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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPB41L2-LAMA2 (FusionGDB2 ID:26833)

Fusion Gene Summary for EPB41L2-LAMA2

check button Fusion gene summary
Fusion gene informationFusion gene name: EPB41L2-LAMA2
Fusion gene ID: 26833
HgeneTgene
Gene symbol

EPB41L2

LAMA2

Gene ID

2037

3908

Gene nameerythrocyte membrane protein band 4.1 like 2laminin subunit alpha 2
Synonyms4.1-G|4.1GLAMM|MDC1A
Cytomap

6q23.1-q23.2

6q22.33

Type of geneprotein-codingprotein-coding
Descriptionband 4.1-like protein 2erythrocyte membrane protein band 4.1 like-protein 2generally expressed protein 4.1laminin subunit alpha-2laminin M chainlaminin, alpha 2laminin-12 subunit alphalaminin-2 subunit alphalaminin-4 subunit alphamerosin heavy chainmutant laminin subunit alpha 2
Modification date2020031320200328
UniProtAcc.

P24043

Ensembl transtripts involved in fusion geneENST00000337057, ENST00000368128, 
ENST00000392427, ENST00000445890, 
ENST00000525193, ENST00000525271, 
ENST00000527411, ENST00000527659, 
ENST00000528282, ENST00000529208, 
ENST00000530481, ENST00000530148, 
ENST00000524581, ENST00000530757, 
ENST00000531410, 		ENST00000498257, 
ENST00000421865, 
Fusion gene scores* DoF score12 X 11 X 7=92416 X 17 X 7=1904
# samples 1317
** MAII scorelog2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1904*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPB41L2 [Title/Abstract] AND LAMA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPB41L2(131247745)-LAMA2(129704267), # samples:2
LAMA2(129419560)-EPB41L2(131230003), # samples:1
Anticipated loss of major functional domain due to fusion event.EPB41L2-LAMA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EPB41L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LAMA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2788-01AEPB41L2chr6

131247745

-LAMA2chr6

129704267

+


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Fusion Gene ORF analysis for EPB41L2-LAMA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337057ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000368128ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000392427ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000445890ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000525193ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000525271ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000527411ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000527659ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000528282ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000529208ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5CDS-intronENST00000530481ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5UTR-3CDSENST00000530148ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
5UTR-intronENST00000530148ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000337057ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000368128ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000392427ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000445890ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000525271ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000527411ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000528282ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000529208ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
Frame-shiftENST00000530481ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
In-frameENST00000525193ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
In-frameENST00000527659ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
intron-3CDSENST00000524581ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
intron-3CDSENST00000530757ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
intron-3CDSENST00000531410ENST00000421865EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
intron-intronENST00000524581ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
intron-intronENST00000530757ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+
intron-intronENST00000531410ENST00000498257EPB41L2chr6

131247745

-LAMA2chr6

129704267

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525193EPB41L2chr6131247745-ENST00000421865LAMA2chr6129704267+5442810052191739
ENST00000527659EPB41L2chr6131247745-ENST00000421865LAMA2chr6129704267+5442810052191739

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525193ENST00000421865EPB41L2chr6131247745-LAMA2chr6129704267+0.0007856680.9992143
ENST00000527659ENST00000421865EPB41L2chr6131247745-LAMA2chr6129704267+0.0007856680.9992143

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Fusion Genomic Features for EPB41L2-LAMA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EPB41L2chr6131247744-LAMA2chr6129704266+2.10E-070.99999976
EPB41L2chr6131247744-LAMA2chr6129704266+2.10E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EPB41L2-LAMA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:131247745/chr6:129704267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LAMA2

P24043

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533652145_232816533123.0DomainLaminin G-like 1
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533652340_252116533123.0DomainLaminin G-like 2
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533652526_271016533123.0DomainLaminin G-like 3
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533652763_293416533123.0DomainLaminin G-like 4
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533652939_311016533123.0DomainLaminin G-like 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000337057-420218_4992701236.3333333333333DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000368128-420218_4992701230.0DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000392427-415218_499270933.0DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000445890-417218_499270980.3333333333334DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000525271-415218_499270645.3333333333334DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000528282-417218_499270985.0DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000530481-418218_4992701111.3333333333333DomainFERM
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000337057-420502_6102701236.3333333333333RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000337057-420611_6762701236.3333333333333RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000337057-420855_10052701236.3333333333333RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000368128-420502_6102701230.0RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000368128-420611_6762701230.0RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000368128-420855_10052701230.0RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000392427-415502_610270933.0RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000392427-415611_676270933.0RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000392427-415855_1005270933.0RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000445890-417502_610270980.3333333333334RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000445890-417611_676270980.3333333333334RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000445890-417855_1005270980.3333333333334RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000525271-415502_610270645.3333333333334RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000525271-415611_676270645.3333333333334RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000525271-415855_1005270645.3333333333334RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000528282-417502_610270985.0RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000528282-417611_676270985.0RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000528282-417855_1005270985.0RegionNote=C-terminal (CTD)
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000530481-418502_6102701111.3333333333333RegionNote=Hydrophilic
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000530481-418611_6762701111.3333333333333RegionNote=Spectrin--actin-binding
HgeneEPB41L2chr6:131247745chr6:129704267ENST00000530481-418855_10052701111.3333333333333RegionNote=C-terminal (CTD)
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651630_215016533123.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651014_105916533123.0DomainLaminin EGF-like 11
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651060_110516533123.0DomainLaminin EGF-like 12
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651106_116516533123.0DomainLaminin EGF-like 13
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651166_117516533123.0DomainLaminin EGF-like 14%3B first part
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651176_137916533123.0DomainLaminin IV type A 2
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651380_141916533123.0DomainLaminin EGF-like 14%3B second part
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651420_146816533123.0DomainLaminin EGF-like 15
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651469_152616533123.0DomainLaminin EGF-like 16
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651527_157316533123.0DomainLaminin EGF-like 17
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365287_34316533123.0DomainLaminin EGF-like 1
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365344_41316533123.0DomainLaminin EGF-like 2
TgeneLAMA2chr6:131247745chr6:129704267ENST00000421865336535_28616533123.0DomainLaminin N-terminal
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365414_46816533123.0DomainLaminin EGF-like 3
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365469_51716533123.0DomainLaminin EGF-like 4
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365518_52716533123.0DomainLaminin EGF-like 5%3B first part
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365531_72316533123.0DomainLaminin IV type A 1
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365724_75616533123.0DomainLaminin EGF-like 5%3B second part
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365757_80616533123.0DomainLaminin EGF-like 6
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365807_86416533123.0DomainLaminin EGF-like 7
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365865_91716533123.0DomainLaminin EGF-like 8
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365918_96616533123.0DomainLaminin EGF-like 9
TgeneLAMA2chr6:131247745chr6:129704267ENST000004218653365967_101316533123.0DomainLaminin EGF-like 10
TgeneLAMA2chr6:131247745chr6:129704267ENST0000042186533651574_214416533123.0RegionNote=Domain II and I


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Fusion Gene Sequence for EPB41L2-LAMA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26833_26833_1_EPB41L2-LAMA2_EPB41L2_chr6_131247745_ENST00000525193_LAMA2_chr6_129704267_ENST00000421865_length(transcript)=5442nt_BP=810nt
ATGACTACTGAAGTAGGCTCTGTGTCTGAAGTGAAGAAGGACTCTAGCCAGTTAGGAACAGATGCAACCAAGGAAAAACCTAAAGAAGTA
GCAGAAAATCAGCAGAATCAGTCTTCCGATCCAGAGGAGGAAAAAGGTTCCCAGCCACCTCCTGCAGCTGAAAGCCAAAGTAGTCTACGC
CGCCAGAAGAGAGAGAAGGAAACATCGGAGAGCAGGGGTATTTCTCGGTTCATACCGCCATGGCTTAAGAAGCAAAAGTCATATACCTTA
GTAGTGGCCAAAGATGGAGGAGATAAAAAAGAGCCTACCCAAGCTGTTGTTGAAGAACAGGTCTTAGATAAAGAGGAACCCCTTCCAGAA
GAACAGAGACAGGCTAAGGGTGATGCTGAAGAAATGGCTCAGAAGAAACAAGAGATTAAAGTTGAAGTCAAGGAAGAAAAACCCTCAGTG
AGCAAGGAAGAAAAACCCTCAGTGAGCAAAGTGGAGATGCAGCCTACTGAATTAGTAAGTAAGGAGAGAGAAGAGAAGGTAAAAGAAACA
CAGGAAGACAAATTAGAAGGAGGAGCAGCAAAAAGGGAGACCAAGGAAGTGCAGACCAATGAGCTGAAAGCAGAGAAGGCATCTCAAAAA
GTCACCAAGAAGACCAAAACTGTCCAGTGTAAAGTGACCCTCTTAGATGGCACCGAATACAGCTGTGACCTGGAGAAACATGCCAAGGGA
CAAGTGTTATTTGACAAAGTGTGTGAACACCTCAATCTCTTGGAGAAAGACTACTTTGGACTTTTGTTTCAGGAAAGCCCTGAGCAGAAA
GCTACCAAAGTGACAGCAGATGGCGAGCAGACCGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTCATTAAG
GAGCTTGCCCGGGATGCAGAAGCTGTAAATGAAAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAGAGAAAT
TTGGAAGGGCTTCAGAAAGAGATTGACCAGATGATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAAGATGAG
TTGGTAGCTGCAGAAGCCCTTCTGAAAAAAGTGAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGATCTCCGG
GAAAAACTGGCTGACTACAAAAACAAAGTTGATGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAATCGCCTA
TTTGCAGTAAATCAGAAAAACATGACTGCATTGGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACTTTAAAA
GAGGGCAATGACATACTCGATGAAGCCAACCGTCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACTAAATTG
CCACCTATGTCTGAGGAGCTTAATGATAAAATAGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCCCAGGCT
GAGAGCCACGCAGCTCAGTTGAATGACTCATCTGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCCACTGCA
GCCTTCAAAGCTTACAGCAATATTAAGGACTATATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAAGCTACA
AAACTGGCAACAGGTCCTCGGGGTTTATTAAAGGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCCAAGAAG
TTAGCAAATGATGTAAAAGAAAATGAAGACCATCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGATCTCTTG
AGAACTTTGAATGACACTTTGGGAAAGTTATCAGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCCAGACAA
GCCAACGACACAGCTAAAGATGTACTGGCACAGATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAACTAGCA
GACAGCGTCGCCAAAACGAATGCTGTGGTTAAAGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAATTTAGAA
CAGGAAGCTGACCGGCTAATAGATAAACTCAAACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAGGAATTG
ATAAACCAAGCTCGGAAACAAGCCAATTCTATCAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAAATCAAG
AAAGGAAGTTACAATAATATTGTTGTCAACGTAAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTTATTGAC
TTTCTGGCTATAGAAATGCGTAAAGGCAAAGTCAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGATTTGACT
ATTGATGACTCATATTGGTACCGTATCGTAGCATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCCAAAGCC
AGCATTGTGCCCAGCACACACCATTCGACGTCTCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGC
CTGACTGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATA
GGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTT
GATGGAGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCG
AGTGCTCTTCTGATGTATCTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGTTACGAT
CTGGGCTCAGGAATGGCTTCCGTTGTCAGCAATCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAAAAACAA
GCCAATATATCAATTGTAGATATAGATACTAATCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGACTTGAAA
GCAGATGACAAAATATATTTTGGTGGCCTGCCAACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAATATTCC
GGCTGCCTCAAAGATATTGAAATTTCAAGAACTCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGTTCCCTG
GAGAATGTTTACACAGTTAGCTTTCCTAAGCCTGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAACCTGTCA
TTCAGCACCAAGAATGAGTCCGGCATCATTCTTTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACTGGACAG
GCCTATTATGCAATACTCCTCAACAGGGGCCGTCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATCAGACCA
GAGCCGAATCTGTTTCATGATGGAAGAGAACATTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAAAACAGA
AGATACATGCAAAACCTGACAGTTGAACAGCCTATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCTTCCCCA
CTCAGAAATATTCCTCCTTTTGAAGGCTGCATATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCCTTCAAA
AATGCTGACATTGGTCGCTGTGCCCATCAGAAACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCTGAGCCA
GTTCCCACCCCAGCCTTTCCTACGCCCACCCCAGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATAGGGAGC
AAGCAGTTCGGGCTTTCAAGAAACAGTCACATTGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTGGAAGTA
AGAACCGAAGCTGAATCCGGCTTGCTTTTTTACATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGATTGCCC
TACTTCAGCTATGACTTGGGGAGTGGGGACACCCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAGATAATG
AGAAGTAAGCAAGAAGGAATTCTTTATGTAGATGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTCGTGGGA
ATGCTGTATGTTGGTGGGTTACCCATCAACTACACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGGAATCTC
CACATGGCAGAGGCCCCTGCCGATCTGGAACAACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGAACATAT
TTTGACGGAACCGGTTTTGCCAAAGCAGTTGGTGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACTACAACG
ACTGGAGTTCTTCTGGGGATCAGTAGTCAAAAAATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTGGACAAT
GGTGCGGGCAGATTCACTGCTGTCTATGATGCTGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAACAAGATC
AAACACCGCATTGAGCTCACAGTCGATGGGAACCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAATGACCCT
GTGTTTGTTGGAGGCTTCCCAGATGACCTCAAGCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTGAAGCTC
ACCAAAGGCACAGGCAAGCCACTGGAGGTTAATTTTGCCAAGGCCCTGGAACTGAGGGGCGTTCAACCTGTATCATGCCCAGCCAACTAA
TAAAAATAAGTGTAACCCCAGGAAGAGTCTGTCAAAACAAGTATATCAAGTAAAACAAACAAATATATTTTACCTATATATGTTAATTAA
ACTAATTTGTGCATGTACATAGAATTCTTTCTGTATTCAGATGGTGCTAATTCAGACTCCAGACTGAATTTTAATTCAAGTTCTTTCTCA

>26833_26833_1_EPB41L2-LAMA2_EPB41L2_chr6_131247745_ENST00000525193_LAMA2_chr6_129704267_ENST00000421865_length(amino acids)=1739AA_BP=270
MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTL
VVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQK
ATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDE
LVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLK
EGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATA
AFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLL
RTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLE
QEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFID
FLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGG
LTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSS
SALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLK
ADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLS
FSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENR
RYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEP
VPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLP
YFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNL
HMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDN
GAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKL

--------------------------------------------------------------
>26833_26833_2_EPB41L2-LAMA2_EPB41L2_chr6_131247745_ENST00000527659_LAMA2_chr6_129704267_ENST00000421865_length(transcript)=5442nt_BP=810nt
ATGACTACTGAAGTAGGCTCTGTGTCTGAAGTGAAGAAGGACTCTAGCCAGTTAGGAACAGATGCAACCAAGGAAAAACCTAAAGAAGTA
GCAGAAAATCAGCAGAATCAGTCTTCCGATCCAGAGGAGGAAAAAGGTTCCCAGCCACCTCCTGCAGCTGAAAGCCAAAGTAGTCTACGC
CGCCAGAAGAGAGAGAAGGAAACATCGGAGAGCAGGGGTATTTCTCGGTTCATACCGCCATGGCTTAAGAAGCAAAAGTCATATACCTTA
GTAGTGGCCAAAGATGGAGGAGATAAAAAAGAGCCTACCCAAGCTGTTGTTGAAGAACAGGTCTTAGATAAAGAGGAACCCCTTCCAGAA
GAACAGAGACAGGCTAAGGGTGATGCTGAAGAAATGGCTCAGAAGAAACAAGAGATTAAAGTTGAAGTCAAGGAAGAAAAACCCTCAGTG
AGCAAGGAAGAAAAACCCTCAGTGAGCAAAGTGGAGATGCAGCCTACTGAATTAGTAAGTAAGGAGAGAGAAGAGAAGGTAAAAGAAACA
CAGGAAGACAAATTAGAAGGAGGAGCAGCAAAAAGGGAGACCAAGGAAGTGCAGACCAATGAGCTGAAAGCAGAGAAGGCATCTCAAAAA
GTCACCAAGAAGACCAAAACTGTCCAGTGTAAAGTGACCCTCTTAGATGGCACCGAATACAGCTGTGACCTGGAGAAACATGCCAAGGGA
CAAGTGTTATTTGACAAAGTGTGTGAACACCTCAATCTCTTGGAGAAAGACTACTTTGGACTTTTGTTTCAGGAAAGCCCTGAGCAGAAA
GCTACCAAAGTGACAGCAGATGGCGAGCAGACCGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTCATTAAG
GAGCTTGCCCGGGATGCAGAAGCTGTAAATGAAAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAGAGAAAT
TTGGAAGGGCTTCAGAAAGAGATTGACCAGATGATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAAGATGAG
TTGGTAGCTGCAGAAGCCCTTCTGAAAAAAGTGAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGATCTCCGG
GAAAAACTGGCTGACTACAAAAACAAAGTTGATGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAATCGCCTA
TTTGCAGTAAATCAGAAAAACATGACTGCATTGGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACTTTAAAA
GAGGGCAATGACATACTCGATGAAGCCAACCGTCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACTAAATTG
CCACCTATGTCTGAGGAGCTTAATGATAAAATAGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCCCAGGCT
GAGAGCCACGCAGCTCAGTTGAATGACTCATCTGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCCACTGCA
GCCTTCAAAGCTTACAGCAATATTAAGGACTATATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAAGCTACA
AAACTGGCAACAGGTCCTCGGGGTTTATTAAAGGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCCAAGAAG
TTAGCAAATGATGTAAAAGAAAATGAAGACCATCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGATCTCTTG
AGAACTTTGAATGACACTTTGGGAAAGTTATCAGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCCAGACAA
GCCAACGACACAGCTAAAGATGTACTGGCACAGATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAACTAGCA
GACAGCGTCGCCAAAACGAATGCTGTGGTTAAAGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAATTTAGAA
CAGGAAGCTGACCGGCTAATAGATAAACTCAAACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAGGAATTG
ATAAACCAAGCTCGGAAACAAGCCAATTCTATCAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAAATCAAG
AAAGGAAGTTACAATAATATTGTTGTCAACGTAAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTTATTGAC
TTTCTGGCTATAGAAATGCGTAAAGGCAAAGTCAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGATTTGACT
ATTGATGACTCATATTGGTACCGTATCGTAGCATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCCAAAGCC
AGCATTGTGCCCAGCACACACCATTCGACGTCTCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGC
CTGACTGGGAAATTAAAGAAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATA
GGTTTGTGGAATTTCCGAGAAAAAGAAGGTGACTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTT
GATGGAGAAGGTTATGCATTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCG
AGTGCTCTTCTGATGTATCTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGTTACGAT
CTGGGCTCAGGAATGGCTTCCGTTGTCAGCAATCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAAAAACAA
GCCAATATATCAATTGTAGATATAGATACTAATCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGACTTGAAA
GCAGATGACAAAATATATTTTGGTGGCCTGCCAACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAATATTCC
GGCTGCCTCAAAGATATTGAAATTTCAAGAACTCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGTTCCCTG
GAGAATGTTTACACAGTTAGCTTTCCTAAGCCTGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAACCTGTCA
TTCAGCACCAAGAATGAGTCCGGCATCATTCTTTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACTGGACAG
GCCTATTATGCAATACTCCTCAACAGGGGCCGTCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATCAGACCA
GAGCCGAATCTGTTTCATGATGGAAGAGAACATTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAAAACAGA
AGATACATGCAAAACCTGACAGTTGAACAGCCTATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCTTCCCCA
CTCAGAAATATTCCTCCTTTTGAAGGCTGCATATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCCTTCAAA
AATGCTGACATTGGTCGCTGTGCCCATCAGAAACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCTGAGCCA
GTTCCCACCCCAGCCTTTCCTACGCCCACCCCAGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATAGGGAGC
AAGCAGTTCGGGCTTTCAAGAAACAGTCACATTGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTGGAAGTA
AGAACCGAAGCTGAATCCGGCTTGCTTTTTTACATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGATTGCCC
TACTTCAGCTATGACTTGGGGAGTGGGGACACCCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAGATAATG
AGAAGTAAGCAAGAAGGAATTCTTTATGTAGATGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTCGTGGGA
ATGCTGTATGTTGGTGGGTTACCCATCAACTACACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGGAATCTC
CACATGGCAGAGGCCCCTGCCGATCTGGAACAACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGAACATAT
TTTGACGGAACCGGTTTTGCCAAAGCAGTTGGTGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACTACAACG
ACTGGAGTTCTTCTGGGGATCAGTAGTCAAAAAATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTGGACAAT
GGTGCGGGCAGATTCACTGCTGTCTATGATGCTGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAACAAGATC
AAACACCGCATTGAGCTCACAGTCGATGGGAACCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAATGACCCT
GTGTTTGTTGGAGGCTTCCCAGATGACCTCAAGCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTGAAGCTC
ACCAAAGGCACAGGCAAGCCACTGGAGGTTAATTTTGCCAAGGCCCTGGAACTGAGGGGCGTTCAACCTGTATCATGCCCAGCCAACTAA
TAAAAATAAGTGTAACCCCAGGAAGAGTCTGTCAAAACAAGTATATCAAGTAAAACAAACAAATATATTTTACCTATATATGTTAATTAA
ACTAATTTGTGCATGTACATAGAATTCTTTCTGTATTCAGATGGTGCTAATTCAGACTCCAGACTGAATTTTAATTCAAGTTCTTTCTCA

>26833_26833_2_EPB41L2-LAMA2_EPB41L2_chr6_131247745_ENST00000527659_LAMA2_chr6_129704267_ENST00000421865_length(amino acids)=1739AA_BP=270
MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTL
VVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKET
QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQK
ATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDE
LVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLK
EGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATA
AFKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLL
RTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLE
QEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFID
FLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGG
LTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSS
SALLMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLK
ADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLS
FSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENR
RYMQNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEP
VPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLP
YFSYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNL
HMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDN
GAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EPB41L2-LAMA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPB41L2-LAMA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EPB41L2-LAMA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource