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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EIF4ENIF1-C22orf24 (FusionGDB2 ID:25995)

Fusion Gene Summary for EIF4ENIF1-C22orf24

Fusion gene summary

Fusion gene information	Fusion gene name: EIF4ENIF1-C22orf24
	Fusion gene ID: 25995
		Hgene	Tgene
	Gene symbol	EIF4ENIF1	C22orf24
	Gene ID	56478	25775
	Gene name	eukaryotic translation initiation factor 4E nuclear import factor 1	chromosome 22 open reading frame 24
	Synonyms	4E-T\|Clast4	HSN44A4A
	Cytomap	22q12.2	22q12.3
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic translation initiation factor 4E transporter2610509L04Rik4E-transportereIF4E transporter	uncharacterized protein C22orf24
	Modification date	20200327	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000330125, ENST00000344710, ENST00000397523, ENST00000397525, ENST00000382180, ENST00000441289,	ENST00000486651, ENST00000248984, ENST00000543051,
Fusion gene scores	* DoF score	5 X 5 X 5=125	3 X 3 X 3=27
	# samples	6	4
	** MAII score	log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EIF4ENIF1 [Title/Abstract] AND C22orf24 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EIF4ENIF1(31867830)-C22orf24(32330435), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EIF4ENIF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C22orf24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-XK-AAIV-01A	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
ChimerDB4	PRAD	TCGA-XK-AAIV	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-

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Fusion Gene ORF analysis for EIF4ENIF1-C22orf24

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000330125	ENST00000486651	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
5CDS-5UTR	ENST00000344710	ENST00000486651	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
5CDS-5UTR	ENST00000397523	ENST00000486651	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
5CDS-5UTR	ENST00000397525	ENST00000486651	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000330125	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000330125	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000344710	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000344710	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000397523	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000397523	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000397525	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
In-frame	ENST00000397525	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
intron-3CDS	ENST00000382180	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
intron-3CDS	ENST00000382180	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
intron-3CDS	ENST00000441289	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
intron-3CDS	ENST00000441289	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
intron-5UTR	ENST00000382180	ENST00000486651	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-
intron-5UTR	ENST00000441289	ENST00000486651	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000344710	EIF4ENIF1	chr22	31867830	-	ENST00000248984	C22orf24	chr22	32330435	-	1257	328	428	0	143
ENST00000344710	EIF4ENIF1	chr22	31867830	-	ENST00000543051	C22orf24	chr22	32330435	-	767	328	312	659	115
ENST00000397525	EIF4ENIF1	chr22	31867830	-	ENST00000248984	C22orf24	chr22	32330435	-	1323	394	494	0	165
ENST00000397525	EIF4ENIF1	chr22	31867830	-	ENST00000543051	C22orf24	chr22	32330435	-	833	394	378	725	115
ENST00000330125	EIF4ENIF1	chr22	31867830	-	ENST00000248984	C22orf24	chr22	32330435	-	1174	245	229	576	115
ENST00000330125	EIF4ENIF1	chr22	31867830	-	ENST00000543051	C22orf24	chr22	32330435	-	684	245	229	576	115
ENST00000397523	EIF4ENIF1	chr22	31867830	-	ENST00000248984	C22orf24	chr22	32330435	-	1126	197	181	528	115
ENST00000397523	EIF4ENIF1	chr22	31867830	-	ENST00000543051	C22orf24	chr22	32330435	-	636	197	181	528	115

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000344710	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.35368124	0.64631873
ENST00000344710	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.27252516	0.72747487
ENST00000397525	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.1630451	0.8369549
ENST00000397525	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.11046454	0.8895355
ENST00000330125	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.24847125	0.7515288
ENST00000330125	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.12369048	0.8763095
ENST00000397523	ENST00000248984	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.36708385	0.63291615
ENST00000397523	ENST00000543051	EIF4ENIF1	chr22	31867830	-	C22orf24	chr22	32330435	-	0.119861364	0.8801386

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Fusion Genomic Features for EIF4ENIF1-C22orf24

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF4ENIF1-C22orf24

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:31867830/chr22:32330435)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

1_24

986.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

1_24

812.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

1_24

986.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

148_210

986.0

Compositional bias

Note=Arg-rich

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

148_210

812.0

Compositional bias

Note=Arg-rich

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

148_210

986.0

Compositional bias

Note=Arg-rich

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

195_211

986.0

Motif

Nuclear localization signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

438_447

986.0

Motif

Nuclear export signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

613_638

986.0

Motif

Nuclear export signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

195_211

812.0

Motif

Nuclear localization signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

438_447

812.0

Motif

Nuclear export signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

613_638

812.0

Motif

Nuclear export signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

195_211

986.0

Motif

Nuclear localization signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

438_447

986.0

Motif

Nuclear export signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

613_638

986.0

Motif

Nuclear export signal

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

664_693

986.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

707_803

986.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000330125

922_953

986.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

664_693

812.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

707_803

812.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000344710

922_953

812.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

664_693

986.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

707_803

986.0

Region

Disordered

Hgene

EIF4ENIF1

chr22:31867830

chr22:32330435

ENST00000397525

922_953

986.0

Region

Disordered

Tgene

C22orf24

chr22:31867830

chr22:32330435

ENST00000248984

27_47

161.0

Transmembrane

Helical

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Fusion Gene Sequence for EIF4ENIF1-C22orf24

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>25995_25995_1_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000330125_C22orf24_chr22_32330435_ENST00000248984_length(transcript)=1174nt_BP=245nt
GGGGAGCGGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGT
ATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTC
TTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTT
TGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCA
CCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTG
CCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGC
CACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTC
ACCTTGGAAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGACGTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTG
GCCTTCACTGCGCAAAATGCAGCCTCTAAGAGCTGGAGGGGCCGTGCAGAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGG
CTTTATAAACCATAAAGCGCCCAACAGATGAGCATTCTGCCGACCCATTTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACAT
GCCTGCAGTGGGACAAGAAGACTGCTGACCAAGCCCGAACACTAAATCAATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAG
CGGGAGAGCAGAGCACTGGTGCCAGCCCAACCTGGACTCCACTCCAGGTTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCAC
TGCTGAGCCTCAGTCCCCCTTATCTGTGAAATGGGAATGATGCTTTCCTTGTAGCACTGCTGTGAAGATTCAATGAAACGAGTGATGCCG

>25995_25995_1_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000330125_C22orf24_chr22_32330435_ENST00000248984_length(amino acids)=115AA_BP=5
MKNMTGFSINLTSFGRIPWPHAGVGTCPSPQSWISPFLQSHREHHYAKTSSHSQPSPQSLALCLAYSRCSINICQMTECISLASGCHQAL

--------------------------------------------------------------
>25995_25995_2_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000330125_C22orf24_chr22_32330435_ENST00000543051_length(transcript)=684nt_BP=245nt
GGGGAGCGGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGT
ATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTC
TTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTT
TGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCA
CCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTG
CCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGC
CACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTC

>25995_25995_2_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000330125_C22orf24_chr22_32330435_ENST00000543051_length(amino acids)=115AA_BP=5
MKNMTGFSINLTSFGRIPWPHAGVGTCPSPQSWISPFLQSHREHHYAKTSSHSQPSPQSLALCLAYSRCSINICQMTECISLASGCHQAL

--------------------------------------------------------------
>25995_25995_3_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000344710_C22orf24_chr22_32330435_ENST00000248984_length(transcript)=1257nt_BP=328nt
GAGACAGCCCAAGCCGGTCGGGGTGGGGGCGCGAGAGCGAAGGCTGCGGGGAGCGGCGCTGGGACCGGTGCGGGCAGCGGGGAGGGGAGC
GGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTG
AAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATA
TAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGG
ATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTAT
GCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATG
ACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCT
TACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGG
AAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGACGTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTGGCCTTCA
CTGCGCAAAATGCAGCCTCTAAGAGCTGGAGGGGCCGTGCAGAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGGCTTTATA
AACCATAAAGCGCCCAACAGATGAGCATTCTGCCGACCCATTTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACATGCCTGCA
GTGGGACAAGAAGACTGCTGACCAAGCCCGAACACTAAATCAATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAGCGGGAGA
GCAGAGCACTGGTGCCAGCCCAACCTGGACTCCACTCCAGGTTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCACTGCTGAG

>25995_25995_3_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000344710_C22orf24_chr22_32330435_ENST00000248984_length(amino acids)=143AA_BP=1
MKKGRNPALWARAGAHSSVRPRDPSKRSQVDTETCHIFQKGMKASVWNGGVLLYPRVLLLYSDGGIWRQEASSGQGKHLHFLFHPYFSYP

--------------------------------------------------------------
>25995_25995_4_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000344710_C22orf24_chr22_32330435_ENST00000543051_length(transcript)=767nt_BP=328nt
GAGACAGCCCAAGCCGGTCGGGGTGGGGGCGCGAGAGCGAAGGCTGCGGGGAGCGGCGCTGGGACCGGTGCGGGCAGCGGGGAGGGGAGC
GGCGGCCGAGGCAAAGGGCCGCCGAGCGGCGGAGGCACCGAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTG
AAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATA
TAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGG
ATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTAT
GCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATG
ACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCT
TACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGG

>25995_25995_4_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000344710_C22orf24_chr22_32330435_ENST00000543051_length(amino acids)=115AA_BP=5
MKNMTGFSINLTSFGRIPWPHAGVGTCPSPQSWISPFLQSHREHHYAKTSSHSQPSPQSLALCLAYSRCSINICQMTECISLASGCHQAL

--------------------------------------------------------------
>25995_25995_5_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397523_C22orf24_chr22_32330435_ENST00000248984_length(transcript)=1126nt_BP=197nt
GTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCT
CCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTT
TCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCC
ACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCT
CGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCT
GAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTC
CTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGAC
GTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTGGCCTTCACTGCGCAAAATGCAGCCTCTAAGAGCTGGAGGGGCCGTGCA
GAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGGCTTTATAAACCATAAAGCGCCCAACAGATGAGCATTCTGCCGACCCAT
TTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACATGCCTGCAGTGGGACAAGAAGACTGCTGACCAAGCCCGAACACTAAATC
AATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAGCGGGAGAGCAGAGCACTGGTGCCAGCCCAACCTGGACTCCACTCCAGG
TTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCACTGCTGAGCCTCAGTCCCCCTTATCTGTGAAATGGGAATGATGCTTTCC

>25995_25995_5_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397523_C22orf24_chr22_32330435_ENST00000248984_length(amino acids)=115AA_BP=5
MKNMTGFSINLTSFGRIPWPHAGVGTCPSPQSWISPFLQSHREHHYAKTSSHSQPSPQSLALCLAYSRCSINICQMTECISLASGCHQAL

--------------------------------------------------------------
>25995_25995_6_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397523_C22orf24_chr22_32330435_ENST00000543051_length(transcript)=636nt_BP=197nt
GTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCCTTGACCTGAAGAAGCCT
CCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAACAGAGGCCTTCATGCCTT
TCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTGGGCACCTGCCCTAGCCC
ACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAGCCGTCTCCGCAGAGCCT
CGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCAGGATGCCACCAGGCCCT
GAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAGTCCTGACAGCCAGCCTC
CTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAAGCGGCCCCGTAATTGAC

>25995_25995_6_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397523_C22orf24_chr22_32330435_ENST00000543051_length(amino acids)=115AA_BP=5
MKNMTGFSINLTSFGRIPWPHAGVGTCPSPQSWISPFLQSHREHHYAKTSSHSQPSPQSLALCLAYSRCSINICQMTECISLASGCHQAL

--------------------------------------------------------------
>25995_25995_7_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397525_C22orf24_chr22_32330435_ENST00000248984_length(transcript)=1323nt_BP=394nt
GCGGGCGCCGGGGCGCCCGCAGGGGGTGGGCAGGGGCGCGAGGCCCGCAAGGCGGCCGGCGGGTAGCCGGCGGGCTGGCTGGCGGGGACC
GAGCCGCCGGGCCGGGGAGGACGGCTGCGGGCCTGCGCTAGCTCCAGCTTGAAGCGCCCGGGCCGGGAGATTCGGCCTCCCTCCTCCCTG
CGGCCGGCCGCCCCTCAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCC
TTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAAC
AGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTG
GGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAG
CCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCA
GGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAG
TCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAA
GCGGCCCCGTAATTGACGTCACAGCGGGGCCAGGAGCTGCCCTGTTAATATTTAATGTGGCCTTCACTGCGCAAAATGCAGCCTCTAAGA
GCTGGAGGGGCCGTGCAGAGTCTCCATGGGGTTGTGAGGAGGGCACAGAAGGGAAAGGGCTTTATAAACCATAAAGCGCCCAACAGATGA
GCATTCTGCCGACCCATTTCAGTCCCTGGCTTAACTCAGAAAGAGCCGGGGCTGCACATGCCTGCAGTGGGACAAGAAGACTGCTGACCA
AGCCCGAACACTAAATCAATGGGGGATTAGGGGCTCCTGGGTACATTCCATTGAGACAGCGGGAGAGCAGAGCACTGGTGCCAGCCCAAC
CTGGACTCCACTCCAGGTTTGCCCCCTGCACAGCTGTGTGACTGGGTCAGCAAGTGCACTGCTGAGCCTCAGTCCCCCTTATCTGTGAAA

>25995_25995_7_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397525_C22orf24_chr22_32330435_ENST00000248984_length(amino acids)=165AA_BP=1
MKKGRNPALWARAGAHSSVRPRDPSKRSQVDTETCHIFQKGMKASVWNGGVLLYPRVLLLYSDGGIWRQEASSGQGKHLHFLFHPYFSYP

--------------------------------------------------------------
>25995_25995_8_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397525_C22orf24_chr22_32330435_ENST00000543051_length(transcript)=833nt_BP=394nt
GCGGGCGCCGGGGCGCCCGCAGGGGGTGGGCAGGGGCGCGAGGCCCGCAAGGCGGCCGGCGGGTAGCCGGCGGGCTGGCTGGCGGGGACC
GAGCCGCCGGGCCGGGGAGGACGGCTGCGGGCCTGCGCTAGCTCCAGCTTGAAGCGCCCGGGCCGGGAGATTCGGCCTCCCTCCTCCCTG
CGGCCGGCCGCCCCTCAGTGCAGAGCATTGTAGACCAAGGAGCCATGGATAGGAGAAGTATGGGTGAAACAGAAAGTGGAGATGCTTTCC
TTGACCTGAAGAAGCCTCCTGCCTCCAAATGCCCCCATCGCTATACAAAAGAAGAACTCTTGGATATAAAAGAACTCCCCCATTCCAAAC
AGAGGCCTTCATGCCTTTCTGAAAAATATGACAGGTTTCAGTATCAACCTGACTTCTTTTGGAAGGATCCCTTGGCCTCACGCTGGAGTG
GGCACCTGCCCTAGCCCACAGAGCTGGATTTCTCCCTTTCTTCAATCACACAGGGAGCACCACTATGCAAAGACCTCATCACATTCACAG
CCGTCTCCGCAGAGCCTCGCACTGTGCTTGGCATATAGCAGGTGCTCAATAAATATCTGCCAAATGACTGAATGCATCTCGCTAGCCTCA
GGATGCCACCAGGCCCTGAGGGAGCCAGGAAGATCAGAGGAAAGCTTTTGGATTCCTGCCACACCTTACATTAGCAACATCTTCTCCGAG
TCCTGACAGCCAGCCTCCTGGGACACCATTCAAGCCAGCTGAATTCCGGTCACCGCTTCACCTTGGAAAGGCATCCGCAGCCCTCACCAA

>25995_25995_8_EIF4ENIF1-C22orf24_EIF4ENIF1_chr22_31867830_ENST00000397525_C22orf24_chr22_32330435_ENST00000543051_length(amino acids)=115AA_BP=5
MKNMTGFSINLTSFGRIPWPHAGVGTCPSPQSWISPFLQSHREHHYAKTSSHSQPSPQSLALCLAYSRCSINICQMTECISLASGCHQAL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EIF4ENIF1-C22orf24

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000330125	-	3	19	131_161	56.666666666666664	986.0	CSDE1
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000344710	-	3	17	131_161	56.666666666666664	812.0	CSDE1
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000397525	-	3	19	131_161	56.666666666666664	986.0	CSDE1
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000330125	-	3	19	219_240	56.666666666666664	986.0	DDX6
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000344710	-	3	17	219_240	56.666666666666664	812.0	DDX6
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000397525	-	3	19	219_240	56.666666666666664	986.0	DDX6
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000330125	-	3	19	448_490	56.666666666666664	986.0	LSM14A
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000330125	-	3	19	940_985	56.666666666666664	986.0	LSM14A
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000344710	-	3	17	448_490	56.666666666666664	812.0	LSM14A
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000344710	-	3	17	940_985	56.666666666666664	812.0	LSM14A
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000397525	-	3	19	448_490	56.666666666666664	986.0	LSM14A
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000397525	-	3	19	940_985	56.666666666666664	986.0	LSM14A
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000330125	-	3	19	695_713	56.666666666666664	986.0	PATL1
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000344710	-	3	17	695_713	56.666666666666664	812.0	PATL1
Hgene	EIF4ENIF1	chr22:31867830	chr22:32330435	ENST00000397525	-	3	19	695_713	56.666666666666664	986.0	PATL1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EIF4ENIF1-C22orf24

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EIF4ENIF1-C22orf24

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source