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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EPB41L4A-REEP5 (FusionGDB2 ID:26857)

Fusion Gene Summary for EPB41L4A-REEP5

Fusion gene summary

Fusion gene information	Fusion gene name: EPB41L4A-REEP5
	Fusion gene ID: 26857
		Hgene	Tgene
	Gene symbol	EPB41L4A	REEP5
	Gene ID	64097	7905
	Gene name	erythrocyte membrane protein band 4.1 like 4A	receptor accessory protein 5
	Synonyms	EPB41L4\|NBL4	C5orf18\|D5S346\|DP1\|POB16\|TB2\|YOP1\|Yip2e
	Cytomap	5q22.1-q22.2	5q22.2
	Type of gene	protein-coding	protein-coding
	Description	band 4.1-like protein 4Aerythrocyte protein band 4.1-like 4	receptor expression-enhancing protein 5deleted in polyposis 1polyposis coli region hypothetical protein DP1polyposis locus protein 1
	Modification date	20200320	20200313
	UniProtAcc	Q9HCS5	.
	Ensembl transtripts involved in fusion gene	ENST00000261486, ENST00000507810,	ENST00000474542, ENST00000504247, ENST00000379638, ENST00000513339, ENST00000545426,
Fusion gene scores	* DoF score	10 X 9 X 8=720	4 X 4 X 3=48
	# samples	11	6
	** MAII score	log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: EPB41L4A [Title/Abstract] AND REEP5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EPB41L4A(111519713)-REEP5(112238215), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EPB41L4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across REEP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-09-1665-01B	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
ChimerDB4	OV	TCGA-09-1665	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-

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Fusion Gene ORF analysis for EPB41L4A-REEP5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000261486	ENST00000474542	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5CDS-5UTR	ENST00000261486	ENST00000474542	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
5CDS-intron	ENST00000261486	ENST00000504247	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5CDS-intron	ENST00000261486	ENST00000504247	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
5UTR-3CDS	ENST00000507810	ENST00000379638	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5UTR-3CDS	ENST00000507810	ENST00000379638	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
5UTR-3CDS	ENST00000507810	ENST00000513339	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5UTR-3CDS	ENST00000507810	ENST00000513339	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
5UTR-3CDS	ENST00000507810	ENST00000545426	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5UTR-3CDS	ENST00000507810	ENST00000545426	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
5UTR-5UTR	ENST00000507810	ENST00000474542	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5UTR-5UTR	ENST00000507810	ENST00000474542	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
5UTR-intron	ENST00000507810	ENST00000504247	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
5UTR-intron	ENST00000507810	ENST00000504247	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
Frame-shift	ENST00000261486	ENST00000545426	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
Frame-shift	ENST00000261486	ENST00000545426	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
In-frame	ENST00000261486	ENST00000379638	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
In-frame	ENST00000261486	ENST00000379638	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-
In-frame	ENST00000261486	ENST00000513339	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-
In-frame	ENST00000261486	ENST00000513339	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261486	EPB41L4A	chr5	111519713	-	ENST00000379638	REEP5	chr5	112238215	-	4656	1899	256	2256	666
ENST00000261486	EPB41L4A	chr5	111519713	-	ENST00000513339	REEP5	chr5	112238215	-	2789	1899	256	2055	599
ENST00000261486	EPB41L4A	chr5	111519712	-	ENST00000379638	REEP5	chr5	112238215	-	4656	1899	256	2256	666
ENST00000261486	EPB41L4A	chr5	111519712	-	ENST00000513339	REEP5	chr5	112238215	-	2789	1899	256	2055	599

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261486	ENST00000379638	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-	0.000368873	0.99963117
ENST00000261486	ENST00000513339	EPB41L4A	chr5	111519713	-	REEP5	chr5	112238215	-	0.000359519	0.99964046
ENST00000261486	ENST00000379638	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-	0.000368873	0.99963117
ENST00000261486	ENST00000513339	EPB41L4A	chr5	111519712	-	REEP5	chr5	112238215	-	0.000359519	0.99964046

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Fusion Genomic Features for EPB41L4A-REEP5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPB41L4A-REEP5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:111519713/chr5:112238215)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPB41L4A Q9HCS5	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPB41L4A

chr5:111519712

chr5:112238215

ENST00000261486

11_299

540

687.0

Domain

FERM

Hgene

EPB41L4A

chr5:111519713

chr5:112238215

ENST00000261486

11_299

540

687.0

Domain

FERM

Tgene

REEP5

chr5:111519712

chr5:112238215

ENST00000379638

90_110

190.0

Transmembrane

Helical

Tgene

REEP5

chr5:111519713

chr5:112238215

ENST00000379638

90_110

190.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

REEP5

chr5:111519712

chr5:112238215

ENST00000379638

35_55

190.0

Transmembrane

Helical

Tgene

REEP5

chr5:111519713

chr5:112238215

ENST00000379638

35_55

190.0

Transmembrane

Helical

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Fusion Gene Sequence for EPB41L4A-REEP5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26857_26857_1_EPB41L4A-REEP5_EPB41L4A_chr5_111519712_ENST00000261486_REEP5_chr5_112238215_ENST00000379638_length(transcript)=4656nt_BP=1899nt
CGCAGGATGCGCGGGGACGCGCCACCGCCCTCCGCGCCCAGTTCCGCCGGCGCTTCCCCGGCGGCTCCCGGGCGCTGACTCTCCCGGGCT
TTTCCGCCTTTCTCGCTCCCGCCCCGCCGGGCGGTTCGGCGGCCGGTCCCCGGACCCCGCCGGGAGCTGCTCGTCTCACCCTCGCCACGG
CGCGGACAATAAATTAATGCATCGCGCTTGAGTGGAGGGGGCGGCTGGGCGCCTCGGTGGTAGCTTTCTCTCCTGGCTGGAGACGACCAC
AACCGACATGGGCTGTTTCTGCGCTGTTCCGGAAGAATTTTACTGCGAAGTTTTGCTCCTGGATGAATCCAAGTTAACCCTTACCACCCA
GCAGCAGGGCATCAAGAAGTCAACGAAAGGTTCCGTTGTCCTTGACCACGTATTCCATCACGTAAACCTTGTGGAGATAGATTATTTTGG
GCTACGTTACTGTGACAGAAGCCATCAGACGTATTGGCTGGATCCTGCAAAAACCCTTGCTGAACACAAAGAACTGATCAACACTGGACC
TCCATATACTTTGTATTTTGGTATTAAATTCTATGCTGAAGATCCATGTAAACTTAAAGAAGAAATAACCAGATATCAGTTTTTCTTGCA
GGTGAAGCAAGATGTCCTTCAGGGCCGTCTGCCCTGTCCCGTCAACACTGCTGCTCAGCTGGGAGCGTATGCCATCCAGTCGGAGCTTGG
AGATTATGACCCATATAAACATACTGCAGGATATGTATCTGAGTACCGGTTTGTTCCTGATCAGAAGGAAGAACTTGAAGAAGCCATAGA
AAGGATTCATAAAACTCTAATGGGTCAGATTCCTTCTGAGGCTGAGCTGAATTACTTGAGGACTGCCAAATCCCTGGAGATGTATGGCGT
TGACCTCCATCCCGTCTATGGAGAAAACAAGTCTGAGTATTTCTTAGGATTAACTCCGGTTGGTGTTGTTGTGTACAAGAATAAAAAGCA
AGTGGGGAAGTATTTCTGGCCTCGGATTACAAAGGTTCACTTCAAGGAGACTCAATTTGAACTCAGAGTACTGGGAAAAGATTGTAACGA
AACCTCATTCTTTTTTGAAGCTCGGAGTAAAACTGCTTGCAAGCACCTCTGGAAGTGCAGTGTGGAACATCATACATTTTTTAGAATGCC
AGAAAATGAATCCAATTCACTGTCAAGAAAACTCAGCAAGTTTGGATCCATACGTTATAAGCACCGCTACAGTGGCAGGACAGCTTTGCA
AATGAGCCGAGATCTTTCTATTCAGCTTCCCCGGCCTGATCAGAATGTGACAAGAAGTCGAAGCAAGACTTACCCTAAGCGAATAGCACA
AACACAGCCAGCTGAATCAAACAGCATCAGTAGGATAACTGCAAACATGGAAAATGGAGAAAATGAAGGAACAATTAAAATTATTGCACC
TTCACCAGTAAAAAGCTTTAAGAAAGCAAAGAATGAAAATAGCCCTGATACCCAAAGAAGCAAATCTCATGCACCGTGGGAAGAAAATGG
CCCCCAGAGTGGACTCTACAATTCTCCCAGTGATCGCACTAAGTCGCCAAAGTTCCCTTACACGCGTCGCCGAAACCCCTCCTGTGGAAG
TGACAATGATTCTGTACAGCCTGTGAGGAGGAGGAAAGCCCATAACAGTGGTGAAGATTCAGATCTTAAGCAAAGGAGGAGGTCACGTTC
ACGCTGTAACACCAGCAGTGGTAGTGAATCAGAAAATTCTAATAGAGAATACCGGAAAAAGAGAAACAGAATACGGCAGGAGAATGATAT
GGTTGATTCAGCGCCTCAGTGGGAAGCTGTATTAAGGAGACAAAAGGAAAAAAACCAAGCCGACCCCAACAACAGGCGATCCAGACACAG
ATCTCGTTCAATTAAAGCTATAGAGAGTCCCAACAAAGAAGATGATACCCAGTGGCTGACCTACTGGGTAGTGTATGGTGTGTTCAGCAT
TGCTGAATTCTTCTCTGATATCTTCCTGTCATGGTTCCCCTTCTACTACATGCTGAAGTGTGGCTTCCTGTTGTGGTGCATGGCCCCGAG
CCCTTCTAATGGGGCTGAACTGCTCTACAAGCGCATCATCCGTCCTTTCTTCCTGAAGCACGAGTCCCAGATGGACAGTGTGGTCAAGGA
CCTTAAAGACAAGGCCAAAGAGACTGCAGATGCCATCACTAAAGAAGCGAAGAAAGCTACCGTGAATTTACTGGGTGAAGAAAAGAAGAG
CACCTAAACCAGACTGGATGGAAACTTCCTGCCCTCTCTGTACCTTCCTACTGGAGCTTGATGTTATATTAGGGACTGTGGTATAATTAT
TTTAATAATGTTGCCTTGGAAACATTTTTGAGATATTAAAGATTGGAATGTGTTGTAAGTTTCTTTGCTTACTTTTACTGTCTATATATA
TAGGGAGCACTTTAAACTTAATGCAGTGGGCAGTGTCCACGTTTTTGGAAAATGTATTTTGCCTCTGGGTAGGAAAAGATGTATGTTGCT
ATCCTGCAGGAAATATAAACTTAAAATAAAATTATATACCCCACAGGCTGTGTACTTTACTGGGCTCTCCCTGCACGCATTTTCTCTGTA
GTTACATTTAGGATAATCTTTATGGTTCTACTTCCTGTAATGTACAATTTTATATAATTCTGAAATGTTTTTAATGTATTTGTGCACATG
TACATATGGAAATGTTACTGTCTGACTACAACATGCATCATGCTCATGGGGAGGGAGCAGGGGAAGGTTGTATGTGTCATTTATAACTTC
TGTACAGTAAGACCACCTGCCAAAAGCTGGAGGAACCATTGTGCTGGTGTGGTCTACTAAATAATACTTTAGGAAATACGTGATTAATAT
GCAAGTGAACAAAGTGAGAAATGAAATCGAATGGAGATTGGCCTGGTTGTTTCCGTAGTATATGGCATATGAATACCAGGATAGCTTTAT
AAAGCAGTTAGTTAGTTAGTTACTCACTCTAGTGATAAATCGGGAAATTTACACACACACACACACACACACACACACACACACACACAC
AGAGTAACCTGTAACTCTCAATTCCCTGAAAAACTAGTAATACTGTCTTATCTGCTATAAACTTTACATATTTGTCTATTGTCAAGATGC
TACAATGGAAACCATTTCTGGTTTTATCTTCAAAGCGGAGAAACATGTTGATTTAGTCTTCTTTCCCAATCTTCTTTTTTAAACCAGTTT
AAGGAACTTCTGAAGATTTGTCCACCTCTGATTACATGTATGTTCTTGTTTGTATCATTAGCAACAACATGCTAATGACGACACCTAGCT
CTAAGAGCAATTCTGGGAGAATGAAAGGAAGTATAAAGTAACCCATAATCTGCTTGGCAATAGTTAAGTCAATCTATCTTCAGTTTTTCT
CTGGCCTTTAAGGTCAAACACAAGAGGCTTCCCTAGTTTACAAGTCAGAGTCACTTGTAGTCCATTTAAATGCCCTCATCCGTATTCTTT
GTGTTGATAAGCTGCACATGACTACATAGTAAGTACAGAACAGTAAAGTTAAAACGGATGTCTCCATTGATCTGCCAAATCGTTATAGAG
AGCAATTTGTCTGGACTAGAAAATCTGAGTTTTACACCATACTGTTAAGAGTCCTTTTGAATTAAACTCGACTAAAACAAGTGTATAACT
AAACTAACAAGATTAAATATCCAGCCAGTACAGTATTTTTTAAGGCAAATAAAGATGATTAGCTCACCTTGAGATAACAATCAGGTAAGA
TCATAACAATGTCTCATGATGTAAAAAATATTAAAGATATCAATACTAAGTGACAGTATCACTCTAATATAATATGGATCAGAGCATTTA
TTTTGGGGAGGAAAACAGTGGTGATTACCGGCATTTTATTAAACTTAAAACTTTGTAGAAAGCAAACAAAATTGTTCTTGGGAGAAAATC
AACTTTTAGATTAAAAAAATTTTAAGTATCTAGGAGTATTTAAATCCTTTTCCCATAAATAAAAGTACAGTTTTCTTGGTGGCAGAATGA
AAATCAGCAACTTCTAGCATATAGACTATATAATCAGATTGACAGCATATAGAATATATTATCAGACAAGATGAGGAGGTACAAAAGTTA
CTATTGCTCATAATGACTTACAGGCTAAAATTAGTTTTAAAATACTATATTAAATTCTGAATGCAATTTTTTTTTGTTCCCTTGAGACCA
AAATTTAAGTTAACTGTTGCTGGCAGTCTAAGTGTAAATGTTAACAGCAGGAGAAGTTAAGAATTGAGCAGTTCTGTTGCATGATTTCCC
AAATGAAATACTGCCTTGGCTAGAGTTTGAAAAACTAATTGAGCCTGTGCCTGGCTAGAAAACAAGCGTTTATTTGAATGTGAATAGTGT
TTCAAAGGTATGTAGTTACAGAATTCCTACCAAACAGCTTAAATTCTTCAAGAAAGAATTCCTGCAGCAGTTATTCCCTTACCTGAAGGC
TTCAATCATTTGGATCAACAACTGCTACTCTCGGGAAGACTCCTCTACTCACAGCTGAAGAAAATGAGCACACCCTTCACACTGTTATCA

>26857_26857_1_EPB41L4A-REEP5_EPB41L4A_chr5_111519712_ENST00000261486_REEP5_chr5_112238215_ENST00000379638_length(amino acids)=666AA_BP=548
METTTTDMGCFCAVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKEL
INTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEEL
EEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLG
KDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYP
KRIAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPYTRRRN
PSCGSDNDSVQPVRRRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNREYRKKRNRIRQENDMVDSAPQWEAVLRRQKEKNQADPNNR
RSRHRSRSIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMD

--------------------------------------------------------------
>26857_26857_2_EPB41L4A-REEP5_EPB41L4A_chr5_111519712_ENST00000261486_REEP5_chr5_112238215_ENST00000513339_length(transcript)=2789nt_BP=1899nt
CGCAGGATGCGCGGGGACGCGCCACCGCCCTCCGCGCCCAGTTCCGCCGGCGCTTCCCCGGCGGCTCCCGGGCGCTGACTCTCCCGGGCT
TTTCCGCCTTTCTCGCTCCCGCCCCGCCGGGCGGTTCGGCGGCCGGTCCCCGGACCCCGCCGGGAGCTGCTCGTCTCACCCTCGCCACGG
CGCGGACAATAAATTAATGCATCGCGCTTGAGTGGAGGGGGCGGCTGGGCGCCTCGGTGGTAGCTTTCTCTCCTGGCTGGAGACGACCAC
AACCGACATGGGCTGTTTCTGCGCTGTTCCGGAAGAATTTTACTGCGAAGTTTTGCTCCTGGATGAATCCAAGTTAACCCTTACCACCCA
GCAGCAGGGCATCAAGAAGTCAACGAAAGGTTCCGTTGTCCTTGACCACGTATTCCATCACGTAAACCTTGTGGAGATAGATTATTTTGG
GCTACGTTACTGTGACAGAAGCCATCAGACGTATTGGCTGGATCCTGCAAAAACCCTTGCTGAACACAAAGAACTGATCAACACTGGACC
TCCATATACTTTGTATTTTGGTATTAAATTCTATGCTGAAGATCCATGTAAACTTAAAGAAGAAATAACCAGATATCAGTTTTTCTTGCA
GGTGAAGCAAGATGTCCTTCAGGGCCGTCTGCCCTGTCCCGTCAACACTGCTGCTCAGCTGGGAGCGTATGCCATCCAGTCGGAGCTTGG
AGATTATGACCCATATAAACATACTGCAGGATATGTATCTGAGTACCGGTTTGTTCCTGATCAGAAGGAAGAACTTGAAGAAGCCATAGA
AAGGATTCATAAAACTCTAATGGGTCAGATTCCTTCTGAGGCTGAGCTGAATTACTTGAGGACTGCCAAATCCCTGGAGATGTATGGCGT
TGACCTCCATCCCGTCTATGGAGAAAACAAGTCTGAGTATTTCTTAGGATTAACTCCGGTTGGTGTTGTTGTGTACAAGAATAAAAAGCA
AGTGGGGAAGTATTTCTGGCCTCGGATTACAAAGGTTCACTTCAAGGAGACTCAATTTGAACTCAGAGTACTGGGAAAAGATTGTAACGA
AACCTCATTCTTTTTTGAAGCTCGGAGTAAAACTGCTTGCAAGCACCTCTGGAAGTGCAGTGTGGAACATCATACATTTTTTAGAATGCC
AGAAAATGAATCCAATTCACTGTCAAGAAAACTCAGCAAGTTTGGATCCATACGTTATAAGCACCGCTACAGTGGCAGGACAGCTTTGCA
AATGAGCCGAGATCTTTCTATTCAGCTTCCCCGGCCTGATCAGAATGTGACAAGAAGTCGAAGCAAGACTTACCCTAAGCGAATAGCACA
AACACAGCCAGCTGAATCAAACAGCATCAGTAGGATAACTGCAAACATGGAAAATGGAGAAAATGAAGGAACAATTAAAATTATTGCACC
TTCACCAGTAAAAAGCTTTAAGAAAGCAAAGAATGAAAATAGCCCTGATACCCAAAGAAGCAAATCTCATGCACCGTGGGAAGAAAATGG
CCCCCAGAGTGGACTCTACAATTCTCCCAGTGATCGCACTAAGTCGCCAAAGTTCCCTTACACGCGTCGCCGAAACCCCTCCTGTGGAAG
TGACAATGATTCTGTACAGCCTGTGAGGAGGAGGAAAGCCCATAACAGTGGTGAAGATTCAGATCTTAAGCAAAGGAGGAGGTCACGTTC
ACGCTGTAACACCAGCAGTGGTAGTGAATCAGAAAATTCTAATAGAGAATACCGGAAAAAGAGAAACAGAATACGGCAGGAGAATGATAT
GGTTGATTCAGCGCCTCAGTGGGAAGCTGTATTAAGGAGACAAAAGGAAAAAAACCAAGCCGACCCCAACAACAGGCGATCCAGACACAG
ATCTCGTTCAATTAAAGCTATAGAGAGTCCCAACAAAGAAGATGATACCCAGTGGCTGACCTACTGGGTAGTGTATGGTGTGTTCAGCAT
TGCTGAATTCTTCTCTGATATCTTCCTGTCATGGTTCCCCTTCTACTACATGCTGAAGCGAAGAAAGCTACCGTGAATTTACTGGGTGAA
GAAAAGAAGAGCACCTAAACCAGACTGGATGGAAACTTCCTGCCCTCTCTGTACCTTCCTACTGGAGCTTGATGTTATATTAGGGACTGT
GGTATAATTATTTTAATAATGTTGCCTTGGAAACATTTTTGAGATATTAAAGATTGGAATGTGTTGTAAGTTTCTTTGCTTACTTTTACT
GTCTATATATATAGGGAGCACTTTAAACTTAATGCAGTGGGCAGTGTCCACGTTTTTGGAAAATGTATTTTGCCTCTGGGTAGGAAAAGA
TGTATGTTGCTATCCTGCAGGAAATATAAACTTAAAATAAAATTATATACCCCACAGGCTGTGTACTTTACTGGGCTCTCCCTGCACGCA
TTTTCTCTGTAGTTACATTTAGGATAATCTTTATGGTTCTACTTCCTGTAATGTACAATTTTATATAATTCTGAAATGTTTTTAATGTAT
TTGTGCACATGTACATATGGAAATGTTACTGTCTGACTACAACATGCATCATGCTCATGGGGAGGGAGCAGGGGAAGGTTGTATGTGTCA
TTTATAACTTCTGTACAGTAAGACCACCTGCCAAAAGCTGGAGGAACCATTGTGCTGGTGTGGTCTACTAAATAATACTTTAGGAAATAC

>26857_26857_2_EPB41L4A-REEP5_EPB41L4A_chr5_111519712_ENST00000261486_REEP5_chr5_112238215_ENST00000513339_length(amino acids)=599AA_BP=548
METTTTDMGCFCAVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKEL
INTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEEL
EEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLG
KDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYP
KRIAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPYTRRRN
PSCGSDNDSVQPVRRRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNREYRKKRNRIRQENDMVDSAPQWEAVLRRQKEKNQADPNNR

--------------------------------------------------------------
>26857_26857_3_EPB41L4A-REEP5_EPB41L4A_chr5_111519713_ENST00000261486_REEP5_chr5_112238215_ENST00000379638_length(transcript)=4656nt_BP=1899nt
CGCAGGATGCGCGGGGACGCGCCACCGCCCTCCGCGCCCAGTTCCGCCGGCGCTTCCCCGGCGGCTCCCGGGCGCTGACTCTCCCGGGCT
TTTCCGCCTTTCTCGCTCCCGCCCCGCCGGGCGGTTCGGCGGCCGGTCCCCGGACCCCGCCGGGAGCTGCTCGTCTCACCCTCGCCACGG
CGCGGACAATAAATTAATGCATCGCGCTTGAGTGGAGGGGGCGGCTGGGCGCCTCGGTGGTAGCTTTCTCTCCTGGCTGGAGACGACCAC
AACCGACATGGGCTGTTTCTGCGCTGTTCCGGAAGAATTTTACTGCGAAGTTTTGCTCCTGGATGAATCCAAGTTAACCCTTACCACCCA
GCAGCAGGGCATCAAGAAGTCAACGAAAGGTTCCGTTGTCCTTGACCACGTATTCCATCACGTAAACCTTGTGGAGATAGATTATTTTGG
GCTACGTTACTGTGACAGAAGCCATCAGACGTATTGGCTGGATCCTGCAAAAACCCTTGCTGAACACAAAGAACTGATCAACACTGGACC
TCCATATACTTTGTATTTTGGTATTAAATTCTATGCTGAAGATCCATGTAAACTTAAAGAAGAAATAACCAGATATCAGTTTTTCTTGCA
GGTGAAGCAAGATGTCCTTCAGGGCCGTCTGCCCTGTCCCGTCAACACTGCTGCTCAGCTGGGAGCGTATGCCATCCAGTCGGAGCTTGG
AGATTATGACCCATATAAACATACTGCAGGATATGTATCTGAGTACCGGTTTGTTCCTGATCAGAAGGAAGAACTTGAAGAAGCCATAGA
AAGGATTCATAAAACTCTAATGGGTCAGATTCCTTCTGAGGCTGAGCTGAATTACTTGAGGACTGCCAAATCCCTGGAGATGTATGGCGT
TGACCTCCATCCCGTCTATGGAGAAAACAAGTCTGAGTATTTCTTAGGATTAACTCCGGTTGGTGTTGTTGTGTACAAGAATAAAAAGCA
AGTGGGGAAGTATTTCTGGCCTCGGATTACAAAGGTTCACTTCAAGGAGACTCAATTTGAACTCAGAGTACTGGGAAAAGATTGTAACGA
AACCTCATTCTTTTTTGAAGCTCGGAGTAAAACTGCTTGCAAGCACCTCTGGAAGTGCAGTGTGGAACATCATACATTTTTTAGAATGCC
AGAAAATGAATCCAATTCACTGTCAAGAAAACTCAGCAAGTTTGGATCCATACGTTATAAGCACCGCTACAGTGGCAGGACAGCTTTGCA
AATGAGCCGAGATCTTTCTATTCAGCTTCCCCGGCCTGATCAGAATGTGACAAGAAGTCGAAGCAAGACTTACCCTAAGCGAATAGCACA
AACACAGCCAGCTGAATCAAACAGCATCAGTAGGATAACTGCAAACATGGAAAATGGAGAAAATGAAGGAACAATTAAAATTATTGCACC
TTCACCAGTAAAAAGCTTTAAGAAAGCAAAGAATGAAAATAGCCCTGATACCCAAAGAAGCAAATCTCATGCACCGTGGGAAGAAAATGG
CCCCCAGAGTGGACTCTACAATTCTCCCAGTGATCGCACTAAGTCGCCAAAGTTCCCTTACACGCGTCGCCGAAACCCCTCCTGTGGAAG
TGACAATGATTCTGTACAGCCTGTGAGGAGGAGGAAAGCCCATAACAGTGGTGAAGATTCAGATCTTAAGCAAAGGAGGAGGTCACGTTC
ACGCTGTAACACCAGCAGTGGTAGTGAATCAGAAAATTCTAATAGAGAATACCGGAAAAAGAGAAACAGAATACGGCAGGAGAATGATAT
GGTTGATTCAGCGCCTCAGTGGGAAGCTGTATTAAGGAGACAAAAGGAAAAAAACCAAGCCGACCCCAACAACAGGCGATCCAGACACAG
ATCTCGTTCAATTAAAGCTATAGAGAGTCCCAACAAAGAAGATGATACCCAGTGGCTGACCTACTGGGTAGTGTATGGTGTGTTCAGCAT
TGCTGAATTCTTCTCTGATATCTTCCTGTCATGGTTCCCCTTCTACTACATGCTGAAGTGTGGCTTCCTGTTGTGGTGCATGGCCCCGAG
CCCTTCTAATGGGGCTGAACTGCTCTACAAGCGCATCATCCGTCCTTTCTTCCTGAAGCACGAGTCCCAGATGGACAGTGTGGTCAAGGA
CCTTAAAGACAAGGCCAAAGAGACTGCAGATGCCATCACTAAAGAAGCGAAGAAAGCTACCGTGAATTTACTGGGTGAAGAAAAGAAGAG
CACCTAAACCAGACTGGATGGAAACTTCCTGCCCTCTCTGTACCTTCCTACTGGAGCTTGATGTTATATTAGGGACTGTGGTATAATTAT
TTTAATAATGTTGCCTTGGAAACATTTTTGAGATATTAAAGATTGGAATGTGTTGTAAGTTTCTTTGCTTACTTTTACTGTCTATATATA
TAGGGAGCACTTTAAACTTAATGCAGTGGGCAGTGTCCACGTTTTTGGAAAATGTATTTTGCCTCTGGGTAGGAAAAGATGTATGTTGCT
ATCCTGCAGGAAATATAAACTTAAAATAAAATTATATACCCCACAGGCTGTGTACTTTACTGGGCTCTCCCTGCACGCATTTTCTCTGTA
GTTACATTTAGGATAATCTTTATGGTTCTACTTCCTGTAATGTACAATTTTATATAATTCTGAAATGTTTTTAATGTATTTGTGCACATG
TACATATGGAAATGTTACTGTCTGACTACAACATGCATCATGCTCATGGGGAGGGAGCAGGGGAAGGTTGTATGTGTCATTTATAACTTC
TGTACAGTAAGACCACCTGCCAAAAGCTGGAGGAACCATTGTGCTGGTGTGGTCTACTAAATAATACTTTAGGAAATACGTGATTAATAT
GCAAGTGAACAAAGTGAGAAATGAAATCGAATGGAGATTGGCCTGGTTGTTTCCGTAGTATATGGCATATGAATACCAGGATAGCTTTAT
AAAGCAGTTAGTTAGTTAGTTACTCACTCTAGTGATAAATCGGGAAATTTACACACACACACACACACACACACACACACACACACACAC
AGAGTAACCTGTAACTCTCAATTCCCTGAAAAACTAGTAATACTGTCTTATCTGCTATAAACTTTACATATTTGTCTATTGTCAAGATGC
TACAATGGAAACCATTTCTGGTTTTATCTTCAAAGCGGAGAAACATGTTGATTTAGTCTTCTTTCCCAATCTTCTTTTTTAAACCAGTTT
AAGGAACTTCTGAAGATTTGTCCACCTCTGATTACATGTATGTTCTTGTTTGTATCATTAGCAACAACATGCTAATGACGACACCTAGCT
CTAAGAGCAATTCTGGGAGAATGAAAGGAAGTATAAAGTAACCCATAATCTGCTTGGCAATAGTTAAGTCAATCTATCTTCAGTTTTTCT
CTGGCCTTTAAGGTCAAACACAAGAGGCTTCCCTAGTTTACAAGTCAGAGTCACTTGTAGTCCATTTAAATGCCCTCATCCGTATTCTTT
GTGTTGATAAGCTGCACATGACTACATAGTAAGTACAGAACAGTAAAGTTAAAACGGATGTCTCCATTGATCTGCCAAATCGTTATAGAG
AGCAATTTGTCTGGACTAGAAAATCTGAGTTTTACACCATACTGTTAAGAGTCCTTTTGAATTAAACTCGACTAAAACAAGTGTATAACT
AAACTAACAAGATTAAATATCCAGCCAGTACAGTATTTTTTAAGGCAAATAAAGATGATTAGCTCACCTTGAGATAACAATCAGGTAAGA
TCATAACAATGTCTCATGATGTAAAAAATATTAAAGATATCAATACTAAGTGACAGTATCACTCTAATATAATATGGATCAGAGCATTTA
TTTTGGGGAGGAAAACAGTGGTGATTACCGGCATTTTATTAAACTTAAAACTTTGTAGAAAGCAAACAAAATTGTTCTTGGGAGAAAATC
AACTTTTAGATTAAAAAAATTTTAAGTATCTAGGAGTATTTAAATCCTTTTCCCATAAATAAAAGTACAGTTTTCTTGGTGGCAGAATGA
AAATCAGCAACTTCTAGCATATAGACTATATAATCAGATTGACAGCATATAGAATATATTATCAGACAAGATGAGGAGGTACAAAAGTTA
CTATTGCTCATAATGACTTACAGGCTAAAATTAGTTTTAAAATACTATATTAAATTCTGAATGCAATTTTTTTTTGTTCCCTTGAGACCA
AAATTTAAGTTAACTGTTGCTGGCAGTCTAAGTGTAAATGTTAACAGCAGGAGAAGTTAAGAATTGAGCAGTTCTGTTGCATGATTTCCC
AAATGAAATACTGCCTTGGCTAGAGTTTGAAAAACTAATTGAGCCTGTGCCTGGCTAGAAAACAAGCGTTTATTTGAATGTGAATAGTGT
TTCAAAGGTATGTAGTTACAGAATTCCTACCAAACAGCTTAAATTCTTCAAGAAAGAATTCCTGCAGCAGTTATTCCCTTACCTGAAGGC
TTCAATCATTTGGATCAACAACTGCTACTCTCGGGAAGACTCCTCTACTCACAGCTGAAGAAAATGAGCACACCCTTCACACTGTTATCA

>26857_26857_3_EPB41L4A-REEP5_EPB41L4A_chr5_111519713_ENST00000261486_REEP5_chr5_112238215_ENST00000379638_length(amino acids)=666AA_BP=548
METTTTDMGCFCAVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKEL
INTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEEL
EEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLG
KDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYP
KRIAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPYTRRRN
PSCGSDNDSVQPVRRRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNREYRKKRNRIRQENDMVDSAPQWEAVLRRQKEKNQADPNNR
RSRHRSRSIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMD

--------------------------------------------------------------
>26857_26857_4_EPB41L4A-REEP5_EPB41L4A_chr5_111519713_ENST00000261486_REEP5_chr5_112238215_ENST00000513339_length(transcript)=2789nt_BP=1899nt
CGCAGGATGCGCGGGGACGCGCCACCGCCCTCCGCGCCCAGTTCCGCCGGCGCTTCCCCGGCGGCTCCCGGGCGCTGACTCTCCCGGGCT
TTTCCGCCTTTCTCGCTCCCGCCCCGCCGGGCGGTTCGGCGGCCGGTCCCCGGACCCCGCCGGGAGCTGCTCGTCTCACCCTCGCCACGG
CGCGGACAATAAATTAATGCATCGCGCTTGAGTGGAGGGGGCGGCTGGGCGCCTCGGTGGTAGCTTTCTCTCCTGGCTGGAGACGACCAC
AACCGACATGGGCTGTTTCTGCGCTGTTCCGGAAGAATTTTACTGCGAAGTTTTGCTCCTGGATGAATCCAAGTTAACCCTTACCACCCA
GCAGCAGGGCATCAAGAAGTCAACGAAAGGTTCCGTTGTCCTTGACCACGTATTCCATCACGTAAACCTTGTGGAGATAGATTATTTTGG
GCTACGTTACTGTGACAGAAGCCATCAGACGTATTGGCTGGATCCTGCAAAAACCCTTGCTGAACACAAAGAACTGATCAACACTGGACC
TCCATATACTTTGTATTTTGGTATTAAATTCTATGCTGAAGATCCATGTAAACTTAAAGAAGAAATAACCAGATATCAGTTTTTCTTGCA
GGTGAAGCAAGATGTCCTTCAGGGCCGTCTGCCCTGTCCCGTCAACACTGCTGCTCAGCTGGGAGCGTATGCCATCCAGTCGGAGCTTGG
AGATTATGACCCATATAAACATACTGCAGGATATGTATCTGAGTACCGGTTTGTTCCTGATCAGAAGGAAGAACTTGAAGAAGCCATAGA
AAGGATTCATAAAACTCTAATGGGTCAGATTCCTTCTGAGGCTGAGCTGAATTACTTGAGGACTGCCAAATCCCTGGAGATGTATGGCGT
TGACCTCCATCCCGTCTATGGAGAAAACAAGTCTGAGTATTTCTTAGGATTAACTCCGGTTGGTGTTGTTGTGTACAAGAATAAAAAGCA
AGTGGGGAAGTATTTCTGGCCTCGGATTACAAAGGTTCACTTCAAGGAGACTCAATTTGAACTCAGAGTACTGGGAAAAGATTGTAACGA
AACCTCATTCTTTTTTGAAGCTCGGAGTAAAACTGCTTGCAAGCACCTCTGGAAGTGCAGTGTGGAACATCATACATTTTTTAGAATGCC
AGAAAATGAATCCAATTCACTGTCAAGAAAACTCAGCAAGTTTGGATCCATACGTTATAAGCACCGCTACAGTGGCAGGACAGCTTTGCA
AATGAGCCGAGATCTTTCTATTCAGCTTCCCCGGCCTGATCAGAATGTGACAAGAAGTCGAAGCAAGACTTACCCTAAGCGAATAGCACA
AACACAGCCAGCTGAATCAAACAGCATCAGTAGGATAACTGCAAACATGGAAAATGGAGAAAATGAAGGAACAATTAAAATTATTGCACC
TTCACCAGTAAAAAGCTTTAAGAAAGCAAAGAATGAAAATAGCCCTGATACCCAAAGAAGCAAATCTCATGCACCGTGGGAAGAAAATGG
CCCCCAGAGTGGACTCTACAATTCTCCCAGTGATCGCACTAAGTCGCCAAAGTTCCCTTACACGCGTCGCCGAAACCCCTCCTGTGGAAG
TGACAATGATTCTGTACAGCCTGTGAGGAGGAGGAAAGCCCATAACAGTGGTGAAGATTCAGATCTTAAGCAAAGGAGGAGGTCACGTTC
ACGCTGTAACACCAGCAGTGGTAGTGAATCAGAAAATTCTAATAGAGAATACCGGAAAAAGAGAAACAGAATACGGCAGGAGAATGATAT
GGTTGATTCAGCGCCTCAGTGGGAAGCTGTATTAAGGAGACAAAAGGAAAAAAACCAAGCCGACCCCAACAACAGGCGATCCAGACACAG
ATCTCGTTCAATTAAAGCTATAGAGAGTCCCAACAAAGAAGATGATACCCAGTGGCTGACCTACTGGGTAGTGTATGGTGTGTTCAGCAT
TGCTGAATTCTTCTCTGATATCTTCCTGTCATGGTTCCCCTTCTACTACATGCTGAAGCGAAGAAAGCTACCGTGAATTTACTGGGTGAA
GAAAAGAAGAGCACCTAAACCAGACTGGATGGAAACTTCCTGCCCTCTCTGTACCTTCCTACTGGAGCTTGATGTTATATTAGGGACTGT
GGTATAATTATTTTAATAATGTTGCCTTGGAAACATTTTTGAGATATTAAAGATTGGAATGTGTTGTAAGTTTCTTTGCTTACTTTTACT
GTCTATATATATAGGGAGCACTTTAAACTTAATGCAGTGGGCAGTGTCCACGTTTTTGGAAAATGTATTTTGCCTCTGGGTAGGAAAAGA
TGTATGTTGCTATCCTGCAGGAAATATAAACTTAAAATAAAATTATATACCCCACAGGCTGTGTACTTTACTGGGCTCTCCCTGCACGCA
TTTTCTCTGTAGTTACATTTAGGATAATCTTTATGGTTCTACTTCCTGTAATGTACAATTTTATATAATTCTGAAATGTTTTTAATGTAT
TTGTGCACATGTACATATGGAAATGTTACTGTCTGACTACAACATGCATCATGCTCATGGGGAGGGAGCAGGGGAAGGTTGTATGTGTCA
TTTATAACTTCTGTACAGTAAGACCACCTGCCAAAAGCTGGAGGAACCATTGTGCTGGTGTGGTCTACTAAATAATACTTTAGGAAATAC

>26857_26857_4_EPB41L4A-REEP5_EPB41L4A_chr5_111519713_ENST00000261486_REEP5_chr5_112238215_ENST00000513339_length(amino acids)=599AA_BP=548
METTTTDMGCFCAVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKEL
INTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEEL
EEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLG
KDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYP
KRIAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPYTRRRN
PSCGSDNDSVQPVRRRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNREYRKKRNRIRQENDMVDSAPQWEAVLRRQKEKNQADPNNR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EPB41L4A-REEP5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EPB41L4A-REEP5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EPB41L4A-REEP5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source