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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EMC2-MTA3 (FusionGDB2 ID:26369)

Fusion Gene Summary for EMC2-MTA3

Fusion gene summary

Fusion gene information	Fusion gene name: EMC2-MTA3
	Fusion gene ID: 26369
		Hgene	Tgene
	Gene symbol	EMC2	MTA3
	Gene ID	9694	57504
	Gene name	ER membrane protein complex subunit 2	metastasis associated 1 family member 3
	Synonyms	KIAA0103\|TTC35	-
	Cytomap	8q23.1	2p21
	Type of gene	protein-coding	protein-coding
	Description	ER membrane protein complex subunit 2TPR repeat protein 35tetratricopeptide repeat domain 35tetratricopeptide repeat protein 35	metastasis-associated protein MTA3metastasis associated gene family, member 3
	Modification date	20200313	20200313
	UniProtAcc	Q15006	Q9BTC8
	Ensembl transtripts involved in fusion gene	ENST00000220853, ENST00000520294,	ENST00000405094, ENST00000406911, ENST00000407270, ENST00000472767, ENST00000405592, ENST00000406652,
Fusion gene scores	* DoF score	5 X 4 X 3=60	10 X 10 X 5=500
	# samples	5	11
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/500*10)=-2.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EMC2 [Title/Abstract] AND MTA3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EMC2(109455927)-MTA3(42946128), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EMC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MTA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-A4MH-01A	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+

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Fusion Gene ORF analysis for EMC2-MTA3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000220853	ENST00000405094	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
5CDS-intron	ENST00000220853	ENST00000406911	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
5CDS-intron	ENST00000220853	ENST00000407270	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
5CDS-intron	ENST00000220853	ENST00000472767	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
In-frame	ENST00000220853	ENST00000405592	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
In-frame	ENST00000220853	ENST00000406652	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
intron-3CDS	ENST00000520294	ENST00000405592	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
intron-3CDS	ENST00000520294	ENST00000406652	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
intron-intron	ENST00000520294	ENST00000405094	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
intron-intron	ENST00000520294	ENST00000406911	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
intron-intron	ENST00000520294	ENST00000407270	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+
intron-intron	ENST00000520294	ENST00000472767	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000220853

EMC2

chr8

109455927

ENST00000405592

MTA3

chr2

42946128

3883

3626

3000

208

ENST00000220853

EMC2

chr8

109455927

ENST00000406652

MTA3

chr2

42946128

3883

3626

3000

208

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000220853	ENST00000405592	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+	0.82756096	0.17243907
ENST00000220853	ENST00000406652	EMC2	chr8	109455927	+	MTA3	chr2	42946128	+	0.82756096	0.17243907

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Fusion Genomic Features for EMC2-MTA3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EMC2	chr8	109455927	+	MTA3	chr2	42946127	+	1.91E-05	0.9999809
EMC2	chr8	109455927	+	MTA3	chr2	42946127	+	1.91E-05	0.9999809

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EMC2-MTA3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:109455927/chr2:42946128)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EMC2 Q15006	MTA3 Q9BTC8
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269\|PubMed:29242231, ECO:0000269\|PubMed:29809151, ECO:0000269\|PubMed:30415835, ECO:0000269\|PubMed:32439656, ECO:0000269\|PubMed:32459176, ECO:0000305}.	FUNCTION: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. {ECO:0000269\|PubMed:12705869, ECO:0000269\|PubMed:15454082}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000407270

148_259

516.0

Domain

ELM2

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000407270

1_147

516.0

Domain

BAH

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000407270

266_318

516.0

Domain

SANT

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000407270

379_406

516.0

Zinc finger

Note=GATA-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EMC2

chr8:109455927

chr2:42946128

ENST00000220853

155_188

298.0

Repeat

TPR 2

Hgene

EMC2

chr8:109455927

chr2:42946128

ENST00000220853

192_225

298.0

Repeat

TPR 3

Hgene

EMC2

chr8:109455927

chr2:42946128

ENST00000220853

87_120

298.0

Repeat

TPR 1

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000405094

148_259

508

595.0

Domain

ELM2

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000405094

1_147

508

595.0

Domain

BAH

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000405094

266_318

508

595.0

Domain

SANT

Tgene

MTA3

chr8:109455927

chr2:42946128

ENST00000405094

379_406

508

595.0

Zinc finger

Note=GATA-type%3B atypical

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Fusion Gene Sequence for EMC2-MTA3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26369_26369_1_EMC2-MTA3_EMC2_chr8_109455927_ENST00000220853_MTA3_chr2_42946128_ENST00000405592_length(transcript)=3883nt_BP=75nt
GCCCTCTCACCCCGCTGCCTCTAGGTTCTGGGAAGATGGCGAAGGTCTCAGAGCTTTACGATGTCACTTGGGAAGATGCAGACAGACATG
CTGAACTATCTGGAAGTCCACTGAAAAGCAAAAGCACTAGGAAGCCTTTGGCATGTATCATTGGGTATTTAGAGATCCATCCTGCAAAGA
AACCTAATGTAATTCGATCTACACCAAGCCTGCAAACCCCAACTACCAAGCGGATGCTAACAACTCCAAATCACACATCTCTGAGCATTC
TGGGGAAAAGAAACTACAGTCATCACAATGGTCTGGATGAACTCACGTGCTGTGTGTCAGACTGAGCTTTCCCTGATTCATTCTACAATC
CAAGACTTGCTGCACTGTCCTGCTGATGTTCACAGCCGTGCCTGGGAAGAAGGCAGCCCCACTCCCAGTACATTTCAGTGGGAGACCTCT
GCGTGCATCCATGGAGACGCAATGGGGCGGGGAAGGAACTGTGGGAGTGCACGTTCCAAATCCTGTGTCTCCACGTGTGGATCAGCAGCA
CCTCGCTTTCTTGTCAGAGACCTCGCTGTTACGGAGCGAGACCTGCTGAGAATTGAGGGGCTGAGGGAACCCCTCCACCTCCTCCCTTCT
GCAGCGCCCTGCGCCCCACCCAGCAACAGCGGCCACTTGGCAGTGGGGCTGCTGCAAGCTCAGAGCCGCTGCCACCCTGCATGTGTCCGC
TCAGCTCGGTCTTATGCTGTATAGTTACTAAATATGTACAGGAGGGCCATGGCATCTTTCTGAATGGATTTTTCTTAAGAAATGCGCCAG
TGTTTATGAGGTTCAAGGTATTTCCCTGTCCTTGCTGTTACCGTCACTCAGCTTTTTCTCGATAGGCTTCATCCTTGTTTTTTTGAAATG
GGGGAATTTGCTGTTTACCCTCTGCATTCCTATATGTGACCCTCCCTCCTACTCCTCCAAGGAACAGAATTACCGAGGTTCTGACAAAAG
ATAAGCCTGTAAACTCATCATCTGTGTTTTGTGGTTGGAGAGAAACTGGTGTTCTGCCCGGCTCTGCTTGGTCACAGACAGCTCCAGCAA
GAGCAGTTGTTAAAAGTGCCAAGCGTGTGTATCACTGTGACAAGCCGTTTGCTTACTGCCCTGTTCCCTTGCAGCCAAACCAGCTGATGA
AGAACTGCTGCCAGGTGGGTCCTACAGCAGGTCACAAATGACCTAGTTTCATTTTAAGCAGACAGACTCTGTTTGGCCTAGAGGTGTGGA
GTGAGAGAACTGTGTTTGTGGGTATGAGTCTGTGTGGCCAACCCCATGACCCCCACCCCTCCAGCCCAACATCTTGTGAGCACATGTGAC
CTAGGCCCCGGGGGACCTGCCTGCTCCTTTGGCTTGGGCTCTTCGTGTTTCCCACCTGCCCTCGGCACGAGCCCTTGGTGGCATCACAGT
TGGCCACTCAGCTGTGCTGAGTAGCTGTGCTACTTGTGCTGGCAGCTGCAAGGATAGGAATAGCTCAGCGCCCGATGAGCTCCCTGAGCA
GATGTGAGGCTGGCAACTCCCCTGCCCTCTGTTTGCAGGCACAGGGTCACAGTCCCAAGAAAGACAACTGGAGTCTGATCTCCCAGCCAT
CTCTGGGGTTACTAGGAGGCAGCTGGATGGCAGATACGAGAGGCCCAAATAGCCAAGCTGTTGCAAGACAGAGTGGCTACAATTGAATTG
ACACCCTGGGAAGCACGAGGTAACTTGGTAAGGATAATGATGCTGTAGATGTCTGTGTCCTCGGAGGCTGAGCTCCGCTTGGCAGAGAGA
GCGTGCTGTGTGAGGTGGAGGGCGGTTTTGCAGACATCTCAGCTTCTTTTCTGAGGAGGAGTTGGTTCTCATCTTAGGCTTCTGCAAGGG
CGAGCATGGGATGTCTCCACCACCACCCACTCTTGGAGCTGTGCTGGGTCTTGGCTTGGGGCGCTGAGGGTGGGGCCTGTGTCAGAAGCA
TTTGGTGAGAGGGGTGGAGGTGGCAGGCAGGGGTTCTCCTCAGGGTTCCCACTGAGGGGTCCCTTCAGCAAAGACCTGGGAGGAGGTGCC
GCATCACGTGGATGTTTCTTCCCTAAAGAAAAAGACACAGGAAAGCTGTCTGTCTGTACCCTGCTCTGGATTTATTGTCGTACTTGGACC
CAGAAGGGGAAATGATTCCCTCACCCTTTCACTTTCTCTCTGAACCCCTACTAAGTGGTGACTGCAGATTCTGGAAACAATTAGCTGCCC
GTGACTCAGCTGCCAGCTTCATTTTCTCTGCCTTTTGGGAGAGGCCCTCTCACCCAGGCCCAAGAGATTTGGAGACAGGAGTCAGGCCAG
GTCTGAAGCAGGAGAAGGGAGGCCCCTCCTATCTACCCAGTTGACATTTGGCTTTGGGAAAAGCGCAGCTTGTTCGAGCCACGTGTGCCA
AGCAGGCTTTTCCTTCCTCTTGTAAGTAAAGCTCGTGGTTCTGTAGTCCAGTCATCCTAGGAGGGTGATGTTGACTGAGACTTCACGCTC
TCCCTTTGTCTCTGGAAACTGCCCCCTCGTTCTGACAGAATCCCCCAGGCAATGGAGGAAGGGTGCCGAGGCGCCTCTAGTCTGTGCCTT
TGCCGTTGGAAGCATTTGGTGCTGAGAGGGTTTCCCAGCCACCCGCTCCCTTTCTGGGGCCATGGTGTCCCTGCTGTGTGTCAGTGGCAT
GTCACTGTGGTTCAGTGAGCACATGGGTGGACGTGCAGAGACTGTCTGCGCAGCCCCCAGCAGACATGCCCCTGGGGTGAGGACACAGGC
TCTGCAGGCTATCTCCCCCTCTGGCTCAGTCATCGCCTGCCCACCCTTCACTTCTTAAAGGTGCGCAAGAGAGGAGGGCCGACTGGAGGG
TGTCGCCGGAAGGTTTCAGCCTGCCCTTCACAATTCCCCTTGTGCACAGCCCAGTTTCCATCTCTCAGGGCCCACCCAGGAAAATGGATT
TCAAGTGGGGGTTTTCATCCAGAGATTTGTTTAACACAAAACAAGAAAAGCTGAGAGGCAAAACAGGGGAGTGAGGGGCAACCCAGAGGT
GGGGAACAACAACAGCAAGCCGCCCCCATCCTGAGACTGGCTGGGCACCAGGGGAGGACGCGTCACCAGAGCCTGGGGCCAAGGCCACTG
GGGGACCTGCCACACTGTGGACCTGTCTGGTGGGGGCTGGAGCCTCGAGAAGCCATGATTCTTGTCAGAAACATTTCCCCAGGCAGAGAG
AGGGGGCCCCAGCCTCTCCCCTCCTCTTGGCCTCCAGAGTCCTGCAGGTGCCTCACAGTAGTGAAACCCAGTTGGAAGCAGCTGCCCTGG
GAGCCTGGGACAGGCGACCCACCGGGTCAGTCCCCTGCCACTCAGAGCAGAGCAGGGGGCTGAGGGCAAGCAGGTGGGGCTGTGCGTGGC
CTCAGTGCACTCGGTGTCATGTCTGAGCCTGGTGTTTATGCCCCACTGCTGTCCTAAGTCCCTGGCGAGGGGAGGTGGAGGAGCTGCCCC
GTGGGTGTTTGGAGATTCTGTTTTACTCTGCCTAGAGAGGAAACGGCTTTGGGGAGGGAGGGGGAAGCCTTTATTCTTTACTGTTGTCCC
TGTTTTCCTTTGGGGGAATTTACTCAGTTAGCAGCCCCTCCTCACCATTCCCCCCAGGAAGGCCATGTCCCAGTTTTCTGTCCACCCCTC
CTGTTCCTCTGCACTATGTCTCTGATTTTCCCTGCCAGGGAAGCTAACCCAGAGCACGCACCTGTGCTCATGAGTGTTTCCGCAGGATAA
TTCGTTCTGAGCATGATACCACAGTGTGGATTGTCTGTCTGTAAGGAGATGCCATCTACTAACCAATTTGTATTGTGTTTCCAATAAATT

>26369_26369_1_EMC2-MTA3_EMC2_chr8_109455927_ENST00000220853_MTA3_chr2_42946128_ENST00000405592_length(amino acids)=208AA_BP=
MSKFPQRKTGTTVKNKGFPLPPQSRFLSRQSKTESPNTHGAAPPPPLARDLGQQWGINTRLRHDTECTEATHSPTCLPSAPCSALSGRGL
TRWVACPRLPGQLLPTGFHYCEAPAGLWRPRGGERLGPPLSAWGNVSDKNHGFSRLQPPPDRSTVWQVPQWPWPQALVTRPPLVPSQSQD

--------------------------------------------------------------
>26369_26369_2_EMC2-MTA3_EMC2_chr8_109455927_ENST00000220853_MTA3_chr2_42946128_ENST00000406652_length(transcript)=3883nt_BP=75nt
GCCCTCTCACCCCGCTGCCTCTAGGTTCTGGGAAGATGGCGAAGGTCTCAGAGCTTTACGATGTCACTTGGGAAGATGCAGACAGACATG
CTGAACTATCTGGAAGTCCACTGAAAAGCAAAAGCACTAGGAAGCCTTTGGCATGTATCATTGGGTATTTAGAGATCCATCCTGCAAAGA
AACCTAATGTAATTCGATCTACACCAAGCCTGCAAACCCCAACTACCAAGCGGATGCTAACAACTCCAAATCACACATCTCTGAGCATTC
TGGGGAAAAGAAACTACAGTCATCACAATGGTCTGGATGAACTCACGTGCTGTGTGTCAGACTGAGCTTTCCCTGATTCATTCTACAATC
CAAGACTTGCTGCACTGTCCTGCTGATGTTCACAGCCGTGCCTGGGAAGAAGGCAGCCCCACTCCCAGTACATTTCAGTGGGAGACCTCT
GCGTGCATCCATGGAGACGCAATGGGGCGGGGAAGGAACTGTGGGAGTGCACGTTCCAAATCCTGTGTCTCCACGTGTGGATCAGCAGCA
CCTCGCTTTCTTGTCAGAGACCTCGCTGTTACGGAGCGAGACCTGCTGAGAATTGAGGGGCTGAGGGAACCCCTCCACCTCCTCCCTTCT
GCAGCGCCCTGCGCCCCACCCAGCAACAGCGGCCACTTGGCAGTGGGGCTGCTGCAAGCTCAGAGCCGCTGCCACCCTGCATGTGTCCGC
TCAGCTCGGTCTTATGCTGTATAGTTACTAAATATGTACAGGAGGGCCATGGCATCTTTCTGAATGGATTTTTCTTAAGAAATGCGCCAG
TGTTTATGAGGTTCAAGGTATTTCCCTGTCCTTGCTGTTACCGTCACTCAGCTTTTTCTCGATAGGCTTCATCCTTGTTTTTTTGAAATG
GGGGAATTTGCTGTTTACCCTCTGCATTCCTATATGTGACCCTCCCTCCTACTCCTCCAAGGAACAGAATTACCGAGGTTCTGACAAAAG
ATAAGCCTGTAAACTCATCATCTGTGTTTTGTGGTTGGAGAGAAACTGGTGTTCTGCCCGGCTCTGCTTGGTCACAGACAGCTCCAGCAA
GAGCAGTTGTTAAAAGTGCCAAGCGTGTGTATCACTGTGACAAGCCGTTTGCTTACTGCCCTGTTCCCTTGCAGCCAAACCAGCTGATGA
AGAACTGCTGCCAGGTGGGTCCTACAGCAGGTCACAAATGACCTAGTTTCATTTTAAGCAGACAGACTCTGTTTGGCCTAGAGGTGTGGA
GTGAGAGAACTGTGTTTGTGGGTATGAGTCTGTGTGGCCAACCCCATGACCCCCACCCCTCCAGCCCAACATCTTGTGAGCACATGTGAC
CTAGGCCCCGGGGGACCTGCCTGCTCCTTTGGCTTGGGCTCTTCGTGTTTCCCACCTGCCCTCGGCACGAGCCCTTGGTGGCATCACAGT
TGGCCACTCAGCTGTGCTGAGTAGCTGTGCTACTTGTGCTGGCAGCTGCAAGGATAGGAATAGCTCAGCGCCCGATGAGCTCCCTGAGCA
GATGTGAGGCTGGCAACTCCCCTGCCCTCTGTTTGCAGGCACAGGGTCACAGTCCCAAGAAAGACAACTGGAGTCTGATCTCCCAGCCAT
CTCTGGGGTTACTAGGAGGCAGCTGGATGGCAGATACGAGAGGCCCAAATAGCCAAGCTGTTGCAAGACAGAGTGGCTACAATTGAATTG
ACACCCTGGGAAGCACGAGGTAACTTGGTAAGGATAATGATGCTGTAGATGTCTGTGTCCTCGGAGGCTGAGCTCCGCTTGGCAGAGAGA
GCGTGCTGTGTGAGGTGGAGGGCGGTTTTGCAGACATCTCAGCTTCTTTTCTGAGGAGGAGTTGGTTCTCATCTTAGGCTTCTGCAAGGG
CGAGCATGGGATGTCTCCACCACCACCCACTCTTGGAGCTGTGCTGGGTCTTGGCTTGGGGCGCTGAGGGTGGGGCCTGTGTCAGAAGCA
TTTGGTGAGAGGGGTGGAGGTGGCAGGCAGGGGTTCTCCTCAGGGTTCCCACTGAGGGGTCCCTTCAGCAAAGACCTGGGAGGAGGTGCC
GCATCACGTGGATGTTTCTTCCCTAAAGAAAAAGACACAGGAAAGCTGTCTGTCTGTACCCTGCTCTGGATTTATTGTCGTACTTGGACC
CAGAAGGGGAAATGATTCCCTCACCCTTTCACTTTCTCTCTGAACCCCTACTAAGTGGTGACTGCAGATTCTGGAAACAATTAGCTGCCC
GTGACTCAGCTGCCAGCTTCATTTTCTCTGCCTTTTGGGAGAGGCCCTCTCACCCAGGCCCAAGAGATTTGGAGACAGGAGTCAGGCCAG
GTCTGAAGCAGGAGAAGGGAGGCCCCTCCTATCTACCCAGTTGACATTTGGCTTTGGGAAAAGCGCAGCTTGTTCGAGCCACGTGTGCCA
AGCAGGCTTTTCCTTCCTCTTGTAAGTAAAGCTCGTGGTTCTGTAGTCCAGTCATCCTAGGAGGGTGATGTTGACTGAGACTTCACGCTC
TCCCTTTGTCTCTGGAAACTGCCCCCTCGTTCTGACAGAATCCCCCAGGCAATGGAGGAAGGGTGCCGAGGCGCCTCTAGTCTGTGCCTT
TGCCGTTGGAAGCATTTGGTGCTGAGAGGGTTTCCCAGCCACCCGCTCCCTTTCTGGGGCCATGGTGTCCCTGCTGTGTGTCAGTGGCAT
GTCACTGTGGTTCAGTGAGCACATGGGTGGACGTGCAGAGACTGTCTGCGCAGCCCCCAGCAGACATGCCCCTGGGGTGAGGACACAGGC
TCTGCAGGCTATCTCCCCCTCTGGCTCAGTCATCGCCTGCCCACCCTTCACTTCTTAAAGGTGCGCAAGAGAGGAGGGCCGACTGGAGGG
TGTCGCCGGAAGGTTTCAGCCTGCCCTTCACAATTCCCCTTGTGCACAGCCCAGTTTCCATCTCTCAGGGCCCACCCAGGAAAATGGATT
TCAAGTGGGGGTTTTCATCCAGAGATTTGTTTAACACAAAACAAGAAAAGCTGAGAGGCAAAACAGGGGAGTGAGGGGCAACCCAGAGGT
GGGGAACAACAACAGCAAGCCGCCCCCATCCTGAGACTGGCTGGGCACCAGGGGAGGACGCGTCACCAGAGCCTGGGGCCAAGGCCACTG
GGGGACCTGCCACACTGTGGACCTGTCTGGTGGGGGCTGGAGCCTCGAGAAGCCATGATTCTTGTCAGAAACATTTCCCCAGGCAGAGAG
AGGGGGCCCCAGCCTCTCCCCTCCTCTTGGCCTCCAGAGTCCTGCAGGTGCCTCACAGTAGTGAAACCCAGTTGGAAGCAGCTGCCCTGG
GAGCCTGGGACAGGCGACCCACCGGGTCAGTCCCCTGCCACTCAGAGCAGAGCAGGGGGCTGAGGGCAAGCAGGTGGGGCTGTGCGTGGC
CTCAGTGCACTCGGTGTCATGTCTGAGCCTGGTGTTTATGCCCCACTGCTGTCCTAAGTCCCTGGCGAGGGGAGGTGGAGGAGCTGCCCC
GTGGGTGTTTGGAGATTCTGTTTTACTCTGCCTAGAGAGGAAACGGCTTTGGGGAGGGAGGGGGAAGCCTTTATTCTTTACTGTTGTCCC
TGTTTTCCTTTGGGGGAATTTACTCAGTTAGCAGCCCCTCCTCACCATTCCCCCCAGGAAGGCCATGTCCCAGTTTTCTGTCCACCCCTC
CTGTTCCTCTGCACTATGTCTCTGATTTTCCCTGCCAGGGAAGCTAACCCAGAGCACGCACCTGTGCTCATGAGTGTTTCCGCAGGATAA
TTCGTTCTGAGCATGATACCACAGTGTGGATTGTCTGTCTGTAAGGAGATGCCATCTACTAACCAATTTGTATTGTGTTTCCAATAAATT

>26369_26369_2_EMC2-MTA3_EMC2_chr8_109455927_ENST00000220853_MTA3_chr2_42946128_ENST00000406652_length(amino acids)=208AA_BP=
MSKFPQRKTGTTVKNKGFPLPPQSRFLSRQSKTESPNTHGAAPPPPLARDLGQQWGINTRLRHDTECTEATHSPTCLPSAPCSALSGRGL
TRWVACPRLPGQLLPTGFHYCEAPAGLWRPRGGERLGPPLSAWGNVSDKNHGFSRLQPPPDRSTVWQVPQWPWPQALVTRPPLVPSQSQD

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Fusion Gene PPI Analysis for EMC2-MTA3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EMC2-MTA3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EMC2-MTA3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source