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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENOX2-SMARCA1 (FusionGDB2 ID:26640)

Fusion Gene Summary for ENOX2-SMARCA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ENOX2-SMARCA1
Fusion gene ID: 26640
HgeneTgene
Gene symbol

ENOX2

SMARCA1

Gene ID

10495

6594

Gene nameecto-NOX disulfide-thiol exchanger 2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SynonymsAPK1|COVA1|tNOXISWI|NURF140|SNF2L|SNF2L1|SNF2LB|SNF2LT|SWI|SWI2|hSNF2L
Cytomap

Xq26.1

Xq25-q26.1

Type of geneprotein-codingprotein-coding
Descriptionecto-NOX disulfide-thiol exchanger 2APK1 antigencytosolic ovarian carcinoma antigen 1ecto-NADPH oxidase disulfide-thiol exchanger 2tumor-associated NADH oxidasetumor-associated hydroquinone oxidaseprobable global transcription activator SNF2L1ATP-dependent helicase SMARCA1SNF2-like 1global transcription activator homologous sequencenucleosome-remodeling factor subunit SNF2Lsucrose nonfermenting 2-like protein 1
Modification date2020031320200320
UniProtAcc

Q16206

.
Ensembl transtripts involved in fusion geneENST00000338144, ENST00000370927, 
ENST00000370935, ENST00000394363, 
ENST00000492263, 		ENST00000478420, 
ENST00000371121, ENST00000371122, 
ENST00000371123, 
Fusion gene scores* DoF score6 X 4 X 4=966 X 6 X 2=72
# samples 56
** MAII scorelog2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENOX2 [Title/Abstract] AND SMARCA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENOX2(129837094)-SMARCA1(128605303), # samples:2
Anticipated loss of major functional domain due to fusion event.ENOX2-SMARCA1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ENOX2-SMARCA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENOX2

GO:0007624

ultradian rhythm

12356293

HgeneENOX2

GO:0055114

oxidation-reduction process

11888291

TgeneSMARCA1

GO:0006338

chromatin remodeling

14609955

TgeneSMARCA1

GO:0043044

ATP-dependent chromatin remodeling

15640247


check buttonFusion gene breakpoints across ENOX2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMARCA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7736-01AENOX2chrX

129837094

-SMARCA1chrX

128605303

-


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Fusion Gene ORF analysis for ENOX2-SMARCA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338144ENST00000478420ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5CDS-intronENST00000370927ENST00000478420ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5CDS-intronENST00000370935ENST00000478420ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5CDS-intronENST00000394363ENST00000478420ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5UTR-3CDSENST00000492263ENST00000371121ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5UTR-3CDSENST00000492263ENST00000371122ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5UTR-3CDSENST00000492263ENST00000371123ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
5UTR-intronENST00000492263ENST00000478420ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000370927ENST00000371121ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000370927ENST00000371122ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000370927ENST00000371123ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000370935ENST00000371121ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000370935ENST00000371122ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000370935ENST00000371123ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000394363ENST00000371121ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000394363ENST00000371122ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
Frame-shiftENST00000394363ENST00000371123ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
In-frameENST00000338144ENST00000371121ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
In-frameENST00000338144ENST00000371122ENOX2chrX

129837094

-SMARCA1chrX

128605303

-
In-frameENST00000338144ENST00000371123ENOX2chrX

129837094

-SMARCA1chrX

128605303

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338144ENOX2chrX129837094-ENST00000371121SMARCA1chrX128605303-21316025571324255
ENST00000338144ENOX2chrX129837094-ENST00000371122SMARCA1chrX128605303-21296025571324255
ENST00000338144ENOX2chrX129837094-ENST00000371123SMARCA1chrX128605303-20616025571324255

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338144ENST00000371121ENOX2chrX129837094-SMARCA1chrX128605303-0.0096320430.990368
ENST00000338144ENST00000371122ENOX2chrX129837094-SMARCA1chrX128605303-0.0096908980.99030906
ENST00000338144ENST00000371123ENOX2chrX129837094-SMARCA1chrX128605303-0.0111778370.9888222

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Fusion Genomic Features for ENOX2-SMARCA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ENOX2-SMARCA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:129837094/chrX:128605303)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENOX2

Q16206

.
FUNCTION: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269|PubMed:12356293, ECO:0000269|PubMed:9932650}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711211724855_9078021232.0DomainSANT 1
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711211724958_10228021232.0DomainSANT 2
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711221825855_9078141237.6666666666667DomainSANT 1
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711221825958_10228141237.6666666666667DomainSANT 2
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711231724855_9078021203.0DomainSANT 1
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711231724958_10228021203.0DomainSANT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENOX2chrX:129837094chrX:128605303ENST00000338144-516293_32861611.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000338144-516381_50561611.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000370927-213293_32861611.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000370927-213381_50561611.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000370935-314293_32832582.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000370935-314381_50532582.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000394363-415293_32832582.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000394363-415381_50532582.0Coiled coilOntology_term=ECO:0000255
HgeneENOX2chrX:129837094chrX:128605303ENST00000338144-51658_12561611.0Compositional biasNote=Pro-rich
HgeneENOX2chrX:129837094chrX:128605303ENST00000370927-21358_12561611.0Compositional biasNote=Pro-rich
HgeneENOX2chrX:129837094chrX:128605303ENST00000370935-31458_12532582.0Compositional biasNote=Pro-rich
HgeneENOX2chrX:129837094chrX:128605303ENST00000394363-41558_12532582.0Compositional biasNote=Pro-rich
HgeneENOX2chrX:129837094chrX:128605303ENST00000338144-516128_20761611.0DomainRRM
HgeneENOX2chrX:129837094chrX:128605303ENST00000370927-213128_20761611.0DomainRRM
HgeneENOX2chrX:129837094chrX:128605303ENST00000370935-314128_20732582.0DomainRRM
HgeneENOX2chrX:129837094chrX:128605303ENST00000394363-415128_20732582.0DomainRRM
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711211724195_3608021232.0DomainHelicase ATP-binding
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711211724490_6538021232.0DomainHelicase C-terminal
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711221825195_3608141237.6666666666667DomainHelicase ATP-binding
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711221825490_6538141237.6666666666667DomainHelicase C-terminal
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711231724195_3608021203.0DomainHelicase ATP-binding
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711231724490_6538021203.0DomainHelicase C-terminal
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711211724311_3148021232.0MotifNote=DEAH box
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711221825311_3148141237.6666666666667MotifNote=DEAH box
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711231724311_3148021203.0MotifNote=DEAH box
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711211724208_2158021232.0Nucleotide bindingATP
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711221825208_2158141237.6666666666667Nucleotide bindingATP
TgeneSMARCA1chrX:129837094chrX:128605303ENST000003711231724208_2158021203.0Nucleotide bindingATP


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Fusion Gene Sequence for ENOX2-SMARCA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26640_26640_1_ENOX2-SMARCA1_ENOX2_chrX_129837094_ENST00000338144_SMARCA1_chrX_128605303_ENST00000371121_length(transcript)=2131nt_BP=602nt
GTGTGTGAGAGTCCAGCCTTGGGCCAGAGTGCCGGGTCTAGGCCTGGAAGCGCGAGGCGGGCATTTCGGAAGAGAGTGGCGCGGCGTGGG
GCGCCGCGAGGGCACTACGAGCCCAGGAACTGCCGCGCCGGCCCGATTTTCCGCGGCTGTATAAGGACTAGCGCTTCGGTAGCCGGGGAG
CTGGAGGGAACCTGATTTGAGATCAATTCTTGGAGAACACAAAGAAGTGTGATGGATTGAACCAGCTGCCCTTTGACCCTGCTAACAACA
ACGAGCCCCTGCAGTTTGGTAGTGCCAGTGGCCCTCTGGTCACAGAAGGCCTCATTGAGAATGGAGGGGAATCAAGCAAGAAAAGAAAGA
GAACAAATACTCCTTCAGAAATGATGACAGAGCTAAGTTCACAGTTGAGGACCACACAATGCAAAGAGATTTTAGATGGCTGTGGGTCTA
CGAAATAGGCTATGCAGCCGATAACAGTAGAACTCTGAACGTGGATTCCACTGCAATGACACTACCTATGTCTGATCCAACTGCATGGGC
CACAGCAATGAATAATCTTGGAATGGCACCGCTGGGAATTGCCGGACAACCAATTTTACCTGGTTCCAAGGAATCCTGATATCCCAAATC
CAGCTCTGGCTCAAAGAGAAGAGCAAAAAAAGATTGATGGAGCTGAACCTCTTACACCAGAAGAGACTGAAGAAAAGGAAAAACTTCTCA
CACAAGGTTTCACAAACTGGACTAAACGAGATTTTAACCAGTTTATTAAAGCTAATGAGAAATATGGAAGAGATGACATTGATAACATAG
CTCGAGAGGTAGAGGGCAAATCCCCTGAGGAGGTCATGGAGTATTCAGCTGTATTTTGGGAACGTTGCAATGAATTACAGGACATTGAGA
AAATTATGGCTCAAATTGAACGTGGAGAAGCAAGAATTCAACGAAGGATCAGTATCAAGAAAGCCCTGGATGCCAAAATTGCAAGATACA
AGGCTCCATTTCATCAGTTGCGCATTCAGTATGGAACCAGCAAAGGAAAGAACTATACTGAGGAAGAAGATAGATTCTTGATTTGTATGT
TACACAAAATGGGCTTTGATAGAGAAAATGTATATGAAGAATTAAGACAGTGTGTACGAAATGCTCCCCAGTTTAGATTTGACTGGTTTA
TCAAGTCTAGGACTGCCATGGAATTCCAGAGACGCTGTAACACTCTGATTTCATTGATTGAGAAAGAAAATATGGAAATTGAGGAAAGAG
AGAGAGCAGAAAAGAAGAAACGGGCAACTAAAACTCCAATGGTAAAATTTTCAGCATTTTCCTAACTTTTAGATTTAACATTGTTGGGCC
ATTTAAAATGTGCATATTGGAGCAGAACATTAAATCTGTTTCCATTTTAGTCACAGAAAAGAAAAGCAGAGTCAGCTACTGAGAGCTCTG
GAAAGAAGGATGTCAAGAAGGTGAAATCCTAAAGCCTAGAAATAAAGTTTTAAATGGGAAACTGCTATTTTCTTGTTCCCATCTTCAAAT
GCTAATTGCCAGTTCCAGTGTATTCATGGTACTCTAAGAAAAATCTCTTTGGTTTTGATTTCTTGCATATTTTATATATTTTACAATGCT
TTCTACCTGAAATGTGTAGCTTTATATTTTATGGCATTCTAGTATTTTTGTGTACTGTATTTTGTGCATTTCATGTCTTCATCAAAATCC
TCTCAGTCCTTGTTCTTTTGAAGCTTGTGCTGAGGTTTTAGCTTTTCTATGTTTTATATGCCGCTGCTTTGAAAGAGAACCTAGATTCTA
TAGTTGTATTATTGTTGTTTCATACTTTAAATTTATATGGCTGTGGAAAAACGAATTAAAATGTTTTGAGGAGAAAGACTTTTTCACTTC
TTTGTTGCTTTCTTTTCTATTGAGTCTGGGCTTGTTTGTGTTACTGCATACTGTGATTAGCATAATAATTGTTTCTTTGAGGTCATCTAA
ATATTTTTTTCCTAAAGGAATAAAGGGTGAGGAAAGAAAAATATTAAAAAAGCTAATATTTGATACTGTGCTTGCTGTCAGTATGCATTA

>26640_26640_1_ENOX2-SMARCA1_ENOX2_chrX_129837094_ENST00000338144_SMARCA1_chrX_128605303_ENST00000371121_length(amino acids)=255AA_BP=15
MEWHRWELPDNQFYLVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEG
KSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGF

--------------------------------------------------------------
>26640_26640_2_ENOX2-SMARCA1_ENOX2_chrX_129837094_ENST00000338144_SMARCA1_chrX_128605303_ENST00000371122_length(transcript)=2129nt_BP=602nt
GTGTGTGAGAGTCCAGCCTTGGGCCAGAGTGCCGGGTCTAGGCCTGGAAGCGCGAGGCGGGCATTTCGGAAGAGAGTGGCGCGGCGTGGG
GCGCCGCGAGGGCACTACGAGCCCAGGAACTGCCGCGCCGGCCCGATTTTCCGCGGCTGTATAAGGACTAGCGCTTCGGTAGCCGGGGAG
CTGGAGGGAACCTGATTTGAGATCAATTCTTGGAGAACACAAAGAAGTGTGATGGATTGAACCAGCTGCCCTTTGACCCTGCTAACAACA
ACGAGCCCCTGCAGTTTGGTAGTGCCAGTGGCCCTCTGGTCACAGAAGGCCTCATTGAGAATGGAGGGGAATCAAGCAAGAAAAGAAAGA
GAACAAATACTCCTTCAGAAATGATGACAGAGCTAAGTTCACAGTTGAGGACCACACAATGCAAAGAGATTTTAGATGGCTGTGGGTCTA
CGAAATAGGCTATGCAGCCGATAACAGTAGAACTCTGAACGTGGATTCCACTGCAATGACACTACCTATGTCTGATCCAACTGCATGGGC
CACAGCAATGAATAATCTTGGAATGGCACCGCTGGGAATTGCCGGACAACCAATTTTACCTGGTTCCAAGGAATCCTGATATCCCAAATC
CAGCTCTGGCTCAAAGAGAAGAGCAAAAAAAGATTGATGGAGCTGAACCTCTTACACCAGAAGAGACTGAAGAAAAGGAAAAACTTCTCA
CACAAGGTTTCACAAACTGGACTAAACGAGATTTTAACCAGTTTATTAAAGCTAATGAGAAATATGGAAGAGATGACATTGATAACATAG
CTCGAGAGGTAGAGGGCAAATCCCCTGAGGAGGTCATGGAGTATTCAGCTGTATTTTGGGAACGTTGCAATGAATTACAGGACATTGAGA
AAATTATGGCTCAAATTGAACGTGGAGAAGCAAGAATTCAACGAAGGATCAGTATCAAGAAAGCCCTGGATGCCAAAATTGCAAGATACA
AGGCTCCATTTCATCAGTTGCGCATTCAGTATGGAACCAGCAAAGGAAAGAACTATACTGAGGAAGAAGATAGATTCTTGATTTGTATGT
TACACAAAATGGGCTTTGATAGAGAAAATGTATATGAAGAATTAAGACAGTGTGTACGAAATGCTCCCCAGTTTAGATTTGACTGGTTTA
TCAAGTCTAGGACTGCCATGGAATTCCAGAGACGCTGTAACACTCTGATTTCATTGATTGAGAAAGAAAATATGGAAATTGAGGAAAGAG
AGAGAGCAGAAAAGAAGAAACGGGCAACTAAAACTCCAATGGTAAAATTTTCAGCATTTTCCTAACTTTTAGATTTAACATTGTTGGGCC
ATTTAAAATGTGCATATTGGAGCAGAACATTAAATCTGTTTCCATTTTAGTCACAGAAAAGAAAAGCAGAGTCAGCTACTGAGAGCTCTG
GAAAGAAGGATGTCAAGAAGGTGAAATCCTAAAGCCTAGAAATAAAGTTTTAAATGGGAAACTGCTATTTTCTTGTTCCCATCTTCAAAT
GCTAATTGCCAGTTCCAGTGTATTCATGGTACTCTAAGAAAAATCTCTTTGGTTTTGATTTCTTGCATATTTTATATATTTTACAATGCT
TTCTACCTGAAATGTGTAGCTTTATATTTTATGGCATTCTAGTATTTTTGTGTACTGTATTTTGTGCATTTCATGTCTTCATCAAAATCC
TCTCAGTCCTTGTTCTTTTGAAGCTTGTGCTGAGGTTTTAGCTTTTCTATGTTTTATATGCCGCTGCTTTGAAAGAGAACCTAGATTCTA
TAGTTGTATTATTGTTGTTTCATACTTTAAATTTATATGGCTGTGGAAAAACGAATTAAAATGTTTTGAGGAGAAAGACTTTTTCACTTC
TTTGTTGCTTTCTTTTCTATTGAGTCTGGGCTTGTTTGTGTTACTGCATACTGTGATTAGCATAATAATTGTTTCTTTGAGGTCATCTAA
ATATTTTTTTCCTAAAGGAATAAAGGGTGAGGAAAGAAAAATATTAAAAAAGCTAATATTTGATACTGTGCTTGCTGTCAGTATGCATTA

>26640_26640_2_ENOX2-SMARCA1_ENOX2_chrX_129837094_ENST00000338144_SMARCA1_chrX_128605303_ENST00000371122_length(amino acids)=255AA_BP=15
MEWHRWELPDNQFYLVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEG
KSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGF

--------------------------------------------------------------
>26640_26640_3_ENOX2-SMARCA1_ENOX2_chrX_129837094_ENST00000338144_SMARCA1_chrX_128605303_ENST00000371123_length(transcript)=2061nt_BP=602nt
GTGTGTGAGAGTCCAGCCTTGGGCCAGAGTGCCGGGTCTAGGCCTGGAAGCGCGAGGCGGGCATTTCGGAAGAGAGTGGCGCGGCGTGGG
GCGCCGCGAGGGCACTACGAGCCCAGGAACTGCCGCGCCGGCCCGATTTTCCGCGGCTGTATAAGGACTAGCGCTTCGGTAGCCGGGGAG
CTGGAGGGAACCTGATTTGAGATCAATTCTTGGAGAACACAAAGAAGTGTGATGGATTGAACCAGCTGCCCTTTGACCCTGCTAACAACA
ACGAGCCCCTGCAGTTTGGTAGTGCCAGTGGCCCTCTGGTCACAGAAGGCCTCATTGAGAATGGAGGGGAATCAAGCAAGAAAAGAAAGA
GAACAAATACTCCTTCAGAAATGATGACAGAGCTAAGTTCACAGTTGAGGACCACACAATGCAAAGAGATTTTAGATGGCTGTGGGTCTA
CGAAATAGGCTATGCAGCCGATAACAGTAGAACTCTGAACGTGGATTCCACTGCAATGACACTACCTATGTCTGATCCAACTGCATGGGC
CACAGCAATGAATAATCTTGGAATGGCACCGCTGGGAATTGCCGGACAACCAATTTTACCTGGTTCCAAGGAATCCTGATATCCCAAATC
CAGCTCTGGCTCAAAGAGAAGAGCAAAAAAAGATTGATGGAGCTGAACCTCTTACACCAGAAGAGACTGAAGAAAAGGAAAAACTTCTCA
CACAAGGTTTCACAAACTGGACTAAACGAGATTTTAACCAGTTTATTAAAGCTAATGAGAAATATGGAAGAGATGACATTGATAACATAG
CTCGAGAGGTAGAGGGCAAATCCCCTGAGGAGGTCATGGAGTATTCAGCTGTATTTTGGGAACGTTGCAATGAATTACAGGACATTGAGA
AAATTATGGCTCAAATTGAACGTGGAGAAGCAAGAATTCAACGAAGGATCAGTATCAAGAAAGCCCTGGATGCCAAAATTGCAAGATACA
AGGCTCCATTTCATCAGTTGCGCATTCAGTATGGAACCAGCAAAGGAAAGAACTATACTGAGGAAGAAGATAGATTCTTGATTTGTATGT
TACACAAAATGGGCTTTGATAGAGAAAATGTATATGAAGAATTAAGACAGTGTGTACGAAATGCTCCCCAGTTTAGATTTGACTGGTTTA
TCAAGTCTAGGACTGCCATGGAATTCCAGAGACGCTGTAACACTCTGATTTCATTGATTGAGAAAGAAAATATGGAAATTGAGGAAAGAG
AGAGAGCAGAAAAGAAGAAACGGGCAACTAAAACTCCAATGGTAAAATTTTCAGCATTTTCCTAACTTTTAGTCACAGAAAAGAAAAGCA
GAGTCAGCTACTGAGAGCTCTGGAAAGAAGGATGTCAAGAAGGTGAAATCCTAAAGCCTAGAAATAAAGTTTTAAATGGGAAACTGCTAT
TTTCTTGTTCCCATCTTCAAATGCTAATTGCCAGTTCCAGTGTATTCATGGTACTCTAAGAAAAATCTCTTTGGTTTTGATTTCTTGCAT
ATTTTATATATTTTACAATGCTTTCTACCTGAAATGTGTAGCTTTATATTTTATGGCATTCTAGTATTTTTGTGTACTGTATTTTGTGCA
TTTCATGTCTTCATCAAAATCCTCTCAGTCCTTGTTCTTTTGAAGCTTGTGCTGAGGTTTTAGCTTTTCTATGTTTTATATGCCGCTGCT
TTGAAAGAGAACCTAGATTCTATAGTTGTATTATTGTTGTTTCATACTTTAAATTTATATGGCTGTGGAAAAACGAATTAAAATGTTTTG
AGGAGAAAGACTTTTTCACTTCTTTGTTGCTTTCTTTTCTATTGAGTCTGGGCTTGTTTGTGTTACTGCATACTGTGATTAGCATAATAA
TTGTTTCTTTGAGGTCATCTAAATATTTTTTTCCTAAAGGAATAAAGGGTGAGGAAAGAAAAATATTAAAAAAGCTAATATTTGATACTG

>26640_26640_3_ENOX2-SMARCA1_ENOX2_chrX_129837094_ENST00000338144_SMARCA1_chrX_128605303_ENST00000371123_length(amino acids)=255AA_BP=15
MEWHRWELPDNQFYLVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQGFTNWTKRDFNQFIKANEKYGRDDIDNIAREVEG
KSPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLICMLHKMGF

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Fusion Gene PPI Analysis for ENOX2-SMARCA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENOX2-SMARCA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENOX2-SMARCA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource