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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENTPD1-FRA10AC1 (FusionGDB2 ID:26686)

Fusion Gene Summary for ENTPD1-FRA10AC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ENTPD1-FRA10AC1
Fusion gene ID: 26686
HgeneTgene
Gene symbol

ENTPD1

FRA10AC1

Gene ID

953

118924

Gene nameectonucleoside triphosphate diphosphohydrolase 1FRA10A associated CGG repeat 1
SynonymsATPDase|CD39|NTPDase-1|SPG64C10orf4|F26C11.1-like|FRA10A
Cytomap

10q24.1

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionectonucleoside triphosphate diphosphohydrolase 1CD39 antigenecto-ATP diphosphohydrolase 1ecto-ATPDase 1ecto-ATPase 1ecto-apyraselymphoid cell activation antigenprotein FRA10AC1fragile site 10q23.3fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1rare folic acid-type fragile site, FRA(10)(q23.3), candidate gene 1
Modification date2020031520200313
UniProtAcc

P49961

Q70Z53

Ensembl transtripts involved in fusion geneENST00000371205, ENST00000371203, 
ENST00000539125, ENST00000371207, 
ENST00000453258, ENST00000490659, 
ENST00000543964, 		ENST00000371430, 
ENST00000394100, ENST00000460752, 
ENST00000536233, ENST00000359204, 
Fusion gene scores* DoF score8 X 7 X 3=1687 X 8 X 4=224
# samples 87
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENTPD1 [Title/Abstract] AND FRA10AC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENTPD1(97516012)-FRA10AC1(95454694), # samples:1
Anticipated loss of major functional domain due to fusion event.ENTPD1-FRA10AC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ENTPD1-FRA10AC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ENTPD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FRA10AC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer271NENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-


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Fusion Gene ORF analysis for ENTPD1-FRA10AC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000371205ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5CDS-intronENST00000371205ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5CDS-intronENST00000371205ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5CDS-intronENST00000371205ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-3CDSENST00000371203ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-3CDSENST00000539125ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000371203ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000371203ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000371203ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000371203ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000539125ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000539125ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000539125ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
5UTR-intronENST00000539125ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
Frame-shiftENST00000371205ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-3CDSENST00000371207ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-3CDSENST00000453258ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-3CDSENST00000490659ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-3CDSENST00000543964ENST00000359204ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000371207ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000371207ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000371207ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000371207ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000453258ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000453258ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000453258ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000453258ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000490659ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000490659ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000490659ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000490659ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000543964ENST00000371430ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000543964ENST00000394100ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000543964ENST00000460752ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-
intron-intronENST00000543964ENST00000536233ENTPD1chr10

97516012

+FRA10AC1chr10

95454694

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ENTPD1-FRA10AC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ENTPD1-FRA10AC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:97516012/:95454694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENTPD1

P49961

FRA10AC1

Q70Z53

FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. {ECO:0000269|PubMed:8955160}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ENTPD1-FRA10AC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ENTPD1-FRA10AC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENTPD1-FRA10AC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENTPD1-FRA10AC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource