FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:EIF4A2-ATG13 (FusionGDB2 ID:25929)

Fusion Gene Summary for EIF4A2-ATG13

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4A2-ATG13
Fusion gene ID: 25929
HgeneTgene
Gene symbol

EIF4A2

ATG13

Gene ID

1974

9776

Gene nameeukaryotic translation initiation factor 4A2autophagy related 13
SynonymsBM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-IIKIAA0652|PARATARG8
Cytomap

3q27.3

11p11.2

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2autophagy-related protein 13ATG13 autophagy related 13 homolog
Modification date2020032220200327
UniProtAcc

Q14240

O75143

Ensembl transtripts involved in fusion geneENST00000323963, ENST00000356531, 
ENST00000440191, 
ENST00000312040, 
ENST00000359513, ENST00000434074, 
ENST00000451945, ENST00000524625, 
ENST00000526485, ENST00000526508, 
ENST00000528494, ENST00000529655, 
ENST00000530500, 
Fusion gene scores* DoF score21 X 21 X 7=30877 X 6 X 7=294
# samples 238
** MAII scorelog2(23/3087*10)=-3.74649971667075
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/294*10)=-1.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF4A2 [Title/Abstract] AND ATG13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF4A2(186507553)-ATG13(46650505), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4A2

GO:1900260

negative regulation of RNA-directed 5'-3' RNA polymerase activity

11922617


check buttonFusion gene breakpoints across EIF4A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATG13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEY123259EIF4A2chr3

186507553

+ATG13chr11

46650505

-


Top

Fusion Gene ORF analysis for EIF4A2-ATG13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000323963ENST00000312040EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000359513EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000434074EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000451945EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000524625EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000526485EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000526508EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000528494EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000529655EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000323963ENST00000530500EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000312040EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000359513EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000434074EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000451945EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000524625EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000526485EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000526508EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000528494EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000529655EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000356531ENST00000530500EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000312040EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000359513EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000434074EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000451945EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000524625EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000526485EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000526508EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000528494EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000529655EIF4A2chr3

186507553

+ATG13chr11

46650505

-
3UTR-intronENST00000440191ENST00000530500EIF4A2chr3

186507553

+ATG13chr11

46650505

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EIF4A2-ATG13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EIF4A2-ATG13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:186507553/:46650505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4A2

Q14240

ATG13

O75143

FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for EIF4A2-ATG13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for EIF4A2-ATG13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EIF4A2-ATG13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for EIF4A2-ATG13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource