FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ENPP2-FAM192A (FusionGDB2 ID:26653)

Fusion Gene Summary for ENPP2-FAM192A

check button Fusion gene summary
Fusion gene informationFusion gene name: ENPP2-FAM192A
Fusion gene ID: 26653
HgeneTgene
Gene symbol

ENPP2

FAM192A

Gene ID

5168

80011

Gene nameectonucleotide pyrophosphatase/phosphodiesterase 2proteasome activator subunit 3 interacting protein 1
SynonymsATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2C16orf94|CDA018|CDA10|FAM192A|NIP30|PIP30
Cytomap

8q24.12

16q13

Type of geneprotein-codingprotein-coding
Descriptionectonucleotide pyrophosphatase/phosphodiesterase family member 2E-NPP 2autotaxin-textracellular lysophospholipase Dphosphodiesterase I/nucleotide pyrophosphatase 2plasma lysophospholipase DPSME3-interacting proteinNEFA-interacting nuclear protein NIP30PA28G interacting protein 30kDaPA28G-interacting proteinPSME3 interacting protein 30kDafamily with sequence similarity 192 member Aprotein FAM192A
Modification date2020031320200313
UniProtAcc

Q13822

.
Ensembl transtripts involved in fusion geneENST00000075322, ENST00000259486, 
ENST00000427067, ENST00000522167, 
ENST00000522826, ENST00000518109, 
ENST00000562400, ENST00000389447, 
ENST00000564108, ENST00000566077, 
ENST00000569266, ENST00000309137, 
ENST00000567439, 
Fusion gene scores* DoF score4 X 4 X 2=3221 X 5 X 9=945
# samples 421
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(21/945*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENPP2 [Title/Abstract] AND FAM192A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENPP2(120592356)-FAM192A(57188419), # samples:1
Anticipated loss of major functional domain due to fusion event.ENPP2-FAM192A seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ENPP2-FAM192A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ENPP2-FAM192A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneENPP2

GO:0009395

phospholipid catabolic process

15280042|26371182

HgeneENPP2

GO:0030149

sphingolipid catabolic process

14500380

HgeneENPP2

GO:0030334

regulation of cell migration

1733949

HgeneENPP2

GO:0034638

phosphatidylcholine catabolic process

21240271

HgeneENPP2

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

18054784


check buttonFusion gene breakpoints across ENPP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM192A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-1980-01AENPP2chr8

120592356

-FAM192Achr16

57188419

-


Top

Fusion Gene ORF analysis for ENPP2-FAM192A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000075322ENST00000562400ENPP2chr8

120592356

-FAM192Achr16

57188419

-
5CDS-intronENST00000259486ENST00000562400ENPP2chr8

120592356

-FAM192Achr16

57188419

-
5CDS-intronENST00000427067ENST00000562400ENPP2chr8

120592356

-FAM192Achr16

57188419

-
5CDS-intronENST00000522167ENST00000562400ENPP2chr8

120592356

-FAM192Achr16

57188419

-
5CDS-intronENST00000522826ENST00000562400ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000075322ENST00000389447ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000075322ENST00000564108ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000075322ENST00000566077ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000075322ENST00000569266ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000259486ENST00000389447ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000259486ENST00000564108ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000259486ENST00000566077ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000259486ENST00000569266ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000427067ENST00000389447ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000427067ENST00000564108ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000427067ENST00000566077ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000427067ENST00000569266ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522167ENST00000309137ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522167ENST00000389447ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522167ENST00000564108ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522167ENST00000566077ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522167ENST00000567439ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522826ENST00000389447ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522826ENST00000564108ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522826ENST00000566077ENPP2chr8

120592356

-FAM192Achr16

57188419

-
Frame-shiftENST00000522826ENST00000569266ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000075322ENST00000309137ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000075322ENST00000567439ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000259486ENST00000309137ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000259486ENST00000567439ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000427067ENST00000309137ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000427067ENST00000567439ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000522167ENST00000569266ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000522826ENST00000309137ENPP2chr8

120592356

-FAM192Achr16

57188419

-
In-frameENST00000522826ENST00000567439ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-3CDSENST00000518109ENST00000309137ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-3CDSENST00000518109ENST00000389447ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-3CDSENST00000518109ENST00000564108ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-3CDSENST00000518109ENST00000566077ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-3CDSENST00000518109ENST00000567439ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-3CDSENST00000518109ENST00000569266ENPP2chr8

120592356

-FAM192Achr16

57188419

-
intron-intronENST00000518109ENST00000562400ENPP2chr8

120592356

-FAM192Achr16

57188419

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000259486ENPP2chr8120592356-ENST00000309137FAM192Achr1657188419-40281986502203717
ENST00000259486ENPP2chr8120592356-ENST00000567439FAM192Achr1657188419-22941986502203717
ENST00000427067ENPP2chr8120592356-ENST00000309137FAM192Achr1657188419-39911949312166711
ENST00000427067ENPP2chr8120592356-ENST00000567439FAM192Achr1657188419-22571949312166711
ENST00000522167ENPP2chr8120592356-ENST00000569266FAM192Achr1657188419-113477186988300
ENST00000522826ENPP2chr8120592356-ENST00000309137FAM192Achr1657188419-3822178001997665
ENST00000522826ENPP2chr8120592356-ENST00000567439FAM192Achr1657188419-2088178001997665
ENST00000075322ENPP2chr8120592356-ENST00000309137FAM192Achr1657188419-38811839592056665
ENST00000075322ENPP2chr8120592356-ENST00000567439FAM192Achr1657188419-21471839592056665

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259486ENST00000309137ENPP2chr8120592356-FAM192Achr1657188419-0.0011096970.99889034
ENST00000259486ENST00000567439ENPP2chr8120592356-FAM192Achr1657188419-0.0022588970.9977411
ENST00000427067ENST00000309137ENPP2chr8120592356-FAM192Achr1657188419-0.0017286710.99827135
ENST00000427067ENST00000567439ENPP2chr8120592356-FAM192Achr1657188419-0.0040514510.9959486
ENST00000522167ENST00000569266ENPP2chr8120592356-FAM192Achr1657188419-0.0007933850.9992066
ENST00000522826ENST00000309137ENPP2chr8120592356-FAM192Achr1657188419-0.0010216430.9989784
ENST00000522826ENST00000567439ENPP2chr8120592356-FAM192Achr1657188419-0.0020501050.9979499
ENST00000075322ENST00000309137ENPP2chr8120592356-FAM192Achr1657188419-0.0011374340.9988626
ENST00000075322ENST00000567439ENPP2chr8120592356-FAM192Achr1657188419-0.0023841180.99761593

Top

Fusion Genomic Features for ENPP2-FAM192A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ENPP2-FAM192A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:120592356/chr16:57188419)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENPP2

Q13822

.
FUNCTION: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767,). Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380). Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993). Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573). Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949). May have a role in induction of parturition (PubMed:12176993). Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252). {ECO:0000269|PubMed:11559573, ECO:0000269|PubMed:12176993, ECO:0000269|PubMed:12354767, ECO:0000269|PubMed:14500380, ECO:0000269|PubMed:15769751, ECO:0000269|PubMed:1733949, ECO:0000269|PubMed:21240271, ECO:0000269|PubMed:21393252, ECO:0000269|PubMed:26371182, ECO:0000269|PubMed:27754931, ECO:0000305|PubMed:15700135}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENPP2chr8:120592356chr16:57188419ENST00000075322-192555_98593864.0DomainSMB 1
HgeneENPP2chr8:120592356chr16:57188419ENST00000075322-192599_143593864.0DomainSMB 2
HgeneENPP2chr8:120592356chr16:57188419ENST00000259486-202655_98645916.0DomainSMB 1
HgeneENPP2chr8:120592356chr16:57188419ENST00000259486-202699_143645916.0DomainSMB 2
HgeneENPP2chr8:120592356chr16:57188419ENST00000522826-192655_98593889.0DomainSMB 1
HgeneENPP2chr8:120592356chr16:57188419ENST00000522826-192699_143593889.0DomainSMB 2
HgeneENPP2chr8:120592356chr16:57188419ENST00000075322-1925127_129593864.0MotifCell attachment site
HgeneENPP2chr8:120592356chr16:57188419ENST00000259486-2026127_129645916.0MotifCell attachment site
HgeneENPP2chr8:120592356chr16:57188419ENST00000522826-1926127_129593889.0MotifCell attachment site
HgeneENPP2chr8:120592356chr16:57188419ENST00000075322-1925211_214593864.0RegionSubstrate binding
HgeneENPP2chr8:120592356chr16:57188419ENST00000075322-1925244_255593864.0RegionSubstrate binding
HgeneENPP2chr8:120592356chr16:57188419ENST00000259486-2026211_214645916.0RegionSubstrate binding
HgeneENPP2chr8:120592356chr16:57188419ENST00000259486-2026244_255645916.0RegionSubstrate binding
HgeneENPP2chr8:120592356chr16:57188419ENST00000522826-1926211_214593889.0RegionSubstrate binding
HgeneENPP2chr8:120592356chr16:57188419ENST00000522826-1926244_255593889.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENPP2chr8:120592356chr16:57188419ENST00000075322-1925830_851593864.0RegionRequired for secretion
HgeneENPP2chr8:120592356chr16:57188419ENST00000259486-2026830_851645916.0RegionRequired for secretion
HgeneENPP2chr8:120592356chr16:57188419ENST00000522826-1926830_851593889.0RegionRequired for secretion


Top

Fusion Gene Sequence for ENPP2-FAM192A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26653_26653_1_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000075322_FAM192A_chr16_57188419_ENST00000309137_length(transcript)=3881nt_BP=1839nt
AGTGCACTCCGTGAAGGCAAAGAGAACACGCTGCAAAAGGCTTTCCAAGAATCCTCGACATGGCAAGGAGGAGCTCGTTCCAGTCGTGTC
AGATAATATCCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCACATCGAATTAAGAGAGCAGAAGGATGGGAGG
AAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAGGGCAGGTGCTTTGAACTTCAAGAGGCTGGAC
CTCCTGATTGTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTGTTTGAAGACAGCCCGTGGCT
GGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGCTCAGAGGACTGCTTGGCCAGGGGAGACTGCT
GTACCAATTACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGCCGCAGAATGCCCTGCAGGGT
TTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAGAAAGGCAGCAAAGTCATGCCTAATATTGAAA
AACTAAGGTCTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTTATACACTTTGGCCACTGGGC
TATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCCACTTTTCATCTGCGAGGGCGAGAGAAATTTA
ATCATAGATGGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATTCTTTTGGTCTGTTGTCATCC
CTCACGAGCGGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGGCCTTCGGTCTATGCCTTCTATTCTGAGCAAC
CTGATTTCTCTGGACACAAATATGGCCCTTTCGGCCCTGAGATGACAAATCCTCTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGG
ATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGATAGAACTG
AGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATG
CTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCACCTTCCCA
AACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATG
TTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTTGTAGGTT
ATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGC
CAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTTACCAGAC
CCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATG
AACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACACCTCCCTGAGTGGCCCCTCCA
TCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGACTCCGAGTCCAGCTCAGACA
GCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGCCCCCTAGTTTCTCCGTCCCT
ACACAGGGAGCTCCTCCCCAAGGGTAGATCGGACCGTTCATGCTGCCTATAGGCATTATGTCCCTCAAAAAAAAACTCCTTTGCCTGCAT
CCTGTGTACAACATGACATTTTTAACCAATCCAATCTAAAAATGTGCCAGAATCCACCTGTGGCCCGAATCGTGTTTGGTTCCTCTTTCT
ACTCCACTGCAGATGACCAAACCTGTCCCGCTGCCACTTTCCTCACTGATATTGGGAGGAGGGCAAGGCCCAGCCGAAGTTCCACTAAAA
ATGCCCCAGGAGAATAGGCACCGGCTGGCTTGCCAAAGGGTTTGGGTTTTATTGCTTTCTGTTTTTTCTTTTCCCGACAGCACAAAGAAG
TAAGGGCAGTTATTGGACAGGTGTTATTTAAACATTCTATTGTAAATGAATGTGTTGTTTGGTTCTACTGCATTGTGGAGCATGCGGGGG
AAGAGAACTGACCCAGGTAGTGAAATGGAGCCCTTCCCTGGAACTAACCAGTCCTTGATGTTGTGTGACTAAGTAAAGATGATAAACCCC
ATCTGCTGGGGGTGTCACTTCACACTCGGCATGCATTGTGAAAGCTTTCCATACCCTTGGCCATTCCCTCTCTCCTCTCTCTCCAACCCC
ATTTATGCAGGAAGGGACTGCTAACAAGAACGCTTCCATCTCAAACCTTTTCTCTGCCTGGGAAATTATTTTATGTTTGTTTTTGAAATA
AAGGATTTAGTTTAAGATTCTAAATTTTAGAGAAACAAACGTAGGCCTTGTTTACTAATAGCCAGACATCAGAACTGCAGGTAGGTATGT
TAATGAGATGACTTATTTCTGGCAGCTCCTGGAATCCTAATATTGTAAATGAGTGGGACACACTTGCATATTGTGACCATTCTATTGAGG
CCCTTCTCTGTTTAATGCATATTATACTTGTGCTTTTAACTGTGGAATCTATTTCTAACCTAAAGGTGCTGCCCTAGTACTTTTCTTTGC
TGCCTCTGCTGCTCTTTTTCCTTTCCAAACAGCAACTCTGAGGCCATGAGCAGCCAAAAACTAGAGGTACTGCTCCACCTCGTCTCATAA
AGGGAAACGGGCTCATCCCTTGGATTCTGGAGGAGGGAGAGGGAGATGGTGTGGAGGCCTCGAGGACAGAGATAGACATGAGCTTTGACA
ACAATCTGTAGGCTCTCCTGCTTTAGAATAAGCATGTACCATTCTTTATCCATTCCCCTTATTCCTACATCAATTGTTTTTACTTTCTTG
GGTGTGAGACTGAGTGAGACACACACAAAATGTGTTGACACTGTGATGCCGGCAGGCAGAGCAGCTACTGACTTTGAACATGGGCAGAGA
GGCCCCTGGATCTCATCCAGCCCACTCCTTTTCCCCTTCCAGTACAGTGACACTCTGGTGCCCATTGGCAGATGGCGACTTCCCTGCACC
CATAACTGATGCTTTGTGAATTCTTCCTCCTTTTCAGAACTACTCTGTGCTAATTGTTCTGCCAGTATGGGCGCATCAGCTCCATCCTGA
CAAACAAGACATTTAGGTAAAACTTTGTAGGCACCTTCTGCTTCTCTGCTTCATTGTTCCTGTGATAGTCCTGTTGTTATTACAGCATGT
ACCCAAAACAGCCTCACATTGTTACAGGAGGCAGGCCAGGACATCAAAGTCATCATCTTTATGTGGCATGACTCTTAAGAGGCCATTACT
GTATCTCATGGCCTCTTGATGTGGAAAGAAGTTGACAGAGGGTTGCAGGGTTTAAAAACATCCATTAACATGAAAGCTAATAAACCTGTC

>26653_26653_1_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000075322_FAM192A_chr16_57188419_ENST00000309137_length(amino acids)=665AA_BP=593
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDF
DELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVK
AGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVER
RWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYS

--------------------------------------------------------------
>26653_26653_2_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000075322_FAM192A_chr16_57188419_ENST00000567439_length(transcript)=2147nt_BP=1839nt
AGTGCACTCCGTGAAGGCAAAGAGAACACGCTGCAAAAGGCTTTCCAAGAATCCTCGACATGGCAAGGAGGAGCTCGTTCCAGTCGTGTC
AGATAATATCCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCACATCGAATTAAGAGAGCAGAAGGATGGGAGG
AAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAGGGCAGGTGCTTTGAACTTCAAGAGGCTGGAC
CTCCTGATTGTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTGTTTGAAGACAGCCCGTGGCT
GGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGCTCAGAGGACTGCTTGGCCAGGGGAGACTGCT
GTACCAATTACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGCCGCAGAATGCCCTGCAGGGT
TTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAGAAAGGCAGCAAAGTCATGCCTAATATTGAAA
AACTAAGGTCTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTTATACACTTTGGCCACTGGGC
TATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCCACTTTTCATCTGCGAGGGCGAGAGAAATTTA
ATCATAGATGGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATTCTTTTGGTCTGTTGTCATCC
CTCACGAGCGGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGGCCTTCGGTCTATGCCTTCTATTCTGAGCAAC
CTGATTTCTCTGGACACAAATATGGCCCTTTCGGCCCTGAGATGACAAATCCTCTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGG
ATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGATAGAACTG
AGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATG
CTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCACCTTCCCA
AACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATG
TTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTTGTAGGTT
ATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGC
CAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTTACCAGAC
CCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATG
AACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACACCTCCCTGAGTGGCCCCTCCA
TCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGACTCCGAGTCCAGCTCAGACA
GCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGCCCCCTAGTTTCTCCGTCCCT

>26653_26653_2_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000075322_FAM192A_chr16_57188419_ENST00000567439_length(amino acids)=665AA_BP=593
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDF
DELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVK
AGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVER
RWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYS

--------------------------------------------------------------
>26653_26653_3_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000259486_FAM192A_chr16_57188419_ENST00000309137_length(transcript)=4028nt_BP=1986nt
CGTGAAGGCAAAGAGAACACGCTGCAAAAGGCTTTCCAAGAATCCTCGACATGGCAAGGAGGAGCTCGTTCCAGTCGTGTCAGATAATAT
CCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCACATCGAATTAAGAGAGCAGAAGGATGGGAGGAAGGTCCTC
CTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAGGGCAGGTGCTTTGAACTTCAAGAGGCTGGACCTCCTGATT
GTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTGTTTGAAGACAGCCCGTGGCTGGGAGTGTA
CTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGCTCAGAGGACTGCTTGGCCAGGGGAGACTGCTGTACCAATT
ACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGCCGCAGAATGCCCTGCAGGGTTTGTTCGCC
CTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAGAAAGGCAGCAAAGTCATGCCTAATATTGAAAAACTAAGGT
CTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTTATACACTTTGGCCACTGGGCTATATCCAG
AATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCCACTTTTCATCTGCGAGGGCGAGAGAAATTTAATCATAGAT
GGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATTCTTTTGGTCTGTTGTCATCCCTCACGAGC
GGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGGCCTTCGGTCTATGCCTTCTATTCTGAGCAACCTGATTTCT
CTGGACACAAATATGGCCCTTTCGGCCCTGAGGAGAGTAGTTATGGCTCACCTTTTACTCCGGCTAAGAGACCTAAGAGGAAAGTTGCCC
CTAAGAGGAGACAGGAAAGACCAGTTGCTCCTCCAAAGAAAAGAAGAAGAAAAATACATAGGATGGATCATTATGCTGCGGAAACTCGTC
AGGACAAAATGACAAATCCTCTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTG
TCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATG
ATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATC
TCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTG
AGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCC
AGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGC
CTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGA
ATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTG
ATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTA
CAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACACCTCCCTGAGTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCA
TCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGACTCCGAGTCCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTG
TCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGCCCCCTAGTTTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGA
CCGTTCATGCTGCCTATAGGCATTATGTCCCTCAAAAAAAAACTCCTTTGCCTGCATCCTGTGTACAACATGACATTTTTAACCAATCCA
ATCTAAAAATGTGCCAGAATCCACCTGTGGCCCGAATCGTGTTTGGTTCCTCTTTCTACTCCACTGCAGATGACCAAACCTGTCCCGCTG
CCACTTTCCTCACTGATATTGGGAGGAGGGCAAGGCCCAGCCGAAGTTCCACTAAAAATGCCCCAGGAGAATAGGCACCGGCTGGCTTGC
CAAAGGGTTTGGGTTTTATTGCTTTCTGTTTTTTCTTTTCCCGACAGCACAAAGAAGTAAGGGCAGTTATTGGACAGGTGTTATTTAAAC
ATTCTATTGTAAATGAATGTGTTGTTTGGTTCTACTGCATTGTGGAGCATGCGGGGGAAGAGAACTGACCCAGGTAGTGAAATGGAGCCC
TTCCCTGGAACTAACCAGTCCTTGATGTTGTGTGACTAAGTAAAGATGATAAACCCCATCTGCTGGGGGTGTCACTTCACACTCGGCATG
CATTGTGAAAGCTTTCCATACCCTTGGCCATTCCCTCTCTCCTCTCTCTCCAACCCCATTTATGCAGGAAGGGACTGCTAACAAGAACGC
TTCCATCTCAAACCTTTTCTCTGCCTGGGAAATTATTTTATGTTTGTTTTTGAAATAAAGGATTTAGTTTAAGATTCTAAATTTTAGAGA
AACAAACGTAGGCCTTGTTTACTAATAGCCAGACATCAGAACTGCAGGTAGGTATGTTAATGAGATGACTTATTTCTGGCAGCTCCTGGA
ATCCTAATATTGTAAATGAGTGGGACACACTTGCATATTGTGACCATTCTATTGAGGCCCTTCTCTGTTTAATGCATATTATACTTGTGC
TTTTAACTGTGGAATCTATTTCTAACCTAAAGGTGCTGCCCTAGTACTTTTCTTTGCTGCCTCTGCTGCTCTTTTTCCTTTCCAAACAGC
AACTCTGAGGCCATGAGCAGCCAAAAACTAGAGGTACTGCTCCACCTCGTCTCATAAAGGGAAACGGGCTCATCCCTTGGATTCTGGAGG
AGGGAGAGGGAGATGGTGTGGAGGCCTCGAGGACAGAGATAGACATGAGCTTTGACAACAATCTGTAGGCTCTCCTGCTTTAGAATAAGC
ATGTACCATTCTTTATCCATTCCCCTTATTCCTACATCAATTGTTTTTACTTTCTTGGGTGTGAGACTGAGTGAGACACACACAAAATGT
GTTGACACTGTGATGCCGGCAGGCAGAGCAGCTACTGACTTTGAACATGGGCAGAGAGGCCCCTGGATCTCATCCAGCCCACTCCTTTTC
CCCTTCCAGTACAGTGACACTCTGGTGCCCATTGGCAGATGGCGACTTCCCTGCACCCATAACTGATGCTTTGTGAATTCTTCCTCCTTT
TCAGAACTACTCTGTGCTAATTGTTCTGCCAGTATGGGCGCATCAGCTCCATCCTGACAAACAAGACATTTAGGTAAAACTTTGTAGGCA
CCTTCTGCTTCTCTGCTTCATTGTTCCTGTGATAGTCCTGTTGTTATTACAGCATGTACCCAAAACAGCCTCACATTGTTACAGGAGGCA
GGCCAGGACATCAAAGTCATCATCTTTATGTGGCATGACTCTTAAGAGGCCATTACTGTATCTCATGGCCTCTTGATGTGGAAAGAAGTT

>26653_26653_3_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000259486_FAM192A_chr16_57188419_ENST00000309137_length(amino acids)=717AA_BP=645
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDF
DELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVK
AGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEESSYGSPFTPAKRPKRKVAPKRRQERPVAPPKKRRR
KIHRMDHYAAETRQDKMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFS
NNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVF
VGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNK

--------------------------------------------------------------
>26653_26653_4_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000259486_FAM192A_chr16_57188419_ENST00000567439_length(transcript)=2294nt_BP=1986nt
CGTGAAGGCAAAGAGAACACGCTGCAAAAGGCTTTCCAAGAATCCTCGACATGGCAAGGAGGAGCTCGTTCCAGTCGTGTCAGATAATAT
CCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCACATCGAATTAAGAGAGCAGAAGGATGGGAGGAAGGTCCTC
CTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAGGGCAGGTGCTTTGAACTTCAAGAGGCTGGACCTCCTGATT
GTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTGTTTGAAGACAGCCCGTGGCTGGGAGTGTA
CTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGCTCAGAGGACTGCTTGGCCAGGGGAGACTGCTGTACCAATT
ACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGCCGCAGAATGCCCTGCAGGGTTTGTTCGCC
CTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAGAAAGGCAGCAAAGTCATGCCTAATATTGAAAAACTAAGGT
CTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTTATACACTTTGGCCACTGGGCTATATCCAG
AATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCCACTTTTCATCTGCGAGGGCGAGAGAAATTTAATCATAGAT
GGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATTCTTTTGGTCTGTTGTCATCCCTCACGAGC
GGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGGCCTTCGGTCTATGCCTTCTATTCTGAGCAACCTGATTTCT
CTGGACACAAATATGGCCCTTTCGGCCCTGAGGAGAGTAGTTATGGCTCACCTTTTACTCCGGCTAAGAGACCTAAGAGGAAAGTTGCCC
CTAAGAGGAGACAGGAAAGACCAGTTGCTCCTCCAAAGAAAAGAAGAAGAAAAATACATAGGATGGATCATTATGCTGCGGAAACTCGTC
AGGACAAAATGACAAATCCTCTGAGGGAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTG
TCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATG
ATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATC
TCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTG
AGGATATCCATTTATTGGTGGAACGCAGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCC
AGGGAGACCACGGATTTGATAACAAGGTCAACAGCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGC
CTCCATTTGAAAACATTGAACTTTACAATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGA
ATCATCTCCTGCGCACTAATACCTTCAGGCCAACCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTG
ATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTA
CAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACACCTCCCTGAGTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCA
TCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGACTCCGAGTCCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTG
TCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGCCCCCTAGTTTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGA

>26653_26653_4_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000259486_FAM192A_chr16_57188419_ENST00000567439_length(amino acids)=717AA_BP=645
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDF
DELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVK
AGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEESSYGSPFTPAKRPKRKVAPKRRQERPVAPPKKRRR
KIHRMDHYAAETRQDKMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFS
NNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVF
VGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNK

--------------------------------------------------------------
>26653_26653_5_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000427067_FAM192A_chr16_57188419_ENST00000309137_length(transcript)=3991nt_BP=1949nt
GTCCCCCGGGACAGCGGCCCCCTGACTACATCTGCACTGGAGAAATCCCAAAAGCAAACGGCCAGTGCAAACAAGAGCAGTCCGCAGCAG
CCGTCCCGAGCACAGCTCCCAGGTCGCGGGGCTGCAGCCCAGGCCGCGTCCGCAGCGCCCGGGCAGGAACAGACGCCGAGACTCCCGCAG
CATGACCCGCCACGCCGATCGGATAATATCCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCACATCGAATTAA
GAGAGCAGAAGGATGGGAGGAAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAGGGCAGGTGCTT
TGAACTTCAAGAGGCTGGACCTCCTGATTGTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTG
TTTGAAGACAGCCCGTGGCTGGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGCTCAGAGGACTG
CTTGGCCAGGGGAGACTGCTGTACCAATTACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGC
CGCAGAATGCCCTGCAGGGTTTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAGAAAGGCAGCAA
AGTCATGCCTAATATTGAAAAACTAAGGTCTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTT
ATACACTTTGGCCACTGGGCTATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCCACTTTTCATCT
GCGAGGGCGAGAGAAATTTAATCATAGATGGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATT
CTTTTGGTCTGTTGTCATCCCTCACGAGCGGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGGCCTTCGGTCTA
TGCCTTCTATTCTGAGCAACCTGATTTCTCTGGACACAAATATGGCCCTTTCGGCCCTGAGATGACAAATCCTCTGAGGGAAATCGACAA
AATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGA
TGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCG
ATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTA
CTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGT
TGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCAT
GCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTG
TGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCAT
GCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGA
GCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACAC
CTCCCTGAGTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGA
CTCCGAGTCCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGC
CCCCTAGTTTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGACCGTTCATGCTGCCTATAGGCATTATGTCCCTCAAAA
AAAAACTCCTTTGCCTGCATCCTGTGTACAACATGACATTTTTAACCAATCCAATCTAAAAATGTGCCAGAATCCACCTGTGGCCCGAAT
CGTGTTTGGTTCCTCTTTCTACTCCACTGCAGATGACCAAACCTGTCCCGCTGCCACTTTCCTCACTGATATTGGGAGGAGGGCAAGGCC
CAGCCGAAGTTCCACTAAAAATGCCCCAGGAGAATAGGCACCGGCTGGCTTGCCAAAGGGTTTGGGTTTTATTGCTTTCTGTTTTTTCTT
TTCCCGACAGCACAAAGAAGTAAGGGCAGTTATTGGACAGGTGTTATTTAAACATTCTATTGTAAATGAATGTGTTGTTTGGTTCTACTG
CATTGTGGAGCATGCGGGGGAAGAGAACTGACCCAGGTAGTGAAATGGAGCCCTTCCCTGGAACTAACCAGTCCTTGATGTTGTGTGACT
AAGTAAAGATGATAAACCCCATCTGCTGGGGGTGTCACTTCACACTCGGCATGCATTGTGAAAGCTTTCCATACCCTTGGCCATTCCCTC
TCTCCTCTCTCTCCAACCCCATTTATGCAGGAAGGGACTGCTAACAAGAACGCTTCCATCTCAAACCTTTTCTCTGCCTGGGAAATTATT
TTATGTTTGTTTTTGAAATAAAGGATTTAGTTTAAGATTCTAAATTTTAGAGAAACAAACGTAGGCCTTGTTTACTAATAGCCAGACATC
AGAACTGCAGGTAGGTATGTTAATGAGATGACTTATTTCTGGCAGCTCCTGGAATCCTAATATTGTAAATGAGTGGGACACACTTGCATA
TTGTGACCATTCTATTGAGGCCCTTCTCTGTTTAATGCATATTATACTTGTGCTTTTAACTGTGGAATCTATTTCTAACCTAAAGGTGCT
GCCCTAGTACTTTTCTTTGCTGCCTCTGCTGCTCTTTTTCCTTTCCAAACAGCAACTCTGAGGCCATGAGCAGCCAAAAACTAGAGGTAC
TGCTCCACCTCGTCTCATAAAGGGAAACGGGCTCATCCCTTGGATTCTGGAGGAGGGAGAGGGAGATGGTGTGGAGGCCTCGAGGACAGA
GATAGACATGAGCTTTGACAACAATCTGTAGGCTCTCCTGCTTTAGAATAAGCATGTACCATTCTTTATCCATTCCCCTTATTCCTACAT
CAATTGTTTTTACTTTCTTGGGTGTGAGACTGAGTGAGACACACACAAAATGTGTTGACACTGTGATGCCGGCAGGCAGAGCAGCTACTG
ACTTTGAACATGGGCAGAGAGGCCCCTGGATCTCATCCAGCCCACTCCTTTTCCCCTTCCAGTACAGTGACACTCTGGTGCCCATTGGCA
GATGGCGACTTCCCTGCACCCATAACTGATGCTTTGTGAATTCTTCCTCCTTTTCAGAACTACTCTGTGCTAATTGTTCTGCCAGTATGG
GCGCATCAGCTCCATCCTGACAAACAAGACATTTAGGTAAAACTTTGTAGGCACCTTCTGCTTCTCTGCTTCATTGTTCCTGTGATAGTC
CTGTTGTTATTACAGCATGTACCCAAAACAGCCTCACATTGTTACAGGAGGCAGGCCAGGACATCAAAGTCATCATCTTTATGTGGCATG
ACTCTTAAGAGGCCATTACTGTATCTCATGGCCTCTTGATGTGGAAAGAAGTTGACAGAGGGTTGCAGGGTTTAAAAACATCCATTAACA

>26653_26653_5_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000427067_FAM192A_chr16_57188419_ENST00000309137_length(amino acids)=711AA_BP=639
MHWRNPKSKRPVQTRAVRSSRPEHSSQVAGLQPRPRPQRPGRNRRRDSRSMTRHADRIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPP
TVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNY
QVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPE
SHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFS
GHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYD
PKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGST
FKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNK

--------------------------------------------------------------
>26653_26653_6_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000427067_FAM192A_chr16_57188419_ENST00000567439_length(transcript)=2257nt_BP=1949nt
GTCCCCCGGGACAGCGGCCCCCTGACTACATCTGCACTGGAGAAATCCCAAAAGCAAACGGCCAGTGCAAACAAGAGCAGTCCGCAGCAG
CCGTCCCGAGCACAGCTCCCAGGTCGCGGGGCTGCAGCCCAGGCCGCGTCCGCAGCGCCCGGGCAGGAACAGACGCCGAGACTCCCGCAG
CATGACCCGCCACGCCGATCGGATAATATCCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCACATCGAATTAA
GAGAGCAGAAGGATGGGAGGAAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAGGGCAGGTGCTT
TGAACTTCAAGAGGCTGGACCTCCTGATTGTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTTGATGAGCTGTG
TTTGAAGACAGCCCGTGGCTGGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGCTCAGAGGACTG
CTTGGCCAGGGGAGACTGCTGTACCAATTACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAGGAAATAAAGGC
CGCAGAATGCCCTGCAGGGTTTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAGAAAGGCAGCAA
AGTCATGCCTAATATTGAAAAACTAAGGTCTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACCTTTCCTAACTT
ATACACTTTGGCCACTGGGCTATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCCACTTTTCATCT
GCGAGGGCGAGAGAAATTTAATCATAGATGGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAAGCTGGAACATT
CTTTTGGTCTGTTGTCATCCCTCACGAGCGGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGGCCTTCGGTCTA
TGCCTTCTATTCTGAGCAACCTGATTTCTCTGGACACAAATATGGCCCTTTCGGCCCTGAGATGACAAATCCTCTGAGGGAAATCGACAA
AATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCATGGAATGGAAGA
TGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAATTCG
ATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGCCTTA
CTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGCATGT
TGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACAGCAT
GCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTATGTG
TGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAACCAT
GCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGGTAGA
GCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACAC
CTCCCTGAGTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGA
CTCCGAGTCCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGC
CCCCTAGTTTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGACCGTTCATGCTGCCTATAGGCATTATGTCCCTCAAAA

>26653_26653_6_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000427067_FAM192A_chr16_57188419_ENST00000567439_length(amino acids)=711AA_BP=639
MHWRNPKSKRPVQTRAVRSSRPEHSSQVAGLQPRPRPQRPGRNRRRDSRSMTRHADRIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPP
TVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNY
QVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPE
SHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFS
GHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYD
PKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGST
FKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNK

--------------------------------------------------------------
>26653_26653_7_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000522167_FAM192A_chr16_57188419_ENST00000569266_length(transcript)=1134nt_BP=771nt
AGCATTGGAATTTGGGGCTTCTCCCTTCTAGTGGAGTTCGGAGGATGAAAATTGGCTGACTCTTTGGCAGTTCTGTTAAGAATGGAATGG
AAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTAGGAAGAA
TTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCACTTTAAGC
CTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGCAGATGGC
ATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAGGTCAACA
GCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTACAATGTTA
TGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTCAGGCCAA
CCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGATGATAAGA
ACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCTCTCGGAAACACCTCCCTGA
GTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCTGGGAGCAGCGACTCCGAGT
CCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACCTTCCTCGAGGCCCCCTAGT
TTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGACCGTTCATGCTGCCTATAGGCATTATGTCCCTCAAAAAAAAACTC

>26653_26653_7_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000522167_FAM192A_chr16_57188419_ENST00000569266_length(amino acids)=300AA_BP=228
MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERR
WHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR
PTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKNKLDELNKRLHTKGSTEEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYSGSSDS

--------------------------------------------------------------
>26653_26653_8_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000522826_FAM192A_chr16_57188419_ENST00000309137_length(transcript)=3822nt_BP=1780nt
ATGGCAAGGAGGAGCTCGTTCCAGTCGTGTCAGATAATATCCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCA
CATCGAATTAAGAGAGCAGAAGGATGGGAGGAAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAG
GGCAGGTGCTTTGAACTTCAAGAGGCTGGACCTCCTGATTGTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTT
GATGAGCTGTGTTTGAAGACAGCCCGTGGCTGGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGC
TCAGAGGACTGCTTGGCCAGGGGAGACTGCTGTACCAATTACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAG
GAAATAAAGGCCGCAGAATGCCCTGCAGGGTTTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAG
AAAGGCAGCAAAGTCATGCCTAATATTGAAAAACTAAGGTCTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACC
TTTCCTAACTTATACACTTTGGCCACTGGGCTATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCC
ACTTTTCATCTGCGAGGGCGAGAGAAATTTAATCATAGATGGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAA
GCTGGAACATTCTTTTGGTCTGTTGTCATCCCTCACGAGCGGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGG
CCTTCGGTCTATGCCTTCTATTCTGAGCAACCTGATTTCTCTGGACACAAATATGGCCCTTTCGGCCCTGAGATGACAAATCCTCTGAGG
GAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCAT
GGAATGGAAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTA
GGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCAC
TTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGC
AGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAG
GTCAACAGCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTAC
AATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTC
AGGCCAACCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGAT
GATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCT
CTCGGAAACACCTCCCTGAGTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCT
GGGAGCAGCGACTCCGAGTCCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACC
TTCCTCGAGGCCCCCTAGTTTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGACCGTTCATGCTGCCTATAGGCATTAT
GTCCCTCAAAAAAAAACTCCTTTGCCTGCATCCTGTGTACAACATGACATTTTTAACCAATCCAATCTAAAAATGTGCCAGAATCCACCT
GTGGCCCGAATCGTGTTTGGTTCCTCTTTCTACTCCACTGCAGATGACCAAACCTGTCCCGCTGCCACTTTCCTCACTGATATTGGGAGG
AGGGCAAGGCCCAGCCGAAGTTCCACTAAAAATGCCCCAGGAGAATAGGCACCGGCTGGCTTGCCAAAGGGTTTGGGTTTTATTGCTTTC
TGTTTTTTCTTTTCCCGACAGCACAAAGAAGTAAGGGCAGTTATTGGACAGGTGTTATTTAAACATTCTATTGTAAATGAATGTGTTGTT
TGGTTCTACTGCATTGTGGAGCATGCGGGGGAAGAGAACTGACCCAGGTAGTGAAATGGAGCCCTTCCCTGGAACTAACCAGTCCTTGAT
GTTGTGTGACTAAGTAAAGATGATAAACCCCATCTGCTGGGGGTGTCACTTCACACTCGGCATGCATTGTGAAAGCTTTCCATACCCTTG
GCCATTCCCTCTCTCCTCTCTCTCCAACCCCATTTATGCAGGAAGGGACTGCTAACAAGAACGCTTCCATCTCAAACCTTTTCTCTGCCT
GGGAAATTATTTTATGTTTGTTTTTGAAATAAAGGATTTAGTTTAAGATTCTAAATTTTAGAGAAACAAACGTAGGCCTTGTTTACTAAT
AGCCAGACATCAGAACTGCAGGTAGGTATGTTAATGAGATGACTTATTTCTGGCAGCTCCTGGAATCCTAATATTGTAAATGAGTGGGAC
ACACTTGCATATTGTGACCATTCTATTGAGGCCCTTCTCTGTTTAATGCATATTATACTTGTGCTTTTAACTGTGGAATCTATTTCTAAC
CTAAAGGTGCTGCCCTAGTACTTTTCTTTGCTGCCTCTGCTGCTCTTTTTCCTTTCCAAACAGCAACTCTGAGGCCATGAGCAGCCAAAA
ACTAGAGGTACTGCTCCACCTCGTCTCATAAAGGGAAACGGGCTCATCCCTTGGATTCTGGAGGAGGGAGAGGGAGATGGTGTGGAGGCC
TCGAGGACAGAGATAGACATGAGCTTTGACAACAATCTGTAGGCTCTCCTGCTTTAGAATAAGCATGTACCATTCTTTATCCATTCCCCT
TATTCCTACATCAATTGTTTTTACTTTCTTGGGTGTGAGACTGAGTGAGACACACACAAAATGTGTTGACACTGTGATGCCGGCAGGCAG
AGCAGCTACTGACTTTGAACATGGGCAGAGAGGCCCCTGGATCTCATCCAGCCCACTCCTTTTCCCCTTCCAGTACAGTGACACTCTGGT
GCCCATTGGCAGATGGCGACTTCCCTGCACCCATAACTGATGCTTTGTGAATTCTTCCTCCTTTTCAGAACTACTCTGTGCTAATTGTTC
TGCCAGTATGGGCGCATCAGCTCCATCCTGACAAACAAGACATTTAGGTAAAACTTTGTAGGCACCTTCTGCTTCTCTGCTTCATTGTTC
CTGTGATAGTCCTGTTGTTATTACAGCATGTACCCAAAACAGCCTCACATTGTTACAGGAGGCAGGCCAGGACATCAAAGTCATCATCTT
TATGTGGCATGACTCTTAAGAGGCCATTACTGTATCTCATGGCCTCTTGATGTGGAAAGAAGTTGACAGAGGGTTGCAGGGTTTAAAAAC

>26653_26653_8_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000522826_FAM192A_chr16_57188419_ENST00000309137_length(amino acids)=665AA_BP=593
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDF
DELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVK
AGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVER
RWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYS

--------------------------------------------------------------
>26653_26653_9_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000522826_FAM192A_chr16_57188419_ENST00000567439_length(transcript)=2088nt_BP=1780nt
ATGGCAAGGAGGAGCTCGTTCCAGTCGTGTCAGATAATATCCCTGTTCACTTTTGCCGTTGGAGTCAATATCTGCTTAGGATTCACTGCA
CATCGAATTAAGAGAGCAGAAGGATGGGAGGAAGGTCCTCCTACAGTGCTATCAGACTCCCCCTGGACCAACATCTCCGGATCTTGCAAG
GGCAGGTGCTTTGAACTTCAAGAGGCTGGACCTCCTGATTGTCGCTGTGACAACTTGTGTAAGAGCTATACCAGTTGCTGCCATGACTTT
GATGAGCTGTGTTTGAAGACAGCCCGTGGCTGGGAGTGTACTAAGGACAGATGTGGAGAAGTCAGAAATGAAGAAAATGCCTGTCACTGC
TCAGAGGACTGCTTGGCCAGGGGAGACTGCTGTACCAATTACCAAGTGGTTTGCAAAGGAGAGTCGCATTGGGTTGATGATGACTGTGAG
GAAATAAAGGCCGCAGAATGCCCTGCAGGGTTTGTTCGCCCTCCATTAATCATCTTCTCCGTGGATGGCTTCCGTGCATCATACATGAAG
AAAGGCAGCAAAGTCATGCCTAATATTGAAAAACTAAGGTCTTGTGGCACACACTCTCCCTACATGAGGCCGGTGTACCCAACTAAAACC
TTTCCTAACTTATACACTTTGGCCACTGGGCTATATCCAGAATCACATGGAATTGTTGGCAATTCAATGTATGATCCTGTATTTGATGCC
ACTTTTCATCTGCGAGGGCGAGAGAAATTTAATCATAGATGGTGGGGAGGTCAACCGCTATGGATTACAGCCACCAAGCAAGGGGTGAAA
GCTGGAACATTCTTTTGGTCTGTTGTCATCCCTCACGAGCGGAGAATATTAACCATATTGCAGTGGCTCACCCTGCCAGATCATGAGAGG
CCTTCGGTCTATGCCTTCTATTCTGAGCAACCTGATTTCTCTGGACACAAATATGGCCCTTTCGGCCCTGAGATGACAAATCCTCTGAGG
GAAATCGACAAAATTGTGGGGCAATTAATGGATGGACTGAAACAACTAAAACTGCATCGGTGTGTCAACGTCATCTTTGTCGGAGACCAT
GGAATGGAAGATGTCACATGTGATAGAACTGAGTTCTTGAGTAATTACCTAACTAATGTGGATGATATTACTTTAGTGCCTGGAACTCTA
GGAAGAATTCGATCCAAATTTAGCAACAATGCTAAATATGACCCCAAAGCCATTATTGCCAATCTCACGTGTAAAAAACCAGATCAGCAC
TTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTATGCCAACAACAGAAGAATTGAGGATATCCATTTATTGGTGGAACGC
AGATGGCATGTTGCAAGGAAACCTTTGGATGTTTATAAGAAACCATCAGGAAAATGCTTTTTCCAGGGAGACCACGGATTTGATAACAAG
GTCAACAGCATGCAGACTGTTTTTGTAGGTTATGGCTCAACATTTAAGTACAAGACTAAAGTGCCTCCATTTGAAAACATTGAACTTTAC
AATGTTATGTGTGATCTCCTGGGATTGAAGCCAGCTCCTAATAATGGGACCCATGGAAGTTTGAATCATCTCCTGCGCACTAATACCTTC
AGGCCAACCATGCCAGAGGAAGTTACCAGACCCAATTATCCAGGGATTATGTACCTTCAGTCTGATTTTGACCTGGGCTGCACTTGTGAT
GATAAGGTAGAGCCAAAGAACAAGTTGGATGAACTCAACAAACGGCTTCATACAAAAGGGTCTACAGAAGAGCCCTCATCCTGCAAGTCT
CTCGGAAACACCTCCCTGAGTGGCCCCTCCATCCACTGCCCCTCTGCTGCAGTATGTATCGGCATCCTCCCAGGCCTGGGTGCCTACTCT
GGGAGCAGCGACTCCGAGTCCAGCTCAGACAGCGAAGGCACCATCAATGCCACCGGAAAGATTGTCTCCTCCATCTTCCGAACCAACACC
TTCCTCGAGGCCCCCTAGTTTCTCCGTCCCTACACAGGGAGCTCCTCCCCAAGGGTAGATCGGACCGTTCATGCTGCCTATAGGCATTAT

>26653_26653_9_ENPP2-FAM192A_ENPP2_chr8_120592356_ENST00000522826_FAM192A_chr16_57188419_ENST00000567439_length(amino acids)=665AA_BP=593
MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDF
DELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVK
AGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVER
RWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ENPP2-FAM192A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneFAM192Achr8:120592356chr16:57188419ENST0000030913757201_254182.33333333333334255.0PSME3
TgeneFAM192Achr8:120592356chr16:57188419ENST0000038944747201_254182.33333333333334318.3333333333333PSME3
TgeneFAM192Achr8:120592356chr16:57188419ENST0000056410868201_254182.33333333333334255.0PSME3
TgeneFAM192Achr8:120592356chr16:57188419ENST0000056743957201_254182.33333333333334255.0PSME3
TgeneFAM192Achr8:120592356chr16:57188419ENST0000056926657201_254182.33333333333334255.0PSME3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ENPP2-FAM192A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ENPP2-FAM192A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource