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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ENTPD5-MICU1 (FusionGDB2 ID:26708)

Fusion Gene Summary for ENTPD5-MICU1

Fusion gene summary

Fusion gene information	Fusion gene name: ENTPD5-MICU1
	Fusion gene ID: 26708
		Hgene	Tgene
	Gene symbol	ENTPD5	MICU1
	Gene ID	957	10367
	Gene name	ectonucleoside triphosphate diphosphohydrolase 5 (inactive)	mitochondrial calcium uptake 1
	Synonyms	CD39L4\|NTPDase-5\|PCPH	CALC\|CBARA1\|EFHA3\|MPXPS\|ara CALC
	Cytomap	14q24.3	10q22.1
	Type of gene	protein-coding	protein-coding
	Description	ectonucleoside triphosphate diphosphohydrolase 5CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase E	calcium uptake protein 1, mitochondrialatopy-related autoantigen CALCcalcium-binding atopy-related autoantigen 1
	Modification date	20200313	20200313
	UniProtAcc	O75356	Q9BPX6
	Ensembl transtripts involved in fusion gene	ENST00000334696, ENST00000557325, ENST00000554664, ENST00000556242,	ENST00000398763, ENST00000418483, ENST00000604025, ENST00000361114, ENST00000398761, ENST00000401998,
Fusion gene scores	* DoF score	9 X 6 X 7=378	22 X 15 X 11=3630
	# samples	9	30
	** MAII score	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/3630*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ENTPD5 [Title/Abstract] AND MICU1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ENTPD5(74436713)-MICU1(74311099), # samples:3
Anticipated loss of major functional domain due to fusion event.	ENTPD5-MICU1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ENTPD5-MICU1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MICU1	GO:0006851	mitochondrial calcium ion transmembrane transport	24560927
Tgene	MICU1	GO:0051260	protein homooligomerization	24514027
Tgene	MICU1	GO:0051561	positive regulation of mitochondrial calcium ion concentration	24560927
Tgene	MICU1	GO:0070509	calcium ion import	20693986

Fusion gene breakpoints across ENTPD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MICU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A4NN-01A	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-

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Fusion Gene ORF analysis for ENTPD5-MICU1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000334696	ENST00000398763	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
5CDS-intron	ENST00000334696	ENST00000418483	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
5CDS-intron	ENST00000334696	ENST00000604025	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
5CDS-intron	ENST00000557325	ENST00000398763	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
5CDS-intron	ENST00000557325	ENST00000418483	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
5CDS-intron	ENST00000557325	ENST00000604025	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
Frame-shift	ENST00000334696	ENST00000361114	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
Frame-shift	ENST00000334696	ENST00000398761	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
Frame-shift	ENST00000334696	ENST00000401998	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
In-frame	ENST00000557325	ENST00000361114	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
In-frame	ENST00000557325	ENST00000398761	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
In-frame	ENST00000557325	ENST00000401998	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-3CDS	ENST00000554664	ENST00000361114	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-3CDS	ENST00000554664	ENST00000398761	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-3CDS	ENST00000554664	ENST00000401998	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-3CDS	ENST00000556242	ENST00000361114	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-3CDS	ENST00000556242	ENST00000398761	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-3CDS	ENST00000556242	ENST00000401998	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-intron	ENST00000554664	ENST00000398763	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-intron	ENST00000554664	ENST00000418483	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-intron	ENST00000554664	ENST00000604025	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-intron	ENST00000556242	ENST00000398763	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-intron	ENST00000556242	ENST00000418483	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-
intron-intron	ENST00000556242	ENST00000604025	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000557325	ENTPD5	chr14	74436713	-	ENST00000401998	MICU1	chr10	74311099	-	3508	1552	352	2652	766
ENST00000557325	ENTPD5	chr14	74436713	-	ENST00000361114	MICU1	chr10	74311099	-	3508	1552	352	2652	766
ENST00000557325	ENTPD5	chr14	74436713	-	ENST00000398761	MICU1	chr10	74311099	-	3514	1552	352	2658	768

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000557325	ENST00000401998	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-	0.001340928	0.998659
ENST00000557325	ENST00000361114	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-	0.001299288	0.99870074
ENST00000557325	ENST00000398761	ENTPD5	chr14	74436713	-	MICU1	chr10	74311099	-	0.001368096	0.9986319

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Fusion Genomic Features for ENTPD5-MICU1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ENTPD5-MICU1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74436713/chr10:74311099)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ENTPD5 O75356	MICU1 Q9BPX6
FUNCTION: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269\|PubMed:10400613}.	FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733). {ECO:0000269\|PubMed:16002733, ECO:0000269\|PubMed:20693986, ECO:0000269\|PubMed:22904319, ECO:0000269\|PubMed:23101630, ECO:0000269\|PubMed:23747253, ECO:0000269\|PubMed:24313810, ECO:0000269\|PubMed:24332854, ECO:0000269\|PubMed:24503055, ECO:0000269\|PubMed:24560927, ECO:0000269\|PubMed:26341627, ECO:0000269\|PubMed:26903221, ECO:0000269\|PubMed:27099988}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

231_242

110

477.0

Calcium binding

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

421_432

110

477.0

Calcium binding

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

231_242

279.0

Calcium binding

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

421_432

279.0

Calcium binding

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

231_242

279.0

Calcium binding

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

421_432

279.0

Calcium binding

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

218_253

110

477.0

Domain

EF-hand 1

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

408_443

110

477.0

Domain

EF-hand 2

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

218_253

279.0

Domain

EF-hand 1

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

408_443

279.0

Domain

EF-hand 2

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

218_253

279.0

Domain

EF-hand 1

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

408_443

279.0

Domain

EF-hand 2

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

455_465

110

477.0

Region

C-helix region

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

455_465

279.0

Region

C-helix region

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

99_110

279.0

Region

Polybasic region

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

455_465

279.0

Region

C-helix region

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

99_110

279.0

Region

Polybasic region

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

53_476

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

53_476

279.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000398763

34_52

279.0

Transmembrane

Helical

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000418483

34_52

279.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

99_110

110

477.0

Region

Polybasic region

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

53_476

110

477.0

Topological domain

Mitochondrial intermembrane

Tgene

MICU1

chr14:74436713

chr10:74311099

ENST00000361114

34_52

110

477.0

Transmembrane

Helical

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Fusion Gene Sequence for ENTPD5-MICU1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26708_26708_1_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000361114_length(transcript)=3508nt_BP=1552nt
TTCCTTGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTT
GTATCCAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGGTCTCACTCTGTCAC
CGAGGCTGGAGTACAGTGGTGCAATCACAGCTCACGGCAGCTTCAAACTCCTGGGCTCAAGCGATCCTCCTGCCTCACCCTCCCGAGTAG
CTGAGACTACAGCCTCTGCAGGTGTGCGAGCAGGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCAC
TTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTAT
CTTCCTGTCTTCCATGTGCCCCATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCA
TGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTT
TGTAGATCAACCTAAGCAGGGTGCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGGAAAAAGAC
CCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAAGCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAG
GAAGTCACCTTTCCTGGTACCAAAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTGAATTTTCT
GACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTAGGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTT
TGAGAAAACTCTGGAACAAACTCCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACATAGTTACCT
GGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACAGAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTT
ACCGAGATGGTTGGAAGCAGAGTGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTTGAGCCCTG
CTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAGGTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTA
TGACCGAGCTGTTGACACAGACATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGGGAAGTGTG
TGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTCAGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTT
TGCAGACAGCACAGTCTTACAGGTGATGGAATATGAGAATAGGATTCGAGCCTACTCCACGCCAGACAAAATCTTCCGATATTTTGCCAC
CTTGAAAGTCATCAGTGAGCCTGGTGAAGCAGAAGTGTTTATGACACCAGAAGATTTTGTGCGATCCATAACACCCAATGAAAAACAACC
AGAACACTTGGGTCTGGATCAATATATAATAAAACGCTTTGATGGAAAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAG
TATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTT
TGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGTTCAGAGCATCATTCGCTCCCA
AACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTT
TGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGA
ACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGAC
CGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAA
CATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGT
GGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATT
TGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATG
TGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCC
CCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTT
TCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAA
GTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACC
TGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTG
TTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGC
TAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGG
GAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAG
TGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGG

>26708_26708_1_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000361114_length(amino acids)=766AA_BP=398
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGL
SAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS
ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNE
KQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSII
RSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSK
KLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSN

--------------------------------------------------------------
>26708_26708_2_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000398761_length(transcript)=3514nt_BP=1552nt
TTCCTTGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTT
GTATCCAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGGTCTCACTCTGTCAC
CGAGGCTGGAGTACAGTGGTGCAATCACAGCTCACGGCAGCTTCAAACTCCTGGGCTCAAGCGATCCTCCTGCCTCACCCTCCCGAGTAG
CTGAGACTACAGCCTCTGCAGGTGTGCGAGCAGGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCAC
TTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTAT
CTTCCTGTCTTCCATGTGCCCCATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCA
TGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTT
TGTAGATCAACCTAAGCAGGGTGCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGGAAAAAGAC
CCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAAGCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAG
GAAGTCACCTTTCCTGGTACCAAAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTGAATTTTCT
GACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTAGGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTT
TGAGAAAACTCTGGAACAAACTCCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACATAGTTACCT
GGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACAGAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTT
ACCGAGATGGTTGGAAGCAGAGTGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTTGAGCCCTG
CTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAGGTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTA
TGACCGAGCTGTTGACACAGACATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGGGAAGTGTG
TGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTCAGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTT
TGCAGACAGCACAGTCTTACAGGTGATGGAATATGAGAATAGGATTCGAGCCTACTCCACGCCAGACAAAATCTTCCGATATTTTGCCAC
CTTGAAAGTCATCAGTGAGCCTGGTGAAGCAGAAGTGTTTATGACACCAGAAGATTTTGTGCGATCCATAACACCCAATGAAAAACAACC
AGAACACTTGGGTCTGGATCAATATATAATAAAACGCTTTGATGGAAAGAATAAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGA
AGGCAGTATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAG
AAATTTTGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCG
CTCCCAAACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTA
CTTTTTTGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGA
GTTTGAACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAA
GCTGACCGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCT
AAAGAACATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAG
GACAGTGGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAA
GGAATTTGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTG
GAAATGTGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCT
GGACCCCCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTG
TCGGTTTCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACAT
GAACAAGTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCA
CACACCTGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTG
CTGGTGTTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACC
CTACGCTAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCT
CAGTGGGAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGA
CTCCAGTGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAG
CTGAGGCCTGGCTCAGAGCCTGTTTGCCCTCTGTCTTAAACAATTGTAAATATCACTTAAATTATAACCATTTGCAATAAACATCCCCAA

>26708_26708_2_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000398761_length(amino acids)=768AA_BP=398
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGL
SAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS
ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNE
KQPEHLGLDQYIIKRFDGKNKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQAIS
IIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQ
SKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGEL

--------------------------------------------------------------
>26708_26708_3_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000401998_length(transcript)=3508nt_BP=1552nt
TTCCTTGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTT
GTATCCAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGGTCTCACTCTGTCAC
CGAGGCTGGAGTACAGTGGTGCAATCACAGCTCACGGCAGCTTCAAACTCCTGGGCTCAAGCGATCCTCCTGCCTCACCCTCCCGAGTAG
CTGAGACTACAGCCTCTGCAGGTGTGCGAGCAGGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCAC
TTCTTGGGGCACAGTCTTTTTCATGCTGGTGGTATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTAT
CTTCCTGTCTTCCATGTGCCCCATCAATGTCAGCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCA
TGTTTACACCTTTGTGCAGAAAATGCCAGGACAGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTT
TGTAGATCAACCTAAGCAGGGTGCTGAGACCGTTCAAGGGCTCTTAGAGGTGGCCAAAGACTCAATCCCCCGAAGTCACTGGAAAAAGAC
CCCAGTGGTCCTAAAGGCAACAGCAGGACTACGCTTACTGCCAGAACACAAAGCCAAGGCTCTGCTCTTTGAGGTAAAGGAGATCTTCAG
GAAGTCACCTTTCCTGGTACCAAAGGGCAGTGTTAGCATCATGGATGGATCCGACGAAGGCATATTAGCTTGGGTTACTGTGAATTTTCT
GACAGGTCAGCTGCATGGCCACAGACAGGAGACTGTGGGGACCTTGGACCTAGGGGGAGCCTCCACCCAAATCACGTTCCTGCCCCAGTT
TGAGAAAACTCTGGAACAAACTCCTAGGGGCTACCTCACTTCCTTTGAGATGTTTAACAGCACTTATAAGCTCTATACACATAGTTACCT
GGGATTTGGATTGAAAGCTGCAAGACTAGCAACCCTGGGAGCCCTGGAGACAGAAGGGACTGATGGGCACACTTTCCGGAGTGCCTGTTT
ACCGAGATGGTTGGAAGCAGAGTGGATCTTTGGGGGTGTGAAATACCAGTATGGTGGCAACCAAGAAGGGGAGGTGGGCTTTGAGCCCTG
CTATGCCGAAGTGCTGAGGGTGGTACGAGGAAAACTTCACCAGCCAGAGGAGGTCCAGAGAGGTTCCTTCTATGCTTTCTCTTACTATTA
TGACCGAGCTGTTGACACAGACATGATTGATTATGAAAAGGGGGGTATTTTAAAAGTTGAAGATTTTGAAAGAAAAGCCAGGGAAGTGTG
TGATAACTTGGAAAACTTCACCTCAGGCAGTCCTTTCCTGTGCATGGATCTCAGCTACATCACAGCCCTGTTAAAGGATGGCTTTGGCTT
TGCAGACAGCACAGTCTTACAGGTGATGGAATATGAGAATAGGATTCGAGCCTACTCCACGCCAGACAAAATCTTCCGATATTTTGCCAC
CTTGAAAGTCATCAGTGAGCCTGGTGAAGCAGAAGTGTTTATGACACCAGAAGATTTTGTGCGATCCATAACACCCAATGAAAAACAACC
AGAACACTTGGGTCTGGATCAATATATAATAAAACGCTTTGATGGAAAGAAAATTTCCCAGGAACGAGAAAAATTTGCTGATGAAGGCAG
TATATTTTACACCCTTGGAGAATGTGGGCTCATATCCTTTTCAGACTACATTTTCCTCACAACTGTTCTTTCCACTCCTCAGAGAAATTT
TGAAATTGCCTTCAAGATGTTTGATTTGAATGGAGATGGAGAAGTAGATATGGAAGAATTTGAACAGGCAATTAGCATCATTCGCTCCCA
AACCAGTATGGGTATGCGCCACAGAGATCGTCCAACTACTGGCAACACCCTCAAGTCTGGCTTGTGTTCAGCCCTCACAACCTACTTTTT
TGGAGCTGATCTGAAGGGAAAGCTGACAATCAAAAACTTCCTCGAATTTCAGCGTAAACTGCAGCATGATGTTCTGAAGCTTGAGTTTGA
ACGCCATGACCCTGTGGATGGGAGAATTACTGAGAGGCAGTTTGGTGGCATGCTACTTGCCTACAGTGGGGTGCAGTCCAAGAAGCTGAC
CGCCATGCAGAGGCAGCTCAAGAAGCACTTCAAAGAAGGAAAGGGTCTGACATTTCAGGAGGTGGAGAACTTCTTTACTTTCCTAAAGAA
CATTAATGATGTGGACACTGCATTGAGTTTTTACCATATGGCTGGAGCATCTCTTGATAAAGTGACCATGCAGCAGGTGGCCAGGACAGT
GGCTAAAGTGGAGCTCTCAGACCACGTGTGTGATGTGGTGTTTGCACTCTTTGACTGTGATGGCAATGGCGAACTGAGCAATAAGGAATT
TGTTTCCATCATGAAGCAACGGCTGATGAGAGGCCTGGAAAAGCCCAAAGACATGGGTTTCACTCGCCTCATGCAGGCCATGTGGAAATG
TGCACAGGAAACTGCCTGGGACTTCGCTTTACCCAAACAGTAACCCCACACTGCAAGAGGGGACCCCTCCACCCCCAGTACCCTGGACCC
CCTCCGCAGAGTCTCGGCAGAGCCCTTTGTGCTGCTGCTTCTGGAAGTAGTCCCCCTTCCTCCCGGGATGACCTCAGGACTCTGTCGGTT
TCCCCTCTTTACCCTTCCCCGTCCCCGTGTTCTGCTGGGCTCTGATTCTGCCCAATGAGTATCCCCATAGGTTCTCAAAAACATGAACAA
GTCTGTAAAGCTCAGACATTTGTCAGCCTCAACAGCACCACCCATTCAAGCATCCTGTGGATAAAGAATTCAGGGAACCATCCACACACC
TGCCAACCCTGGGAAGCATCCAGTTCTCAAATCGTTTTTGCTATGGATTTATACTAACAAGAACATTCCTTGACTTCCCTCCTGCTGGTG
TTTTAAAGCCACAAGTAGGGAAGATATCTGGCAGGCAGAAAGAAGTCTGTGATGATAAACAATGATGAGGATGACCTAGGCACCCTACGC
TAGTGTGAGAAGCCTGCGCCCCAGGAAGGATCTGTGTTAGTCCCTGGGATGGCTCCAAGGCCTGCTCTAGGAAGGCAGCATGCTCAGTGG
GAACACAGCAAGATTCAGAATTTAAAGTAGTTGCTTCATGGCTCTGTGCACTCCCTTTTCTTCCTCGCAGCCTCCCTAAGATGACTCCAG
TGTGACCCTGTGCTTAGTGAGCAATAGTGATTGAGCTCATGTTCCCTGCAAGTGCCATTTCCTCTCCAGGATGGGCCTCTAAAGCTGAGG

>26708_26708_3_ENTPD5-MICU1_ENTPD5_chr14_74436713_ENST00000557325_MICU1_chr10_74311099_ENST00000401998_length(amino acids)=766AA_BP=398
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGL
SAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTV
NFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRS
ACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAR
EVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNE
KQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQAISII
RSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSK
KLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ENTPD5-MICU1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ENTPD5-MICU1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ENTPD5-MICU1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source