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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF4A2-DNAJB11 (FusionGDB2 ID:25930)

Fusion Gene Summary for EIF4A2-DNAJB11

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4A2-DNAJB11
Fusion gene ID: 25930
HgeneTgene
Gene symbol

EIF4A2

DNAJB11

Gene ID

1974

51726

Gene nameeukaryotic translation initiation factor 4A2DnaJ heat shock protein family (Hsp40) member B11
SynonymsBM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-IIABBP-2|ABBP2|DJ9|Dj-9|EDJ|ERdj3|ERj3|ERj3p|PKD6|PRO1080|UNQ537
Cytomap

3q27.3

3q27.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2dnaJ homolog subfamily B member 11APOBEC1-binding protein 2DnaJ (Hsp40) homolog, subfamily B, member 11DnaJ protein 9ER-associated DNAJ protein 3ER-associated Hsp40 co-chaperoneER-resident protein ERdj3PWP1-interacting protein 4endoplasmic reticul
Modification date2020032220200313
UniProtAcc

Q14240

Q9UBS4

Ensembl transtripts involved in fusion geneENST00000323963, ENST00000440191, 
ENST00000356531, 		ENST00000265028, 
ENST00000439351, ENST00000538831, 
Fusion gene scores* DoF score21 X 21 X 7=30874 X 4 X 3=48
# samples 234
** MAII scorelog2(23/3087*10)=-3.74649971667075
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF4A2 [Title/Abstract] AND DNAJB11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF4A2(186502302)-DNAJB11(186314843), # samples:1
EIF4A2(186502266)-DNAJB11(186314843), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4A2

GO:1900260

negative regulation of RNA-directed 5'-3' RNA polymerase activity

11922617

TgeneDNAJB11

GO:0032781

positive regulation of ATPase activity

20335166


check buttonFusion gene breakpoints across EIF4A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DNAJB11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-A5FT-01AEIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
ChimerDB4OVTCGA-13-A5FT-01AEIF4A2chr3

186502302

+DNAJB11chr3

186314843

+


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Fusion Gene ORF analysis for EIF4A2-DNAJB11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000323963ENST00000265028EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5CDS-intronENST00000323963ENST00000439351EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5CDS-intronENST00000323963ENST00000538831EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5CDS-intronENST00000440191ENST00000265028EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5CDS-intronENST00000440191ENST00000439351EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5CDS-intronENST00000440191ENST00000538831EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5UTR-intronENST00000356531ENST00000265028EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5UTR-intronENST00000356531ENST00000439351EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
5UTR-intronENST00000356531ENST00000538831EIF4A2chr3

186502266

+DNAJB11chr3

186314843

+
intron-intronENST00000323963ENST00000265028EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000323963ENST00000439351EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000323963ENST00000538831EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000356531ENST00000265028EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000356531ENST00000439351EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000356531ENST00000538831EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000440191ENST00000265028EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000440191ENST00000439351EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+
intron-intronENST00000440191ENST00000538831EIF4A2chr3

186502302

+DNAJB11chr3

186314843

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EIF4A2-DNAJB11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF4A2-DNAJB11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:186502302/:186314843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4A2

Q14240

DNAJB11

Q9UBS4

FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.FUNCTION: As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). {ECO:0000269|PubMed:10827079, ECO:0000269|PubMed:15525676, ECO:0000269|PubMed:29706351}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EIF4A2-DNAJB11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EIF4A2-DNAJB11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF4A2-DNAJB11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF4A2-DNAJB11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource