FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:EIF4A1-PHOSPHO1 (FusionGDB2 ID:25926)

Fusion Gene Summary for EIF4A1-PHOSPHO1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4A1-PHOSPHO1
Fusion gene ID: 25926
HgeneTgene
Gene symbol

EIF4A1

PHOSPHO1

Gene ID

1973

162466

Gene nameeukaryotic translation initiation factor 4A1phosphoethanolamine/phosphocholine phosphatase 1
SynonymsDDX2A|EIF-4A|EIF4A|eIF-4A-I|eIF4A-I-
Cytomap

17p13.1

17q21.32

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic initiation factor 4A-IATP-dependent RNA helicase eIF4A-1eukaryotic initiation factor 4AIeukaryotic translation initiation factor 4Aphosphoethanolamine/phosphocholine phosphatasephosphatase, orphan 1
Modification date2020032220200313
UniProtAcc

P60842

.
Ensembl transtripts involved in fusion geneENST00000293831, ENST00000380512, 
ENST00000577269, ENST00000582746, 
ENST00000581808, 		ENST00000413580, 
ENST00000514112, ENST00000310544, 
Fusion gene scores* DoF score3 X 2 X 2=122 X 3 X 2=12
# samples 53
** MAII scorelog2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF4A1 [Title/Abstract] AND PHOSPHO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF4A1(7478576)-PHOSPHO1(47302366), # samples:5
EIF4A1(7478576)-PHOSPHO1(47302493), # samples:5
Anticipated loss of major functional domain due to fusion event.EIF4A1-PHOSPHO1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF4A1-PHOSPHO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF4A1-PHOSPHO1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EIF4A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHOSPHO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-1034-01AEIF4A1chr17

7478576

-PHOSPHO1chr17

47302366

-
ChimerDB4GBMTCGA-14-1034-01AEIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
ChimerDB4GBMTCGA-14-1034-01AEIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
ChimerDB4GBMTCGA-14-1034-02BEIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
ChimerDB4GBMTCGA-14-1034-02BEIF4A1chr17

7478576

-PHOSPHO1chr17

47302493

-
ChimerDB4GBMTCGA-14-1034-02BEIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
ChimerDB4GBMTCGA-14-1034EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
ChimerDB4GBMTCGA-14-1034EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-


Top

Fusion Gene ORF analysis for EIF4A1-PHOSPHO1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000293831ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000293831ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000380512ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000380512ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000577269ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000577269ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000582746ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-5UTRENST00000582746ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-intronENST00000293831ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-intronENST00000380512ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-intronENST00000577269ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
5CDS-intronENST00000582746ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
Frame-shiftENST00000293831ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000293831ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000293831ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000380512ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000577269ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000577269ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000577269ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000582746ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000582746ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
Frame-shiftENST00000582746ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
In-frameENST00000380512ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
In-frameENST00000380512ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
intron-3CDSENST00000581808ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
intron-3CDSENST00000581808ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
intron-3CDSENST00000581808ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302366

-
intron-5UTRENST00000581808ENST00000413580EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
intron-5UTRENST00000581808ENST00000514112EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-
intron-intronENST00000581808ENST00000310544EIF4A1chr17

7478576

+PHOSPHO1chr17

47302493

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380512EIF4A1chr177478576+ENST00000413580PHOSPHO1chr1747302366-24047697291754341
ENST00000380512EIF4A1chr177478576+ENST00000514112PHOSPHO1chr1747302366-21147697291754341

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380512ENST00000413580EIF4A1chr177478576+PHOSPHO1chr1747302366-0.0183906960.9816093
ENST00000380512ENST00000514112EIF4A1chr177478576+PHOSPHO1chr1747302366-0.0198663120.98013365

Top

Fusion Genomic Features for EIF4A1-PHOSPHO1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EIF4A1-PHOSPHO1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:7478576/chr17:47302366)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4A1

P60842

.
FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000293831+41132_60115407.0MotifNote=Q motif
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000577269+41132_60115348.0MotifNote=Q motif
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000293831+41176_83115407.0Nucleotide bindingATP
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000577269+41176_83115348.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000293831+411245_406115407.0DomainHelicase C-terminal
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000293831+41163_234115407.0DomainHelicase ATP-binding
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000577269+411245_406115348.0DomainHelicase C-terminal
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000577269+41163_234115348.0DomainHelicase ATP-binding
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000293831+411182_185115407.0MotifNote=DEAD box
HgeneEIF4A1chr17:7478576chr17:47302366ENST00000577269+411182_185115348.0MotifNote=DEAD box


Top

Fusion Gene Sequence for EIF4A1-PHOSPHO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25926_25926_1_EIF4A1-PHOSPHO1_EIF4A1_chr17_7478576_ENST00000380512_PHOSPHO1_chr17_47302366_ENST00000413580_length(transcript)=2404nt_BP=769nt
CTAGTTTCTAAGGATCATGTCTGCGAGCCAGGATTCCCGGACTGAGCCTAACCCCGAGGAGCGGCCGCGTGAGGCACCAGGAGCCCACCC
GGCGCCGGGCGGGCGGGTCCATTTTGCCGCACAAGCCGGGCTATTGGCAAACTGCGGATGGGCAGGTCCACCTTCCTTCGGGGGTGAGCG
GCCTGAGATCCAGAGACAATGGCCCCGATGGGATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATG
ACATGAACCTCTCGGAGTCCCTTCTCCGTGGCATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAGCGAGCCATTCTACCTT
GTATCAAGGGTAAGAGTGGCTTCTATTCCCTCCTTCAGGGCTGATTTAGGGATGATGAGTATAATCCAAGGACCAGAGAAGTCTTCTCTG
ATCACCACCTTGGGAGGAAGACATGGGTGCCCTAACACTCTCGAGACCTGCTGGGTTAATTAAAAGCTATTTCTTACCCAAACGTAACCA
TTGCTTCCTCCACCCATTTCCTGAGTCAAATGGGAAAGCTGTTGGGTGAAGCCTGGCTGGCTGGGCAAGTTTGACTGTGTTCTGAATAAG
CACCTTCACTATGGGCTAAGAGATCCCTTGGTGTGGGGGTGATCTTACAGTAGTCAGAGCAGATGGACAGTCCTTTTCACCCTTGCTTAA
TAGCCAGAGCTGTTTCATGCCTGGGGCACACACAATTCTAATGCTGGACGACGGCAGGATGGCCGCGCAGGGCGCGCCGCGCTTCCTCCT
GACCTTCGACTTCGACGAGACTATCGTGGACGAAAACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCT
GCGAGCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGCGAGCAGGGCGTGCGGCCGCGGGACCT
GAGCGCCATCTACGAAGCCATCCCTTTGTCGCCAGGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGAT
TCTCATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGCCTGTTCCGCCGCATCCTCAGCAACCC
GTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTGCGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAA
GGTGCTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTACGTGGGCGACGGCGCCAACGACTTCTG
CCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCCTTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGA
GCCCAGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTGCAACAGGTGCTGAAGTCGTGCTGAGT
CTGGCCGCCTGCAGGGGGGTACCCGGGCCAACGGCGGAGGGGGCGGGGAAGGGAGATTCGGCAAAGACAGCTTTACTACTCCCTTTTCCC
TTTGGCTTTGTTATGTCCCTCTGGGAATTTCTGGAATCTCGTATTTGGGGGCTTGGGGAAGGGGGCTCAGAGCCGTCCCTATCTATTCAG
TTAACCCACCTCGGCTGCCTCCCCCACTCCACTGTGCACGGTTGAGTTCTGGAGTCTGACCCATCGCGGGGTGGCGCGCAAACCTTGGAA
GGCAGCAGTATTTCCTGGTCCTCCCAACTGGGAGGAAGGGGCCCCCCCGGCAGGTGAGAGAAGGAACATCTCCCGCCGCTGTAACTTGTT
GCCTCGGGCTGCGTGACCGCCCCTCCTCCAGTCTACTGTGGAGGGAACCCAGGATCCTGAAATTCTCCTGGCCGCAAGAACTCCCCACAG
AGGCAGAAGAGGGTCTCCACCTATGGCCCCAGGCCTTTGCGATCTTGCTTCACCCACCGCGACCCCACACTATTTCTGTGCTGTCCACAC
TCTCTTGCCTCCCGACCCCCGCACTCCCTTCTAGCACCCCCAAAGGAAAAGCCAGAGGAACAATCGCCTCCTGGTGGTGGTACGAGGTAG
CGCACCGTCCGGCTCGGGTCCGGACAGCCAGTAACCTCGCAGAGAGTGACGGTGTCTCCTTGCATCCCAGCCTCGTCTATGCAGCAAGAG
ACCAGGGACTTCACCAAAGTCACCCTCGCGGGCTGGGCCTTCCACGCATCCCCCCCACCCCCCATGGAACAGAAAGCCATGTTTTTAAGC

>25926_25926_1_EIF4A1-PHOSPHO1_EIF4A1_chr17_7478576_ENST00000380512_PHOSPHO1_chr17_47302366_ENST00000413580_length(amino acids)=341AA_BP=14
MFHAWGTHNSNAGRRQDGRAGRAALPPDLRLRRDYRGRKQRRFDRARRAGPAAPGEPASHLPRGLLQRVHAARLQVPGRAGRAAAGPERH
LRSHPFVARHERPAAVCGKTGRLLRGDSHLRCQHLWRGELAARRRPPQPVPPHPQQPVGAGCAGTAGSAAVPHTQLRALPRQHVQAQGAQ
RLPARAGPRRRALRAPLLRGRRRQRLLPHGAAGGRRRGLPAPRLPHAPPHSGGPEGRAQLVPRQRGALGNGCRCAPPPATGAEVVLSLAA

--------------------------------------------------------------
>25926_25926_2_EIF4A1-PHOSPHO1_EIF4A1_chr17_7478576_ENST00000380512_PHOSPHO1_chr17_47302366_ENST00000514112_length(transcript)=2114nt_BP=769nt
CTAGTTTCTAAGGATCATGTCTGCGAGCCAGGATTCCCGGACTGAGCCTAACCCCGAGGAGCGGCCGCGTGAGGCACCAGGAGCCCACCC
GGCGCCGGGCGGGCGGGTCCATTTTGCCGCACAAGCCGGGCTATTGGCAAACTGCGGATGGGCAGGTCCACCTTCCTTCGGGGGTGAGCG
GCCTGAGATCCAGAGACAATGGCCCCGATGGGATGGAGCCCGAAGGCGTCATCGAGAGTAACTGGAATGAGATTGTTGACAGCTTTGATG
ACATGAACCTCTCGGAGTCCCTTCTCCGTGGCATCTACGCGTATGGTTTTGAGAAGCCCTCTGCCATCCAGCAGCGAGCCATTCTACCTT
GTATCAAGGGTAAGAGTGGCTTCTATTCCCTCCTTCAGGGCTGATTTAGGGATGATGAGTATAATCCAAGGACCAGAGAAGTCTTCTCTG
ATCACCACCTTGGGAGGAAGACATGGGTGCCCTAACACTCTCGAGACCTGCTGGGTTAATTAAAAGCTATTTCTTACCCAAACGTAACCA
TTGCTTCCTCCACCCATTTCCTGAGTCAAATGGGAAAGCTGTTGGGTGAAGCCTGGCTGGCTGGGCAAGTTTGACTGTGTTCTGAATAAG
CACCTTCACTATGGGCTAAGAGATCCCTTGGTGTGGGGGTGATCTTACAGTAGTCAGAGCAGATGGACAGTCCTTTTCACCCTTGCTTAA
TAGCCAGAGCTGTTTCATGCCTGGGGCACACACAATTCTAATGCTGGACGACGGCAGGATGGCCGCGCAGGGCGCGCCGCGCTTCCTCCT
GACCTTCGACTTCGACGAGACTATCGTGGACGAAAACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTCCCGGAGAGCCT
GCGAGCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTCTTCAAGTACCTGGGCGAGCAGGGCGTGCGGCCGCGGGACCT
GAGCGCCATCTACGAAGCCATCCCTTTGTCGCCAGGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGCTTCGAGGTGAT
TCTCATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCCGCCGGCCACCACAGCCTGTTCCGCCGCATCCTCAGCAACCC
GTCGGGGCCGGATGCGCGGGGACTGCTGGCTCTGCGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATGTGCAAGCACAA
GGTGCTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTCGAGCGCCTCTTCTACGTGGGCGACGGCGCCAACGACTTCTG
CCCCATGGGGCTGCTGGCGGGCGGCGACGTGGCCTTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCCCAGAAGGCCGA
GCCCAGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGATGTGCGCCTCCACCTGCAACAGGTGCTGAAGTCGTGCTGAGT
CTGGCCGCCTGCAGGGGGGTACCCGGGCCAACGGCGGAGGGGGCGGGGAAGGGAGATTCGGCAAAGACAGCTTTACTACTCCCTTTTCCC
TTTGGCTTTGTTATGTCCCTCTGGGAATTTCTGGAATCTCGTATTTGGGGGCTTGGGGAAGGGGGCTCAGAGCCGTCCCTATCTATTCAG
TTAACCCACCTCGGCTGCCTCCCCCACTCCACTGTGCACGGTTGAGTTCTGGAGTCTGACCCATCGCGGGGTGGCGCGCAAACCTTGGAA
GGCAGCAGTATTTCCTGGTCCTCCCAACTGGGAGGAAGGGGCCCCCCCGGCAGGTGAGAGAAGGAACATCTCCCGCCGCTGTAACTTGTT
GCCTCGGGCTGCGTGACCGCCCCTCCTCCAGTCTACTGTGGAGGGAACCCAGGATCCTGAAATTCTCCTGGCCGCAAGAACTCCCCACAG
AGGCAGAAGAGGGTCTCCACCTATGGCCCCAGGCCTTTGCGATCTTGCTTCACCCACCGCGACCCCACACTATTTCTGTGCTGTCCACAC

>25926_25926_2_EIF4A1-PHOSPHO1_EIF4A1_chr17_7478576_ENST00000380512_PHOSPHO1_chr17_47302366_ENST00000514112_length(amino acids)=341AA_BP=14
MFHAWGTHNSNAGRRQDGRAGRAALPPDLRLRRDYRGRKQRRFDRARRAGPAAPGEPASHLPRGLLQRVHAARLQVPGRAGRAAAGPERH
LRSHPFVARHERPAAVCGKTGRLLRGDSHLRCQHLWRGELAARRRPPQPVPPHPQQPVGAGCAGTAGSAAVPHTQLRALPRQHVQAQGAQ
RLPARAGPRRRALRAPLLRGRRRQRLLPHGAAGGRRRGLPAPRLPHAPPHSGGPEGRAQLVPRQRGALGNGCRCAPPPATGAEVVLSLAA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EIF4A1-PHOSPHO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EIF4A1-PHOSPHO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for EIF4A1-PHOSPHO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource