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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EML1-GPI (FusionGDB2 ID:26432)

Fusion Gene Summary for EML1-GPI

check button Fusion gene summary
Fusion gene informationFusion gene name: EML1-GPI
Fusion gene ID: 26432
HgeneTgene
Gene symbol

EML1

GPI

Gene ID

2009

10007

Gene nameEMAP like 1glucosamine-6-phosphate deaminase 1
SynonymsBH|ELP79|EMAP|EMAP-1|EMAPLGNP1|GNPDA|GNPI|GPI|HLN
Cytomap

14q32.2

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionechinoderm microtubule-associated protein-like 1echinoderm microtubule associated protein like 1glucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin
Modification date2020031320200313
UniProtAcc

O00423

Q8IV16

Ensembl transtripts involved in fusion geneENST00000262233, ENST00000334192, 
ENST00000327921, ENST00000556758, 
ENST00000356487, ENST00000415930, 
ENST00000586425, 
Fusion gene scores* DoF score15 X 8 X 11=132019 X 17 X 10=3230
# samples 1723
** MAII scorelog2(17/1320*10)=-2.95693127810811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3230*10)=-3.81182839863691
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EML1 [Title/Abstract] AND GPI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEML1(100259880)-GPI(34884633), # samples:1
EML1(100259880)-GPI(34884153), # samples:1
Anticipated loss of major functional domain due to fusion event.EML1-GPI seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EML1-GPI seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EML1-GPI seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EML1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GPI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-RN-AAAQ-01AEML1chr14

100259880

-GPIchr19

34884153

+
ChimerDB4SARCTCGA-RN-AAAQ-01AEML1chr14

100259880

+GPIchr19

34884633

+


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Fusion Gene ORF analysis for EML1-GPI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000262233ENST00000356487EML1chr14

100259880

-GPIchr19

34884153

+
Frame-shiftENST00000262233ENST00000415930EML1chr14

100259880

-GPIchr19

34884153

+
Frame-shiftENST00000262233ENST00000586425EML1chr14

100259880

-GPIchr19

34884153

+
Frame-shiftENST00000334192ENST00000356487EML1chr14

100259880

-GPIchr19

34884153

+
Frame-shiftENST00000334192ENST00000415930EML1chr14

100259880

-GPIchr19

34884153

+
Frame-shiftENST00000334192ENST00000586425EML1chr14

100259880

-GPIchr19

34884153

+
In-frameENST00000262233ENST00000356487EML1chr14

100259880

+GPIchr19

34884633

+
In-frameENST00000262233ENST00000415930EML1chr14

100259880

+GPIchr19

34884633

+
In-frameENST00000262233ENST00000586425EML1chr14

100259880

+GPIchr19

34884633

+
In-frameENST00000334192ENST00000356487EML1chr14

100259880

+GPIchr19

34884633

+
In-frameENST00000334192ENST00000415930EML1chr14

100259880

+GPIchr19

34884633

+
In-frameENST00000334192ENST00000586425EML1chr14

100259880

+GPIchr19

34884633

+
intron-3CDSENST00000327921ENST00000356487EML1chr14

100259880

-GPIchr19

34884153

+
intron-3CDSENST00000327921ENST00000356487EML1chr14

100259880

+GPIchr19

34884633

+
intron-3CDSENST00000327921ENST00000415930EML1chr14

100259880

-GPIchr19

34884153

+
intron-3CDSENST00000327921ENST00000415930EML1chr14

100259880

+GPIchr19

34884633

+
intron-3CDSENST00000327921ENST00000586425EML1chr14

100259880

-GPIchr19

34884153

+
intron-3CDSENST00000327921ENST00000586425EML1chr14

100259880

+GPIchr19

34884633

+
intron-3CDSENST00000556758ENST00000356487EML1chr14

100259880

-GPIchr19

34884153

+
intron-3CDSENST00000556758ENST00000356487EML1chr14

100259880

+GPIchr19

34884633

+
intron-3CDSENST00000556758ENST00000415930EML1chr14

100259880

-GPIchr19

34884153

+
intron-3CDSENST00000556758ENST00000415930EML1chr14

100259880

+GPIchr19

34884633

+
intron-3CDSENST00000556758ENST00000586425EML1chr14

100259880

-GPIchr19

34884153

+
intron-3CDSENST00000556758ENST00000586425EML1chr14

100259880

+GPIchr19

34884633

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262233EML1chr14100259880+ENST00000415930GPIchr1934884633+31382061391017292
ENST00000262233EML1chr14100259880+ENST00000356487GPIchr1934884633+1310206103573320
ENST00000262233EML1chr14100259880+ENST00000586425GPIchr1934884633+111520679273239
ENST00000334192EML1chr14100259880+ENST00000415930GPIchr1934884633+31332011341012292
ENST00000334192EML1chr14100259880+ENST00000356487GPIchr1934884633+1305201103068320
ENST00000334192EML1chr14100259880+ENST00000586425GPIchr1934884633+111020178768239

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262233ENST00000415930EML1chr14100259880+GPIchr1934884633+0.0119924030.98800755
ENST00000262233ENST00000356487EML1chr14100259880+GPIchr1934884633+0.0184942990.9815057
ENST00000262233ENST00000586425EML1chr14100259880+GPIchr1934884633+0.0295555890.97044444
ENST00000334192ENST00000415930EML1chr14100259880+GPIchr1934884633+0.0124411850.98755884
ENST00000334192ENST00000356487EML1chr14100259880+GPIchr1934884633+0.0197125950.98028743
ENST00000334192ENST00000586425EML1chr14100259880+GPIchr1934884633+0.029943360.9700566

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Fusion Genomic Features for EML1-GPI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EML1chr14100259880+GPIchr1934884632+2.79E-091
EML1chr14100259880+GPIchr1934884632+2.79E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EML1-GPI


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:100259880/chr19:34884633)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EML1

O00423

GPI

Q8IV16

FUNCTION: Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se. {ECO:0000250|UniProtKB:Q05BC3}.FUNCTION: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity). {ECO:0000250|UniProtKB:Q9D1N2, ECO:0000269|PubMed:17997385, ECO:0000269|PubMed:19304573, ECO:0000269|PubMed:21314738, ECO:0000269|PubMed:27929370, ECO:0000269|PubMed:29899144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122160_16622816.0Compositional biasNote=Poly-Ser
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123160_16622835.0Compositional biasNote=Poly-Ser
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122176_81522816.0RegionNote=Tandem atypical propeller in EMLs
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123176_81522835.0RegionNote=Tandem atypical propeller in EMLs
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122261_31022816.0RepeatNote=WD 1
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122315_35822816.0RepeatNote=WD 2
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122363_40022816.0RepeatNote=WD 3
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122409_44622816.0RepeatNote=WD 4
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122450_48922816.0RepeatNote=WD 5
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122493_53022816.0RepeatNote=WD 6
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122535_57222816.0RepeatNote=WD 7
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122578_61322816.0RepeatNote=WD 8
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122617_65522816.0RepeatNote=WD 9
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122664_70122816.0RepeatNote=WD 10
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122709_76822816.0RepeatNote=WD 11
HgeneEML1chr14:100259880chr19:34884633ENST00000262233+122775_81422816.0RepeatNote=WD 12
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123261_31022835.0RepeatNote=WD 1
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123315_35822835.0RepeatNote=WD 2
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123363_40022835.0RepeatNote=WD 3
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123409_44622835.0RepeatNote=WD 4
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123450_48922835.0RepeatNote=WD 5
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123493_53022835.0RepeatNote=WD 6
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123535_57222835.0RepeatNote=WD 7
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123578_61322835.0RepeatNote=WD 8
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123617_65522835.0RepeatNote=WD 9
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123664_70122835.0RepeatNote=WD 10
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123709_76822835.0RepeatNote=WD 11
HgeneEML1chr14:100259880chr19:34884633ENST00000334192+123775_81422835.0RepeatNote=WD 12
TgeneGPIchr14:100259880chr19:34884633ENST00000356487918159_160288559.0RegionGlucose-6-phosphate binding
TgeneGPIchr14:100259880chr19:34884633ENST00000356487918210_215288559.0RegionGlucose-6-phosphate binding
TgeneGPIchr14:100259880chr19:34884633ENST00000415930918159_160299570.0RegionGlucose-6-phosphate binding
TgeneGPIchr14:100259880chr19:34884633ENST00000415930918210_215299570.0RegionGlucose-6-phosphate binding


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Fusion Gene Sequence for EML1-GPI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26432_26432_1_EML1-GPI_EML1_chr14_100259880_ENST00000262233_GPI_chr19_34884633_ENST00000356487_length(transcript)=1310nt_BP=206nt
ATGGTAACCGGCAGCAGCAGCCGCCACAGCAGGGCCGGCCCCAGCGCCAGCGCCGGTCGCGGTCGGGCTCAGCTCAGTGTGTGGTGAGCG
GCGGCGGCGCGGCCGGGCCGGGGAGCGGGCGCGGCCCGGCGGCCTCAGCATGGAGGACGGCTTCTCCAGCTACAGCAGCCTGTACGACAC
GTCCTCGCTGCTCCAGTTCTGCAACGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGAC
GCCCCTGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCC
CTATGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCG
TGTGGACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAA
GATGATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTT
GGCCCAGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGA
GAGGCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTT
GGTCGCCATGTATGAGCACAAGATCTTCGTTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCA
GCTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAA
GCAGCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGG
AGCCGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCC
CCCAGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCA

>26432_26432_1_EML1-GPI_EML1_chr14_100259880_ENST00000262233_GPI_chr19_34884633_ENST00000356487_length(amino acids)=320AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

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>26432_26432_2_EML1-GPI_EML1_chr14_100259880_ENST00000262233_GPI_chr19_34884633_ENST00000415930_length(transcript)=3138nt_BP=206nt
ATGGTAACCGGCAGCAGCAGCCGCCACAGCAGGGCCGGCCCCAGCGCCAGCGCCGGTCGCGGTCGGGCTCAGCTCAGTGTGTGGTGAGCG
GCGGCGGCGCGGCCGGGCCGGGGAGCGGGCGCGGCCCGGCGGCCTCAGCATGGAGGACGGCTTCTCCAGCTACAGCAGCCTGTACGACAC
GTCCTCGCTGCTCCAGTTCTGCAACGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGAC
GCCCCTGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCC
CTATGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCG
TGTGGACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAA
GATGATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTT
GGCCCAGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGA
GAGGCTGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTT
GGTCGCCATGTATGAGCACAAGATCTTCGTTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCA
GCTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAA
GCAGCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGG
AGCCGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCC
CCCAGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCA
TGTTCACGTTGTTCACATCCCATGTAGAAAAATAAAGATGCCACGGAGGAGGTTGTAGGCTCAGCCTCTGATTTTTTTTTTCCTGTGATG
GTGCTTTATGTAGCAGAGGGCAGGAGCGCTCAGCAGGACGCAGGCTGTGCCTCTGCGGACACTTAACACTAAGTGGTGAGCGGGTCTAGA
GTGGAGCAAGGTGCCCTGAGAAGACAATAGTGGGGTGGGGGCACAATCAGTCAGGACGGCAACTTGGCCTGTGTCACCAAATCCCAAGAC
TGTTTTCCACTCCTCACCTCTGTGACTGCAGAAATTGGATACTCTGTTCACTCGATGGTTCTAAAAACTGCATTGAGATTATGTTTGTTT
CGGGTGAATTCCTGGACAAGACCGAGGATGACTGCCATCTCCTGGCAAGACGCTCAGGTAGTTCTTTTGCTTTAAAAGGCAGATATTGAA
AACTGGAATTTTTTTTTTTTGAGTCTCGCTCTGTCACCCAGACTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCCTCCCG
GGTTCAAGCTATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACACGGCGCACACCACCATACCCAGCTAATTTTTGTATTTTTAGT
AGTGAAGGGGTTTTACCATGTTGGGCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCACAGTGCTGGGAT
TACAGGTATGAGCCACCACGCCCGGCCCATTTTTTTTTTTTTTTTGACAACTTTTTTTTTTTTTTGAGACAGGGTCTTGTTCCATTGCCC
AGACTGGAGTGCAGTGGCATGATCACAGCTCACTGCAGCCAGTAATCCTCTTGCCTCAGCCTCCCAAGTAGTTGAGACTACAGGTTGTAC
CACTATGCCCTGCTAGTTTTTTCATTTTTTGTAGAGAGACGGGTCTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAAGCTGGA
GTGCAGTAGCACGGTCTCAGCTCATTGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGACTCCTGTGTAGCTGGGAGTAC
AGGCACCTGCCACCATGCCCGGCTAATTTTTTATATATTTTTTTAGCAGAGACAGTGTCTCACTGTGTTAGTCAGGATGGTCTCGATCTC
CTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCAAGGCGGGTCTTGCTGTGT
TTCCCAGACTAGACTGGTCTTGAATTCCAGGGCTCAAGAGATCTCCCACCTCAGCCTCCCACAGTGCTGGGATTACAGGCGTGAGCCGCC
ACACCCAGCCTATTCAAAATTTTTTTTTCTTAGAGACAGGGTCTTTGTTGCCCAGGCTGGACTGCAGTGATACAATCATAGCTGACTGAA
GCCTCAAATTCCCAGGCTAAGGTGATCTTCTCACCTCAGCCTTCCAAGTAGCTGGGTCCGCAGATGCATGCCAGTACACCCAGCTCATTT
AAAAAAAAATTTTTTTCTTTTTTGAGAGTCTTGCTTTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAAGCTCCACC
TCCCGGCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTATTT
TTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCATGATCCGCCTGCTTTGGCCTCCCAAAGTGCTGG

>26432_26432_2_EML1-GPI_EML1_chr14_100259880_ENST00000262233_GPI_chr19_34884633_ENST00000415930_length(amino acids)=292AA_BP=22
MEDGFSSYSSLYDTSSLLQFCNGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGD
MESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEAR
KELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVT

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>26432_26432_3_EML1-GPI_EML1_chr14_100259880_ENST00000262233_GPI_chr19_34884633_ENST00000586425_length(transcript)=1115nt_BP=206nt
ATGGTAACCGGCAGCAGCAGCCGCCACAGCAGGGCCGGCCCCAGCGCCAGCGCCGGTCGCGGTCGGGCTCAGCTCAGTGTGTGGTGAGCG
GCGGCGGCGCGGCCGGGCCGGGGAGCGGGCGCGGCCCGGCGGCCTCAGCATGGAGGACGGCTTCTCCAGCTACAGCAGCCTGTACGACAC
GTCCTCGCTGCTCCAGTTCTGCAACGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGAC
GCCCCTGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCC
CTATGACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCG
TGTGGACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAA
GATGATACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTT
GGCCCAGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGA
GAGGCTGCTGCCACATAAGAGTGGAGCTGGGAAAGCAGCTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTC
ACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTC
TGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGC
TTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTG

>26432_26432_3_EML1-GPI_EML1_chr14_100259880_ENST00000262233_GPI_chr19_34884633_ENST00000586425_length(amino acids)=239AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL

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>26432_26432_4_EML1-GPI_EML1_chr14_100259880_ENST00000334192_GPI_chr19_34884633_ENST00000356487_length(transcript)=1305nt_BP=201nt
AACCGGCAGCAGCAGCCGCCACAGCAGGGCCGGCCCCAGCGCCAGCGCCGGTCGCGGTCGGGCTCAGCTCAGTGTGTGGTGAGCGGCGGC
GGCGCGGCCGGGCCGGGGAGCGGGCGCGGCCCGGCGGCCTCAGCATGGAGGACGGCTTCTCCAGCTACAGCAGCCTGTACGACACGTCCT
CGCTGCTCCAGTTCTGCAACGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCCCC
TGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTATG
ACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGTGG
ACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGATGA
TACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGCCC
AGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAGGC
TGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTTGGTCG
CCATGTATGAGCACAAGATCTTCGTTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAGCTGG
CTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGC
AGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCG
GCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAG
CCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCATGTTC

>26432_26432_4_EML1-GPI_EML1_chr14_100259880_ENST00000334192_GPI_chr19_34884633_ENST00000356487_length(amino acids)=320AA_BP=1
MQMSTSLLDSGLALLLDEVDEPIGRSVVRGHLSTAIKLRLYFLSQLLSQLHSPLVKAVDVPDDALNEDLVLIHGDQGSKHEWCELGEHNR
VGWAISFKDLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVDELVKSMLAI
GPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVLVHPVSPREQ

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>26432_26432_5_EML1-GPI_EML1_chr14_100259880_ENST00000334192_GPI_chr19_34884633_ENST00000415930_length(transcript)=3133nt_BP=201nt
AACCGGCAGCAGCAGCCGCCACAGCAGGGCCGGCCCCAGCGCCAGCGCCGGTCGCGGTCGGGCTCAGCTCAGTGTGTGGTGAGCGGCGGC
GGCGCGGCCGGGCCGGGGAGCGGGCGCGGCCCGGCGGCCTCAGCATGGAGGACGGCTTCTCCAGCTACAGCAGCCTGTACGACACGTCCT
CGCTGCTCCAGTTCTGCAACGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCCCC
TGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTATG
ACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGTGG
ACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGATGA
TACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGCCC
AGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAGGC
TGCTGCCACATAAGGTCTTTGAAGGAAATCGCCCAACCAACTCTATTGTGTTCACCAAGCTCACACCATTCATGCTTGGAGCCTTGGTCG
CCATGTATGAGCACAAGATCTTCGTTCAGGGCATCATCTGGGACATCAACAGCTTTGACCAGTGGGGAGTGGAGCTGGGAAAGCAGCTGG
CTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGACGCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGC
AGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGACTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCG
GCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGACCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAG
CCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGAAGTGTTTTTGTGCAGCTGACTTTTCTGACCCATGTTC
ACGTTGTTCACATCCCATGTAGAAAAATAAAGATGCCACGGAGGAGGTTGTAGGCTCAGCCTCTGATTTTTTTTTTCCTGTGATGGTGCT
TTATGTAGCAGAGGGCAGGAGCGCTCAGCAGGACGCAGGCTGTGCCTCTGCGGACACTTAACACTAAGTGGTGAGCGGGTCTAGAGTGGA
GCAAGGTGCCCTGAGAAGACAATAGTGGGGTGGGGGCACAATCAGTCAGGACGGCAACTTGGCCTGTGTCACCAAATCCCAAGACTGTTT
TCCACTCCTCACCTCTGTGACTGCAGAAATTGGATACTCTGTTCACTCGATGGTTCTAAAAACTGCATTGAGATTATGTTTGTTTCGGGT
GAATTCCTGGACAAGACCGAGGATGACTGCCATCTCCTGGCAAGACGCTCAGGTAGTTCTTTTGCTTTAAAAGGCAGATATTGAAAACTG
GAATTTTTTTTTTTTGAGTCTCGCTCTGTCACCCAGACTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCCTCCCGGGTTC
AAGCTATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACACGGCGCACACCACCATACCCAGCTAATTTTTGTATTTTTAGTAGTGA
AGGGGTTTTACCATGTTGGGCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCGCCTCAGCCTCCCACAGTGCTGGGATTACAG
GTATGAGCCACCACGCCCGGCCCATTTTTTTTTTTTTTTTGACAACTTTTTTTTTTTTTTGAGACAGGGTCTTGTTCCATTGCCCAGACT
GGAGTGCAGTGGCATGATCACAGCTCACTGCAGCCAGTAATCCTCTTGCCTCAGCCTCCCAAGTAGTTGAGACTACAGGTTGTACCACTA
TGCCCTGCTAGTTTTTTCATTTTTTGTAGAGAGACGGGTCTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAAGCTGGAGTGCA
GTAGCACGGTCTCAGCTCATTGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGACTCCTGTGTAGCTGGGAGTACAGGCA
CCTGCCACCATGCCCGGCTAATTTTTTATATATTTTTTTAGCAGAGACAGTGTCTCACTGTGTTAGTCAGGATGGTCTCGATCTCCTGAC
CTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCAAGGCGGGTCTTGCTGTGTTTCCC
AGACTAGACTGGTCTTGAATTCCAGGGCTCAAGAGATCTCCCACCTCAGCCTCCCACAGTGCTGGGATTACAGGCGTGAGCCGCCACACC
CAGCCTATTCAAAATTTTTTTTTCTTAGAGACAGGGTCTTTGTTGCCCAGGCTGGACTGCAGTGATACAATCATAGCTGACTGAAGCCTC
AAATTCCCAGGCTAAGGTGATCTTCTCACCTCAGCCTTCCAAGTAGCTGGGTCCGCAGATGCATGCCAGTACACCCAGCTCATTTAAAAA
AAAATTTTTTTCTTTTTTGAGAGTCTTGCTTTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAAGCTCCACCTCCCG
GCTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGT
AGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCATGATCCGCCTGCTTTGGCCTCCCAAAGTGCTGGGATTA

>26432_26432_5_EML1-GPI_EML1_chr14_100259880_ENST00000334192_GPI_chr19_34884633_ENST00000415930_length(amino acids)=292AA_BP=22
MEDGFSSYSSLYDTSSLLQFCNGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGD
MESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEAR
KELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVT

--------------------------------------------------------------
>26432_26432_6_EML1-GPI_EML1_chr14_100259880_ENST00000334192_GPI_chr19_34884633_ENST00000586425_length(transcript)=1110nt_BP=201nt
AACCGGCAGCAGCAGCCGCCACAGCAGGGCCGGCCCCAGCGCCAGCGCCGGTCGCGGTCGGGCTCAGCTCAGTGTGTGGTGAGCGGCGGC
GGCGCGGCCGGGCCGGGGAGCGGGCGCGGCCCGGCGGCCTCAGCATGGAGGACGGCTTCTCCAGCTACAGCAGCCTGTACGACACGTCCT
CGCTGCTCCAGTTCTGCAACGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGACCAGCACTTCCGCACGACGCCCC
TGGAGAAGAACGCCCCCGTCTTGCTGGCCCTGCTGGGTATCTGGTACATCAACTGCTTTGGGTGTGAGACACACGCCATGCTGCCCTATG
ACCAGTACCTGCACCGCTTTGCTGCGTACTTCCAGCAGGGCGACATGGAGTCCAATGGGAAATACATCACCAAATCTGGAACCCGTGTGG
ACCACCAGACAGGCCCCATTGTGTGGGGGGAGCCAGGGACCAATGGCCAGCATGCTTTTTACCAGCTCATCCACCAAGGCACCAAGATGA
TACCCTGTGACTTCCTCATCCCGGTCCAGACCCAGCACCCCATACGGAAGGGTCTGCATCACAAGATCCTCCTGGCCAACTTCTTGGCCC
AGACAGAGGCCCTGATGAGGGGAAAATCGACGGAGGAGGCCCGAAAGGAGCTCCAGGCTGCGGGCAAGAGTCCAGAGGACCTTGAGAGGC
TGCTGCCACATAAGAGTGGAGCTGGGAAAGCAGCTGGCTAAGAAAATAGAGCCTGAGCTTGATGGCAGTGCTCAAGTGACCTCTCACGAC
GCTTCTACCAATGGGCTCATCAACTTCATCAAGCAGCAGCGCGAGGCCAGAGTCCAATAAACTCGTGCTCATCTGCAGCCTCCTCTGTGA
CTCCCCTTTCTCTTCTCGTCCCTCCTCCCCGGAGCCGGCACTGCATGTTCCTGGACACCACCCAGAGCACCCTCTGGTTGTGGGCTTGGA
CCACGAGCCCTTAGCAGGGAAGGCTGGTCTCCCCCAGCCTAACCCCCAGCCCCTCCATGTCTATGCTCCCTCTGTGTTAGAATTGGCTGA

>26432_26432_6_EML1-GPI_EML1_chr14_100259880_ENST00000334192_GPI_chr19_34884633_ENST00000586425_length(amino acids)=239AA_BP=1
MPSSSGSIFLASCFPSSTLMWQQPLKVLWTLARSLELLSGLLRRFSPHQGLCLGQEVGQEDLVMQTLPYGVLGLDRDEEVTGYHLGALVD
ELVKSMLAIGPWLPPHNGACLVVHTGSRFGDVFPIGLHVALLEVRSKAVQVLVIGQHGVCLTPKAVDVPDTQQGQQDGGVLLQGRRAEVL

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Fusion Gene PPI Analysis for EML1-GPI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EML1-GPI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EML1-GPI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource