAAGGAAAATGCCTATGATCTGGAAGCCAACCTGGCTGTCCTGAAGCTGTACCAGTTCAACCCAGCCTTCTTTCAGACCACGGT
CACCGCCCAGATCCTGCTGAAGGCCCTCACCAACTTGCCGCACACAGACTTCACCCTGTGCAAGTGCATGATCGACCAGGCACATCAAGA
AGAACGGCCAATCCGACAGATTTTGTACCTCGGGGACCTGCTGGAGACCTGCCATTTCCAGGCCTTCTGGCAAGCCCTGGATGAAAACAT
GGACCTCTTGGAAGGTATAACTGGCTTTGAAGACTCTGTCCGAAAGTTTATCTGCCATGTTGTGGGTATCACTTACCAGCACATTGACCG
CTGGCTGCTGGCCGAGATGCTCGGGGATCTGTCGGCATCAATTCCAAAGAATGTCTTTTTAGCACTGCATGAAAAACTCTATATTATGTT
GAAAGGGAAAATGGGGACTGTCAATCTCCATCAGTTTACTGGGCAACTGACTGAAGAATTACATGAACAACTGGAGAATTTAGGCACTCA
TGGGACAATGGACCTGAACAACTTAGTAAGACATCTCCTTTATCCAGTCACAGTGAATATGCTCTTTAATAAAAGTTTGTTTTCCACAAA
CAAGAAAAAAATCAAGGAGTTCCATCAGTATTTTCAAGTTTATGATGAAGATTTTGAGTATGGGTCCCAGTTGCCAGAGTGTCTTCTAAG
AAACTGGTCAAAATCCAAAAAGTGGTTCCTGGAACTGTTTGAGAAAAACATTCCAGATATAAAAGCATGTAAATCTGCAAAAGATAATTC
CATGACATTATTGCAAGCTACGCTGGATATTGTAGAGACGGAAACAAGTAAGGAAAACTCACCCAATTATGGGCTCTTACTGCTTTGGGC
TTCTCTGTCTAATGCTGTTCCTGTTGCATTTTGGACACTTGCATACGTCCTTTCTCATCCTGATATCCACAAGGCCATTATGGAAGGCAT
ATCTTCTGTGTTTGGCAAAGCAGGCAAAGATAAGATTAAAGTGTCTGAGGATGACCTGGAGAATCTCCTTCTAATTAAATGGTGTGTTTT
GGAAACCATTCGTTTAAAAGCTCCTGGTGTCATTACTAGAAAAGTGGTGAAGCCTGTGGAAATTTTGAATTACATCATTCCTTCTGGTGA
CTTGTTGATGTTGTCTCCATTTTGGCTGCATAGAAATCCAAAGTATTTTCCTGAGCCTGAATTGTTCAAACCTGAACGTTGGAAAAAGGC
AAATTTAGAGAAGCACTCTTTCTTGGACTGCTTCATGGCATTTGGAAGCGGGAAGTTCCAGTGTCCTGCAAGGTGGTTTGCTCTGTTAGA
GGTTCAGATGTGTATTATTTTAATACTTTATAAATATGACTGTAGTCTTCTGGACCCATTACCCAAACAGAGTTATCTCCATTTGGTGGG
TGTCCCCCAGCCGGAAGGGCAATGCCGAATTGAATATAAACAAAGAATATGACATCTGTTGGGCCTCACAAGGACCAGGGCCTTCTGGAG
GAGTGGCACTACCCCACCTGGCAGCACCTAGACCTGAGCTCTACAAAAACACACTGCTTCACTTTGTTTTAGGACTTAGTTCAAGAACAC
ATTCAAATGGTGCATGTGTTTGGTATCTTCAACAGTAGACCAAGAATCTAACATCACTCTCAGTAATATAGAGACCGGAATACATGGTTT
ATAGGAAATGATCAAATGATCCAAAAAAACTCCACATTTTTTAAGAAGTTGGAATTTGATTTCATGCATAACTGTATTAAAACATTAAAT
AGAAATAATGTCATTTGAATGAAAATCTTATCACATTAAATTCACTGTGAAGGCAGCATACTTAAATTTTTATTTTGAAAAGTCTAAAAG
GCTTAGATTTTTAAAATTTAATAATTATTTCTACAAATTTTCTATTTTTCTTGAGGTGATTCTCAACTAGCAATTGGAACTCCTAGGCTC

>25883_25883_3_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000545173_CYP39A1_chr6_46607405_ENST00000275016_length(amino acids)=556AA_BP=191
LFPSLRTPCRVSVSLQPWLWKATEVMAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTV
TAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDR
WLLAEMLGDLSASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTN
KKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWA
SLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGD
LLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVG

--------------------------------------------------------------
>25883_25883_4_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000593149_CYP39A1_chr6_46607405_ENST00000275016_length(transcript)=2228nt_BP=569nt
CCGGAAAGCGTGGCGGCTGCTGCTAGAGCCTTTCCCTTTACCGCACCCAAGGAGCTGGAGCGACAACAACGACGTCGTTTCCGTTTCCAC
CACCTCTTCCTGTTCCCGTCCTTGAGGACGCCGTGCCGGGTACAATCCTGAGAACCTGGCCACCCTGGAGCGCTATGTAGAGACGCAGGC
CAAGGAAAATGCCTATGATCTGGAAGCCAACCTGGCTGTCCTGAAGCTGTACCAGTTCAACCCAGCCTTCTTTCAGACCACGGTCACCGC
CCAGATCCTGCTGAAGGCCCTCACCAACTTGCCGCACACAGACTTCACCCTGTGCAAGTGCATGATCGACCAGGCACATCAAGAAGAACG
GCCAATCCGACAGATTTTGTACCTCGGGGACCTGCTGGAGACCTGCCATTTCCAGGCCTTCTGGCAAGCCCTGGATGAAAACATGGACCT
CTTGGAAGGTATAACTGGCTTTGAAGACTCTGTCCGAAAGTTTATCTGCCATGTTGTGGGTATCACTTACCAGCACATTGACCGCTGGCT
GCTGGCCGAGATGCTCGGGGATCTGTCGGCATCAATTCCAAAGAATGTCTTTTTAGCACTGCATGAAAAACTCTATATTATGTTGAAAGG
GAAAATGGGGACTGTCAATCTCCATCAGTTTACTGGGCAACTGACTGAAGAATTACATGAACAACTGGAGAATTTAGGCACTCATGGGAC
AATGGACCTGAACAACTTAGTAAGACATCTCCTTTATCCAGTCACAGTGAATATGCTCTTTAATAAAAGTTTGTTTTCCACAAACAAGAA
AAAAATCAAGGAGTTCCATCAGTATTTTCAAGTTTATGATGAAGATTTTGAGTATGGGTCCCAGTTGCCAGAGTGTCTTCTAAGAAACTG
GTCAAAATCCAAAAAGTGGTTCCTGGAACTGTTTGAGAAAAACATTCCAGATATAAAAGCATGTAAATCTGCAAAAGATAATTCCATGAC
ATTATTGCAAGCTACGCTGGATATTGTAGAGACGGAAACAAGTAAGGAAAACTCACCCAATTATGGGCTCTTACTGCTTTGGGCTTCTCT
GTCTAATGCTGTTCCTGTTGCATTTTGGACACTTGCATACGTCCTTTCTCATCCTGATATCCACAAGGCCATTATGGAAGGCATATCTTC
TGTGTTTGGCAAAGCAGGCAAAGATAAGATTAAAGTGTCTGAGGATGACCTGGAGAATCTCCTTCTAATTAAATGGTGTGTTTTGGAAAC
CATTCGTTTAAAAGCTCCTGGTGTCATTACTAGAAAAGTGGTGAAGCCTGTGGAAATTTTGAATTACATCATTCCTTCTGGTGACTTGTT
GATGTTGTCTCCATTTTGGCTGCATAGAAATCCAAAGTATTTTCCTGAGCCTGAATTGTTCAAACCTGAACGTTGGAAAAAGGCAAATTT
AGAGAAGCACTCTTTCTTGGACTGCTTCATGGCATTTGGAAGCGGGAAGTTCCAGTGTCCTGCAAGGTGGTTTGCTCTGTTAGAGGTTCA
GATGTGTATTATTTTAATACTTTATAAATATGACTGTAGTCTTCTGGACCCATTACCCAAACAGAGTTATCTCCATTTGGTGGGTGTCCC
CCAGCCGGAAGGGCAATGCCGAATTGAATATAAACAAAGAATATGACATCTGTTGGGCCTCACAAGGACCAGGGCCTTCTGGAGGAGTGG
CACTACCCCACCTGGCAGCACCTAGACCTGAGCTCTACAAAAACACACTGCTTCACTTTGTTTTAGGACTTAGTTCAAGAACACATTCAA
ATGGTGCATGTGTTTGGTATCTTCAACAGTAGACCAAGAATCTAACATCACTCTCAGTAATATAGAGACCGGAATACATGGTTTATAGGA
AATGATCAAATGATCCAAAAAAACTCCACATTTTTTAAGAAGTTGGAATTTGATTTCATGCATAACTGTATTAAAACATTAAATAGAAAT
AATGTCATTTGAATGAAAATCTTATCACATTAAATTCACTGTGAAGGCAGCATACTTAAATTTTTATTTTGAAAAGTCTAAAAGGCTTAG
ATTTTTAAAATTTAATAATTATTTCTACAAATTTTCTATTTTTCTTGAGGTGATTCTCAACTAGCAATTGGAACTCCTAGGCTCTATTAA

>25883_25883_4_EIF3K-CYP39A1_EIF3K_chr19_39123318_ENST00000593149_CYP39A1_chr6_46607405_ENST00000275016_length(amino acids)=506AA_BP=141
MATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQ
AFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEEL
HEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDI
KACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDLE
NLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQ

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Fusion Gene PPI Analysis for EIF3K-CYP39A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3K-CYP39A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3K-CYP39A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource