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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENPP2-ENPP2 (FusionGDB2 ID:26650)

Fusion Gene Summary for ENPP2-ENPP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ENPP2-ENPP2
Fusion gene ID: 26650
HgeneTgene
Gene symbol

ENPP2

ENPP2

Gene ID

5168

5168

Gene nameectonucleotide pyrophosphatase/phosphodiesterase 2ectonucleotide pyrophosphatase/phosphodiesterase 2
SynonymsATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2ATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2
Cytomap

8q24.12

8q24.12

Type of geneprotein-codingprotein-coding
Descriptionectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase Dectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase D
Modification date2020031320200313
UniProtAcc

Q13822

Q13822

Ensembl transtripts involved in fusion geneENST00000075322, ENST00000259486, 
ENST00000427067, ENST00000518109, 
ENST00000522167, ENST00000522826, 
ENST00000259486, ENST00000427067, 
ENST00000075322, ENST00000518109, 
ENST00000522167, ENST00000522826, 
Fusion gene scores* DoF score4 X 4 X 2=3210 X 9 X 6=540
# samples 411
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/540*10)=-2.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENPP2 [Title/Abstract] AND ENPP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENPP2(120606065)-ENPP2(120612940), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENPP2

GO:0009395

phospholipid catabolic process

15280042|26371182

HgeneENPP2

GO:0030149

sphingolipid catabolic process

14500380

HgeneENPP2

GO:0030334

regulation of cell migration

1733949

HgeneENPP2

GO:0034638

phosphatidylcholine catabolic process

21240271

HgeneENPP2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

18054784

TgeneENPP2

GO:0009395

phospholipid catabolic process

15280042|26371182

TgeneENPP2

GO:0030149

sphingolipid catabolic process

14500380

TgeneENPP2

GO:0030334

regulation of cell migration

1733949

TgeneENPP2

GO:0034638

phosphatidylcholine catabolic process

21240271

TgeneENPP2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

18054784


check buttonFusion gene breakpoints across ENPP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ENPP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA720743ENPP2chr8

120606065

-ENPP2chr8

120612940

+


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Fusion Gene ORF analysis for ENPP2-ENPP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000075322ENST00000259486ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000075322ENST00000427067ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000259486ENST00000259486ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000259486ENST00000427067ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000427067ENST00000259486ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000427067ENST00000427067ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000518109ENST00000259486ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000518109ENST00000427067ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000522167ENST00000259486ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000522167ENST00000427067ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000522826ENST00000259486ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-3CDSENST00000522826ENST00000427067ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000075322ENST00000075322ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000075322ENST00000518109ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000075322ENST00000522167ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000075322ENST00000522826ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000259486ENST00000075322ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000259486ENST00000518109ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000259486ENST00000522167ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000259486ENST00000522826ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000427067ENST00000075322ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000427067ENST00000518109ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000427067ENST00000522167ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000427067ENST00000522826ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000518109ENST00000075322ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000518109ENST00000518109ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000518109ENST00000522167ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000518109ENST00000522826ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522167ENST00000075322ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522167ENST00000518109ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522167ENST00000522167ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522167ENST00000522826ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522826ENST00000075322ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522826ENST00000518109ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522826ENST00000522167ENPP2chr8

120606065

-ENPP2chr8

120612940

+
intron-intronENST00000522826ENST00000522826ENPP2chr8

120606065

-ENPP2chr8

120612940

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ENPP2-ENPP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ENPP2-ENPP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:120606065/:120612940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENPP2

Q13822

ENPP2

Q13822

FUNCTION: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767,). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252). {ECO:0000269|PubMed:11559573, ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:12354767, ECO:0000269|PubMed:14500380, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:21393252, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931, ECO:0000305|PubMed:15700135}.FUNCTION: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767,). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252). {ECO:0000269|PubMed:11559573, ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:12354767, ECO:0000269|PubMed:14500380, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:21393252, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931, ECO:0000305|PubMed:15700135}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ENPP2-ENPP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ENPP2-ENPP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENPP2-ENPP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENPP2-ENPP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource