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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENTPD5-TSHR (FusionGDB2 ID:26712)

Fusion Gene Summary for ENTPD5-TSHR

check button Fusion gene summary
Fusion gene informationFusion gene name: ENTPD5-TSHR
Fusion gene ID: 26712
HgeneTgene
Gene symbol

ENTPD5

TSHR

Gene ID

957

7253

Gene nameectonucleoside triphosphate diphosphohydrolase 5 (inactive)thyroid stimulating hormone receptor
SynonymsCD39L4|NTPDase-5|PCPHCHNG1|LGR3|hTSHR-I
Cytomap

14q24.3

14q31.1

Type of geneprotein-codingprotein-coding
Descriptionectonucleoside triphosphate diphosphohydrolase 5CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5nucleoside diphosphataseproto-oncogene CPHuridine-diphosphatase Ethyrotropin receptorTSH receptorseven transmembrane helix receptorthyrotropin receptor-I, hTSHR-I
Modification date2020031320200329
UniProtAcc

O75356

.
Ensembl transtripts involved in fusion geneENST00000334696, ENST00000557325, 
ENST00000554664, ENST00000556242, 
ENST00000557096, ENST00000298171, 
ENST00000342443, ENST00000541158, 
ENST00000554263, ENST00000554435, 
Fusion gene scores* DoF score9 X 6 X 7=3788 X 7 X 7=392
# samples 99
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENTPD5 [Title/Abstract] AND TSHR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENTPD5(74453517)-TSHR(81558875), # samples:2
Anticipated loss of major functional domain due to fusion event.ENTPD5-TSHR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ENTPD5-TSHR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ENTPD5-TSHR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ENTPD5-TSHR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ENTPD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TSHR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01AENTPD5chr14

74453517

-TSHRchr14

81558875

+


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Fusion Gene ORF analysis for ENTPD5-TSHR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334696ENST00000557096ENTPD5chr14

74453517

-TSHRchr14

81558875

+
5CDS-intronENST00000557325ENST00000557096ENTPD5chr14

74453517

-TSHRchr14

81558875

+
Frame-shiftENST00000557325ENST00000298171ENTPD5chr14

74453517

-TSHRchr14

81558875

+
Frame-shiftENST00000557325ENST00000342443ENTPD5chr14

74453517

-TSHRchr14

81558875

+
Frame-shiftENST00000557325ENST00000541158ENTPD5chr14

74453517

-TSHRchr14

81558875

+
Frame-shiftENST00000557325ENST00000554263ENTPD5chr14

74453517

-TSHRchr14

81558875

+
Frame-shiftENST00000557325ENST00000554435ENTPD5chr14

74453517

-TSHRchr14

81558875

+
In-frameENST00000334696ENST00000298171ENTPD5chr14

74453517

-TSHRchr14

81558875

+
In-frameENST00000334696ENST00000342443ENTPD5chr14

74453517

-TSHRchr14

81558875

+
In-frameENST00000334696ENST00000541158ENTPD5chr14

74453517

-TSHRchr14

81558875

+
In-frameENST00000334696ENST00000554263ENTPD5chr14

74453517

-TSHRchr14

81558875

+
In-frameENST00000334696ENST00000554435ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000554664ENST00000298171ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000554664ENST00000342443ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000554664ENST00000541158ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000554664ENST00000554263ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000554664ENST00000554435ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000556242ENST00000298171ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000556242ENST00000342443ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000556242ENST00000541158ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000556242ENST00000554263ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-3CDSENST00000556242ENST00000554435ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-intronENST00000554664ENST00000557096ENTPD5chr14

74453517

-TSHRchr14

81558875

+
intron-intronENST00000556242ENST00000557096ENTPD5chr14

74453517

-TSHRchr14

81558875

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334696ENTPD5chr1474453517-ENST00000541158TSHRchr1481558875+43946176392444601
ENST00000334696ENTPD5chr1474453517-ENST00000342443TSHRchr1481558875+1181617541134135
ENST00000334696ENTPD5chr1474453517-ENST00000298171TSHRchr1481558875+43946176392444601
ENST00000334696ENTPD5chr1474453517-ENST00000554263TSHRchr1481558875+1308617541134135
ENST00000334696ENTPD5chr1474453517-ENST00000554435TSHRchr1481558875+1213617639974111

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334696ENST00000541158ENTPD5chr1474453517-TSHRchr1481558875+0.0003606880.9996393
ENST00000334696ENST00000342443ENTPD5chr1474453517-TSHRchr1481558875+0.041155840.9588441
ENST00000334696ENST00000298171ENTPD5chr1474453517-TSHRchr1481558875+0.0003606880.9996393
ENST00000334696ENST00000554263ENTPD5chr1474453517-TSHRchr1481558875+0.06332470.93667525
ENST00000334696ENST00000554435ENTPD5chr1474453517-TSHRchr1481558875+0.0238342530.9761657

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Fusion Genomic Features for ENTPD5-TSHR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ENTPD5chr1474453516-TSHRchr1481558874+2.67E-050.9999733
ENTPD5chr1474453516-TSHRchr1481558874+2.67E-050.9999733

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ENTPD5-TSHR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74453517/chr14:81558875)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENTPD5

O75356

.
FUNCTION: Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. {ECO:0000269|PubMed:10400613}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349762_764155254.0MotifNote=PDZ-binding
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549762_764155275.0MotifNote=PDZ-binding
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349176_199155254.0RepeatNote=LRR 4
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349200_223155254.0RepeatNote=LRR 5
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349227_248155254.0RepeatNote=LRR 6
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349250_271155254.0RepeatNote=LRR 7
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549176_199155275.0RepeatNote=LRR 4
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549200_223155275.0RepeatNote=LRR 5
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549227_248155275.0RepeatNote=LRR 6
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549250_271155275.0RepeatNote=LRR 7
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349442_450155254.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349474_494155254.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349518_537155254.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349561_580155254.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349603_625155254.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349650_660155254.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349683_764155254.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549442_450155275.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549474_494155275.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549518_537155275.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549561_580155275.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549603_625155275.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549650_660155275.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549683_764155275.0Topological domainCytoplasmic
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349414_441155254.0TransmembraneHelical%3B Name%3D1
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349451_473155254.0TransmembraneHelical%3B Name%3D2
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349495_517155254.0TransmembraneHelical%3B Name%3D3
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349538_560155254.0TransmembraneHelical%3B Name%3D4
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349581_602155254.0TransmembraneHelical%3B Name%3D5
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349626_649155254.0TransmembraneHelical%3B Name%3D6
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349661_682155254.0TransmembraneHelical%3B Name%3D7
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549414_441155275.0TransmembraneHelical%3B Name%3D1
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549451_473155275.0TransmembraneHelical%3B Name%3D2
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549495_517155275.0TransmembraneHelical%3B Name%3D3
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549538_560155275.0TransmembraneHelical%3B Name%3D4
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549581_602155275.0TransmembraneHelical%3B Name%3D5
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549626_649155275.0TransmembraneHelical%3B Name%3D6
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549661_682155275.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349100_124155254.0RepeatNote=LRR 1
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349125_150155254.0RepeatNote=LRR 2
TgeneTSHRchr14:74453517chr14:81558875ENST0000034244349152_174155254.0RepeatNote=LRR 3
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549100_124155275.0RepeatNote=LRR 1
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549125_150155275.0RepeatNote=LRR 2
TgeneTSHRchr14:74453517chr14:81558875ENST0000055443549152_174155275.0RepeatNote=LRR 3
TgeneTSHRchr14:74453517chr14:81558875ENST000003424434921_413155254.0Topological domainExtracellular
TgeneTSHRchr14:74453517chr14:81558875ENST000005544354921_413155275.0Topological domainExtracellular


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Fusion Gene Sequence for ENTPD5-TSHR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26712_26712_1_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000298171_length(transcript)=4394nt_BP=617nt
TAGCCCAGGCGCCGCGGCGCGCGGGGTGGGGCGGAGGTCGCGCCGAGGGCGGCGGGCTGCCGCGCAAGGGTGGCGCGCGCGCGTTTTCCT
TGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTTGTATC
CAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGCCTCTGCAGGTGTGCGAGCA
GGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCACTTCTTGGGGCACAGTCTTTTTCATGCTGGTGG
TATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTATCTTCCTGTCTTCCATGTGCCCCATCAATGTCA
GCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCATGTTTACACCTTTGTGCAGAAAATGCCAGGAC
AGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTTTGTAGATCAACCTAAGCAGTGAAATTACAGAC
AACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACT
TCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCA
TTTGGAGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAG
GAACTGATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCA
AGCCACTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGC
CAGAGAAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAG
TCCAAGTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTC
AAAAACCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCC
AAGTCCGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTG
GGCAATGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGAT
TTCTGCATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACA
GGCCCTGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGG
TATGCCATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTC
CTTCTCGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTG
GCATATATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAAT
CCGCAGTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATC
TCATTCTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAAC
TCCTGTGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAA
CGCCAGGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAG
GGTCTCCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATG
CAAACGGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCAT
GACACCCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAG
TATTAACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGA
AGACTTTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTT
TTGTATAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGC
TCAGTTCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACA
GCTATTATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCT
TCACAAGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGA
ATTGCTCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGC
ACACTCAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTT
CTTCCAATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCT
GTTTTTCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATT
ATGATGTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATA
TCAGGCCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAG
TCACTTCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTT
CTTTTCTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGT
CAGGATCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGAC
ATTACTTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGA
TGGTCCCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTAT
AAACATCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCT
GTGACATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAG

>26712_26712_1_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000298171_length(amino acids)=601AA_BP=
MTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELI
ARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKF
QDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNV
FVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI
TFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQY
NPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQA

--------------------------------------------------------------
>26712_26712_2_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000342443_length(transcript)=1181nt_BP=617nt
TAGCCCAGGCGCCGCGGCGCGCGGGGTGGGGCGGAGGTCGCGCCGAGGGCGGCGGGCTGCCGCGCAAGGGTGGCGCGCGCGCGTTTTCCT
TGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTTGTATC
CAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGCCTCTGCAGGTGTGCGAGCA
GGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCACTTCTTGGGGCACAGTCTTTTTCATGCTGGTGG
TATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTATCTTCCTGTCTTCCATGTGCCCCATCAATGTCA
GCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCATGTTTACACCTTTGTGCAGAAAATGCCAGGAC
AGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTTTGTAGATCAACCTAAGCAGTGAAATTACAGAC
AACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACT
TCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCA
TTTGGAGGAGTATACAGTGGACCAAGCTTGCTGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGT
ATGCCATCATGATGCCTGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTT
GAAATGCAAGATCCACAACTAGATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAA
AGAAGGAAGAATATAAATGATAGTTCGACTCGTCTGTGGAAGAACTTACAATCATGGGGAAAGATGGAATAAAAACATTTTTTAAACAGC

>26712_26712_2_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000342443_length(amino acids)=135AA_BP=
MSWHFLHKGVNMNSSSSAPCIKHNSIQGAGADIDGAHGRQEDTLKPSLLVPVGDSAANTGYHQHEKDCAPRSGHSFPKMWLGGGFCCRSN

--------------------------------------------------------------
>26712_26712_3_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000541158_length(transcript)=4394nt_BP=617nt
TAGCCCAGGCGCCGCGGCGCGCGGGGTGGGGCGGAGGTCGCGCCGAGGGCGGCGGGCTGCCGCGCAAGGGTGGCGCGCGCGCGTTTTCCT
TGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTTGTATC
CAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGCCTCTGCAGGTGTGCGAGCA
GGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCACTTCTTGGGGCACAGTCTTTTTCATGCTGGTGG
TATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTATCTTCCTGTCTTCCATGTGCCCCATCAATGTCA
GCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCATGTTTACACCTTTGTGCAGAAAATGCCAGGAC
AGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTTTGTAGATCAACCTAAGCAGTGAAATTACAGAC
AACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACT
TCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCA
TTTGGAGGAGTATACAGTGGACCAAGCTTGCTGGACGTGTCTCAAACCAGTGTCACTGCCCTTCCATCCAAAGGCCTGGAGCACCTGAAG
GAACTGATAGCAAGAAACACCTGGACTCTTAAGAAACTTCCACTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTACCCA
AGCCACTGCTGTGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTGAGTCCTTGATGTGTAATGAGAGCAGTATGCAGAGCTTGCGC
CAGAGAAAATCTGTGAATGCCTTGAATAGCCCCCTCCACCAGGAATATGAAGAGAATCTGGGTGACAGCATTGTTGGGTACAAGGAAAAG
TCCAAGTTCCAGGATACTCATAACAACGCTCATTATTACGTCTTCTTTGAAGAACAAGAGGATGAGATCATTGGTTTTGGCCAGGAGCTC
AAAAACCCCCAGGAAGAGACTCTACAAGCTTTTGACAGCCATTATGACTACACCATATGTGGGGACAGTGAAGACATGGTGTGTACCCCC
AAGTCCGATGAGTTCAACCCGTGTGAAGACATAATGGGCTACAAGTTCCTGAGAATTGTGGTGTGGTTCGTTAGTCTGCTGGCTCTCCTG
GGCAATGTCTTTGTCCTGCTTATTCTCCTCACCAGCCACTACAAACTGAACGTCCCCCGCTTTCTCATGTGCAACCTGGCCTTTGCGGAT
TTCTGCATGGGGATGTACCTGCTCCTCATCGCCTCTGTAGACCTCTACACTCACTCTGAGTACTACAACCATGCCATCGACTGGCAGACA
GGCCCTGGGTGCAACACGGCTGGTTTCTTCACTGTCTTTGCAAGCGAGTTATCGGTGTATACGCTGACGGTCATCACCCTGGAGCGCTGG
TATGCCATCACCTTCGCCATGCGCCTGGACCGGAAGATCCGCCTCAGGCACGCATGTGCCATCATGGTTGGGGGCTGGGTTTGCTGCTTC
CTTCTCGCCCTGCTTCCTTTGGTGGGAATAAGTAGCTATGCCAAAGTCAGTATCTGCCTGCCCATGGACACCGAGACCCCTCTTGCTCTG
GCATATATTGTTTTTGTTCTGACGCTCAACATAGTTGCCTTCGTCATCGTCTGCTGCTGTTATGTGAAGATCTACATCACAGTCCGAAAT
CCGCAGTACAACCCAGGGGACAAAGATACCAAAATTGCCAAGAGGATGGCTGTGTTGATCTTCACCGACTTCATATGCATGGCCCCAATC
TCATTCTATGCTCTGTCAGCAATTCTGAACAAGCCTCTCATCACTGTTAGCAACTCCAAAATCTTGCTGGTACTCTTCTATCCACTTAAC
TCCTGTGCCAATCCATTCCTCTATGCTATTTTCACCAAGGCCTTCCAGAGGGATGTGTTCATCCTACTCAGCAAGTTTGGCATCTGTAAA
CGCCAGGCTCAGGCATACCGGGGGCAGAGGGTTCCTCCAAAGAACAGCACTGATATTCAGGTTCAAAAGGTTACCCACGAGATGAGGCAG
GGTCTCCACAACATGGAAGATGTCTATGAACTGATTGAAAACTCCCATCTAACCCCAAAGAAGCAAGGCCAAATCTCAGAAGAGTATATG
CAAACGGTTTTGTAAGTTAACACTACACTACTCACAATGGTAGGGGAACTTACAAAATAATAGTTTCTTGAATATGCATTCCAATCCCAT
GACACCCCCAACACATAGCTGCCCTCACTCTTGTGCAGGCGATGTTTCAATGTTTCATGGGGCAAGAGTTTATCTCTGGAGAGTGATTAG
TATTAACCTAATCATTGCCCCCAAGAAGGAAGTTAGGCTACCAGCATATTTGAATGCCAGGTGAAATCAAAATAATCTACACTATCTAGA
AGACTTTCTTGATGCCAAGTCCAGAGATGTCATTGTGTAGGATGTTCAGTAAATATTAACTGAGCTATGTCAATATAGAGCTTCTCAGTT
TTGTATAACATTTCATACTAAAGATTCAGCAAATGGAAAATGCTATTAATTTGGTTGGTGACCACAAGATAAAATCAGTCCCACGTTGGC
TCAGTTCAACTAGATGTTCCCTGATACAAAGAGAACTTGATTTCCTTAAAACTGAAAAGCCAAACACAGCTAGCTGTCATACAAGAAACA
GCTATTATGAGACATGAAGGAGGGTAAGAATTAGCTTTAAGTTTTGTTTTGCTTTGTTTTGTTTTTTAACTCAACCTATTAATCATCTCT
TCACAAGAATCCACCTGATGTGACCAAGCTATTATGTGTTGCCTGGAAAAACTGGCAAGATTTCAGCTTATGTGGCCTAGCAAACTAAGA
ATTGCTCTTCTTGGCCAGCCTCATAGCATAAAAGATGTGAACTCTAGGAAGTCTTTCTGAGTAGCAATAAGTGGGAATTATGGGCAGAGC
ACACTCAATCCCCTGTTGATTAATAAAACAGGCTGGACACTAATTAACTATGGGACTTAAATCTGTAGAAATGAAGGAGTCCAATAGCTT
CTTCCAATTTTAAAACTCTAGTACATCCCTTTCCCTCAAATATATATTTCTAAGATAAAGAGAAAGAAGAGCACTAAGTAAGTAGAATCT
GTTTTTCCTATTTTGTAGGGCTGCTGACTCCTAGTCCTTGAAGCCTAGACACATGACCCAGGAAATTTTTCCTTTGTTTCACTTTTGATT
ATGATGTCTGAGCCAAAAATTCAATTAAGTAAACATACTCGCCTGGATCTGAATCATTCATTTAATTACTAGATCTACCCAGCTGTTATA
TCAGGCCAAAAACAGATTCGTGTTTATATAAAAGAGTAAACGATGGTTGCAAATTTTGGCTATTTAGAGTTGCTACTTCACTATGAAGAG
TCACTTCAAAACACTTCGCTTGTCTTTAGGGATGATTTTTGCCATTTCCAGTCCACGGTATGATACTAAAGCTGTCAAGAGAGGTTTCTT
CTTTTCTGAAACTGCCAGCTCTTTCCAGCCCTGTTGATCACTGGACATAAAGCTTCTTTTCCCCAATAATTCTTCTTTACTTAAAATAGT
CAGGATCTTTATCTACAGATGTACTCTCCAGGTTACCTGTGATGATAGCCCCCTAATGTCCTGCTAGAAAAGTCTCCAAGCAGAGATGAC
ATTACTTCTGAATGCTCATAAACCACACCATGAAATAAAAGCTCTTTGTTGTTTTAAGATTGTGAAGTGTCGTTAATGGGTCCCCACAGA
TGGTCCCTGCTGGACTCACCTGGAATCTCTCCACAGCCATACCCACTCATCACTATCATTGAGACCTGCACATCTTAATAGAAATATTAT
AAACATCGAAAATCATGACTTACCTAGAAGTTCGCTTGTAACTAATGAAATTAAACAAATGTGTTGCCTTTTGTCATGTGTTTCTCTCCT
GTGACATTTCAAAATATCACATCTTGATAAATAATGTGTTTCATCTTGAATAGCTGAACTAATTGCTTTGGAAACAGAGTCCTAGAAAAG

>26712_26712_3_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000541158_length(amino acids)=601AA_BP=
MTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELI
ARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKF
QDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNV
FVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI
TFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQY
NPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQA

--------------------------------------------------------------
>26712_26712_4_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000554263_length(transcript)=1308nt_BP=617nt
TAGCCCAGGCGCCGCGGCGCGCGGGGTGGGGCGGAGGTCGCGCCGAGGGCGGCGGGCTGCCGCGCAAGGGTGGCGCGCGCGCGTTTTCCT
TGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTTGTATC
CAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGCCTCTGCAGGTGTGCGAGCA
GGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCACTTCTTGGGGCACAGTCTTTTTCATGCTGGTGG
TATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTATCTTCCTGTCTTCCATGTGCCCCATCAATGTCA
GCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCATGTTTACACCTTTGTGCAGAAAATGCCAGGAC
AGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTTTGTAGATCAACCTAAGCAGTGAAATTACAGAC
AACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACT
TCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCA
TTTGGAGGAGTATACAGTGGACCAAGCTTGCTGTGAGTAAGACATACAAAAGAATATTTTAGTCTTTTTTTTTCTTTTTTTTTTTTTGGA
ATAAATGGAGACATTAAGGGGAGAATCTTATGTTCAAGGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCC
TGGCTGTATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTA
AGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTA
GATGGAAGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGAT

>26712_26712_4_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000554263_length(amino acids)=135AA_BP=
MSWHFLHKGVNMNSSSSAPCIKHNSIQGAGADIDGAHGRQEDTLKPSLLVPVGDSAANTGYHQHEKDCAPRSGHSFPKMWLGGGFCCRSN

--------------------------------------------------------------
>26712_26712_5_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000554435_length(transcript)=1213nt_BP=617nt
TAGCCCAGGCGCCGCGGCGCGCGGGGTGGGGCGGAGGTCGCGCCGAGGGCGGCGGGCTGCCGCGCAAGGGTGGCGCGCGCGCGTTTTCCT
TGTTCCTGGTCAACAAAGAAATGTGGAGTGTCTTGGCTGAATCCTCATACAGACAAGATCATTATGGTGCTGTTAGGTAGGACTTGTATC
CAGATGTAAGGTTGAAAAAGTGATATAATAAAGGAACCAAGGAGAAAATTCAGAAGGAAAGAAAAAATTGCCTCTGCAGGTGTGCGAGCA
GGATTGCTTCTGCAACAAAAGCCTCCACCCAGCCACATCTTGGGAAAAGAATGGCCACTTCTTGGGGCACAGTCTTTTTCATGCTGGTGG
TATCCTGTGTTTGCAGCGCTGTCTCCCACAGGAACCAGCAGACTTGGTTTGAGGGTATCTTCCTGTCTTCCATGTGCCCCATCAATGTCA
GCGCCAGCACCTTGTATGGAATTATGTTTGATGCAGGGAGCACTGGAACTCGAATTCATGTTTACACCTTTGTGCAGAAAATGCCAGGAC
AGCTTCCAATTCTAGAAGGGGAAGTTTTTGATTCTGTGAAGCCAGGACTTTCTGCTTTTGTAGATCAACCTAAGCAGTGAAATTACAGAC
AACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTATGCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACT
TCAGTCCAAGGATATGCTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTATTGACAAAGATGCA
TTTGGAGGAGTATACAGTGGACCAAGCTTGCTGGTAGAAAATGTTGCTGTCTCGGGTAAAGGCTTCTGCAAGTCCCTCTTTTCCTGGCTG
TATAGGCTACCTCTTGGAAGAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCACGCTCCAGTATGCCATCATGATGCCTGCTAAGGCAG
CCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCTGTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGGA
AGGCACTCTAGTCTTTGCAGAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAAATGATAGTTCG

>26712_26712_5_ENTPD5-TSHR_ENTPD5_chr14_74453517_ENST00000334696_TSHR_chr14_81558875_ENST00000554435_length(amino acids)=111AA_BP=
MTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLVENVAVSGKGFCKSLFSWLYRL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ENTPD5-TSHR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENTPD5-TSHR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENTPD5-TSHR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource