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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF4G1-NCOR2 (FusionGDB2 ID:26010)

Fusion Gene Summary for EIF4G1-NCOR2

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G1-NCOR2
Fusion gene ID: 26010
HgeneTgene
Gene symbol

EIF4G1

NCOR2

Gene ID

1981

9612

Gene nameeukaryotic translation initiation factor 4 gamma 1nuclear receptor corepressor 2
SynonymsEIF-4G1|EIF4F|EIF4G|EIF4GI|P220|PARK18CTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1
Cytomap

3q27.1

12q24.31

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 1EIF4-gammaeIF-4-gamma 1eucaryotic translation initiation factor 4Gnuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor
Modification date2020031320200313
UniProtAcc

Q04637

Q9Y618

Ensembl transtripts involved in fusion geneENST00000319274, ENST00000342981, 
ENST00000346169, ENST00000350481, 
ENST00000352767, ENST00000382330, 
ENST00000392537, ENST00000414031, 
ENST00000424196, ENST00000434061, 
ENST00000435046, ENST00000411531, 
ENST00000427845, ENST00000441154, 
ENST00000356219, ENST00000397355, 
ENST00000404121, ENST00000404621, 
ENST00000405201, ENST00000429285, 
Fusion gene scores* DoF score14 X 18 X 8=201619 X 18 X 11=3762
# samples 1819
** MAII scorelog2(18/2016*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/3762*10)=-4.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF4G1 [Title/Abstract] AND NCOR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF4G1(184052769)-NCOR2(124824735), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4G1

GO:1905612

positive regulation of mRNA cap binding

23409027

HgeneEIF4G1

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027


check buttonFusion gene breakpoints across EIF4G1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NCOR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3516-01AEIF4G1chr3

184052769

+NCOR2chr12

124824735

-
ChimerDB4COADTCGA-AA-3715-01AEIF4G1chr3

184052769

+NCOR2chr12

124824735

-
ChimerDB4COADTCGA-AA-A00J-01AEIF4G1chr3

184052769

+NCOR2chr12

124824735

-
ChimerDB4UCECTCGA-D1-A175-01AEIF4G1chr3

184052769

+NCOR2chr12

124824735

-
ChimerDB4UCECTCGA-D1-A17D-01AEIF4G1chr3

184052769

+NCOR2chr12

124824735

-


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Fusion Gene ORF analysis for EIF4G1-NCOR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000319274ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000319274ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000319274ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000319274ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000319274ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000319274ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000342981ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000342981ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000342981ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000342981ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000342981ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000342981ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000346169ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000346169ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000346169ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000346169ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000346169ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000346169ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000350481ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000350481ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000350481ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000350481ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000350481ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000350481ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000352767ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000352767ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000352767ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000352767ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000352767ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000352767ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000382330ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000382330ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000382330ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000382330ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000382330ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000382330ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000392537ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000392537ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000392537ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000392537ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000392537ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000392537ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000414031ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000414031ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000414031ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000414031ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000414031ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000414031ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000424196ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000424196ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000424196ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000424196ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000424196ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000424196ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000434061ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000434061ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000434061ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000434061ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000434061ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000434061ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000435046ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000435046ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000435046ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000435046ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000435046ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
3UTR-3CDSENST00000435046ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000411531ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000411531ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000411531ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000411531ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000411531ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000411531ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000427845ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000427845ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000427845ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000427845ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000427845ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000427845ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000441154ENST00000356219EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000441154ENST00000397355EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000441154ENST00000404121EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000441154ENST00000404621EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000441154ENST00000405201EIF4G1chr3

184052769

+NCOR2chr12

124824735

-
intron-3CDSENST00000441154ENST00000429285EIF4G1chr3

184052769

+NCOR2chr12

124824735

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for EIF4G1-NCOR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF4G1-NCOR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:184052769/:124824735)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G1

Q04637

NCOR2

Q9Y618

FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). {ECO:0000269|PubMed:29062139}.FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:23911289}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EIF4G1-NCOR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EIF4G1-NCOR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF4G1-NCOR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF4G1-NCOR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource