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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EIF4E-UBXN7 (FusionGDB2 ID:26001)

Fusion Gene Summary for EIF4E-UBXN7

Fusion gene summary

Fusion gene information	Fusion gene name: EIF4E-UBXN7
	Fusion gene ID: 26001
		Hgene	Tgene
	Gene symbol	EIF4E	UBXN7
	Gene ID	1977	26043
	Gene name	eukaryotic translation initiation factor 4E	UBX domain protein 7
	Synonyms	AUTS19\|CBP\|EIF4E1\|EIF4EL1\|EIF4F\|eIF-4E	UBXD7
	Cytomap	4q23	3q29
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic translation initiation factor 4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein	UBX domain-containing protein 7UBX domain containing 7
	Modification date	20200322	20200327
	UniProtAcc	P06730	.
	Ensembl transtripts involved in fusion gene	ENST00000280892, ENST00000450253, ENST00000504432, ENST00000505992, ENST00000504472,	ENST00000428095, ENST00000535858, ENST00000296328,
Fusion gene scores	* DoF score	2 X 2 X 1=4	8 X 8 X 4=256
	# samples	2	8
	** MAII score	log2(2/4*10)=2.32192809488736	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EIF4E [Title/Abstract] AND UBXN7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EIF4E(99823025)-UBXN7(196134267), # samples:1
Anticipated loss of major functional domain due to fusion event.	EIF4E-UBXN7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. EIF4E-UBXN7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EIF4E-UBXN7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EIF4E	GO:0006417	regulation of translation	22578813

Fusion gene breakpoints across EIF4E (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBXN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	DA724990	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-

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Fusion Gene ORF analysis for EIF4E-UBXN7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000280892	ENST00000428095	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000280892	ENST00000535858	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000450253	ENST00000428095	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000450253	ENST00000535858	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000504432	ENST00000428095	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000504432	ENST00000535858	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000505992	ENST00000428095	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5CDS-intron	ENST00000505992	ENST00000535858	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5UTR-3CDS	ENST00000504472	ENST00000296328	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5UTR-intron	ENST00000504472	ENST00000428095	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
5UTR-intron	ENST00000504472	ENST00000535858	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
Frame-shift	ENST00000280892	ENST00000296328	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
Frame-shift	ENST00000450253	ENST00000296328	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
Frame-shift	ENST00000505992	ENST00000296328	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-
In-frame	ENST00000504432	ENST00000296328	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000504432

EIF4E

chr4

99823025

ENST00000296328

UBXN7

chr3

196134267

10840

420

254

1816

520

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000504432	ENST00000296328	EIF4E	chr4	99823025	-	UBXN7	chr3	196134267	-	0.000201675	0.99979836

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Fusion Genomic Features for EIF4E-UBXN7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF4E-UBXN7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:99823025/chr3:196134267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EIF4E P06730	.
FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). {ECO:0000250\|UniProtKB:P63073, ECO:0000250\|UniProtKB:P63074, ECO:0000269\|PubMed:16271312, ECO:0000269\|PubMed:22578813, ECO:0000269\|PubMed:24335285}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000280892

37_40

238.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000280892

56_57

238.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000450253

37_40

218.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000505992

37_40

249.0

Region

EIF4EBP1/2/3 binding

Tgene

UBXN7

chr4:99823025

chr3:196134267

ENST00000296328

337_342

490.0

Compositional bias

Note=Poly-Glu

Tgene

UBXN7

chr4:99823025

chr3:196134267

ENST00000296328

285_304

490.0

Domain

Note=UIM

Tgene

UBXN7

chr4:99823025

chr3:196134267

ENST00000296328

408_485

490.0

Domain

UBX

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000280892

102_103

238.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000280892

132_139

238.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000280892

157_162

238.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000280892

73_77

238.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000450253

102_103

218.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000450253

132_139

218.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000450253

157_162

218.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000450253

56_57

218.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000450253

73_77

218.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000505992

102_103

249.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000505992

132_139

249.0

Region

EIF4EBP1/2/3 binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000505992

157_162

249.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000505992

56_57

249.0

Region

7-methylguanosine-containing mRNA cap binding

Hgene

EIF4E

chr4:99823025

chr3:196134267

ENST00000505992

73_77

249.0

Region

EIF4EBP1/2/3 binding

Tgene

UBXN7

chr4:99823025

chr3:196134267

ENST00000296328

2_54

490.0

Domain

Note=UBA

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Fusion Gene Sequence for EIF4E-UBXN7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26001_26001_1_EIF4E-UBXN7_EIF4E_chr4_99823025_ENST00000504432_UBXN7_chr3_196134267_ENST00000296328_length(transcript)=10840nt_BP=420nt
AGATCGATCTAAGATGGCGACTGTCGAACCGGGTGCTGTGAGGAAATGCATGGTTTGTTGAAAAGAACTGAGGACTGACAGCCGCCTCCT
CCATGATTACCCTGGCTCTCTGTCCCACCCTTCTCATGGCGCTTGGGGGACCATGGCTGATCCTGTCCTGAGACAAATTAAGACTCCTGT
GGTGAAGCAGTTGGTCGAGAAAAAGTGATGCATGAAAAAGAAGCAAAACAAGAAGGAAAGAAAAAAAATGAGAGCTGAAGATGGTGAAAA
TGATGCCATTAAAAAGCAGGCAGAAAGTCTGCGAGAATCCCAGGAAACCACCCCTACTCCTAATCCCCCGACTACAGAAGAGGAGAAAAC
GGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGGTGCAAGTGAAAGTGTAGGAAAACATATGC
TTGAAGCGTGCAACAATAATCTGGAAATGGCAGTCACTATGTTTTTGGATGGTGGAGGAATCGCTGAAGAGCCCAGTACCAGTTCAGCAA
GTGTCTCTACTGTCAGACCACACACAGAAGAAGAAGTTCGTGCCCCAATTCCTCAAAAGCAGGAAATACTGGTGGAACCAGAACCATTAT
TTGGTGCTCCTAAAAGACGACGGCCTGCACGTTCAATTTTTGATGGTTTCCGGGATTTTCAGACTGAAACTATTCGGCAAGAACAAGAAT
TAAGAAATGGAGGAGCTATCGATAAGAAATTAACTACCCTTGCAGATCTATTCCGGCCACCCATTGATTTGATGCATAAAGGCAGCTTTG
AAACAGCCAAAGAGTGTGGCCAGATGCAAAATAAGTGGCTGATGATAAACATTCAAAATGTTCAAGACTTTGCATGTCAGTGCCTCAACC
GCGATGTGTGGAGCAACGAAGCTGTGAAGAATATTATCCGGGAACATTTCATTTTCTGGCAGGTTTATCATGACAGTGAGGAAGGTCAGA
GATACATACAGTTTTATAAGTTAGGGGATTTCCCCTATGTTTCCATATTGGACCCACGGACAGGTCAGAAGCTAGTAGAATGGCACCAGT
TAGATGTATCTTCTTTCTTGGACCAAGTGACGGGATTTCTGGGTGAACATGGACAACTGGATGGACTTTCTAGCAGTCCCCCCAAAAAAT
GTGCCCGTTCAGAGAGCCTTATAGATGCAAGTGAAGACAGCCAGCTAGAAGCTGCCATCAGAGCCTCCTTACAAGAAACACATTTTGATT
CAACACAGACAAAACAGGATAGCCGCTCAGATGAAGAATCTGAATCTGAACTTTTTTCTGGCAGTGAGGAGTTCATATCCGTTTGTGGCT
CTGATGAAGAAGAAGAGGTAGAGAATCTTGCCAAGTCCAGAAAGTCTCCCCACAAAGATTTGGGGCATAGAAAAGAGGAGAATAGAAGGC
CGCTGACTGAGCCACCAGTCAGAACTGATCCTGGAACAGCCACAAACCACCAAGGATTGCCAGCTGTGGATTCAGAGATACTGGAGATGC
CACCTGAAAAAGCAGATGGAGTAGTGGAGGGGATAGATGTAAATGGACCAAAAGCACAGCTGATGTTGCGGTATCCAGATGGAAAAAGGG
AACAGATCACTCTTCCAGAGCAAGCTAAACTGCTAGCTTTGGTGAAGCACGTGCAGTCTAAAGGATACCCAAATGAACGTTTTGAACTTC
TCACCAACTTTCCTCGAAGGAAATTATCTCATCTGGACTATGATATTACATTGCAAGAGGCAGGCCTTTGTCCTCAAGAGACTGTCTTTG
TACAGGAAAGAAATTAACACCATGGCTTGACCTCTCTCAGCTTACCCCTTTTTTCCCTTTTCCTGTGAGATACATGTCACTAAGTATGCA
TTTTGGCTCATAGGACCACAGAGCCAAAGTTGGGCAAGCAAGTCACCTTCCTTCTCTTATTTCTTGATCTCTCCTATAATCAGTCTCTTT
CTCCCCCTTTGTTTCTTTCTCCTCTTCTGTTTTCTCGCTCCCCACTCCGTACCCTTCTGCCTCCCCCTCCCCCCACACTTTTCTTTCTTA
CCTAATCTGGTGACCAAACTGAAGTGTAAGGATAAGACCTCTCCTAGTACTAGCAGCAGGAATTGTGTGTTCCAGTAAGTGGTCTCTTGC
ACGGCACTTTTTTGGGATCAAATGTTAACGTTACTCCCCAGACTCTTCGGGCAAAGGAATGGCTAGATTCAGAGTAAGAACAACCCTCCC
TTTTTTGTAAGTCCCCGTGTTTAGCAGGGAGAAGAAATTCTCTAACATGGGTTTGGTTTTGTTGTGTTCTTCATGTGGAAATGTCGCTTA
ACAAAATATCCAGGCTTTTGTTTACGTGGAAAAAGCATCCCTTGTAATGATTGCTCATCATACTTAAAAACCTTTTTCAAAGGATTTTCA
TGTTCCCAGCTATAAGGACTATTTCCATGACATGTGTTATTGGCAGAATGAGTGTTAAATATGGAGCATATAGCATGGGGTGACTTTCAT
TGTCCTAACCTGAGACAGTTTTCCTTATTACTCTGTATTGATCCTGCTAGTCCAAGAATGGACATGAAGTGAACCTATCGTGGTGACTGG
GATAGGAAGGTGCTTGCTATTTTTGCCAGCACAGCATATTAGTTCCTTTGGAGCCCTCCATTGTCTGAGTCTGCAGTGATCTGTAGGAAG
GCAGCTGGTCAATAATCATGTAGTACAATGGCTTGGAATTGTAACCACTATGGTTATTGATTGTCCTGTGTTGTTTCAGGCATACTTAGG
TATGTCCCTGGGGAAAAAGAAAACCATTCAGCTGAGAGTTGCTAACCATGTTCTTTTGGTTAGAAATAATGGTTCATTTTTTGCCCCTGG
TTGGAATAGTCTCTAAAAGGCTCTGGTGACTGAATTGAACATGAGTCCGCATGCTGTTTTCTTTCAAAAGGTATCAAAACGGAAAGCCTC
TCTAAGGGGAAGACCTTTCAACTCCATTCAGAAGACAACATTTAGTAAGGAGGATGGCGGAGGTTACTAGTAATTTTCAGATGTCTTGGG
CTTTTTCTGCCAACAAAACCCAAAATCAAATTAGAGTTGGTGAAAGCTTTCTTCAGTGTTTTTAGAAGAGGCCATCTTGAATCTGTAGAA
TACCATTTACACATCAACTTCACCCTATGCTCATTTCGTATTTTGAGCTTAAATGGAGTCCTCTGAAGGGGGGGTAGTCGTGATTCTGGT
GGCAAAACTAGAACTTTTAACTTGTAAAATGAAAAATATTAAATGGACCTTTTTGTCAGTTGAGGATTTAGATTGATTCTTTTATCTGAG
GAGCGTATGTTCCTCAGATGTTGCGTAGAGACCTTTAGGTTTTCATCTACTTTAAGATTGCTCTCTTGGCAATTAGGGGATTTGGGAAAA
GAAGAAAAAAAGATGCCATGTGTTGCTAGTACACAGTTATAGGATATGGTTTCTAATGGTTGAATTTTGAGGAACTCTCCCTAAAGAATG
AGTTTTATATCTCCTCAAGGAAATCATGGAAAAATCTGTTTATTCTTCAGTGAGTCCTTTTGAATTAATGTTCTTAAATTTTTTTCTAAG
TCTGTGTAAGTGCTTATGTATAAGTATATAATTGTATAAATATTTATAAATATATTTATATAATTACGGTTTCATTTCTACCTTGAGTCA
AAGTTCTGTCTTTAGATTGGTGACTGAGTAATACTTACACTTTGGTGTTTTTTCTTAGGTTCTTGAGGCTTACTTAACTAGCAGCTTCTG
ATTTATTGAGTGAAAGATGGTTTTCATGTTAATTCCTCAGTTGCATCTCTGAACTTGGATAACATACTTGCCGTTTGAAAAATAGAGCTG
TATACTGTCAAAGGTGCACTGGAGGGTAAAACATTTGTTGGTAGTAGACAAGCTCAGAAATCCAAAAATTCAGGGAGGGCACAGGGTAAG
AAGAGAGGTTTGCTCAGCTTTGTGCTCTGATGGCACCCATCTGTACTCCAGCAAAGTCATAGCTGAAGCCCAAATCGCTCAAACGTGTGA
AGTCAATCATTTTTCCTATAGGGCTCTGTTTCCTTTTCTTTACCTTCTAGCTTCTCTTGATAAAACAGTTGGGAGAACTGCCAACGTGTT
CATCAGTGAGAGGGTGTGGTTCTTTCCGATATGTTCAGCACGTGCATATTCATTTATGAGAAACCAAAGTAACTTCTTCAACTCGGGTTA
CTGTGGGATGATTAAGTAGATATAAAGTGATTTAAAAGACAGCATGGTACTTTCACTCAGCTTAACATGCAGCTGGGATGTCTACAATAC
AAGATGTGGTGGGTTTTATTTTATTTTATTTTGAGGCAGGAGTGTAATTATCTTAGGGTTGATATAAAGGCCCATGGGAAGAGTTACGGA
TTGTACATGGGAAGAATCCATAAGGAGTATTGCCTTGCTCAAGAATTTAATCCGCTGACAGTATGCTTCTTCCAGTTTGCCTTACTTCCT
CTGCAAGTTTCTTTGCTCCTTAGGGCAGAGGTTTTATTGAATAGATTAAATGAGGTCAGTAAGATTAGTTAAAAATAGTCATTCCTTGTG
GGTGTTGGACACAGCTTGAAAGGAGTGTTTAAAAAAAAAAAGCTAGGGAGGAAAAGAACAAGAAAGATAGACTTCGAGAGTGATAAGAGA
AAAATACAGGGAGATGGAATGGAAACTACCAGGAAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCGGAGGTGG
GCAGATCACCTAAGGTCAGGAGATCGAGGCCAGCCTGAGCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTACCTGGGTGT
GGTGGCGTGCACCTGTAATCCCAGCTACTCAGAGGCTGAGGCAGGGGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAAGAT
CGCACCATTACACTCCAGCCTGGGCGACAAAGCGACACTCCATCTCAAATTTAAAAAAAAAAAAGAAGAAGAAGAAGAAAACTAGTGGGA
AAAAAGTGAGAGGAATACTTTTTTGAAATTGGTATCGGAAGGAACTGGAGAAGAGAAAACAACAGTGCCAAATGAGAAAAGAACAGGAAA
CTTAATACTAATTGGCATGCACCAGATACTTTTGTGTACATTTGCCTCTTCAATCTCCCGAAGAATCGTACAAAATGTATACTTTCTTCC
CATGTTAAGAAAACAGGTATAGAGAACTTATTCAGGACTCATAGCTAGTGAGTGGCAAATCAGAATTGGAATCCAGAGTCCATGCTGTGG
TCTCCTTCAGCAAGAGAATCAAGCTACCCAGATGATTCTCTTCTCATTGTTTGGCTTTGTAAAGTGTCACTTAGTTTTGTTCCCATAAAT
ATAGAGGAAGTAGTTGGGTTAAAGTTGTGGGATTTGCACTATGCCTATACATTTTTATTTATGCCATTATTTTGAGAGGCTGATTATTGC
TTTTTTAAAATGATGCACTGGTGAAGATGTGAAAGTAAAATTGCCACGTGGCATTATTTGCCAAGAATAAATGAAAAGGGTAAAAAAACA
ATTTTTTCTTTTTTTAAACATTTTTCAGAAAAGATACAATTACCTTTTTTAATAGGTGAGCGCCACCACGCCCGGCTAATTTTTGCATTT
TTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGATCTCGTGTTCCGCCCACCTCGGCCTCCTAAAGTGCTGG
GATTACAGGCATGAGCCACTGCGCCCGATCTACAATTCTGTTTTCTGTGTCCCATCCATACCAGATTATTGAACCCTCTGTGTGTATGTT
TTTAAATCTTGTATATAATTCTACTTCCTTGACTTACAAGTCAACAATTAGCTATTGAGTTCTTTATAGAAGTTGGAAGTATTTTGAAAT
CTGAGATCTAATTCCTGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAATATTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTTGG
GAGTTCGAGATCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTGAAAAATACAAAAATTAGCCAGGCATGGTGGCTGTCTGTAATCC
CAGCTAATGGGGAGGCTGAGGCACAAGAATCTCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCATCC
TGGGCAATGGAGCGAGACTCTGTCTCAAAAAATAATAAATAAGATATGATTCCTGCCTGTTTTATCCAGTTAGAGAGACACACTACACAT
GAAATAATTGGAGAGCATGTAAATGTTTACCTATTAGTTCAAACTTAGAAAAAGGGAAGAATATGTTTTAGTTAGCAAAGTCTTAAACAA
GACTGAAGTGGCAAGCACTGTAGCTCACGTTTTCTTTTGACTCACCTTTTTCTTTAGCTCCACCTTTTGTAACTTCTAGATTTGGGGCAT
GAAGTTCTGCCACTAAGGCATAACCAGTACCCAAGTAGGAAAGGATTATTGATCCCTGGAGTAAAGATTCCTAGCTTGCGGGGATCTCAC
TATTGATCCCCCGGAGTAAAGATTCCTAGCTCGCAGGAATCTTACTTGCACACTTAGGGAAAATACCAGAGGGAGCCACTAGCAACCGAA
AAATGAAGGAAAGATTTAATTTCTCTACCCAGGTACAAATCCAATGCATAGTATAGTATATGTTATATGCAGAAAGGGCACTGGAGGTGT
GAGAGCCCTTTGGGTAACAGCTCTGCTAGTTGTTACCTTCACACTTCTCTTTCTTCTTAATCTCTGGTTTCTCGTCTGAAAAATGAGATA
ATTGGACTAGATTAATAGTTCTCAGCCTTTTCTAGAACAACAAATTAGATTATCTCTGAAGTCCTTTTCCAAAATTTCATGCTTCCAGTC
TCTCCCCGTGATTGCGTATTATCCCTAGGCTAATTAAAAGTGTGCTGGTTAATCAGTTTCTTTACTTTTTTTTTCTCTCTTTTTTTTATT
CTGTGTTCAGGTATCATTTGACCAACAACTTGCTCTTAATCTTACTGCGATGACTGAAATCTCCAAAGAGGAGAGTATAGTAGTTATAGG
TCTAGTAATAATAATCTTGTAAACAATTCATTATTTTTTAAAACTTAATGCTGTGTGCCTAATCAGTGTTGAGTATGACTAAAATGTAAA
TGAGAACCAAATATGACACTAACGCTGGCACTAAATTTTATTTTTACTTGTGTACTTAAAGTACTTTACTGGCCTGTTGGGAAATTGATT
TGTATAAGATTCACACCTGGTTTTGGCAGAAACAGCTTTTTAAAGATACAATTAGGCTGACTTAAAAATGTTTTTTATTCCACAGAATGT
ATCTTTATTATGTCATTCTTACCGTCTCTCTGCCTTTTTTGACCATCATGTAACTACGCAGTAGTAAATCATGGGGTGCAGGCTGATGAA
TTAGTAGTCTTTGTAAAACTAAAATGTAATGAGCATAGGAAGAGACAGCTCTTCTGGTGAACATGGCAGTTTTCCGGTAATACCAGCCTT
GATGAATAGGCTAAAGACAGCTGTGTACTATGGACATTCAACTTCACTGGATTGCCTGGCTTAGCTTTTCAGTTATTGTCTTGCCGTGAA
ACATGGTGTTGCACTGTACACATTTTAGAATAGTGGCAAGAATGTTCTTTAGAACTGCAGATAACCCAACAGAGAATACCATACCAATAT
ATCGGTTTCTCCTGTTACATAGAGATTTGGTATTTCAGTGATGGTTATGGTTTTTGACTCACCTGTGTGTCAGTCCTGCTAGAGAGACAG
TATAGAATCAAGAATTTCTTGATGTCTTTTTAAAAATAGAGATTATAATGGCCTTGCTAGTTGTCCTGTGAAGTGACAGACCCTTAATTA
GAAATCTTTTAATCCTGCTTTCCATTTTACTTCTCCACCATTTATTTTTAACATTCATTCTCTGAAAATAGTTATGATTTTTAGTGTAAT
TGGCTATGTTTAAGAAATTCCATTTCAAAGTCTTAATATGTAACAATCTTCATTTTTTATAAAATTGAAGGACATTTTTGAGGCAAACTT
ACTTTTATAGCTCATTTTCTCCCTAGTTAAGGAGAATTCTCTGGTTTCATATAGAGAATGGCTAGCTCTGTGATACCCCACCCTCTTTGT
GGCCTACCAGTTGCTGTTGTGTTGCTTAAAATTGCAGATATTCTCATAAACATGATGATTTTTGGCACAGGCCTTTCTTTGCTATTGATT
TCAAAATAAAGTTGGGCAATCCAATTTGAACTACTTTAATAAACATAATTTAGCATTCCTGTAATGAGAAAGTATTTTCAAAAGATAACC
AGATTTATTTCTAGGATTAGAGATGGCAAATACCAATGATAGTATTTTTCCCAAGAGCAATCACAGATTAATCTATAAATATGAGAAGTC
GCATTATTGTACTTAATTCTTTGGCAACAAACAGCAAGTTTTTATTGTTTAATTGTATTTCCTCTCTAGAGATCACAATACTCTGGGTAT
TTTATATCCCTTCTAAAGGTCATTTGGGTTTTCAAATGGGAAGAATAGTCAAGCTAAGCTGGACTAAACCTAAGTAATATTTTTTCTCAT
CAAAAGAAGTTATTAATCTAACTGGGTTAGCATGAGTCATTCATTTTTTAGACATGATAAATGGGAAACATATCAAATCATTAGATAAAT
TCTGACCTGGAATTGAATTCCCCCTTTCTTAAAATCTTTTTAATTTGCTTTTTTCATAGACTCAGTATGGAACTCTTAACTGATAAGGGA
GAGATTCTTGATCTGGAACCGTTCCCTGCCATTCTCCTTTTTTCTCTCTATCTAGGTAGCTGGTTCCATAGTGCCCGTCACGAGGGTCCA
TTTCAGTTTGATGACATTAGACTGCTTACACTCAGCTGGATGCCTTGCTGTTTGCAGCAACATGATTTTACAGTATGCTTTTCTCAAAGC
TTTGCATTCTTAATGGAGATATCAAATGGTGTAATTCCAAATATAAATATGTTTATGACACTAATCATATGCTTTTAACAATAACTTTTT
GATAACTTATTGCCCTGTAAGTTAAACCTTACACGGAGTGACTGTTGCCATCAGAAAATCCCCTTTCACCTGCTAGAGAGAGTGAAAGTA
GTGCGTGGCCTCCACTTTTCAGTTAACGAGTAGCAAGCTTCTAGTAGGGGCTGCTTATCTGACCCATGTGGGGTCTTGGGCCTTGTTACT
TTCCTGGGTTCGTCCCTTCAGCTGGAAAGGCTGTTGAAAACACTTGCCAGGAAACAGTAAAGCTGTGAGAGAATCTTCTAGTCTTAGATA
TAGAGAAATGAGTACCAGTTGATGCTAACACGATACTTAGACTTTGAGGGGCTTCCATCCAAGCTTTGGCATGAATCTGTTAGACACGGT
TTTCTTCACTCCTCTGATAATCTTTTTTTCCAGAATGGTTTTTTGTTGTTGTTGTTGTTAACAAATTCTAAACATCCAGTGTTACTTTTT
GTTTTGTTTGTTTTGTTTTGTTTTGTTTTGTTTTGTTTGCCCTTCAGGAAAGTCCTTTTTCGAGTAGGTATTGATTGTTCCCTGGAAACT
CTCAGCAGTGTCTGTGCAGGCTCTGTGCATGCTTTGTATGAGTTCGGCTTGAACAATGCATTTGAAGTCACCTGGGATGTCCAGTTCTGG
CATGTCTTCATTGATTGTGTTTTTAAACATGTTTCATGTTTCATGTCATTTTCCAAACCTCACTTTACATCTTACTCAGAGAAGTTAATC
AAGGAATGAAATTTCTAGGGGGATAGGGATGATGAGGGTGGGTTGGGGGCTTGAGTGAAGTCAACTTGGGGTATTTGCTTTAAAGTGTTT
TCTAAAGCAGTTCCTAACAGTATTTAGAGATTCCCTGGGATGTTTGTGGCTCAACTTATTCTGGACAAAGTGTGTGTGGGGGTGGTCTTA
CTGAGATTTGCATTCTTAATGCAGGACAGGCTCTAAATTTCATCTGTACTCTAAATTTGTGATTGAATCCAAGAAGATAACAGAGACAGT
GCTCCTGTTGTAATGTTTCTGGCAAGTGCTCCCTAAAATGCACATCGAATTCTGTTTTCTGGGCCTTTTCTCCAATGGTGCTAGGAGATA
CCGTTGATTTCTGCAGCTCTTCTCAGTGGTGGGAAGAAGTCTTTGGGATTGTTGAGCAAGGGGCAGCTGGACCATCCACTAAATTTTTTT
GTTCAAGACACATTAGAGACCCTCCTGTATATCTAGTAAGTCATAATAAAGGTGCTTGGGAAAGCCTTAAATTTGAAGACACATGGAGGC
GGTAGAAAATTAAACTTGTAAGAGGAGAAAAACATGCCATTAGGTAACGCAGAGTTGTAACTACTGGCTAAGACTCAATGGAACTTCCAC
TTGCTCTAAAACCAGGGAAATCTTAGATAACTGGGTGTGATCTACCTATAGATCTACCTAGTCTATAGGTAATAATTTCCAGAAGGAGGA
TCTTGCTGTCAGTTGGGGATCCTCTGGTTTGGTCTGTACCAAATTGTGAATACTCTTGCTGTGTTGTACCCAGTTGCTTTATATTAATAC
TGCAACTTGAAACGGGGAGGGTGGGGGGACAATGGGGTGGGGGAGGGAAGGGAGTGGGACGATAAGTCTTTTGAAGACATCAGCTCACTG
TGCTGAGAGAGGGACCAAACTCAAGGAAACCTCTGATCTATACATTCAACTGCTGCATTTTTTTATAAATACATGTAAATGTCCTGTTGT

>26001_26001_1_EIF4E-UBXN7_EIF4E_chr4_99823025_ENST00000504432_UBXN7_chr3_196134267_ENST00000296328_length(amino acids)=520AA_BP=55
MKMVKMMPLKSRQKVCENPRKPPLLLIPRLQKRRKRNLIRRLLTQNTILNIPYRTGASESVGKHMLEACNNNLEMAVTMFLDGGGIAEEP
STSSASVSTVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRRPARSIFDGFRDFQTETIRQEQELRNGGAIDKKLTTLADLFRPPIDLM
HKGSFETAKECGQMQNKWLMINIQNVQDFACQCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQFYKLGDFPYVSILDPRTGQKL
VEWHQLDVSSFLDQVTGFLGEHGQLDGLSSSPPKKCARSESLIDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESESELFSGSEEF
ISVCGSDEEEEVENLAKSRKSPHKDLGHRKEENRRPLTEPPVRTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRY

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Top

Fusion Gene PPI Analysis for EIF4E-UBXN7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EIF4E-UBXN7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EIF4E-UBXN7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source