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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPC1-AKR1E2 (FusionGDB2 ID:26883)

Fusion Gene Summary for EPC1-AKR1E2

check button Fusion gene summary
Fusion gene informationFusion gene name: EPC1-AKR1E2
Fusion gene ID: 26883
HgeneTgene
Gene symbol

EPC1

AKR1E2

Gene ID

80314

83592

Gene nameenhancer of polycomb homolog 1aldo-keto reductase family 1 member E2
SynonymsEpl1AKR1CL2|AKRDC1|LoopADR|TAKR|hTSP|htAKR
Cytomap

10p11.22

10p15.1

Type of geneprotein-codingprotein-coding
Descriptionenhancer of polycomb homolog 11,5-anhydro-D-fructose reductaseAF reductasealdo-keto reductase family 1 member C-like protein 2aldo-keto reductase family 1, member C-like 2aldo-keto reductase loopADRtestis aldo-keto reductasetestis-specific protein
Modification date2020031320200313
UniProtAcc.

Q96JD6

Ensembl transtripts involved in fusion geneENST00000263062, ENST00000319778, 
ENST00000375110, ENST00000480402, 
ENST00000334019, ENST00000345253, 
ENST00000525281, ENST00000532248, 
ENST00000298375, 
Fusion gene scores* DoF score17 X 14 X 8=19046 X 3 X 6=108
# samples 208
** MAII scorelog2(20/1904*10)=-3.25096157353322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPC1 [Title/Abstract] AND AKR1E2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPC1(32635691)-AKR1E2(4872867), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPC1

GO:0000122

negative regulation of transcription by RNA polymerase II

10976108

HgeneEPC1

GO:0043967

histone H4 acetylation

14966270

HgeneEPC1

GO:0043968

histone H2A acetylation

14966270

HgeneEPC1

GO:0045814

negative regulation of gene expression, epigenetic

10976108

HgeneEPC1

GO:0045892

negative regulation of transcription, DNA-templated

10976108

HgeneEPC1

GO:0045944

positive regulation of transcription by RNA polymerase II

10976108

TgeneAKR1E2

GO:0055114

oxidation-reduction process

15118078


check buttonFusion gene breakpoints across EPC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKR1E2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A8O2-01AEPC1chr10

32635691

-AKR1E2chr10

4872867

+
ChimerDB4ESCATCGA-IG-A8O2EPC1chr10

32635690

-AKR1E2chr10

4872866

+
ChimerDB4ESCATCGA-IG-A8O2EPC1chr10

32635691

-AKR1E2chr10

4872867

+
ChimerDB4ESCATCGA-IG-A8O2EPC1chr10

32667419

-AKR1E2chr10

4872867

+


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Fusion Gene ORF analysis for EPC1-AKR1E2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263062ENST00000334019EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000263062ENST00000334019EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000263062ENST00000345253EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000263062ENST00000345253EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000263062ENST00000525281EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000263062ENST00000525281EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000263062ENST00000532248EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000263062ENST00000532248EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000319778ENST00000334019EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000319778ENST00000334019EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000319778ENST00000345253EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000319778ENST00000345253EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000319778ENST00000525281EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000319778ENST00000525281EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000319778ENST00000532248EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000319778ENST00000532248EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5CDS-3UTRENST00000375110ENST00000334019EPC1chr10

32667419

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000375110ENST00000345253EPC1chr10

32667419

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000375110ENST00000525281EPC1chr10

32667419

-AKR1E2chr10

4872867

+
5CDS-3UTRENST00000375110ENST00000532248EPC1chr10

32667419

-AKR1E2chr10

4872867

+
5UTR-3CDSENST00000480402ENST00000298375EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5UTR-3CDSENST00000480402ENST00000298375EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5UTR-3UTRENST00000480402ENST00000334019EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5UTR-3UTRENST00000480402ENST00000334019EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5UTR-3UTRENST00000480402ENST00000345253EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5UTR-3UTRENST00000480402ENST00000345253EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5UTR-3UTRENST00000480402ENST00000525281EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5UTR-3UTRENST00000480402ENST00000525281EPC1chr10

32635690

-AKR1E2chr10

4872866

+
5UTR-3UTRENST00000480402ENST00000532248EPC1chr10

32635691

-AKR1E2chr10

4872867

+
5UTR-3UTRENST00000480402ENST00000532248EPC1chr10

32635690

-AKR1E2chr10

4872866

+
In-frameENST00000263062ENST00000298375EPC1chr10

32635691

-AKR1E2chr10

4872867

+
In-frameENST00000263062ENST00000298375EPC1chr10

32635690

-AKR1E2chr10

4872866

+
In-frameENST00000319778ENST00000298375EPC1chr10

32635691

-AKR1E2chr10

4872867

+
In-frameENST00000319778ENST00000298375EPC1chr10

32635690

-AKR1E2chr10

4872866

+
In-frameENST00000375110ENST00000298375EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3CDSENST00000263062ENST00000298375EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3CDSENST00000319778ENST00000298375EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3CDSENST00000375110ENST00000298375EPC1chr10

32635691

-AKR1E2chr10

4872867

+
intron-3CDSENST00000375110ENST00000298375EPC1chr10

32635690

-AKR1E2chr10

4872866

+
intron-3CDSENST00000480402ENST00000298375EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000263062ENST00000334019EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000263062ENST00000345253EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000263062ENST00000525281EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000263062ENST00000532248EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000319778ENST00000334019EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000319778ENST00000345253EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000319778ENST00000525281EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000319778ENST00000532248EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000375110ENST00000334019EPC1chr10

32635691

-AKR1E2chr10

4872867

+
intron-3UTRENST00000375110ENST00000334019EPC1chr10

32635690

-AKR1E2chr10

4872866

+
intron-3UTRENST00000375110ENST00000345253EPC1chr10

32635691

-AKR1E2chr10

4872867

+
intron-3UTRENST00000375110ENST00000345253EPC1chr10

32635690

-AKR1E2chr10

4872866

+
intron-3UTRENST00000375110ENST00000525281EPC1chr10

32635691

-AKR1E2chr10

4872867

+
intron-3UTRENST00000375110ENST00000525281EPC1chr10

32635690

-AKR1E2chr10

4872866

+
intron-3UTRENST00000375110ENST00000532248EPC1chr10

32635691

-AKR1E2chr10

4872867

+
intron-3UTRENST00000375110ENST00000532248EPC1chr10

32635690

-AKR1E2chr10

4872866

+
intron-3UTRENST00000480402ENST00000334019EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000480402ENST00000345253EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000480402ENST00000525281EPC1chr10

32667419

-AKR1E2chr10

4872867

+
intron-3UTRENST00000480402ENST00000532248EPC1chr10

32667419

-AKR1E2chr10

4872867

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000319778EPC1chr1032635691-ENST00000298375AKR1E2chr104872867+19124563031379358
ENST00000263062EPC1chr1032635691-ENST00000298375AKR1E2chr104872867+18794232701346358
ENST00000319778EPC1chr1032635690-ENST00000298375AKR1E2chr104872866+19124563031379358
ENST00000263062EPC1chr1032635690-ENST00000298375AKR1E2chr104872866+18794232701346358
ENST00000375110EPC1chr1032667419-ENST00000298375AKR1E2chr104872867+17643082811231316

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000319778ENST00000298375EPC1chr1032635691-AKR1E2chr104872867+0.0011625110.99883753
ENST00000263062ENST00000298375EPC1chr1032635691-AKR1E2chr104872867+0.0011579910.99884206
ENST00000319778ENST00000298375EPC1chr1032635690-AKR1E2chr104872866+0.0011625110.99883753
ENST00000263062ENST00000298375EPC1chr1032635690-AKR1E2chr104872866+0.0011579910.99884206
ENST00000375110ENST00000298375EPC1chr1032667419-AKR1E2chr104872867+0.0010621180.9989379

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Fusion Genomic Features for EPC1-AKR1E2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EPC1chr1032635690-AKR1E2chr104872866+2.69E-131
EPC1chr1032635690-AKR1E2chr104872866+2.69E-131
EPC1chr1032667418-AKR1E2chr104872866+1.13E-081
EPC1chr1032635690-AKR1E2chr104872866+2.69E-131
EPC1chr1032635690-AKR1E2chr104872866+2.69E-131
EPC1chr1032667418-AKR1E2chr104872866+1.13E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EPC1-AKR1E2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:32635691/chr10:4872867)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AKR1E2

Q96JD6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078). {ECO:0000250|UniProtKB:Q9DCT1, ECO:0000269|PubMed:12604216, ECO:0000269|PubMed:15118078}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKR1E2chr10:32635690chr10:4872866ENST00000298375010265_27713321.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635690chr10:4872866ENST0000033401908265_27713264.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635690chr10:4872866ENST0000034525307265_27713223.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635690chr10:4872866ENST0000053224807265_27713251.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635691chr10:4872867ENST00000298375010265_27713321.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635691chr10:4872867ENST0000033401908265_27713264.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635691chr10:4872867ENST0000034525307265_27713223.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32635691chr10:4872867ENST0000053224807265_27713251.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32667419chr10:4872867ENST00000298375010265_27713321.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32667419chr10:4872867ENST0000033401908265_27713264.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32667419chr10:4872867ENST0000034525307265_27713223.0Nucleotide bindingNADP
TgeneAKR1E2chr10:32667419chr10:4872867ENST0000053224807265_27713251.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for EPC1-AKR1E2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>26883_26883_1_EPC1-AKR1E2_EPC1_chr10_32635690_ENST00000263062_AKR1E2_chr10_4872866_ENST00000298375_length(transcript)=1879nt_BP=423nt
GAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGGCCATGGCGTATTGAAGAGAGCGAGCGAGAGAGG
AGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGCTCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGG
TTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTTCCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAG
ATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTTTTCCGCTGTGAGGATCTGCCCGACCTGCACGAA
TACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAGGAGTCGGCTTCTCCAGGGAAAGTGACCGAGGCA
GTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGC
AAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACA
GCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCA
GAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATT
CCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTC
AACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACT
CAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTG
ATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTG
ATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAAC
ATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGA
CGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGC
TGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAA
GGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTT
AAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACC
CATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCT

>26883_26883_1_EPC1-AKR1E2_EPC1_chr10_32635690_ENST00000263062_AKR1E2_chr10_4872866_ENST00000298375_length(amino acids)=358AA_BP=51
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRC
KIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVI
PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDL

--------------------------------------------------------------
>26883_26883_2_EPC1-AKR1E2_EPC1_chr10_32635690_ENST00000319778_AKR1E2_chr10_4872866_ENST00000298375_length(transcript)=1912nt_BP=456nt
GCGTGCCCGCGCCGCTGCGCGATGCAGTGTGGGGAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGG
CCATGGCGTATTGAAGAGAGCGAGCGAGAGAGGAGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGC
TCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGGTTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTT
CCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAGATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTT
TTCCGCTGTGAGGATCTGCCCGACCTGCACGAATACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAG
GAGTCGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCAC
AATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTGTGG
TGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATA
CACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAG
GACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACC
GGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTA
ACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGT
CCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAG
ATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTT
GATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCAC
AAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTT
GACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGA
CAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTG
ATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTG
TAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGA
CCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAAG

>26883_26883_2_EPC1-AKR1E2_EPC1_chr10_32635690_ENST00000319778_AKR1E2_chr10_4872866_ENST00000298375_length(amino acids)=358AA_BP=51
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRC
KIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVI
PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDL

--------------------------------------------------------------
>26883_26883_3_EPC1-AKR1E2_EPC1_chr10_32635691_ENST00000263062_AKR1E2_chr10_4872867_ENST00000298375_length(transcript)=1879nt_BP=423nt
GAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGGCCATGGCGTATTGAAGAGAGCGAGCGAGAGAGG
AGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGCTCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGG
TTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTTCCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAG
ATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTTTTCCGCTGTGAGGATCTGCCCGACCTGCACGAA
TACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAGGAGTCGGCTTCTCCAGGGAAAGTGACCGAGGCA
GTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGC
AAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACA
GCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCA
GAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATT
CCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTC
AACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACT
CAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTG
ATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTG
ATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAAC
ATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGA
CGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGC
TGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAA
GGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTT
AAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACC
CATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCT

>26883_26883_3_EPC1-AKR1E2_EPC1_chr10_32635691_ENST00000263062_AKR1E2_chr10_4872867_ENST00000298375_length(amino acids)=358AA_BP=51
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRC
KIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVI
PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDL

--------------------------------------------------------------
>26883_26883_4_EPC1-AKR1E2_EPC1_chr10_32635691_ENST00000319778_AKR1E2_chr10_4872867_ENST00000298375_length(transcript)=1912nt_BP=456nt
GCGTGCCCGCGCCGCTGCGCGATGCAGTGTGGGGAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGG
CCATGGCGTATTGAAGAGAGCGAGCGAGAGAGGAGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGC
TCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGGTTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTT
CCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAGATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTT
TTCCGCTGTGAGGATCTGCCCGACCTGCACGAATACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAG
GAGTCGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCAC
AATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTGTGG
TGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATA
CACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAG
GACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACC
GGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTA
ACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGT
CCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAG
ATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTT
GATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCAC
AAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTT
GACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGA
CAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTG
ATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTG
TAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGA
CCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAAG

>26883_26883_4_EPC1-AKR1E2_EPC1_chr10_32635691_ENST00000319778_AKR1E2_chr10_4872867_ENST00000298375_length(amino acids)=358AA_BP=51
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRC
KIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVI
PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDL

--------------------------------------------------------------
>26883_26883_5_EPC1-AKR1E2_EPC1_chr10_32667419_ENST00000375110_AKR1E2_chr10_4872867_ENST00000298375_length(transcript)=1764nt_BP=308nt
AGCGCTCGCCTGCTTGCCATCGCAAAGTTGTTAACCCCAGAGTCTTCTGGCTGTGCTGCCTCCTCTGCTTTTAATCTTCTGTGGATATTT
CTCCGATTTCCCCCAAAAGCCCACAGATCCTGGGGGAAGCCACCCCATTCGGCCACCGATCATGGAAGAAAGTATTACTTTTTATTTACC
AAACATTTTAAAGATGTTGGAAGATCCATATGCTGCCTGGAGGCTGTTGTTTCTAGGGACACAAGTATCCAGCCTATATTGTTACAATTT
TTTTTCAAGAACTGCCGTCTTCTTTGCCTGCACTAATGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGT
ACCGGCACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGAC
GGGAGGATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCT
TGAAGCTGAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAAC
TTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACA
CGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTT
TGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCC
AATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGA
TTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCC
CAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCC
GACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTC
AGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAG
TCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGC
CTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTA
TTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGT
CACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGA

>26883_26883_5_EPC1-AKR1E2_EPC1_chr10_32667419_ENST00000375110_AKR1E2_chr10_4872867_ENST00000298375_length(amino acids)=316AA_BP=7
MPSSLPALMASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKLN
YLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKP
GLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EPC1-AKR1E2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPC1-AKR1E2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EPC1-AKR1E2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource