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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENDOD1-UBE2Q2 (FusionGDB2 ID:26556)

Fusion Gene Summary for ENDOD1-UBE2Q2

check button Fusion gene summary
Fusion gene informationFusion gene name: ENDOD1-UBE2Q2
Fusion gene ID: 26556
HgeneTgene
Gene symbol

ENDOD1

UBE2Q2

Gene ID

23052

92912

Gene nameendonuclease domain containing 1ubiquitin conjugating enzyme E2 Q2
Synonyms--
Cytomap

11q21

15q24.2

Type of geneprotein-codingprotein-coding
Descriptionendonuclease domain-containing 1 proteinubiquitin-conjugating enzyme E2 Q2E2 ubiquitin-conjugating enzyme Q2ubiquitin carrier protein Q2ubiquitin conjugating enzyme E2Q family member 2ubiquitin-protein ligase Q2
Modification date2020031320200314
UniProtAcc

O94919

.
Ensembl transtripts involved in fusion geneENST00000278505, ENST00000562635, 
ENST00000267938, ENST00000338677, 
ENST00000561851, ENST00000569423, 
Fusion gene scores* DoF score5 X 3 X 4=606 X 6 X 3=108
# samples 56
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENDOD1 [Title/Abstract] AND UBE2Q2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENDOD1(94823391)-UBE2Q2(76146726), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2Q2

GO:0070936

protein K48-linked ubiquitination

20061386


check buttonFusion gene breakpoints across ENDOD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBE2Q2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-E3-A3E1ENDOD1chr11

94823391

+UBE2Q2chr15

76146726

+


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Fusion Gene ORF analysis for ENDOD1-UBE2Q2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000278505ENST00000562635ENDOD1chr11

94823391

+UBE2Q2chr15

76146726

+
In-frameENST00000278505ENST00000267938ENDOD1chr11

94823391

+UBE2Q2chr15

76146726

+
In-frameENST00000278505ENST00000338677ENDOD1chr11

94823391

+UBE2Q2chr15

76146726

+
In-frameENST00000278505ENST00000561851ENDOD1chr11

94823391

+UBE2Q2chr15

76146726

+
In-frameENST00000278505ENST00000569423ENDOD1chr11

94823391

+UBE2Q2chr15

76146726

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000278505ENDOD1chr1194823391+ENST00000338677UBE2Q2chr1576146726+27354181181182354
ENST00000278505ENDOD1chr1194823391+ENST00000267938UBE2Q2chr1576146726+29864181181365415
ENST00000278505ENDOD1chr1194823391+ENST00000569423UBE2Q2chr1576146726+28474181181260380
ENST00000278505ENDOD1chr1194823391+ENST00000561851UBE2Q2chr1576146726+15584181181365415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000278505ENST00000338677ENDOD1chr1194823391+UBE2Q2chr1576146726+0.0001624810.9998375
ENST00000278505ENST00000267938ENDOD1chr1194823391+UBE2Q2chr1576146726+0.0001332780.9998667
ENST00000278505ENST00000569423ENDOD1chr1194823391+UBE2Q2chr1576146726+0.0002228760.99977714
ENST00000278505ENST00000561851ENDOD1chr1194823391+UBE2Q2chr1576146726+0.0006433830.99935657

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Fusion Genomic Features for ENDOD1-UBE2Q2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ENDOD1chr1194823391+UBE2Q2chr1576146726+0.0006292610.99937075
ENDOD1chr1194823391+UBE2Q2chr1576146726+0.0006292610.99937075

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ENDOD1-UBE2Q2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:94823391/chr15:76146726)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENDOD1

O94919

.
FUNCTION: May act as a DNase and a RNase. {ECO:0000305}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBE2Q2chr11:94823391chr15:76146726ENST00000267938013134_17860376.0Compositional biasNote=Glu-rich
TgeneUBE2Q2chr11:94823391chr15:76146726ENST00000561851013134_17844360.0Compositional biasNote=Glu-rich
TgeneUBE2Q2chr11:94823391chr15:76146726ENST00000267938013204_36860376.0DomainUBC core
TgeneUBE2Q2chr11:94823391chr15:76146726ENST00000561851013204_36844360.0DomainUBC core

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ENDOD1-UBE2Q2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26556_26556_1_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000267938_length(transcript)=2986nt_BP=418nt
AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT
CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG
CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC
CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT
CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGGAATCCTATCCATCTTCTTCACCGATATGGTT
TGTGGATTCTGAAGACCCAAATCTGACATCAGTTCTGGAACGTCTAGAAGATACTAAGAACAACAATTTGCTTCGTCAGCAATTGAAGTG
GTTGATATGTGAACTCTGCAGTTTATATAACCTTCCTAAGCACCTGGATGTTGAGATGCTAGATCAACCACTACCCACGGGTCAGAATGG
GACAACAGAAGAAGTGACTTCAGAAGAAGAGGAAGAAGAAGAAGAGATGGCTGAAGATATAGAAGACTTAGATCACTATGAGATGAAGGA
AGAAGAGCCTATTAGTGGGAAAAAGTCAGAGGATGAAGGAATTGAAAAAGAAAATTTGGCAATATTAGAGAAAATTAGGAAGACTCAAAG
GCAAGACCATTTAAATGGTGCAGTGTCTGGGTCAGTGCAAGCTTCAGATAGACTTATGAAAGAGCTCAGGGACATATACAGATCACAGAG
TTATAAAACAGGGATTTATTCAGTGGAACTCATAAATGACAGTTTATATGACTGGCATGTTAAACTGCAGAAGGTTGACCCTGATAGTCC
TTTGCACAGTGATCTTCAGATCTTAAAAGAAAAAGAAGGCATAGAATATATTTTGCTTAACTTCTCTTTTAAGGATAACTTTCCATTTGA
TCCTCCATTTGTTCGAGTGGTGTTACCTGTTCTCTCAGGAGGGTATGTATTGGGTGGAGGAGCATTATGTATGGAACTTCTCACAAAACA
GGGCTGGAGCAGTGCCTACTCAATAGAATCGGTCATCATGCAAATAAATGCCACCTTAGTCAAAGGCAAAGCCAGAGTGCAGTTTGGAGC
AAATAAGAATCAATATAATCTAGCAAGAGCCCAACAATCCTATAATTCCATTGTACAGATACATGAGAAAAATGGCTGGTACACCCCTCC
AAAGGAAGATGGCTAAATGTGTTGACTGTTGTATGTTTGGACTAATGTTGCTTTAAAGAAAATCTTTCTAACATGCAGACAAAAGCTTTG
AGTGCCCCTATTACAGCAGTACCGAAGATGTTAGTTAATAGATATTTTAGTGGATAATCTGTCATCTGACATCCAGTATAAGTTACAGCC
TTTGCATTTTGCTCATTTTAGATATCTTGGACTGAGCAGTGGGGCCTTTACTGTATTTTTCCTGATAAATACACATACTGGCCACTCCTT
ATCTCTTTTTCTTGAAAAGTGAACTTTTTAAAGCAGCCAAGTCAACATCAGGCTACTGAAGTTGAGGCTTTAGGGTAACTTTCCTATATT
GAGCCCATGGGTTACAAGGATTTGCAATATATTGTTCCATTTACAGCCAATACAGGTTTAATCGATGTTCAATATTGGTTTAGGAAATTT
AAGGCCTTCTAAATCATAATAGCTCTTTCATGTCTAAAACCATTTTATGATATTGCCAAAATGTGATAGGAAACCTACTCATTAAATTGT
TAAACTTTTTAATGACTATGTGAAGATATGAATTGTTTCCTGAAGATAATACTCTTAATTGAGTTGTATTGTACTTCTTAGGCAAAGCAG
TGTAAAACTGTATCAATTAAGGCTTGTGAGTAGTGATTTCCACTGGGGCATCAGAGTCTTGGCTGGGCTGAATCTGCTGCTTGTTGGTTC
AGTGTTTCTTATGAACAAGAGCCACAGTACAGAGCTTCAAGTTATTTAAAATACTAAGTCATCTTACGTTTCCATTTTATTAACGGGATG
TTGCAATCGTTTGTAAACTAATAAACTTATAAAGTGATTGGCACAAAGACTCCTTGAGCAAAAGCTGTGCAGTTAAGTACAAAAAGATAC
TTAATTTGGAGACTCTTACAGTAATTTTTGCCATGTCAAAACAATGGCTTTTACATTGAAAGATTAATAGAAACTCTACATATGTTAATT
TTTTTATAGAACCTGACTCAAATCAAGGTACTCTCCATTTTATTGCCTTACCTGAATCAGTCCTTTTTGGTTGGTAATAGATTTTTTTAT
ACACCCACGTTTGATTTAAAAGTAAATTCTAGTTCTTAAGCACTTTTAACAAATCCAGAAGCACATTTTTCTGCACAAACAAGTTACAAA
GTTCAAAAGTGTTTCTTGTGCATTAGCTTTGAGATTCAGTTTTTAACTTTGTAAACCACATCTGAGAGACTTGTCATTTCTACATTGTGT
GTGTTTAATTTCTTTTGATTCCATTTTGGTTAAGAGAGCAGTAAATAGATTTTCTGGTATTCTTGTTCACTTGATTACATTTGTATAAAG
TTCTGATTGCCAGTTGCTCAGATAACAAGTGACAAGGCAGAATTCTTTAAATCAGTAAAGTTCCTTAAGCCTAAGGCTAAATCTTGAATA
CATTGTTGAATTCTTTAATATCCTGATGGCAAGCAGACTGATAGCTGCACATTTGGCATGCTTTGTTTAATGGATTTTATTTTTAATTGC
AGATTTATTTGGCAATGTACAGTAAATTTTGTAAACTTGCATCAAGTTTATGAATAAAGAACCATTTAAAAATTTTGTTTGTGCTGATCA

>26556_26556_1_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000267938_length(amino acids)=415AA_BP=99
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG
AEQRWLVEPQESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEE
EEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVE
LINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIE

--------------------------------------------------------------
>26556_26556_2_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000338677_length(transcript)=2735nt_BP=418nt
AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT
CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG
CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC
CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT
CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGGAATCCTATCCATCTTCTTCACCGATATGGTT
TGTGGATTCTGAAGACCCAAATCTGACATCAGTTCTGGAACGTCTAGAAGATACTAAGAACAACAATTTGCTTCGTCAGCAATTGAAGTG
GTTGATATGTGAACTCTGCAGTTTATATAACCTTCCTAAGCACCTGGATGTTGAGATGCTAGATCAACCACTACCCACGGGTCAGAATGG
GACAACAGAAGAAGTGACTTCAGAAGAAGAGGAAGAAGAAGAAGAGATGGCTGAAGATATAGAAGACTTAGATCACTATGAGATGAAGGA
AGAAGAGCCTATTAGTGGGAAAAAGTCAGAGGATGAAGGAATTGAAAAAGAAAATTTGGCAATATTAGAGAAAATTAGGAAGACTCAAAG
GCAAGACCATTTAAATGGTGCAGTGTCTGGGTCAGTGCAAGCTTCAGATAGACTTATGAAAGAGCTCAGGGACATATACAGATCACAGAG
TTATAAAACAGGGATTTATTCAGTGGAACTCATAAATGACAGTTTATATGACTGGCATGTTAAACTGCAGAAGGTTGACCCTGATAGTCC
TTTGCACAGTGATCTTCAGATCTTAAAAGAAAAAGAAGGCATAGAATATATTTTGCTTAACTTCTCTTTTAAGGATAACTTTCCATTTGA
TCCTCCATTTGTTCGAGTGGTGTTACCTGTTCTCTCAGGAGGGCTGGTACACCCCTCCAAAGGAAGATGGCTAAATGTGTTGACTGTTGT
ATGTTTGGACTAATGTTGCTTTAAAGAAAATCTTTCTAACATGCAGACAAAAGCTTTGAGTGCCCCTATTACAGCAGTACCGAAGATGTT
AGTTAATAGATATTTTAGTGGATAATCTGTCATCTGACATCCAGTATAAGTTACAGCCTTTGCATTTTGCTCATTTTAGATATCTTGGAC
TGAGCAGTGGGGCCTTTACTGTATTTTTCCTGATAAATACACATACTGGCCACTCCTTATCTCTTTTTCTTGAAAAGTGAACTTTTTAAA
GCAGCCAAGTCAACATCAGGCTACTGAAGTTGAGGCTTTAGGGTAACTTTCCTATATTGAGCCCATGGGTTACAAGGATTTGCAATATAT
TGTTCCATTTACAGCCAATACAGGTTTAATCGATGTTCAATATTGGTTTAGGAAATTTAAGGCCTTCTAAATCATAATAGCTCTTTCATG
TCTAAAACCATTTTATGATATTGCCAAAATGTGATAGGAAACCTACTCATTAAATTGTTAAACTTTTTAATGACTATGTGAAGATATGAA
TTGTTTCCTGAAGATAATACTCTTAATTGAGTTGTATTGTACTTCTTAGGCAAAGCAGTGTAAAACTGTATCAATTAAGGCTTGTGAGTA
GTGATTTCCACTGGGGCATCAGAGTCTTGGCTGGGCTGAATCTGCTGCTTGTTGGTTCAGTGTTTCTTATGAACAAGAGCCACAGTACAG
AGCTTCAAGTTATTTAAAATACTAAGTCATCTTACGTTTCCATTTTATTAACGGGATGTTGCAATCGTTTGTAAACTAATAAACTTATAA
AGTGATTGGCACAAAGACTCCTTGAGCAAAAGCTGTGCAGTTAAGTACAAAAAGATACTTAATTTGGAGACTCTTACAGTAATTTTTGCC
ATGTCAAAACAATGGCTTTTACATTGAAAGATTAATAGAAACTCTACATATGTTAATTTTTTTATAGAACCTGACTCAAATCAAGGTACT
CTCCATTTTATTGCCTTACCTGAATCAGTCCTTTTTGGTTGGTAATAGATTTTTTTATACACCCACGTTTGATTTAAAAGTAAATTCTAG
TTCTTAAGCACTTTTAACAAATCCAGAAGCACATTTTTCTGCACAAACAAGTTACAAAGTTCAAAAGTGTTTCTTGTGCATTAGCTTTGA
GATTCAGTTTTTAACTTTGTAAACCACATCTGAGAGACTTGTCATTTCTACATTGTGTGTGTTTAATTTCTTTTGATTCCATTTTGGTTA
AGAGAGCAGTAAATAGATTTTCTGGTATTCTTGTTCACTTGATTACATTTGTATAAAGTTCTGATTGCCAGTTGCTCAGATAACAAGTGA
CAAGGCAGAATTCTTTAAATCAGTAAAGTTCCTTAAGCCTAAGGCTAAATCTTGAATACATTGTTGAATTCTTTAATATCCTGATGGCAA
GCAGACTGATAGCTGCACATTTGGCATGCTTTGTTTAATGGATTTTATTTTTAATTGCAGATTTATTTGGCAATGTACAGTAAATTTTGT

>26556_26556_2_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000338677_length(amino acids)=354AA_BP=99
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG
AEQRWLVEPQESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEE
EEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVE

--------------------------------------------------------------
>26556_26556_3_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000561851_length(transcript)=1558nt_BP=418nt
AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT
CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG
CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC
CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT
CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGGAATCCTATCCATCTTCTTCACCGATATGGTT
TGTGGATTCTGAAGACCCAAATCTGACATCAGTTCTGGAACGTCTAGAAGATACTAAGAACAACAATTTGCTTCGTCAGCAATTGAAGTG
GTTGATATGTGAACTCTGCAGTTTATATAACCTTCCTAAGCACCTGGATGTTGAGATGCTAGATCAACCACTACCCACGGGTCAGAATGG
GACAACAGAAGAAGTGACTTCAGAAGAAGAGGAAGAAGAAGAAGAGATGGCTGAAGATATAGAAGACTTAGATCACTATGAGATGAAGGA
AGAAGAGCCTATTAGTGGGAAAAAGTCAGAGGATGAAGGAATTGAAAAAGAAAATTTGGCAATATTAGAGAAAATTAGGAAGACTCAAAG
GCAAGACCATTTAAATGGTGCAGTGTCTGGGTCAGTGCAAGCTTCAGATAGACTTATGAAAGAGCTCAGGGACATATACAGATCACAGAG
TTATAAAACAGGGATTTATTCAGTGGAACTCATAAATGACAGTTTATATGACTGGCATGTTAAACTGCAGAAGGTTGACCCTGATAGTCC
TTTGCACAGTGATCTTCAGATCTTAAAAGAAAAAGAAGGCATAGAATATATTTTGCTTAACTTCTCTTTTAAGGATAACTTTCCATTTGA
TCCTCCATTTGTTCGAGTGGTGTTACCTGTTCTCTCAGGAGGGTATGTATTGGGTGGAGGAGCATTATGTATGGAACTTCTCACAAAACA
GGGCTGGAGCAGTGCCTACTCAATAGAATCGGTCATCATGCAAATAAATGCCACCTTAGTCAAAGGCAAAGCCAGAGTGCAGTTTGGAGC
AAATAAGAATCAATATAATCTAGCAAGAGCCCAACAATCCTATAATTCCATTGTACAGATACATGAGAAAAATGGCTGGTACACCCCTCC
AAAGGAAGATGGCTAAATGTGTTGACTGTTGTATGTTTGGACTAATGTTGCTTTAAAGAAAATCTTTCTAACATGCAGACAAAAGCTTTG
AGTGCCCCTATTACAGCAGTACCGAAGATGTTAGTTAATAGATATTTTAGTGGATAATCTGTCATCTGACATCCAGTATAAGTTACAGCC

>26556_26556_3_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000561851_length(amino acids)=415AA_BP=99
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG
AEQRWLVEPQESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEE
EEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVE
LINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIE

--------------------------------------------------------------
>26556_26556_4_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000569423_length(transcript)=2847nt_BP=418nt
AGGTTGCGACTTCCCTTCCCTACCCTGCTCGGCTGCGTAGTGCGCTCCCCGCCCAGCCTGCAGAGCTCGCGCCGCGGCAGCCCAGCCGCT
CGGCCCCGCCGCGCTCGCAGAGGCCGCCATGGGCACCGCGCGCTGGCTCGCGCTGGGCAGCCTCTTCGCCCTGGCTGGGCTGCTGGAAGG
CCGGCTCGTGGGCGAGGAGGAAGCCGGCTTTGGCGAATGTGACAAGTTCTTCTACGCCGGGACCCCGCCTGCGGGGCTGGCGGCCGATTC
CCACGTGAAGATCTGTCAGCGCGCGGAGGGTGCTGAGCGCTTCGCCACCCTCTACAGCACCCGGGACCGCATCCCCGTGTACTCCGCGTT
CCGCGCCCCGCGCCCTGCGCCCGGCGGCGCCGAGCAGCGATGGCTGGTGGAGCCGCAGGAATCCTATCCATCTTCTTCACCGATATGGTT
TGTGGATTCTGAAGACCCAAATCTGACATCAGTTCTGGAACGTCTAGAAGATACTAAGAACAACAATTTGAATGGGACAACAGAAGAAGT
GACTTCAGAAGAAGAGGAAGAAGAAGAAGAGATGGCTGAAGATATAGAAGACTTAGATCACTATGAGATGAAGGAAGAAGAGCCTATTAG
TGGGAAAAAGTCAGAGGATGAAGGAATTGAAAAAGAAAATTTGGCAATATTAGAGAAAATTAGGAAGACTCAAAGGCAAGACCATTTAAA
TGGTGCAGTGTCTGGGTCAGTGCAAGCTTCAGATAGACTTATGAAAGAGCTCAGGGACATATACAGATCACAGAGTTATAAAACAGGGAT
TTATTCAGTGGAACTCATAAATGACAGTTTATATGACTGGCATGTTAAACTGCAGAAGGTTGACCCTGATAGTCCTTTGCACAGTGATCT
TCAGATCTTAAAAGAAAAAGAAGGCATAGAATATATTTTGCTTAACTTCTCTTTTAAGGATAACTTTCCATTTGATCCTCCATTTGTTCG
AGTGGTGTTACCTGTTCTCTCAGGAGGGTATGTATTGGGTGGAGGAGCATTATGTATGGAACTTCTCACAAAACAGGGCTGGAGCAGTGC
CTACTCAATAGAATCGGTCATCATGCAAATAAATGCCACCTTAGTCAAAGGCAAAGCCAGAGTGCAGTTTGGAGCAAATAAGAATCAATA
TAATCTAGCAAGAGCCCAACAATCCTATAATTCCATTGTACAGATACATGAGAAAAATGGCTGGTACACCCCTCCAAAGGAAGATGGCTA
AATGTGTTGACTGTTGTATGTTTGGACTAATGTTGCTTTAAAGAAAATCTTTCTAACATGCAGACAAAAGCTTTGAGTGCCCCTATTACA
GCAGTACCGAAGATGTTAGTTAATAGATATTTTAGTGGATAATCTGTCATCTGACATCCAGTATAAGTTACAGCCTTTGCATTTTGCTCA
TTTTAGATATCTTGGACTGAGCAGTGGGGCCTTTACTGTATTTTTCCTGATAAATACACATACTGGCCACTCCTTATCTCTTTTTCTTGA
AAAGTGAACTTTTTAAAGCAGCCAAGTCAACATCAGGCTACTGAAGTTGAGGCTTTAGGGTAACTTTCCTATATTGAGCCCATGGGTTAC
AAGGATTTGCAATATATTGTTCCATTTACAGCCAATACAGGTTTAATCGATGTTCAATATTGGTTTAGGAAATTTAAGGCCTTCTAAATC
ATAATAGCTCTTTCATGTCTAAAACCATTTTATGATATTGCCAAAATGTGATAGGAAACCTACTCATTAAATTGTTAAACTTTTTAATGA
CTATGTGAAGATATGAATTGTTTCCTGAAGATAATACTCTTAATTGAGTTGTATTGTACTTCTTAGGCAAAGCAGTGTAAAACTGTATCA
ATTAAGGCTTGTGAGTAGTGATTTCCACTGGGGCATCAGAGTCTTGGCTGGGCTGAATCTGCTGCTTGTTGGTTCAGTGTTTCTTATGAA
CAAGAGCCACAGTACAGAGCTTCAAGTTATTTAAAATACTAAGTCATCTTACGTTTCCATTTTATTAACGGGATGTTGCAATCGTTTGTA
AACTAATAAACTTATAAAGTGATTGGCACAAAGACTCCTTGAGCAAAAGCTGTGCAGTTAAGTACAAAAAGATACTTAATTTGGAGACTC
TTACAGTAATTTTTGCCATGTCAAAACAATGGCTTTTACATTGAAAGATTAATAGAAACTCTACATATGTTAATTTTTTTATAGAACCTG
ACTCAAATCAAGGTACTCTCCATTTTATTGCCTTACCTGAATCAGTCCTTTTTGGTTGGTAATAGATTTTTTTATACACCCACGTTTGAT
TTAAAAGTAAATTCTAGTTCTTAAGCACTTTTAACAAATCCAGAAGCACATTTTTCTGCACAAACAAGTTACAAAGTTCAAAAGTGTTTC
TTGTGCATTAGCTTTGAGATTCAGTTTTTAACTTTGTAAACCACATCTGAGAGACTTGTCATTTCTACATTGTGTGTGTTTAATTTCTTT
TGATTCCATTTTGGTTAAGAGAGCAGTAAATAGATTTTCTGGTATTCTTGTTCACTTGATTACATTTGTATAAAGTTCTGATTGCCAGTT
GCTCAGATAACAAGTGACAAGGCAGAATTCTTTAAATCAGTAAAGTTCCTTAAGCCTAAGGCTAAATCTTGAATACATTGTTGAATTCTT
TAATATCCTGATGGCAAGCAGACTGATAGCTGCACATTTGGCATGCTTTGTTTAATGGATTTTATTTTTAATTGCAGATTTATTTGGCAA

>26556_26556_4_ENDOD1-UBE2Q2_ENDOD1_chr11_94823391_ENST00000278505_UBE2Q2_chr15_76146726_ENST00000569423_length(amino acids)=380AA_BP=99
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGG
AEQRWLVEPQESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLNGTTEEVTSEEEEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGI
EKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGI
EYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSY

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Fusion Gene PPI Analysis for ENDOD1-UBE2Q2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENDOD1-UBE2Q2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENDOD1-UBE2Q2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource