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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EMID1-CBY1 (FusionGDB2 ID:26404)

Fusion Gene Summary for EMID1-CBY1

Fusion gene summary

Fusion gene information	Fusion gene name: EMID1-CBY1
	Fusion gene ID: 26404
		Hgene	Tgene
	Gene symbol	EMID1	CBY1
	Gene ID	129080	25776
	Gene name	EMI domain containing 1	chibby family member 1, beta catenin antagonist
	Synonyms	EMI5\|EMU1	C22orf2\|CBY\|Chibby1\|HS508I15A\|PGEA1\|PIGEA-14\|PIGEA14\|arb1
	Cytomap	22q12.2	22q13.1
	Type of gene	protein-coding	protein-coding
	Description	EMI domain-containing protein 1emilin and multimerin domain-containing protein 1	protein chibby homolog 1ARPP-binding proteinPKD2 interactor, Golgi and endoplasmic reticulum-associated 1chibby CTNNB1-mediated transcription inhibitorchibby homolog 1coiled-coil protein PIGEA-14cytosolic leucine-rich proteinpolycystin-2 interactor
	Modification date	20200313	20200313
	UniProtAcc	Q96A84	Q9Y3M2
	Ensembl transtripts involved in fusion gene	ENST00000334018, ENST00000404755, ENST00000404820, ENST00000484039,	ENST00000216029,
Fusion gene scores	* DoF score	5 X 5 X 4=100	3 X 4 X 3=36
	# samples	6	4
	** MAII score	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EMID1 [Title/Abstract] AND CBY1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EMID1(29630338)-CBY1(39069164), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CBY1	GO:0030178	negative regulation of Wnt signaling pathway	12712206\|16424001
Tgene	CBY1	GO:0045892	negative regulation of transcription, DNA-templated	12712206
Tgene	CBY1	GO:0051289	protein homotetramerization	21182262

Fusion gene breakpoints across EMID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CBY1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-04-1341-01A	EMID1	chr22	29630338	-	CBY1	chr22	39069164	+
ChimerDB4	OV	TCGA-04-1341-01A	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+
ChimerDB4	OV	TCGA-04-1341	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+

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Fusion Gene ORF analysis for EMID1-CBY1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000334018	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+
In-frame	ENST00000334018	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+
In-frame	ENST00000404755	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+
In-frame	ENST00000404755	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+
In-frame	ENST00000404820	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+
In-frame	ENST00000404820	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+
intron-3CDS	ENST00000484039	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+
intron-3CDS	ENST00000484039	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000334018	EMID1	chr22	29630338	+	ENST00000216029	CBY1	chr22	39069164	+	1958	1262	50	1339	429
ENST00000404820	EMID1	chr22	29630338	+	ENST00000216029	CBY1	chr22	39069164	+	1897	1201	43	1278	411
ENST00000404755	EMID1	chr22	29630338	+	ENST00000216029	CBY1	chr22	39069164	+	1834	1138	43	1215	390
ENST00000334018	EMID1	chr22	29630338	+	ENST00000216029	CBY1	chr22	39069163	+	1958	1262	50	1339	429
ENST00000404820	EMID1	chr22	29630338	+	ENST00000216029	CBY1	chr22	39069163	+	1897	1201	43	1278	411
ENST00000404755	EMID1	chr22	29630338	+	ENST00000216029	CBY1	chr22	39069163	+	1834	1138	43	1215	390

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000334018	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+	0.3310842	0.6689158
ENST00000404820	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+	0.32662943	0.67337054
ENST00000404755	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069164	+	0.31175622	0.68824375
ENST00000334018	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	0.3310842	0.6689158
ENST00000404820	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	0.32662943	0.67337054
ENST00000404755	ENST00000216029	EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	0.31175622	0.68824375

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Fusion Genomic Features for EMID1-CBY1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	5.65E-06	0.9999944
EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	5.65E-06	0.9999944
EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	5.65E-06	0.9999944
EMID1	chr22	29630338	+	CBY1	chr22	39069163	+	5.65E-06	0.9999944

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EMID1-CBY1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29630338/chr22:39069164)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EMID1 Q96A84	CBY1 Q9Y3M2
	FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. {ECO:0000269\|PubMed:12712206, ECO:0000269\|PubMed:15194699}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EMID1

chr22:29630338

chr22:39069163

ENST00000334018

33_106

358

444.0

Domain

EMI

Hgene

EMID1

chr22:29630338

chr22:39069164

ENST00000334018

33_106

358

444.0

Domain

EMI

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EMID1

chr22:29630338

chr22:39069163

ENST00000334018

179_368

358

444.0

Domain

Note=Collagen-like

Hgene

EMID1

chr22:29630338

chr22:39069164

ENST00000334018

179_368

358

444.0

Domain

Note=Collagen-like

Tgene

CBY1

chr22:29630338

chr22:39069163

ENST00000216029

67_125

101

127.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CBY1

chr22:29630338

chr22:39069164

ENST00000216029

67_125

101

127.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for EMID1-CBY1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26404_26404_1_EMID1-CBY1_EMID1_chr22_29630338_ENST00000334018_CBY1_chr22_39069163_ENST00000216029_length(transcript)=1958nt_BP=1262nt
GGGCCGGGCGAGGCCGGGAGCGCGCGCCCCCGCCCCCGCCCGCCCGCCTCCTGCCCGCCCTCCGGCCGCGGAGCTGGAAACCGGGCTCCG
CGCGTCCGGGGCGGCTGGCGGCGCGGGCAGGCAGGCGGGGAGGACAGGCTGGGGGCGGCGACCGCGAGGGGCCGCGCGCGGAGGGCGCCT
GGTGCAGCATGGGCGGCCCGCGGGCTTGGGCGCTGCTCTGCCTCGGGCTCCTGCTCCCGGGAGGCGGCGCTGCGTGGAGCATCGGGGCAG
CTCCGTTCTCCGGACGCAGGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCATGTGCAGAATGGCACCTACCTTCAGCGAG
TGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAGACCCACATACAAGGTGATGTACAAGATAG
TGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCCCATGT
GGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGACAGAGC
GGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCC
CGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCG
GCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTG
GAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCC
ATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTC
CAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCA
CTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGC
GGCTTTCAGAGTCCACTGCTGAATCCCACTTAATGGAGAAGGAACTGGATGAACTGAGGATCAGCCGGAAGAGAAAATGAAGACCCCAGA
GACATTTATTGGGGAGTAGGATGTGGCTGAGTGCTTTTTTTTTGGCCAGACTAGCGGATTCAGTCCTGGAAGAGAGTATCATATAATGAG
ACCCACAGGCACTGGCACCCTTGGGTTGGCAATAGAAGGTGACATGGAATGGAGAAAACCAAGATTCCAGATGGGGATAGTAACTAGAAG
GTGCTTCAGATGCACTGCCTGCGGGTGCCAGTCTGAAAACCAGACCGCACAGAGGCCTGGGGCTGCTGATGAGCTTTTTGGTGCTCTCCA
CACACAAGCTCGCAAACACACATGTCCCAGAATAGCTCTGTTGGGTTGTGTTGGGAGAAGCGGCTGGAGTTCATTCTCTCACCCCCTTAT
GTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGAGCTCTGTGTTGGGGTCATGGATGAGCGGCTCTCTTGGCTCTTAAAGGCAGGCCTCT
CTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCACACCTGGCCTCCTCTGGCTTCAGCTTCTCAGCAGCAAGCACCAGCCTTCCACAACAA

>26404_26404_1_EMID1-CBY1_EMID1_chr22_29630338_ENST00000334018_CBY1_chr22_39069163_ENST00000216029_length(amino acids)=429AA_BP=404
MPALRPRSWKPGSARPGRLAARAGRRGGQAGGGDREGPRAEGAWCSMGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRT
ISCHVQNGTYLQRVLQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFS
GCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGP
PGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTG

--------------------------------------------------------------
>26404_26404_2_EMID1-CBY1_EMID1_chr22_29630338_ENST00000334018_CBY1_chr22_39069164_ENST00000216029_length(transcript)=1958nt_BP=1262nt
GGGCCGGGCGAGGCCGGGAGCGCGCGCCCCCGCCCCCGCCCGCCCGCCTCCTGCCCGCCCTCCGGCCGCGGAGCTGGAAACCGGGCTCCG
CGCGTCCGGGGCGGCTGGCGGCGCGGGCAGGCAGGCGGGGAGGACAGGCTGGGGGCGGCGACCGCGAGGGGCCGCGCGCGGAGGGCGCCT
GGTGCAGCATGGGCGGCCCGCGGGCTTGGGCGCTGCTCTGCCTCGGGCTCCTGCTCCCGGGAGGCGGCGCTGCGTGGAGCATCGGGGCAG
CTCCGTTCTCCGGACGCAGGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCATGTGCAGAATGGCACCTACCTTCAGCGAG
TGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAGACCCACATACAAGGTGATGTACAAGATAG
TGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGCAGCTTCCTCTGCCTCCTTGGAGCCCATGT
GGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAACTGCAGCAAAGTGTCAGAGCTGACAGAGC
GGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCCAACACCAGCTACCCCTGAGGACCCTGCCC
CGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGTCGGTGCTTGGGGGCTTCCCGGGCCCACCG
GCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACAGGGCCCCCCAGGGAGCCCTGGCCGGGCTG
GAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCCTGGGCCCCCAGCCCCTGTTGGGCCACCCC
ATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAACCACTGGCCCCAGGGACCCACTGGGCCTC
CAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAGTCCTGGTCACATAGGACCCCCAGGCCCCA
CTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGC
GGCTTTCAGAGTCCACTGCTGAATCCCACTTAATGGAGAAGGAACTGGATGAACTGAGGATCAGCCGGAAGAGAAAATGAAGACCCCAGA
GACATTTATTGGGGAGTAGGATGTGGCTGAGTGCTTTTTTTTTGGCCAGACTAGCGGATTCAGTCCTGGAAGAGAGTATCATATAATGAG
ACCCACAGGCACTGGCACCCTTGGGTTGGCAATAGAAGGTGACATGGAATGGAGAAAACCAAGATTCCAGATGGGGATAGTAACTAGAAG
GTGCTTCAGATGCACTGCCTGCGGGTGCCAGTCTGAAAACCAGACCGCACAGAGGCCTGGGGCTGCTGATGAGCTTTTTGGTGCTCTCCA
CACACAAGCTCGCAAACACACATGTCCCAGAATAGCTCTGTTGGGTTGTGTTGGGAGAAGCGGCTGGAGTTCATTCTCTCACCCCCTTAT
GTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGAGCTCTGTGTTGGGGTCATGGATGAGCGGCTCTCTTGGCTCTTAAAGGCAGGCCTCT
CTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCACACCTGGCCTCCTCTGGCTTCAGCTTCTCAGCAGCAAGCACCAGCCTTCCACAACAA

>26404_26404_2_EMID1-CBY1_EMID1_chr22_29630338_ENST00000334018_CBY1_chr22_39069164_ENST00000216029_length(amino acids)=429AA_BP=404
MPALRPRSWKPGSARPGRLAARAGRRGGQAGGGDREGPRAEGAWCSMGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRT
ISCHVQNGTYLQRVLQNCPWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFS
GCLNCSKVSELTERLKVLEAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGP
PGPQGPPGSPGRAGAVGTPGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTG

--------------------------------------------------------------
>26404_26404_3_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404755_CBY1_chr22_39069163_ENST00000216029_length(transcript)=1834nt_BP=1138nt
CCGGCCGCGGAGCTGGAAACCGGGCTCCGCGCGTCCGGGGCGGCTGGCGGCGCGGGCAGGCAGGCGGGGAGGACAGGCTGGGGGCGGCGA
CCGCGAGGGGCCGCGCGCGGAGGGCGCCTGGTGCAGCATGGGCGGCCCGCGGGCTTGGGCGCTGCTCTGCCTCGGGCTCCTGCTCCCGGG
AGGCGGCGCTGCGTGGAGCATCGGGGCAGCTCCGTTCTCCGGACGCAGGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCA
TGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAG
ACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGC
AGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAA
CTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCC
AACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGT
CGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACA
GGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCC
TGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAA
CCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAG
TCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGCTTTCAGAGTCCACTGCTGAATCCCACTTAAT
GGAGAAGGAACTGGATGAACTGAGGATCAGCCGGAAGAGAAAATGAAGACCCCAGAGACATTTATTGGGGAGTAGGATGTGGCTGAGTGC
TTTTTTTTTGGCCAGACTAGCGGATTCAGTCCTGGAAGAGAGTATCATATAATGAGACCCACAGGCACTGGCACCCTTGGGTTGGCAATA
GAAGGTGACATGGAATGGAGAAAACCAAGATTCCAGATGGGGATAGTAACTAGAAGGTGCTTCAGATGCACTGCCTGCGGGTGCCAGTCT
GAAAACCAGACCGCACAGAGGCCTGGGGCTGCTGATGAGCTTTTTGGTGCTCTCCACACACAAGCTCGCAAACACACATGTCCCAGAATA
GCTCTGTTGGGTTGTGTTGGGAGAAGCGGCTGGAGTTCATTCTCTCACCCCCTTATGTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGA
GCTCTGTGTTGGGGTCATGGATGAGCGGCTCTCTTGGCTCTTAAAGGCAGGCCTCTCTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCAC
ACCTGGCCTCCTCTGGCTTCAGCTTCTCAGCAGCAAGCACCAGCCTTCCACAACAACACTATATTTTTATGCTACTTTCCTGTTTGCACT

>26404_26404_3_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404755_CBY1_chr22_39069163_ENST00000216029_length(amino acids)=390AA_BP=365
MAARAGRRGGQAGGGDREGPRAEGAWCSMGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQNC
PWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVL
EAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGT
PGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEPGPQG

--------------------------------------------------------------
>26404_26404_4_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404755_CBY1_chr22_39069164_ENST00000216029_length(transcript)=1834nt_BP=1138nt
CCGGCCGCGGAGCTGGAAACCGGGCTCCGCGCGTCCGGGGCGGCTGGCGGCGCGGGCAGGCAGGCGGGGAGGACAGGCTGGGGGCGGCGA
CCGCGAGGGGCCGCGCGCGGAGGGCGCCTGGTGCAGCATGGGCGGCCCGCGGGCTTGGGCGCTGCTCTGCCTCGGGCTCCTGCTCCCGGG
AGGCGGCGCTGCGTGGAGCATCGGGGCAGCTCCGTTCTCCGGACGCAGGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCA
TGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAG
ACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGC
AGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAA
CTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCC
AACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGT
CGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACA
GGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCC
TGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAA
CCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAG
TCCTGGTCACATAGGACTGCGTGGGGAGCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGCTTTCAGAGTCCACTGCTGAATCCCACTTAAT
GGAGAAGGAACTGGATGAACTGAGGATCAGCCGGAAGAGAAAATGAAGACCCCAGAGACATTTATTGGGGAGTAGGATGTGGCTGAGTGC
TTTTTTTTTGGCCAGACTAGCGGATTCAGTCCTGGAAGAGAGTATCATATAATGAGACCCACAGGCACTGGCACCCTTGGGTTGGCAATA
GAAGGTGACATGGAATGGAGAAAACCAAGATTCCAGATGGGGATAGTAACTAGAAGGTGCTTCAGATGCACTGCCTGCGGGTGCCAGTCT
GAAAACCAGACCGCACAGAGGCCTGGGGCTGCTGATGAGCTTTTTGGTGCTCTCCACACACAAGCTCGCAAACACACATGTCCCAGAATA
GCTCTGTTGGGTTGTGTTGGGAGAAGCGGCTGGAGTTCATTCTCTCACCCCCTTATGTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGA
GCTCTGTGTTGGGGTCATGGATGAGCGGCTCTCTTGGCTCTTAAAGGCAGGCCTCTCTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCAC
ACCTGGCCTCCTCTGGCTTCAGCTTCTCAGCAGCAAGCACCAGCCTTCCACAACAACACTATATTTTTATGCTACTTTCCTGTTTGCACT

>26404_26404_4_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404755_CBY1_chr22_39069164_ENST00000216029_length(amino acids)=390AA_BP=365
MAARAGRRGGQAGGGDREGPRAEGAWCSMGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQNC
PWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVL
EAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGT
PGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGLRGEPGPQG

--------------------------------------------------------------
>26404_26404_5_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404820_CBY1_chr22_39069163_ENST00000216029_length(transcript)=1897nt_BP=1201nt
CCGGCCGCGGAGCTGGAAACCGGGCTCCGCGCGTCCGGGGCGGCTGGCGGCGCGGGCAGGCAGGCGGGGAGGACAGGCTGGGGGCGGCGA
CCGCGAGGGGCCGCGCGCGGAGGGCGCCTGGTGCAGCATGGGCGGCCCGCGGGCTTGGGCGCTGCTCTGCCTCGGGCTCCTGCTCCCGGG
AGGCGGCGCTGCGTGGAGCATCGGGGCAGCTCCGTTCTCCGGACGCAGGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCA
TGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAG
ACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGC
AGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAA
CTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCC
AACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGT
CGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACA
GGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCC
TGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAA
CCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAG
TCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGA
GCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGCTTTCAGAGTCCACTGCTGAATCCCACTTAATGGAGAAGGAACTGGATGAACTGAGGAT
CAGCCGGAAGAGAAAATGAAGACCCCAGAGACATTTATTGGGGAGTAGGATGTGGCTGAGTGCTTTTTTTTTGGCCAGACTAGCGGATTC
AGTCCTGGAAGAGAGTATCATATAATGAGACCCACAGGCACTGGCACCCTTGGGTTGGCAATAGAAGGTGACATGGAATGGAGAAAACCA
AGATTCCAGATGGGGATAGTAACTAGAAGGTGCTTCAGATGCACTGCCTGCGGGTGCCAGTCTGAAAACCAGACCGCACAGAGGCCTGGG
GCTGCTGATGAGCTTTTTGGTGCTCTCCACACACAAGCTCGCAAACACACATGTCCCAGAATAGCTCTGTTGGGTTGTGTTGGGAGAAGC
GGCTGGAGTTCATTCTCTCACCCCCTTATGTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGAGCTCTGTGTTGGGGTCATGGATGAGCG
GCTCTCTTGGCTCTTAAAGGCAGGCCTCTCTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCACACCTGGCCTCCTCTGGCTTCAGCTTCT
CAGCAGCAAGCACCAGCCTTCCACAACAACACTATATTTTTATGCTACTTTCCTGTTTGCACTACTACTTTTTTATTAAACGATGTTAAA

>26404_26404_5_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404820_CBY1_chr22_39069163_ENST00000216029_length(amino acids)=411AA_BP=386
MAARAGRRGGQAGGGDREGPRAEGAWCSMGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQNC
PWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVL
EAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGT
PGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKG

--------------------------------------------------------------
>26404_26404_6_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404820_CBY1_chr22_39069164_ENST00000216029_length(transcript)=1897nt_BP=1201nt
CCGGCCGCGGAGCTGGAAACCGGGCTCCGCGCGTCCGGGGCGGCTGGCGGCGCGGGCAGGCAGGCGGGGAGGACAGGCTGGGGGCGGCGA
CCGCGAGGGGCCGCGCGCGGAGGGCGCCTGGTGCAGCATGGGCGGCCCGCGGGCTTGGGCGCTGCTCTGCCTCGGGCTCCTGCTCCCGGG
AGGCGGCGCTGCGTGGAGCATCGGGGCAGCTCCGTTCTCCGGACGCAGGAACTGGTGCTCCTATGTGGTGACCCGCACCATCTCATGCCA
TGTGCAGAATGGCACCTACCTTCAGCGAGTGCTGCAGAACTGCCCCTGGCCCATGAGCTGTCCGGGGAGCAGCTACAGAACTGTGGTGAG
ACCCACATACAAGGTGATGTACAAGATAGTGACCGCCCGTGAGTGGAGGTGCTGCCCTGGGCACTCAGGAGTGAGCTGCGAGGAAGTTGC
AGCTTCCTCTGCCTCCTTGGAGCCCATGTGGTCGGGCAGTACCATGCGGCGGATGGCGCTTCGGCCCACAGCCTTCTCAGGTTGTCTCAA
CTGCAGCAAAGTGTCAGAGCTGACAGAGCGGCTGAAGGTGCTGGAGGCCAAGATGACCATGCTGACTGTCATAGAGCAGCCAGTACCTCC
AACACCAGCTACCCCTGAGGACCCTGCCCCGCTCTGGGGTCCCCCTCCTGCCCAGGGCAGCCCCGGAGATGGAGGCCTCCAGGACCAAGT
CGGTGCTTGGGGGCTTCCCGGGCCCACCGGCCCCAAGGGAGATGCCGGCAGTCGGGGCCCAATGGGGATGAGAGGCCCACCAGGTCCACA
GGGCCCCCCAGGGAGCCCTGGCCGGGCTGGAGCTGTGGGCACCCCTGGAGAGAGGGGACCTCCTGGGCCACCAGGGCCTCCTGGCCCCCC
TGGGCCCCCAGCCCCTGTTGGGCCACCCCATGCCCGGATCTCCCAGCATGGAGACCCATTGCTGTCCAACACCTTCACTGAGACCAACAA
CCACTGGCCCCAGGGACCCACTGGGCCTCCAGGCCCTCCAGGGCCCATGGGTCCCCCTGGGCCTCCTGGCCCCACAGGTGTCCCTGGGAG
TCCTGGTCACATAGGACCCCCAGGCCCCACTGGACCCAAAGGAATCTCTGGCCACCCAGGAGAGAAGGGCGAGAGAGGACTGCGTGGGGA
GCCTGGCCCCCAAGGCTCTGCTGGGCAGCGGCTTTCAGAGTCCACTGCTGAATCCCACTTAATGGAGAAGGAACTGGATGAACTGAGGAT
CAGCCGGAAGAGAAAATGAAGACCCCAGAGACATTTATTGGGGAGTAGGATGTGGCTGAGTGCTTTTTTTTTGGCCAGACTAGCGGATTC
AGTCCTGGAAGAGAGTATCATATAATGAGACCCACAGGCACTGGCACCCTTGGGTTGGCAATAGAAGGTGACATGGAATGGAGAAAACCA
AGATTCCAGATGGGGATAGTAACTAGAAGGTGCTTCAGATGCACTGCCTGCGGGTGCCAGTCTGAAAACCAGACCGCACAGAGGCCTGGG
GCTGCTGATGAGCTTTTTGGTGCTCTCCACACACAAGCTCGCAAACACACATGTCCCAGAATAGCTCTGTTGGGTTGTGTTGGGAGAAGC
GGCTGGAGTTCATTCTCTCACCCCCTTATGTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGAGCTCTGTGTTGGGGTCATGGATGAGCG
GCTCTCTTGGCTCTTAAAGGCAGGCCTCTCTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCACACCTGGCCTCCTCTGGCTTCAGCTTCT
CAGCAGCAAGCACCAGCCTTCCACAACAACACTATATTTTTATGCTACTTTCCTGTTTGCACTACTACTTTTTTATTAAACGATGTTAAA

>26404_26404_6_EMID1-CBY1_EMID1_chr22_29630338_ENST00000404820_CBY1_chr22_39069164_ENST00000216029_length(amino acids)=411AA_BP=386
MAARAGRRGGQAGGGDREGPRAEGAWCSMGGPRAWALLCLGLLLPGGGAAWSIGAAPFSGRRNWCSYVVTRTISCHVQNGTYLQRVLQNC
PWPMSCPGSSYRTVVRPTYKVMYKIVTAREWRCCPGHSGVSCEEVAASSASLEPMWSGSTMRRMALRPTAFSGCLNCSKVSELTERLKVL
EAKMTMLTVIEQPVPPTPATPEDPAPLWGPPPAQGSPGDGGLQDQVGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGT
PGERGPPGPPGPPGPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPGPPGPMGPPGPPGPTGVPGSPGHIGPPGPTGPKG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EMID1-CBY1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EMID1-CBY1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EMID1-CBY1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source