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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3L-MTUS1 (FusionGDB2 ID:25900)

Fusion Gene Summary for EIF3L-MTUS1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3L-MTUS1
Fusion gene ID: 25900
HgeneTgene
Gene symbol

EIF3L

MTUS1

Gene ID

51386

57509

Gene nameeukaryotic translation initiation factor 3 subunit Lmicrotubule associated scaffold protein 1
SynonymsEIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005ATBP|ATIP|ATIP3|ICIS|MP44|MTSG1
Cytomap

22q13.1

8p22

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit LeIEF associated protein HSPC021eukaryotic translation initiation factor 3 subunit 6-interacting proteineukaryotic translation initiation factor 3 subunit E-interacting proteinmicrotubule-associated tumor suppressor 1AT2 receptor-binding proteinAT2 receptor-interacting proteinAT2R binding proteinangiotensin-II type 2 receptor-interacting proteinerythroid differentiation-relatedmicrotubule associated tumor suppressor 1mit
Modification date2020032220200313
UniProtAcc

Q9Y262

Q9ULD2

Ensembl transtripts involved in fusion geneENST00000476955, ENST00000381683, 
ENST00000406934, ENST00000412331, 
ENST00000262102, ENST00000381861, 
ENST00000381869, ENST00000519263, 
ENST00000544260, ENST00000297488, 
ENST00000381862, ENST00000400046, 
ENST00000518713, 
Fusion gene scores* DoF score13 X 8 X 9=9367 X 7 X 2=98
# samples 187
** MAII scorelog2(18/936*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3L [Title/Abstract] AND MTUS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3L(38247497)-MTUS1(17573414), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3L

GO:0006413

translational initiation

17581632

HgeneEIF3L

GO:0075525

viral translational termination-reinitiation

21347434


check buttonFusion gene breakpoints across EIF3L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MTUS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA039338EIF3Lchr22

38247497

+MTUS1chr8

17573414

-


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Fusion Gene ORF analysis for EIF3L-MTUS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000476955ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-5UTRENST00000476955ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
3UTR-intronENST00000476955ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000381683ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000406934ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000262102EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000381861EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000381869EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000519263EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-5UTRENST00000412331ENST00000544260EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000381683ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000406934ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000297488EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000381862EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000400046EIF3Lchr22

38247497

+MTUS1chr8

17573414

-
5CDS-intronENST00000412331ENST00000518713EIF3Lchr22

38247497

+MTUS1chr8

17573414

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EIF3L-MTUS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF3L-MTUS1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38247497/:17573414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3L

Q9Y262

MTUS1

Q9ULD2

FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EIF3L-MTUS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EIF3L-MTUS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3L-MTUS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3L-MTUS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource