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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3L-AK7 (FusionGDB2 ID:25890)

Fusion Gene Summary for EIF3L-AK7

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3L-AK7
Fusion gene ID: 25890
HgeneTgene
Gene symbol

EIF3L

AK7

Gene ID

51386

122481

Gene nameeukaryotic translation initiation factor 3 subunit Ladenylate kinase 7
SynonymsEIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005AK 7|CFAP75|FAP75|SPGF27
Cytomap

22q13.1

14q32.2

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit LeIEF associated protein HSPC021eukaryotic translation initiation factor 3 subunit 6-interacting proteineukaryotic translation initiation factor 3 subunit E-interacting proteinadenylate kinase 7ATP-AMP transphosphorylase 7putative adenylate kinase 7
Modification date2020032220200313
UniProtAcc

Q9Y262

Q96M32

Ensembl transtripts involved in fusion geneENST00000381683, ENST00000406934, 
ENST00000412331, ENST00000476955, 
ENST00000554313, ENST00000555570, 
ENST00000267584, 
Fusion gene scores* DoF score13 X 8 X 9=9366 X 7 X 4=168
# samples 188
** MAII scorelog2(18/936*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3L [Title/Abstract] AND AK7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3L(38270531)-AK7(96922684), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3L

GO:0006413

translational initiation

17581632

HgeneEIF3L

GO:0075525

viral translational termination-reinitiation

21347434

TgeneAK7

GO:0006165

nucleoside diphosphate phosphorylation

23416111

TgeneAK7

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check buttonFusion gene breakpoints across EIF3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AK7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10R-01AEIF3Lchr22

38270531

-AK7chr14

96922684

+
ChimerDB4LIHCTCGA-BC-A10R-01AEIF3Lchr22

38270531

+AK7chr14

96922684

+
ChimerDB4LIHCTCGA-BC-A10REIF3Lchr22

38270531

+AK7chr14

96922683

+


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Fusion Gene ORF analysis for EIF3L-AK7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381683ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922684

+
5CDS-intronENST00000381683ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922683

+
5CDS-intronENST00000381683ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922684

+
5CDS-intronENST00000381683ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922683

+
5CDS-intronENST00000406934ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922684

+
5CDS-intronENST00000406934ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922683

+
5CDS-intronENST00000406934ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922684

+
5CDS-intronENST00000406934ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922683

+
5CDS-intronENST00000412331ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922684

+
5CDS-intronENST00000412331ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922683

+
5CDS-intronENST00000412331ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922684

+
5CDS-intronENST00000412331ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922683

+
In-frameENST00000381683ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922684

+
In-frameENST00000381683ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922683

+
In-frameENST00000406934ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922684

+
In-frameENST00000406934ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922683

+
In-frameENST00000412331ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922684

+
In-frameENST00000412331ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922683

+
intron-3CDSENST00000476955ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922684

+
intron-3CDSENST00000476955ENST00000267584EIF3Lchr22

38270531

+AK7chr14

96922683

+
intron-intronENST00000476955ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922684

+
intron-intronENST00000476955ENST00000554313EIF3Lchr22

38270531

+AK7chr14

96922683

+
intron-intronENST00000476955ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922684

+
intron-intronENST00000476955ENST00000555570EIF3Lchr22

38270531

+AK7chr14

96922683

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000412331EIF3Lchr2238270531+ENST00000267584AK7chr1496922684+364614884442561705
ENST00000381683EIF3Lchr2238270531+ENST00000267584AK7chr1496922684+2953795331868611
ENST00000406934EIF3Lchr2238270531+ENST00000267584AK7chr1496922684+348513277002400566
ENST00000412331EIF3Lchr2238270531+ENST00000267584AK7chr1496922683+364614884442561705
ENST00000381683EIF3Lchr2238270531+ENST00000267584AK7chr1496922683+2953795331868611
ENST00000406934EIF3Lchr2238270531+ENST00000267584AK7chr1496922683+348513277002400566

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000412331ENST00000267584EIF3Lchr2238270531+AK7chr1496922684+0.0011700610.9988299
ENST00000381683ENST00000267584EIF3Lchr2238270531+AK7chr1496922684+0.0012991890.99870074
ENST00000406934ENST00000267584EIF3Lchr2238270531+AK7chr1496922684+0.000652430.9993475
ENST00000412331ENST00000267584EIF3Lchr2238270531+AK7chr1496922683+0.0011700610.9988299
ENST00000381683ENST00000267584EIF3Lchr2238270531+AK7chr1496922683+0.0012991890.99870074
ENST00000406934ENST00000267584EIF3Lchr2238270531+AK7chr1496922683+0.000652430.9993475

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Fusion Genomic Features for EIF3L-AK7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EIF3Lchr2238270531+AK7chr1496922683+5.42E-060.99999464
EIF3Lchr2238270531+AK7chr1496922683+5.42E-060.99999464
EIF3Lchr2238270531+AK7chr1496922683+5.42E-060.99999464
EIF3Lchr2238270531+AK7chr1496922683+5.42E-060.99999464

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EIF3L-AK7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:38270531/chr14:96922684)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3L

Q9Y262

AK7

Q96M32

FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. {ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918609_677366724.0Coiled coilOntology_term=ECO:0000255
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918609_677366724.0Coiled coilOntology_term=ECO:0000255
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918420_432366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918497_502366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918616_674366724.0Compositional biasNote=Glu-rich
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918420_432366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918497_502366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918616_674366724.0Compositional biasNote=Glu-rich
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918377_382366724.0Nucleotide bindingATP
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918432_455366724.0Nucleotide bindingAMP
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918482_485366724.0Nucleotide bindingAMP
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918377_382366724.0Nucleotide bindingATP
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918432_455366724.0Nucleotide bindingAMP
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918482_485366724.0Nucleotide bindingAMP
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918367_612366724.0RegionAdenylate kinase
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918397_455366724.0RegionNMP
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918537_547366724.0RegionLID
TgeneAK7chr22:38270531chr14:96922683ENST00000267584918679_723366724.0RegionDPY-30
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918367_612366724.0RegionAdenylate kinase
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918397_455366724.0RegionNMP
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918537_547366724.0RegionLID
TgeneAK7chr22:38270531chr14:96922684ENST00000267584918679_723366724.0RegionDPY-30

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Lchr22:38270531chr14:96922683ENST00000381683+711331_537254517.0DomainPCI
HgeneEIF3Lchr22:38270531chr14:96922683ENST00000412331+913331_537302565.0DomainPCI
HgeneEIF3Lchr22:38270531chr14:96922684ENST00000381683+711331_537254517.0DomainPCI
HgeneEIF3Lchr22:38270531chr14:96922684ENST00000412331+913331_537302565.0DomainPCI
TgeneAK7chr22:38270531chr14:96922683ENST0000026758491846_458366724.0Coiled coilOntology_term=ECO:0000255
TgeneAK7chr22:38270531chr14:96922684ENST0000026758491846_458366724.0Coiled coilOntology_term=ECO:0000255
TgeneAK7chr22:38270531chr14:96922683ENST000002675849183_6366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922683ENST0000026758491851_58366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922684ENST000002675849183_6366724.0Compositional biasNote=Poly-Glu
TgeneAK7chr22:38270531chr14:96922684ENST0000026758491851_58366724.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for EIF3L-AK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25890_25890_1_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000381683_AK7_chr14_96922683_ENST00000267584_length(transcript)=2953nt_BP=795nt
CTCTTTCCGGCGGTGCTCGCAAGCGAGGCAGCCATGTCTTATCCCGCTGATGATTATGAGTCTGAGGCGGCTTATGACCCCTACGCTTAT
CCCAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACCTTGCTTATGAACGTCAGTATGAACAGCAAACCTATCAGGTGATCCCT
GAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAACTGTCTCAGATTTGATTGACCAGAAAGTGTATGAGCTACAGGCCAGTCGTGTC
TCCAGTGATGTCATTGACCAGAAGGTGTATGAGATCCAGGACATCTATGAGAACAGCTGGACCAAGCTGACTGAAAGATTCTTCAAGAAT
ACACCTTGGCCCGAGGCTGAAGCCATTGCTCCACAGGTTGGCAATGATGCTGTCTTCCTGATTTTATACAAAGAATTATACTACAGGCAC
ATATATGCCAAAGTCAGTTTTCAGTCATTCAGTCAGTACCGCTGTAAGACTGCCAAGAAGTCAGAGGAGGAGATTGACTTTCTTCGTTCC
AATCCCAAAATCTGGAATGTTCATAGTGTCCTCAATGTCCTTCATTCCCTGGTAGACAAATCCAACATCAACCGACAGTTGGAGGTATAC
ACAAGCGGAGGTGACCCTGAGAGTGTGGCTGGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTCGGGCTT
CTCCGCCTGCACTCCCTGTTAGGAGATTACTACCAGGCCATCAAGGTGCTGGAGAACATCGAACTGAACAAGAAGCCAATCAAGATCTGC
ATTCTTGGTCCCCCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTC
ATTTCTGAAGCCATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAG
GAGAATGTGGAAGATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATT
AGATTTATGAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAA
GACCTGTTCAATCAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTT
TGTGCACTGGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGAC
CGATTCCTCCGGGCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCG
ATACATATTGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTAT
GGTTTAACAGACGAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAG
CACCAGGAGGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAA
TTACTGGAGGCTCAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAAC
GTCCGACCCGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGTGAAACTTGAAAGATCTGGTATTA
TCTACCTTTACAGAACCACAGATCACTTATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCAGTTCTTAGAAAATTCTTTTTTTG
TAGACAAATATTCTATAAACTAGAATCTCTATTAAAAGCTATATGACATGACTATGTCATTAAAACTATATTTGAAATGTAAATTGATAA
AGACATTTGTGCATAGCTCATGAGACAAATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAATATACCGCTTCTGTACACTAATGT
TTATAGGTATTTATAGCATGAAGAAAATCAGACTATATATTGTAGACTATGTATTATTCTAACATGTAGGCTAATTTACATGACTTGTTA
TCGCCCCAATAACAATGTTATTAGAAATGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAGTAAATCAGACAAGATTGGTGCCT
GTAAGGTGGCTTTTTTTTTTTTTTTTTTTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTCAGGGTCAGGATCCCAGACAATGA
ATCGGAGAGAACTGTAAACCTTTAGGCGGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGATAAGTGAGAAGTTGCTAAATATTT
TCAACACACTTTATAACATAGGCATAAGTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCATAAGATTCCTAGAATTACCCTAA
ATGAGAAATTAGTTTAGGTTTAATGGCATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAACTGCCCGACTTTTTATTTGTGCT
AAAATACATGTAACATAAAATTGACCACTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGTTCATTCACAATGATCTGCAGCCA
CCACTATCTAGTCCAGAACTTTCTCATCACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGCTCCATTATTCCCTCCCCCCAGTT

>25890_25890_1_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000381683_AK7_chr14_96922683_ENST00000267584_length(amino acids)=611AA_BP=254
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYE
IQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVL
NVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKPIKICILGPPAVGKSS
IAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMP
CRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRD
INIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKI

--------------------------------------------------------------
>25890_25890_2_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000381683_AK7_chr14_96922684_ENST00000267584_length(transcript)=2953nt_BP=795nt
CTCTTTCCGGCGGTGCTCGCAAGCGAGGCAGCCATGTCTTATCCCGCTGATGATTATGAGTCTGAGGCGGCTTATGACCCCTACGCTTAT
CCCAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACCTTGCTTATGAACGTCAGTATGAACAGCAAACCTATCAGGTGATCCCT
GAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAACTGTCTCAGATTTGATTGACCAGAAAGTGTATGAGCTACAGGCCAGTCGTGTC
TCCAGTGATGTCATTGACCAGAAGGTGTATGAGATCCAGGACATCTATGAGAACAGCTGGACCAAGCTGACTGAAAGATTCTTCAAGAAT
ACACCTTGGCCCGAGGCTGAAGCCATTGCTCCACAGGTTGGCAATGATGCTGTCTTCCTGATTTTATACAAAGAATTATACTACAGGCAC
ATATATGCCAAAGTCAGTTTTCAGTCATTCAGTCAGTACCGCTGTAAGACTGCCAAGAAGTCAGAGGAGGAGATTGACTTTCTTCGTTCC
AATCCCAAAATCTGGAATGTTCATAGTGTCCTCAATGTCCTTCATTCCCTGGTAGACAAATCCAACATCAACCGACAGTTGGAGGTATAC
ACAAGCGGAGGTGACCCTGAGAGTGTGGCTGGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTCGGGCTT
CTCCGCCTGCACTCCCTGTTAGGAGATTACTACCAGGCCATCAAGGTGCTGGAGAACATCGAACTGAACAAGAAGCCAATCAAGATCTGC
ATTCTTGGTCCCCCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTC
ATTTCTGAAGCCATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAG
GAGAATGTGGAAGATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATT
AGATTTATGAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAA
GACCTGTTCAATCAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTT
TGTGCACTGGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGAC
CGATTCCTCCGGGCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCG
ATACATATTGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTAT
GGTTTAACAGACGAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAG
CACCAGGAGGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAA
TTACTGGAGGCTCAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAAC
GTCCGACCCGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGTGAAACTTGAAAGATCTGGTATTA
TCTACCTTTACAGAACCACAGATCACTTATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCAGTTCTTAGAAAATTCTTTTTTTG
TAGACAAATATTCTATAAACTAGAATCTCTATTAAAAGCTATATGACATGACTATGTCATTAAAACTATATTTGAAATGTAAATTGATAA
AGACATTTGTGCATAGCTCATGAGACAAATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAATATACCGCTTCTGTACACTAATGT
TTATAGGTATTTATAGCATGAAGAAAATCAGACTATATATTGTAGACTATGTATTATTCTAACATGTAGGCTAATTTACATGACTTGTTA
TCGCCCCAATAACAATGTTATTAGAAATGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAGTAAATCAGACAAGATTGGTGCCT
GTAAGGTGGCTTTTTTTTTTTTTTTTTTTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTCAGGGTCAGGATCCCAGACAATGA
ATCGGAGAGAACTGTAAACCTTTAGGCGGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGATAAGTGAGAAGTTGCTAAATATTT
TCAACACACTTTATAACATAGGCATAAGTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCATAAGATTCCTAGAATTACCCTAA
ATGAGAAATTAGTTTAGGTTTAATGGCATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAACTGCCCGACTTTTTATTTGTGCT
AAAATACATGTAACATAAAATTGACCACTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGTTCATTCACAATGATCTGCAGCCA
CCACTATCTAGTCCAGAACTTTCTCATCACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGCTCCATTATTCCCTCCCCCCAGTT

>25890_25890_2_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000381683_AK7_chr14_96922684_ENST00000267584_length(amino acids)=611AA_BP=254
MSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYE
IQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKELYYRHIYAKVSFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVL
NVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKPIKICILGPPAVGKSS
IAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMP
CRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRD
INIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKI

--------------------------------------------------------------
>25890_25890_3_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000406934_AK7_chr14_96922683_ENST00000267584_length(transcript)=3485nt_BP=1327nt
AGGTAAGGTGGCCGTAAGGGCGCGGTGGGCTCCACGACGGGGTGATCTCTGGGACCACTGGATGTGGGTCCCGGCGCGAGGCAGCTTCCG
GGTCGCGGCCAGCTCCGGCCGACCTCCCGCCCGGCCCTCAGGCTGCTCCCACAGTTCCCGGTCCCTAGACAACCCTGGCTCTGCCCGCCC
ACTTCGCGTGTTCGATTGGCTTGTCCTTCCCCTTTCTAAGACCGGAGACTAAGGCCTGTTAGACGTTTCTGTGTTTCTGCACCTGAGTTT
TTTTGGTCTAGGCTCCGTCTGGTCAAATCTCGCTGATTCCCACAGCCTCTTGTCCTTTGCTCCACCTCATTGCACCCGTAATGTTGTATT
GTCATTGTCTGTTTACTGTCCCTTTTCTCTAAGGCGTGTGAGTTCCTCAAAGGCAGGCACAGTGTCTTATTCGCCTCTGTATCCTTAGCT
CTCTGCTTGGCATCTAGACTCTAGGATGAGCGTTTTGAATTCACGACTTGGCGGCTGTCCTTGACTGTGTCTCTTTCCTTCTAGGCGGCT
TATGACCCCTACGCTTATCCCAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACCTTGCTTATGAACGTCAGTATGAACAGCAA
ACCTATCAGGTGATCCCTGAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAACTGTCTCAGATTTGATTGACCAGAAAGTGTATGAG
CTACAGGCCAGTCGTGTCTCCAGTGATGTCATTGACCAGAAGGTGTATGAGATCCAGGACATCTATGAGAACAGATGCTGTCTTCCTGAT
TTTATACAAAGAATTATACTACAGGCACATATATGCCAAAGTCAGTGGGGGACCTTCCTTGGAGCAGAGGTTTGAATCCTATTACAACTA
CTGCAATCTCTTCAACTACATTCTTAATGCCGATGGTCCTGCTCCCCTTGAACTACCCAACCAGTGGCTCTGGGATATTATCGATGAGTT
CATCTACCAGTTTCAGTCATTCAGTCAGTACCGCTGTAAGACTGCCAAGAAGTCAGAGGAGGAGATTGACTTTCTTCGTTCCAATCCCAA
AATCTGGAATGTTCATAGTGTCCTCAATGTCCTTCATTCCCTGGTAGACAAATCCAACATCAACCGACAGTTGGAGGTATACACAAGCGG
AGGTGACCCTGAGAGTGTGGCTGGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTCGGGCTTCTCCGCCT
GCACTCCCTGTTAGGAGATTACTACCAGGCCATCAAGGTGCTGGAGAACATCGAACTGAACAAGAAGCCAATCAAGATCTGCATTCTTGG
TCCCCCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTCATTTCTGA
AGCCATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGT
GGAAGATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATTAGATTTAT
GAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTT
CAATCAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTTTGTGCACT
GGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCT
CCGGGCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCGATACATAT
TGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAAC
AGACGAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGA
GGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGA
GGCTCAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAACGTCCGACC
CGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGTGAAACTTGAAAGATCTGGTATTATCTACCTT
TACAGAACCACAGATCACTTATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCAGTTCTTAGAAAATTCTTTTTTTGTAGACAAA
TATTCTATAAACTAGAATCTCTATTAAAAGCTATATGACATGACTATGTCATTAAAACTATATTTGAAATGTAAATTGATAAAGACATTT
GTGCATAGCTCATGAGACAAATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAATATACCGCTTCTGTACACTAATGTTTATAGGT
ATTTATAGCATGAAGAAAATCAGACTATATATTGTAGACTATGTATTATTCTAACATGTAGGCTAATTTACATGACTTGTTATCGCCCCA
ATAACAATGTTATTAGAAATGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAGTAAATCAGACAAGATTGGTGCCTGTAAGGTG
GCTTTTTTTTTTTTTTTTTTTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTCAGGGTCAGGATCCCAGACAATGAATCGGAGA
GAACTGTAAACCTTTAGGCGGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGATAAGTGAGAAGTTGCTAAATATTTTCAACACA
CTTTATAACATAGGCATAAGTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCATAAGATTCCTAGAATTACCCTAAATGAGAAA
TTAGTTTAGGTTTAATGGCATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAACTGCCCGACTTTTTATTTGTGCTAAAATACA
TGTAACATAAAATTGACCACTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGTTCATTCACAATGATCTGCAGCCACCACTATC
TAGTCCAGAACTTTCTCATCACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGCTCCATTATTCCCTCCCCCCAGTTCCAGGCAA

>25890_25890_3_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000406934_AK7_chr14_96922683_ENST00000267584_length(amino acids)=566AA_BP=209
MTRKCMSYRPVVSPVMSLTRRCMRSRTSMRTDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWL
WDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFS
LVGLLRLHSLLGDYYQAIKVLENIELNKKPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEE
EEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLII
PEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGE
PRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLN

--------------------------------------------------------------
>25890_25890_4_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000406934_AK7_chr14_96922684_ENST00000267584_length(transcript)=3485nt_BP=1327nt
AGGTAAGGTGGCCGTAAGGGCGCGGTGGGCTCCACGACGGGGTGATCTCTGGGACCACTGGATGTGGGTCCCGGCGCGAGGCAGCTTCCG
GGTCGCGGCCAGCTCCGGCCGACCTCCCGCCCGGCCCTCAGGCTGCTCCCACAGTTCCCGGTCCCTAGACAACCCTGGCTCTGCCCGCCC
ACTTCGCGTGTTCGATTGGCTTGTCCTTCCCCTTTCTAAGACCGGAGACTAAGGCCTGTTAGACGTTTCTGTGTTTCTGCACCTGAGTTT
TTTTGGTCTAGGCTCCGTCTGGTCAAATCTCGCTGATTCCCACAGCCTCTTGTCCTTTGCTCCACCTCATTGCACCCGTAATGTTGTATT
GTCATTGTCTGTTTACTGTCCCTTTTCTCTAAGGCGTGTGAGTTCCTCAAAGGCAGGCACAGTGTCTTATTCGCCTCTGTATCCTTAGCT
CTCTGCTTGGCATCTAGACTCTAGGATGAGCGTTTTGAATTCACGACTTGGCGGCTGTCCTTGACTGTGTCTCTTTCCTTCTAGGCGGCT
TATGACCCCTACGCTTATCCCAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACCTTGCTTATGAACGTCAGTATGAACAGCAA
ACCTATCAGGTGATCCCTGAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAACTGTCTCAGATTTGATTGACCAGAAAGTGTATGAG
CTACAGGCCAGTCGTGTCTCCAGTGATGTCATTGACCAGAAGGTGTATGAGATCCAGGACATCTATGAGAACAGATGCTGTCTTCCTGAT
TTTATACAAAGAATTATACTACAGGCACATATATGCCAAAGTCAGTGGGGGACCTTCCTTGGAGCAGAGGTTTGAATCCTATTACAACTA
CTGCAATCTCTTCAACTACATTCTTAATGCCGATGGTCCTGCTCCCCTTGAACTACCCAACCAGTGGCTCTGGGATATTATCGATGAGTT
CATCTACCAGTTTCAGTCATTCAGTCAGTACCGCTGTAAGACTGCCAAGAAGTCAGAGGAGGAGATTGACTTTCTTCGTTCCAATCCCAA
AATCTGGAATGTTCATAGTGTCCTCAATGTCCTTCATTCCCTGGTAGACAAATCCAACATCAACCGACAGTTGGAGGTATACACAAGCGG
AGGTGACCCTGAGAGTGTGGCTGGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTCGGGCTTCTCCGCCT
GCACTCCCTGTTAGGAGATTACTACCAGGCCATCAAGGTGCTGGAGAACATCGAACTGAACAAGAAGCCAATCAAGATCTGCATTCTTGG
TCCCCCTGCTGTGGGAAAATCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTCATTTCTGA
AGCCATAGCAAAACTGGAGGCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGT
GGAAGATGCACAGGAGCTCCTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATTAGATTTAT
GAAAGAAAAGCTAAAATCAATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTT
CAATCAGGAAGATGAGGAGGAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTTTGTGCACT
GGATGCTTCGGATGAGTTTCTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCT
CCGGGCTCTGAGCAACTACCGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCGATACATAT
TGATGTAGGAAAACTTGAAGATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAAC
AGACGAAGAAAAGGCAGAAGAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGA
GGCCGTGGAGATGGCAGAGAAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGA
GGCTCAGTCAATTCCCCTGAGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAACGTCCGACC
CGAAGACCCTGTTGATTTTCTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGTGAAACTTGAAAGATCTGGTATTATCTACCTT
TACAGAACCACAGATCACTTATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCAGTTCTTAGAAAATTCTTTTTTTGTAGACAAA
TATTCTATAAACTAGAATCTCTATTAAAAGCTATATGACATGACTATGTCATTAAAACTATATTTGAAATGTAAATTGATAAAGACATTT
GTGCATAGCTCATGAGACAAATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAATATACCGCTTCTGTACACTAATGTTTATAGGT
ATTTATAGCATGAAGAAAATCAGACTATATATTGTAGACTATGTATTATTCTAACATGTAGGCTAATTTACATGACTTGTTATCGCCCCA
ATAACAATGTTATTAGAAATGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAGTAAATCAGACAAGATTGGTGCCTGTAAGGTG
GCTTTTTTTTTTTTTTTTTTTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTCAGGGTCAGGATCCCAGACAATGAATCGGAGA
GAACTGTAAACCTTTAGGCGGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGATAAGTGAGAAGTTGCTAAATATTTTCAACACA
CTTTATAACATAGGCATAAGTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCATAAGATTCCTAGAATTACCCTAAATGAGAAA
TTAGTTTAGGTTTAATGGCATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAACTGCCCGACTTTTTATTTGTGCTAAAATACA
TGTAACATAAAATTGACCACTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGTTCATTCACAATGATCTGCAGCCACCACTATC
TAGTCCAGAACTTTCTCATCACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGCTCCATTATTCCCTCCCCCCAGTTCCAGGCAA

>25890_25890_4_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000406934_AK7_chr14_96922684_ENST00000267584_length(amino acids)=566AA_BP=209
MTRKCMSYRPVVSPVMSLTRRCMRSRTSMRTDAVFLILYKELYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWL
WDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFS
LVGLLRLHSLLGDYYQAIKVLENIELNKKPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEE
EEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLII
PEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGE
PRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLN

--------------------------------------------------------------
>25890_25890_5_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000412331_AK7_chr14_96922683_ENST00000267584_length(transcript)=3646nt_BP=1488nt
AACTTTGCCTCTCCTTTACGCCAAATACGTGTCCTTATATCTGAATCTACACCACTATTATAGATTCACCTTCTTTGAGAAGTCCCTATT
TGAAGAGAGGAAAATTCAGGCTACTTGTAACCCTCTTATTCTTTTTAGACGGAGTTTTCCCTCTTGTTGCCCAGGCTAGAGTGCAATGGC
GCGATCTCGGCTCACCGCAACCTCCGCCTCCCGGGTTCAAGCGACTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCATGCGC
CACCACTCCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATATTGGTCAGGCTGGTCTCAAACCCCCGGCCTCAGCCTCAG
GTGATCCGCCCGCCTCGGCCTCCCAAACTGGTGGGGTTACAGGTGTGAGCCACGGAACGCGGCTCCTCTTCCTTCTGGATATGGCTGTCT
CAGATGGCCAGAGGCCTCGGAAAGGCTTCCGGTTTCCCGGCAGGCCCGAGTGGGGCTGAACTTCCGGCCTCAGGACGCAGGCGCGGGCCG
CTCATTTCGCTCTTTCCGGCGGTGCTCGCAAGCGAGGCAGCCATGTCTTATCCCGCTGATGATTATGAGTCTGAGGCGGCTTATGACCCC
TACGCTTATCCCAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACCTTGCTTATGAACGTCAGTATGAACAGCAAACCTATCAG
GTGATCCCTGAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAACTGTCTCAGATTTGATTGACCAGAAAGTGTATGAGCTACAGGCC
AGTCGTGTCTCCAGTGATGTCATTGACCAGAAGGTGTATGAGATCCAGGACATCTATGAGAACAGCTGGACCAAGCTGACTGAAAGATTC
TTCAAGAATACACCTTGGCCCGAGGCTGAAGCCATTGCTCCACAGGTTGGCAATGATGCTGTCTTCCTGATTTTATACAAAGAATTATAC
TACAGGCACATATATGCCAAAGTCAGTGGGGGACCTTCCTTGGAGCAGAGGTTTGAATCCTATTACAACTACTGCAATCTCTTCAACTAC
ATTCTTAATGCCGATGGTCCTGCTCCCCTTGAACTACCCAACCAGTGGCTCTGGGATATTATCGATGAGTTCATCTACCAGTTTCAGTCA
TTCAGTCAGTACCGCTGTAAGACTGCCAAGAAGTCAGAGGAGGAGATTGACTTTCTTCGTTCCAATCCCAAAATCTGGAATGTTCATAGT
GTCCTCAATGTCCTTCATTCCCTGGTAGACAAATCCAACATCAACCGACAGTTGGAGGTATACACAAGCGGAGGTGACCCTGAGAGTGTG
GCTGGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTCGGGCTTCTCCGCCTGCACTCCCTGTTAGGAGAT
TACTACCAGGCCATCAAGGTGCTGGAGAACATCGAACTGAACAAGAAGCCAATCAAGATCTGCATTCTTGGTCCCCCTGCTGTGGGAAAA
TCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTCATTTCTGAAGCCATAGCAAAACTGGAG
GCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAAGATGCACAGGAGCTC
CTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATTAGATTTATGAAAGAAAAGCTAAAATCA
ATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAATCAGGAAGATGAGGAG
GAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTTTGTGCACTGGATGCTTCGGATGAGTTT
CTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGGGCTCTGAGCAACTAC
CGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCGATACATATTGATGTAGGAAAACTTGAA
GATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGACGAAGAAAAGGCAGAA
GAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGAGGCCGTGGAGATGGCAGAG
AAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCTCAGTCAATTCCCCTG
AGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAACGTCCGACCCGAAGACCCTGTTGATTTT
CTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGTGAAACTTGAAAGATCTGGTATTATCTACCTTTACAGAACCACAGATCACT
TATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCAGTTCTTAGAAAATTCTTTTTTTGTAGACAAATATTCTATAAACTAGAATC
TCTATTAAAAGCTATATGACATGACTATGTCATTAAAACTATATTTGAAATGTAAATTGATAAAGACATTTGTGCATAGCTCATGAGACA
AATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAATATACCGCTTCTGTACACTAATGTTTATAGGTATTTATAGCATGAAGAAAA
TCAGACTATATATTGTAGACTATGTATTATTCTAACATGTAGGCTAATTTACATGACTTGTTATCGCCCCAATAACAATGTTATTAGAAA
TGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAGTAAATCAGACAAGATTGGTGCCTGTAAGGTGGCTTTTTTTTTTTTTTTTT
TTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTCAGGGTCAGGATCCCAGACAATGAATCGGAGAGAACTGTAAACCTTTAGGC
GGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGATAAGTGAGAAGTTGCTAAATATTTTCAACACACTTTATAACATAGGCATAA
GTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCATAAGATTCCTAGAATTACCCTAAATGAGAAATTAGTTTAGGTTTAATGGC
ATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAACTGCCCGACTTTTTATTTGTGCTAAAATACATGTAACATAAAATTGACCA
CTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGTTCATTCACAATGATCTGCAGCCACCACTATCTAGTCCAGAACTTTCTCAT
CACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGCTCCATTATTCCCTCCCCCCAGTTCCAGGCAACCACGAATCTGCTTTCTGT

>25890_25890_5_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000412331_AK7_chr14_96922683_ENST00000267584_length(amino acids)=705AA_BP=348
MSQMARGLGKASGFPAGPSGAELPASGRRRGPLISLFPAVLASEAAMSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQT
YQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKE
LYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNV
HSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKPIKICILGPPAV
GKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKL
KSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALS
NYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEM

--------------------------------------------------------------
>25890_25890_6_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000412331_AK7_chr14_96922684_ENST00000267584_length(transcript)=3646nt_BP=1488nt
AACTTTGCCTCTCCTTTACGCCAAATACGTGTCCTTATATCTGAATCTACACCACTATTATAGATTCACCTTCTTTGAGAAGTCCCTATT
TGAAGAGAGGAAAATTCAGGCTACTTGTAACCCTCTTATTCTTTTTAGACGGAGTTTTCCCTCTTGTTGCCCAGGCTAGAGTGCAATGGC
GCGATCTCGGCTCACCGCAACCTCCGCCTCCCGGGTTCAAGCGACTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTACAGGCATGCGC
CACCACTCCCGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCCATATTGGTCAGGCTGGTCTCAAACCCCCGGCCTCAGCCTCAG
GTGATCCGCCCGCCTCGGCCTCCCAAACTGGTGGGGTTACAGGTGTGAGCCACGGAACGCGGCTCCTCTTCCTTCTGGATATGGCTGTCT
CAGATGGCCAGAGGCCTCGGAAAGGCTTCCGGTTTCCCGGCAGGCCCGAGTGGGGCTGAACTTCCGGCCTCAGGACGCAGGCGCGGGCCG
CTCATTTCGCTCTTTCCGGCGGTGCTCGCAAGCGAGGCAGCCATGTCTTATCCCGCTGATGATTATGAGTCTGAGGCGGCTTATGACCCC
TACGCTTATCCCAGCGACTATGATATGCACACAGGAGATCCAAAGCAGGACCTTGCTTATGAACGTCAGTATGAACAGCAAACCTATCAG
GTGATCCCTGAGGTGATCAAAAACTTCATCCAGTATTTCCACAAAACTGTCTCAGATTTGATTGACCAGAAAGTGTATGAGCTACAGGCC
AGTCGTGTCTCCAGTGATGTCATTGACCAGAAGGTGTATGAGATCCAGGACATCTATGAGAACAGCTGGACCAAGCTGACTGAAAGATTC
TTCAAGAATACACCTTGGCCCGAGGCTGAAGCCATTGCTCCACAGGTTGGCAATGATGCTGTCTTCCTGATTTTATACAAAGAATTATAC
TACAGGCACATATATGCCAAAGTCAGTGGGGGACCTTCCTTGGAGCAGAGGTTTGAATCCTATTACAACTACTGCAATCTCTTCAACTAC
ATTCTTAATGCCGATGGTCCTGCTCCCCTTGAACTACCCAACCAGTGGCTCTGGGATATTATCGATGAGTTCATCTACCAGTTTCAGTCA
TTCAGTCAGTACCGCTGTAAGACTGCCAAGAAGTCAGAGGAGGAGATTGACTTTCTTCGTTCCAATCCCAAAATCTGGAATGTTCATAGT
GTCCTCAATGTCCTTCATTCCCTGGTAGACAAATCCAACATCAACCGACAGTTGGAGGTATACACAAGCGGAGGTGACCCTGAGAGTGTG
GCTGGGGAGTATGGGCGGCACTCCCTCTACAAAATGCTTGGTTACTTCAGCCTGGTCGGGCTTCTCCGCCTGCACTCCCTGTTAGGAGAT
TACTACCAGGCCATCAAGGTGCTGGAGAACATCGAACTGAACAAGAAGCCAATCAAGATCTGCATTCTTGGTCCCCCTGCTGTGGGAAAA
TCCAGTATTGCTAAAGAATTGGCCAACTACTACAAACTGCATCACATCCAACTGAAGGATGTCATTTCTGAAGCCATAGCAAAACTGGAG
GCGATTGTTGCCCCTAACGATGTAGGGGAAGGAGAAGAAGAAGTCGAAGAGGAAGAGGAGGAGGAGAATGTGGAAGATGCACAGGAGCTC
CTAGATGGCATCAAGGAGAGCATGGAGCAGAATGCAGGTCAACTAGACGATCAATATATAATTAGATTTATGAAAGAAAAGCTAAAATCA
ATGCCTTGCAGGAATCAAGGTTATATTTTGGATGGATTCCCAAAGACCTATGATCAAGCAAAAGACCTGTTCAATCAGGAAGATGAGGAG
GAGGAAGATGATGTCAGAGGCAGAATGTTTCCCTTTGATAAATTAATTATACCTGAATTCGTTTGTGCACTGGATGCTTCGGATGAGTTT
CTGAAGGAGCGTGTGATAAACCTTCCTGAGAGCATCGTGGCGGGGACCCACTACAGCCAAGACCGATTCCTCCGGGCTCTGAGCAACTAC
CGGGACATCAATATCGACGATGAGACTGTCTTCAACTATTTTGATGAACTTGAAATTCACCCGATACATATTGATGTAGGAAAACTTGAA
GATGCTCAGAATAGACTTGCTATCAAACAGCTCATCAAAGAGATTGGGGAGCCTCGAAATTATGGTTTAACAGACGAAGAAAAGGCAGAA
GAGGAGCGGAAGGCTGCGGAGGAGCGGCTGGCCAGGGAGGCTGCTGAGGAAGCAGAACGCGAGCACCAGGAGGCCGTGGAGATGGCAGAG
AAGATAGCTCGCTGGGAGGAGTGGAATAAACGACTGGAGGAAGTGAAAAGAGAAGAAAGAGAATTACTGGAGGCTCAGTCAATTCCCCTG
AGAAACTATTTAATGACCTATGTGATGCCAACTCTTATTCAGGGCCTGAATGAATGTTGCAACGTCCGACCCGAAGACCCTGTTGATTTT
CTGGCAGAATATCTCTTCAAGAACAATCCTGAAGCACAGTGAAACTTGAAAGATCTGGTATTATCTACCTTTACAGAACCACAGATCACT
TATTATACTTTGAAAAATTGCTTTGAAAAATGCTTTTCCAGTTCTTAGAAAATTCTTTTTTTGTAGACAAATATTCTATAAACTAGAATC
TCTATTAAAAGCTATATGACATGACTATGTCATTAAAACTATATTTGAAATGTAAATTGATAAAGACATTTGTGCATAGCTCATGAGACA
AATACTGATTTAATATTTTATTCTTTAGTCAGATCTAAATATACCGCTTCTGTACACTAATGTTTATAGGTATTTATAGCATGAAGAAAA
TCAGACTATATATTGTAGACTATGTATTATTCTAACATGTAGGCTAATTTACATGACTTGTTATCGCCCCAATAACAATGTTATTAGAAA
TGGAAATAAATTGAAGTGATTTATGCCTGTTGACTCACAGTAAATCAGACAAGATTGGTGCCTGTAAGGTGGCTTTTTTTTTTTTTTTTT
TTAAATGAAGCAATGGTTAGGGAAAGGTTGCTTTGAGTTCAGGGTCAGGATCCCAGACAATGAATCGGAGAGAACTGTAAACCTTTAGGC
GGAGAAATCTGCATAACAGGATAATTCCAATCTTTGTGATAAGTGAGAAGTTGCTAAATATTTTCAACACACTTTATAACATAGGCATAA
GTTATCAATCCTATAGTCTTTTCCAGTTCTAAAAATCCCATAAGATTCCTAGAATTACCCTAAATGAGAAATTAGTTTAGGTTTAATGGC
ATATGTATTTTATCTCTTTAAATAATGTAACCTAATATAACTGCCCGACTTTTTATTTGTGCTAAAATACATGTAACATAAAATTGACCA
CTGTAACCATTTTAAAGTGTATAATTCAGTGGCACTAAGTTCATTCACAATGATCTGCAGCCACCACTATCTAGTCCAGAACTTTCTCAT
CACCCCAAATGGAAACCCAGCACCTATTAGGCAGTCACGCTCCATTATTCCCTCCCCCCAGTTCCAGGCAACCACGAATCTGCTTTCTGT

>25890_25890_6_EIF3L-AK7_EIF3L_chr22_38270531_ENST00000412331_AK7_chr14_96922684_ENST00000267584_length(amino acids)=705AA_BP=348
MSQMARGLGKASGFPAGPSGAELPASGRRRGPLISLFPAVLASEAAMSYPADDYESEAAYDPYAYPSDYDMHTGDPKQDLAYERQYEQQT
YQVIPEVIKNFIQYFHKTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAEAIAPQVGNDAVFLILYKE
LYYRHIYAKVSGGPSLEQRFESYYNYCNLFNYILNADGPAPLELPNQWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNV
HSVLNVLHSLVDKSNINRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELNKKPIKICILGPPAV
GKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKL
KSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALS
NYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEM

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Fusion Gene PPI Analysis for EIF3L-AK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3L-AK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3L-AK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource