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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ENTPD1-IKZF1 (FusionGDB2 ID:26687)

Fusion Gene Summary for ENTPD1-IKZF1

Fusion gene summary

Fusion gene information	Fusion gene name: ENTPD1-IKZF1
	Fusion gene ID: 26687
		Hgene	Tgene
	Gene symbol	ENTPD1	IKZF1
	Gene ID	953	10320
	Gene name	ectonucleoside triphosphate diphosphohydrolase 1	IKAROS family zinc finger 1
	Synonyms	ATPDase\|CD39\|NTPDase-1\|SPG64	CVID13\|Hs.54452\|IK1\|IKAROS\|LYF1\|LyF-1\|PPP1R92\|PRO0758\|ZNFN1A1
	Cytomap	10q24.1	7p12.2
	Type of gene	protein-coding	protein-coding
	Description	ectonucleoside triphosphate diphosphohydrolase 1CD39 antigenecto-ATP diphosphohydrolase 1ecto-ATPDase 1ecto-ATPase 1ecto-apyraselymphoid cell activation antigen	DNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)
	Modification date	20200315	20200329
	UniProtAcc	P49961	Q13422
	Ensembl transtripts involved in fusion gene	ENST00000371203, ENST00000371205, ENST00000371207, ENST00000453258, ENST00000490659, ENST00000539125, ENST00000543964,	ENST00000331340, ENST00000343574, ENST00000346667, ENST00000349824, ENST00000357364, ENST00000359197, ENST00000413698, ENST00000438033, ENST00000439701, ENST00000440768, ENST00000492782,
Fusion gene scores	* DoF score	8 X 7 X 3=168	6 X 5 X 4=120
	# samples	8	6
	** MAII score	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ENTPD1 [Title/Abstract] AND IKZF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ENTPD1(97553089)-IKZF1(50470625), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ENTPD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IKZF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF374130	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+

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Fusion Gene ORF analysis for ENTPD1-IKZF1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000371203	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371203	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371203	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371203	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371203	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371205	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371205	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371205	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371205	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371205	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371207	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371207	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371207	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371207	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000371207	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000453258	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000453258	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000453258	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000453258	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000453258	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000490659	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000490659	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000490659	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000490659	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000490659	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000539125	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000539125	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000539125	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000539125	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000539125	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000543964	ENST00000331340	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000543964	ENST00000343574	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000543964	ENST00000346667	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000543964	ENST00000349824	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-3UTR	ENST00000543964	ENST00000357364	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371203	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371203	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371203	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371203	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371203	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371203	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371205	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371205	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371205	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371205	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371205	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371205	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371207	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371207	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371207	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371207	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371207	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000371207	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000453258	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000453258	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000453258	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000453258	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000453258	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000453258	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000490659	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000490659	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000490659	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000490659	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000490659	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000490659	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000539125	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000539125	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000539125	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000539125	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000539125	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000539125	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000543964	ENST00000359197	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000543964	ENST00000413698	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000543964	ENST00000438033	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000543964	ENST00000439701	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000543964	ENST00000440768	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+
intron-intron	ENST00000543964	ENST00000492782	ENTPD1	chr10	97553089	+	IKZF1	chr7	50470625	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ENTPD1-IKZF1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ENTPD1-IKZF1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:97553089/:50470625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ENTPD1 P49961	IKZF1 Q13422
FUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. {ECO:0000269\|PubMed:8955160}.	FUNCTION: Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250\|UniProtKB:Q03267, ECO:0000269\|PubMed:10204490, ECO:0000269\|PubMed:17135265, ECO:0000269\|PubMed:17934067, ECO:0000269\|PubMed:19141594}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ENTPD1-IKZF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ENTPD1-IKZF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ENTPD1-IKZF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ENTPD1-IKZF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source