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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EPC1-ARHGAP12 (FusionGDB2 ID:26884)

Fusion Gene Summary for EPC1-ARHGAP12

Fusion gene summary

Fusion gene information	Fusion gene name: EPC1-ARHGAP12
	Fusion gene ID: 26884
		Hgene	Tgene
	Gene symbol	EPC1	ARHGAP12
	Gene ID	80314	94134
	Gene name	enhancer of polycomb homolog 1	Rho GTPase activating protein 12
	Synonyms	Epl1	-
	Cytomap	10p11.22	10p11.22
	Type of gene	protein-coding	protein-coding
	Description	enhancer of polycomb homolog 1	rho GTPase-activating protein 12rho-type GTPase-activating protein 12
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IWW6
	Ensembl transtripts involved in fusion gene	ENST00000375110, ENST00000263062, ENST00000319778, ENST00000480402,	ENST00000344936, ENST00000375245, ENST00000375250, ENST00000396144, ENST00000492028, ENST00000311380,
Fusion gene scores	* DoF score	17 X 14 X 8=1904	12 X 14 X 5=840
	# samples	20	15
	** MAII score	log2(20/1904*10)=-3.25096157353322 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/840*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EPC1 [Title/Abstract] AND ARHGAP12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EPC1(32635690)-ARHGAP12(32120728), # samples:1 EPC1(32667419)-ARHGAP12(32199491), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EPC1	GO:0000122	negative regulation of transcription by RNA polymerase II	10976108
Hgene	EPC1	GO:0043967	histone H4 acetylation	14966270
Hgene	EPC1	GO:0043968	histone H2A acetylation	14966270
Hgene	EPC1	GO:0045814	negative regulation of gene expression, epigenetic	10976108
Hgene	EPC1	GO:0045892	negative regulation of transcription, DNA-templated	10976108
Hgene	EPC1	GO:0045944	positive regulation of transcription by RNA polymerase II	10976108

Fusion gene breakpoints across EPC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-HC-8260	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
ChimerDB4	STAD	TCGA-BR-8080-01A	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-

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Fusion Gene ORF analysis for EPC1-ARHGAP12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000375110	ENST00000344936	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
5CDS-5UTR	ENST00000375110	ENST00000375245	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
5CDS-5UTR	ENST00000375110	ENST00000375250	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
5CDS-5UTR	ENST00000375110	ENST00000396144	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
5CDS-intron	ENST00000263062	ENST00000344936	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000263062	ENST00000375245	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000263062	ENST00000396144	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000263062	ENST00000492028	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000319778	ENST00000344936	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000319778	ENST00000375245	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000319778	ENST00000396144	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000319778	ENST00000492028	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5CDS-intron	ENST00000375110	ENST00000311380	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
5CDS-intron	ENST00000375110	ENST00000492028	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
5UTR-3CDS	ENST00000480402	ENST00000311380	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5UTR-3CDS	ENST00000480402	ENST00000375250	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5UTR-intron	ENST00000480402	ENST00000344936	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5UTR-intron	ENST00000480402	ENST00000375245	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5UTR-intron	ENST00000480402	ENST00000396144	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
5UTR-intron	ENST00000480402	ENST00000492028	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
In-frame	ENST00000263062	ENST00000311380	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
In-frame	ENST00000263062	ENST00000375250	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
In-frame	ENST00000319778	ENST00000311380	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
In-frame	ENST00000319778	ENST00000375250	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-3CDS	ENST00000375110	ENST00000311380	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-3CDS	ENST00000375110	ENST00000375250	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-5UTR	ENST00000263062	ENST00000344936	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000263062	ENST00000375245	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000263062	ENST00000375250	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000263062	ENST00000396144	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000319778	ENST00000344936	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000319778	ENST00000375245	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000319778	ENST00000375250	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000319778	ENST00000396144	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000480402	ENST00000344936	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000480402	ENST00000375245	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000480402	ENST00000375250	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-5UTR	ENST00000480402	ENST00000396144	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-intron	ENST00000263062	ENST00000311380	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-intron	ENST00000263062	ENST00000492028	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-intron	ENST00000319778	ENST00000311380	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-intron	ENST00000319778	ENST00000492028	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-intron	ENST00000375110	ENST00000344936	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-intron	ENST00000375110	ENST00000375245	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-intron	ENST00000375110	ENST00000396144	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-intron	ENST00000375110	ENST00000492028	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-
intron-intron	ENST00000480402	ENST00000311380	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-
intron-intron	ENST00000480402	ENST00000492028	EPC1	chr10	32667419	-	ARHGAP12	chr10	32199491	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000319778	EPC1	chr10	32635690	-	ENST00000311380	ARHGAP12	chr10	32120728	-	3832	456	303	1610	435
ENST00000319778	EPC1	chr10	32635690	-	ENST00000375250	ARHGAP12	chr10	32120728	-	3832	456	303	1610	435
ENST00000263062	EPC1	chr10	32635690	-	ENST00000311380	ARHGAP12	chr10	32120728	-	3799	423	270	1577	435
ENST00000263062	EPC1	chr10	32635690	-	ENST00000375250	ARHGAP12	chr10	32120728	-	3799	423	270	1577	435

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000319778	ENST00000311380	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-	0.000177126	0.9998229
ENST00000319778	ENST00000375250	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-	0.000177126	0.9998229
ENST00000263062	ENST00000311380	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-	0.00018118	0.99981886
ENST00000263062	ENST00000375250	EPC1	chr10	32635690	-	ARHGAP12	chr10	32120728	-	0.00018118	0.99981886

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Fusion Genomic Features for EPC1-ARHGAP12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPC1-ARHGAP12

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:32635690/chr10:32120728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ARHGAP12 Q8IWW6
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000311380

463_575

410

795.0

Domain

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000311380

656_844

410

795.0

Domain

Rho-GAP

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000344936

463_575

462

847.0

Domain

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000344936

656_844

462

847.0

Domain

Rho-GAP

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375245

463_575

410

795.0

Domain

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375245

656_844

410

795.0

Domain

Rho-GAP

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375250

463_575

432

817.0

Domain

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375250

656_844

432

817.0

Domain

Rho-GAP

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000396144

463_575

457

842.0

Domain

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000396144

656_844

457

842.0

Domain

Rho-GAP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000311380

12_74

410

795.0

Domain

SH3

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000311380

265_298

410

795.0

Domain

WW 1

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000311380

358_391

410

795.0

Domain

WW 2

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000344936

12_74

462

847.0

Domain

SH3

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000344936

265_298

462

847.0

Domain

WW 1

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000344936

358_391

462

847.0

Domain

WW 2

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375245

12_74

410

795.0

Domain

SH3

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375245

265_298

410

795.0

Domain

WW 1

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375245

358_391

410

795.0

Domain

WW 2

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375250

12_74

432

817.0

Domain

SH3

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375250

265_298

432

817.0

Domain

WW 1

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000375250

358_391

432

817.0

Domain

WW 2

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000396144

12_74

457

842.0

Domain

SH3

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000396144

265_298

457

842.0

Domain

WW 1

Tgene

ARHGAP12

chr10:32635690

chr10:32120728

ENST00000396144

358_391

457

842.0

Domain

WW 2

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Fusion Gene Sequence for EPC1-ARHGAP12

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26884_26884_1_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000263062_ARHGAP12_chr10_32120728_ENST00000311380_length(transcript)=3799nt_BP=423nt
GAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGGCCATGGCGTATTGAAGAGAGCGAGCGAGAGAGG
AGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGCTCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGG
TTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTTCCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAG
ATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTTTTCCGCTGTGAGGATCTGCCCGACCTGCACGAA
TACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAGGAGTCGGATCAAGAGAAATATGGATTATTAAAT
GTAACAAAAATTGCTGAAAATGGGAAAAAGGTTCGAAAGAACTGGTTGTCTTCTTGGGCGGTGTTGCAGGGTTCATCTTTACTTTTTACC
AAAACTCAAGGAAGTAGCACAAGTTGGTTTGGCAGTAATCAGTCCAAACCAGAGTTCACAGTGGACCTCAAGGGGGCAACAATTGAGATG
GCTTCAAAGGATAAATCCAGCAAAAAGAATGTATTTGAGCTGAAAACTCGTCAAGGAACAGAACTGCTAATTCAGTCTGACAATGACACT
GTTATTAATGATTGGTTTAAAGTTCTTAGTAGTACAATCAATAATCAGGCAGTAGAAACTGATGAAGGAATTGAAGAGGAGATACCGGAT
TCACCAGGAATAGAAAAGCATGATAAAGAAAAGGAACAAAAGGATCCCAAAAAGCTTCGTTCCTTTAAAGTATCTAGCATAGATTCTTCA
GAACAGAAAAAAACCAAGAAAAACTTAAAGAAGTTTCTTACACGACGCCCCACTTTGCAAGCTGTTCGTGAAAAAGGTTATATTAAAGAT
CAGGTATTTGGATCCAATCTCGCTAATCTGTGTCAGAGAGAGAATGGCACAGTACCAAAGTTTGTGAAGTTATGTATTGAACATGTTGAA
GAACATGGTTTGGATATTGATGGGATATACAGAGTAAGTGGCAACCTCGCAGTGATCCAGAAACTAAGGTTTGCAGTCAATCATGATGAG
AAATTGGACTTGAATGACAGTAAATGGGAAGATATTCATGTCATTACTGGAGCCCTCAAAATGTTTTTTCGAGAATTACCAGAACCTCTT
TTTACATTTAATCATTTTAATGATTTTGTTAATGCAATTAAGCAAGAACCAAGACAGCGAGTCGCTGCTGTTAAGGACCTAATCAGACAG
TTGCCAAAGCCAAACCAAGACACAATGCAGATTCTTTTCCGACATCTCAGAAGAGTTATAGAAAATGGAGAGAAAAATCGAATGACCTAT
CAGAGTATAGCAATTGTTTTTGGTCCCACTCTATTAAAACCAGAAAAAGAGACTGGTAATATAGCAGTTCATACTGTGTACCAGAATCAG
ATTGTAGAATTAATTCTTCTGGAACTGAGTTCCATCTTCGGACGTTGATTCTTACTGAAGACAACCTGTGGAATAGAAGCTGGATTCCAT
CAGATTTCAAATGTTTATACACAATGTATTTTATTTTTTGGACCAAGCAGTGACTCTTTGATTTTGCACTTTTTTTTTGAGGGATCAGAA
GGGAAGGGGAGAGTCGAGATGTGTGTTAGGCCCTCATATTTGCTGCTTTGTTGCAAGTTGATATAACTGCGTGTAATTATGAATTCATTT
TATCCTGAATGTTTGCATTTCATACTCTGAATTTCAGTAAAAATCAAAACTTAAAATTCTAACCAGTCATATACACTGGATAATTTGGTA
AGAAAACTGTATTTTTTTTCCCTGAAATTGGATAATGTACTTTCTTCTCAAGATTCATGACTTGATAGAACAATACTTTCAGTTATGTTG
CAAAGGCTCTTGGGCATTTTAAACAAAATGAAGTATATCCATTTTGAAACCTGTGTATTTCTTTTTCGGGGTTTCTGCATGCAGTGGCAG
TCTTAAGTGCCAAAATTCATTATAACCCCAAAATAACCCCTTGATGAAGGCTTGCTGTCTTTTACTGTGTTACACAGCATCCTTACTGGA
TATCTTAGTTGCTTGTTTGGGCAGCACACTAATATTACTTAAAACACTGTGATATACTGGAGTTTTAGTTAGCGGAAGTCAGTTCAGGGC
ATTTTAGGGCTGTCTTGCTATACTGAATTGTAGCTAACAATCCTAATTATATCTAGTACCATACTGAGTTATTGGTATGACCCTGTGGAA
ACACACATTATTTTATGTAAATATAGGCTAAAGACTTAATGTCCTTTAGCTTGTGTATATAATTGTGTTGTATAGTCTCAGAGTACATTC
TAACCCTACATTTCTAATCATTGTTATTGGTAATCTTTTCTGTGAATATTAGGTTTCCTCCAGAAATAGTCCGTTATTTGGGAAAGTTAA
CTGTGTGCACTTTTAGATATTAACTACATTTACAGGCAAATCACTGTAATGAGAATGGTACTGGAAAAATACTGAATAGACTTGCTAAAT
GGCACATGCACTACAAGAGGAACCTTTTGGGTTATTTAATATGTACAGAAAACATTAGAAAAAATTTATTACAGAATTCTAATTCCAGTA
TGAATAGTGGAAACCCATCTGTAAATTAGATGGATGTTGGATGGAAAATGACATTGCTAAATTTGAGAATTTCTTTTTACCTACTAATGT
AGATTGCTTTGTATAATAAAACACAGGGTTTGGAAGGTTTTGTTACAGGGAGCATGGTCTGTTGAAGATTTTTAAAATGTATTTTTCTAG
ATTAACTTCTGTACATGAAATGTCTAATAAAACTATAAGAGGTTTAGAGATTTTTCCATTGGAAATGTGCATTTTGGTTTCTAATTTTTT
TGTTTTTTCATTTACTGGCATACTGTTATACCTCATTTTTAAAAATCAACTGAATCCAATATTTCCTGTGGCAAATAACACTTTCCTCAT
TTCATACCTTTTCTCCTCTCTTCCATGCCAACATTTCTCCACCCACAACGTACACTTTTTATTTCTCCATCAATATTTGAAAGCGAGTGA
TTTGTGACCAGGATTTTTTTTTCTTAGGGTTGCATTTATAATTTACAGATTGCCTTCCTTGGGAACAAGTATTTTTTTGTATGATCTGTC
TAAAAACCTCTCACCTGAATTTTGTGGTAGAAAGTCTGTATTTGTTGTTGTGAGCGTGTTAAATTGATAACAAACCAAACTACTTGATAG
CTAAAGCAGATTGTTTCGGGTGGGGAGAAAAAGCCCTAAATCAGAATGTTTATATTTGCCTAAAGATGTCCTTAATAATACAATATGCTT
TAGATCTTGCTTATTTAGTGATTGTATACCAGGAAAACAATTAGACTCAAATCAGTGATGTTCTTGTTCTTGGTGTTCATGAACATATAT
CAAAGATTAAAATTGTCCTGTGTTTCTTGTTTCAAGGTACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAGTCTTAAATGT
TTTATTAGTCTACAGCTAATCAGTTTATTGTAATATTGTATGTACAGTGAGATTAATGTCTTGCGTTTTCATCCTTTGTGAATTAAAAAT
TCTCACTTGTTTTGTAATAACAAAGCTAGTAATATTTTCCTGTCTTGACAGCTTGGTTTTATAGTAGAAAATATATTAAAAGCTGAAATA

>26884_26884_1_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000263062_ARHGAP12_chr10_32120728_ENST00000311380_length(amino acids)=435AA_BP=0
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFT
KTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD
SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVE
EHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQ

--------------------------------------------------------------
>26884_26884_2_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000263062_ARHGAP12_chr10_32120728_ENST00000375250_length(transcript)=3799nt_BP=423nt
GAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGGCCATGGCGTATTGAAGAGAGCGAGCGAGAGAGG
AGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGCTCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGG
TTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTTCCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAG
ATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTTTTCCGCTGTGAGGATCTGCCCGACCTGCACGAA
TACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAGGAGTCGGATCAAGAGAAATATGGATTATTAAAT
GTAACAAAAATTGCTGAAAATGGGAAAAAGGTTCGAAAGAACTGGTTGTCTTCTTGGGCGGTGTTGCAGGGTTCATCTTTACTTTTTACC
AAAACTCAAGGAAGTAGCACAAGTTGGTTTGGCAGTAATCAGTCCAAACCAGAGTTCACAGTGGACCTCAAGGGGGCAACAATTGAGATG
GCTTCAAAGGATAAATCCAGCAAAAAGAATGTATTTGAGCTGAAAACTCGTCAAGGAACAGAACTGCTAATTCAGTCTGACAATGACACT
GTTATTAATGATTGGTTTAAAGTTCTTAGTAGTACAATCAATAATCAGGCAGTAGAAACTGATGAAGGAATTGAAGAGGAGATACCGGAT
TCACCAGGAATAGAAAAGCATGATAAAGAAAAGGAACAAAAGGATCCCAAAAAGCTTCGTTCCTTTAAAGTATCTAGCATAGATTCTTCA
GAACAGAAAAAAACCAAGAAAAACTTAAAGAAGTTTCTTACACGACGCCCCACTTTGCAAGCTGTTCGTGAAAAAGGTTATATTAAAGAT
CAGGTATTTGGATCCAATCTCGCTAATCTGTGTCAGAGAGAGAATGGCACAGTACCAAAGTTTGTGAAGTTATGTATTGAACATGTTGAA
GAACATGGTTTGGATATTGATGGGATATACAGAGTAAGTGGCAACCTCGCAGTGATCCAGAAACTAAGGTTTGCAGTCAATCATGATGAG
AAATTGGACTTGAATGACAGTAAATGGGAAGATATTCATGTCATTACTGGAGCCCTCAAAATGTTTTTTCGAGAATTACCAGAACCTCTT
TTTACATTTAATCATTTTAATGATTTTGTTAATGCAATTAAGCAAGAACCAAGACAGCGAGTCGCTGCTGTTAAGGACCTAATCAGACAG
TTGCCAAAGCCAAACCAAGACACAATGCAGATTCTTTTCCGACATCTCAGAAGAGTTATAGAAAATGGAGAGAAAAATCGAATGACCTAT
CAGAGTATAGCAATTGTTTTTGGTCCCACTCTATTAAAACCAGAAAAAGAGACTGGTAATATAGCAGTTCATACTGTGTACCAGAATCAG
ATTGTAGAATTAATTCTTCTGGAACTGAGTTCCATCTTCGGACGTTGATTCTTACTGAAGACAACCTGTGGAATAGAAGCTGGATTCCAT
CAGATTTCAAATGTTTATACACAATGTATTTTATTTTTTGGACCAAGCAGTGACTCTTTGATTTTGCACTTTTTTTTTGAGGGATCAGAA
GGGAAGGGGAGAGTCGAGATGTGTGTTAGGCCCTCATATTTGCTGCTTTGTTGCAAGTTGATATAACTGCGTGTAATTATGAATTCATTT
TATCCTGAATGTTTGCATTTCATACTCTGAATTTCAGTAAAAATCAAAACTTAAAATTCTAACCAGTCATATACACTGGATAATTTGGTA
AGAAAACTGTATTTTTTTTCCCTGAAATTGGATAATGTACTTTCTTCTCAAGATTCATGACTTGATAGAACAATACTTTCAGTTATGTTG
CAAAGGCTCTTGGGCATTTTAAACAAAATGAAGTATATCCATTTTGAAACCTGTGTATTTCTTTTTCGGGGTTTCTGCATGCAGTGGCAG
TCTTAAGTGCCAAAATTCATTATAACCCCAAAATAACCCCTTGATGAAGGCTTGCTGTCTTTTACTGTGTTACACAGCATCCTTACTGGA
TATCTTAGTTGCTTGTTTGGGCAGCACACTAATATTACTTAAAACACTGTGATATACTGGAGTTTTAGTTAGCGGAAGTCAGTTCAGGGC
ATTTTAGGGCTGTCTTGCTATACTGAATTGTAGCTAACAATCCTAATTATATCTAGTACCATACTGAGTTATTGGTATGACCCTGTGGAA
ACACACATTATTTTATGTAAATATAGGCTAAAGACTTAATGTCCTTTAGCTTGTGTATATAATTGTGTTGTATAGTCTCAGAGTACATTC
TAACCCTACATTTCTAATCATTGTTATTGGTAATCTTTTCTGTGAATATTAGGTTTCCTCCAGAAATAGTCCGTTATTTGGGAAAGTTAA
CTGTGTGCACTTTTAGATATTAACTACATTTACAGGCAAATCACTGTAATGAGAATGGTACTGGAAAAATACTGAATAGACTTGCTAAAT
GGCACATGCACTACAAGAGGAACCTTTTGGGTTATTTAATATGTACAGAAAACATTAGAAAAAATTTATTACAGAATTCTAATTCCAGTA
TGAATAGTGGAAACCCATCTGTAAATTAGATGGATGTTGGATGGAAAATGACATTGCTAAATTTGAGAATTTCTTTTTACCTACTAATGT
AGATTGCTTTGTATAATAAAACACAGGGTTTGGAAGGTTTTGTTACAGGGAGCATGGTCTGTTGAAGATTTTTAAAATGTATTTTTCTAG
ATTAACTTCTGTACATGAAATGTCTAATAAAACTATAAGAGGTTTAGAGATTTTTCCATTGGAAATGTGCATTTTGGTTTCTAATTTTTT
TGTTTTTTCATTTACTGGCATACTGTTATACCTCATTTTTAAAAATCAACTGAATCCAATATTTCCTGTGGCAAATAACACTTTCCTCAT
TTCATACCTTTTCTCCTCTCTTCCATGCCAACATTTCTCCACCCACAACGTACACTTTTTATTTCTCCATCAATATTTGAAAGCGAGTGA
TTTGTGACCAGGATTTTTTTTTCTTAGGGTTGCATTTATAATTTACAGATTGCCTTCCTTGGGAACAAGTATTTTTTTGTATGATCTGTC
TAAAAACCTCTCACCTGAATTTTGTGGTAGAAAGTCTGTATTTGTTGTTGTGAGCGTGTTAAATTGATAACAAACCAAACTACTTGATAG
CTAAAGCAGATTGTTTCGGGTGGGGAGAAAAAGCCCTAAATCAGAATGTTTATATTTGCCTAAAGATGTCCTTAATAATACAATATGCTT
TAGATCTTGCTTATTTAGTGATTGTATACCAGGAAAACAATTAGACTCAAATCAGTGATGTTCTTGTTCTTGGTGTTCATGAACATATAT
CAAAGATTAAAATTGTCCTGTGTTTCTTGTTTCAAGGTACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAGTCTTAAATGT
TTTATTAGTCTACAGCTAATCAGTTTATTGTAATATTGTATGTACAGTGAGATTAATGTCTTGCGTTTTCATCCTTTGTGAATTAAAAAT
TCTCACTTGTTTTGTAATAACAAAGCTAGTAATATTTTCCTGTCTTGACAGCTTGGTTTTATAGTAGAAAATATATTAAAAGCTGAAATA

>26884_26884_2_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000263062_ARHGAP12_chr10_32120728_ENST00000375250_length(amino acids)=435AA_BP=0
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFT
KTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD
SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVE
EHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQ

--------------------------------------------------------------
>26884_26884_3_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000319778_ARHGAP12_chr10_32120728_ENST00000311380_length(transcript)=3832nt_BP=456nt
GCGTGCCCGCGCCGCTGCGCGATGCAGTGTGGGGAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGG
CCATGGCGTATTGAAGAGAGCGAGCGAGAGAGGAGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGC
TCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGGTTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTT
CCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAGATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTT
TTCCGCTGTGAGGATCTGCCCGACCTGCACGAATACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAG
GAGTCGGATCAAGAGAAATATGGATTATTAAATGTAACAAAAATTGCTGAAAATGGGAAAAAGGTTCGAAAGAACTGGTTGTCTTCTTGG
GCGGTGTTGCAGGGTTCATCTTTACTTTTTACCAAAACTCAAGGAAGTAGCACAAGTTGGTTTGGCAGTAATCAGTCCAAACCAGAGTTC
ACAGTGGACCTCAAGGGGGCAACAATTGAGATGGCTTCAAAGGATAAATCCAGCAAAAAGAATGTATTTGAGCTGAAAACTCGTCAAGGA
ACAGAACTGCTAATTCAGTCTGACAATGACACTGTTATTAATGATTGGTTTAAAGTTCTTAGTAGTACAATCAATAATCAGGCAGTAGAA
ACTGATGAAGGAATTGAAGAGGAGATACCGGATTCACCAGGAATAGAAAAGCATGATAAAGAAAAGGAACAAAAGGATCCCAAAAAGCTT
CGTTCCTTTAAAGTATCTAGCATAGATTCTTCAGAACAGAAAAAAACCAAGAAAAACTTAAAGAAGTTTCTTACACGACGCCCCACTTTG
CAAGCTGTTCGTGAAAAAGGTTATATTAAAGATCAGGTATTTGGATCCAATCTCGCTAATCTGTGTCAGAGAGAGAATGGCACAGTACCA
AAGTTTGTGAAGTTATGTATTGAACATGTTGAAGAACATGGTTTGGATATTGATGGGATATACAGAGTAAGTGGCAACCTCGCAGTGATC
CAGAAACTAAGGTTTGCAGTCAATCATGATGAGAAATTGGACTTGAATGACAGTAAATGGGAAGATATTCATGTCATTACTGGAGCCCTC
AAAATGTTTTTTCGAGAATTACCAGAACCTCTTTTTACATTTAATCATTTTAATGATTTTGTTAATGCAATTAAGCAAGAACCAAGACAG
CGAGTCGCTGCTGTTAAGGACCTAATCAGACAGTTGCCAAAGCCAAACCAAGACACAATGCAGATTCTTTTCCGACATCTCAGAAGAGTT
ATAGAAAATGGAGAGAAAAATCGAATGACCTATCAGAGTATAGCAATTGTTTTTGGTCCCACTCTATTAAAACCAGAAAAAGAGACTGGT
AATATAGCAGTTCATACTGTGTACCAGAATCAGATTGTAGAATTAATTCTTCTGGAACTGAGTTCCATCTTCGGACGTTGATTCTTACTG
AAGACAACCTGTGGAATAGAAGCTGGATTCCATCAGATTTCAAATGTTTATACACAATGTATTTTATTTTTTGGACCAAGCAGTGACTCT
TTGATTTTGCACTTTTTTTTTGAGGGATCAGAAGGGAAGGGGAGAGTCGAGATGTGTGTTAGGCCCTCATATTTGCTGCTTTGTTGCAAG
TTGATATAACTGCGTGTAATTATGAATTCATTTTATCCTGAATGTTTGCATTTCATACTCTGAATTTCAGTAAAAATCAAAACTTAAAAT
TCTAACCAGTCATATACACTGGATAATTTGGTAAGAAAACTGTATTTTTTTTCCCTGAAATTGGATAATGTACTTTCTTCTCAAGATTCA
TGACTTGATAGAACAATACTTTCAGTTATGTTGCAAAGGCTCTTGGGCATTTTAAACAAAATGAAGTATATCCATTTTGAAACCTGTGTA
TTTCTTTTTCGGGGTTTCTGCATGCAGTGGCAGTCTTAAGTGCCAAAATTCATTATAACCCCAAAATAACCCCTTGATGAAGGCTTGCTG
TCTTTTACTGTGTTACACAGCATCCTTACTGGATATCTTAGTTGCTTGTTTGGGCAGCACACTAATATTACTTAAAACACTGTGATATAC
TGGAGTTTTAGTTAGCGGAAGTCAGTTCAGGGCATTTTAGGGCTGTCTTGCTATACTGAATTGTAGCTAACAATCCTAATTATATCTAGT
ACCATACTGAGTTATTGGTATGACCCTGTGGAAACACACATTATTTTATGTAAATATAGGCTAAAGACTTAATGTCCTTTAGCTTGTGTA
TATAATTGTGTTGTATAGTCTCAGAGTACATTCTAACCCTACATTTCTAATCATTGTTATTGGTAATCTTTTCTGTGAATATTAGGTTTC
CTCCAGAAATAGTCCGTTATTTGGGAAAGTTAACTGTGTGCACTTTTAGATATTAACTACATTTACAGGCAAATCACTGTAATGAGAATG
GTACTGGAAAAATACTGAATAGACTTGCTAAATGGCACATGCACTACAAGAGGAACCTTTTGGGTTATTTAATATGTACAGAAAACATTA
GAAAAAATTTATTACAGAATTCTAATTCCAGTATGAATAGTGGAAACCCATCTGTAAATTAGATGGATGTTGGATGGAAAATGACATTGC
TAAATTTGAGAATTTCTTTTTACCTACTAATGTAGATTGCTTTGTATAATAAAACACAGGGTTTGGAAGGTTTTGTTACAGGGAGCATGG
TCTGTTGAAGATTTTTAAAATGTATTTTTCTAGATTAACTTCTGTACATGAAATGTCTAATAAAACTATAAGAGGTTTAGAGATTTTTCC
ATTGGAAATGTGCATTTTGGTTTCTAATTTTTTTGTTTTTTCATTTACTGGCATACTGTTATACCTCATTTTTAAAAATCAACTGAATCC
AATATTTCCTGTGGCAAATAACACTTTCCTCATTTCATACCTTTTCTCCTCTCTTCCATGCCAACATTTCTCCACCCACAACGTACACTT
TTTATTTCTCCATCAATATTTGAAAGCGAGTGATTTGTGACCAGGATTTTTTTTTCTTAGGGTTGCATTTATAATTTACAGATTGCCTTC
CTTGGGAACAAGTATTTTTTTGTATGATCTGTCTAAAAACCTCTCACCTGAATTTTGTGGTAGAAAGTCTGTATTTGTTGTTGTGAGCGT
GTTAAATTGATAACAAACCAAACTACTTGATAGCTAAAGCAGATTGTTTCGGGTGGGGAGAAAAAGCCCTAAATCAGAATGTTTATATTT
GCCTAAAGATGTCCTTAATAATACAATATGCTTTAGATCTTGCTTATTTAGTGATTGTATACCAGGAAAACAATTAGACTCAAATCAGTG
ATGTTCTTGTTCTTGGTGTTCATGAACATATATCAAAGATTAAAATTGTCCTGTGTTTCTTGTTTCAAGGTACGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGAAGTCTTAAATGTTTTATTAGTCTACAGCTAATCAGTTTATTGTAATATTGTATGTACAGTGAGATTAAT
GTCTTGCGTTTTCATCCTTTGTGAATTAAAAATTCTCACTTGTTTTGTAATAACAAAGCTAGTAATATTTTCCTGTCTTGACAGCTTGGT

>26884_26884_3_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000319778_ARHGAP12_chr10_32120728_ENST00000311380_length(amino acids)=435AA_BP=0
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFT
KTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD
SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVE
EHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQ

--------------------------------------------------------------
>26884_26884_4_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000319778_ARHGAP12_chr10_32120728_ENST00000375250_length(transcript)=3832nt_BP=456nt
GCGTGCCCGCGCCGCTGCGCGATGCAGTGTGGGGAATGGCTGGGGTTGGCTGAAGAGCGCACAGTGGAGTTTTAATGTCCGCCATGTTGG
CCATGGCGTATTGAAGAGAGCGAGCGAGAGAGGAGCGGAGCGGCACAGCCTCCCACCCTCCCGGCTGGTGTTAGTGCCCGGACGGCGGGC
TCTGCGCTCCGCCCCTCAAGTCCCCGGCAGCGGTTGGCGAGTGGGGACCGAACCCCCGGTTCTCCATGATCCCGCTGGCCGGGGCCGTTT
CCCCAGAGCGGAGAGGTATCTGCTGCGCCTGAGATGAGTAAACTGTCGTTTCGGGCGCGGGCGCTAGACGCCTCGAAGCCGCTGCCGGTT
TTCCGCTGTGAGGATCTGCCCGACCTGCACGAATACGCCTCGATAAACAGGGCCGTGCCGCAGATGCCCACCGGAATGGAGAAGGAAGAG
GAGTCGGATCAAGAGAAATATGGATTATTAAATGTAACAAAAATTGCTGAAAATGGGAAAAAGGTTCGAAAGAACTGGTTGTCTTCTTGG
GCGGTGTTGCAGGGTTCATCTTTACTTTTTACCAAAACTCAAGGAAGTAGCACAAGTTGGTTTGGCAGTAATCAGTCCAAACCAGAGTTC
ACAGTGGACCTCAAGGGGGCAACAATTGAGATGGCTTCAAAGGATAAATCCAGCAAAAAGAATGTATTTGAGCTGAAAACTCGTCAAGGA
ACAGAACTGCTAATTCAGTCTGACAATGACACTGTTATTAATGATTGGTTTAAAGTTCTTAGTAGTACAATCAATAATCAGGCAGTAGAA
ACTGATGAAGGAATTGAAGAGGAGATACCGGATTCACCAGGAATAGAAAAGCATGATAAAGAAAAGGAACAAAAGGATCCCAAAAAGCTT
CGTTCCTTTAAAGTATCTAGCATAGATTCTTCAGAACAGAAAAAAACCAAGAAAAACTTAAAGAAGTTTCTTACACGACGCCCCACTTTG
CAAGCTGTTCGTGAAAAAGGTTATATTAAAGATCAGGTATTTGGATCCAATCTCGCTAATCTGTGTCAGAGAGAGAATGGCACAGTACCA
AAGTTTGTGAAGTTATGTATTGAACATGTTGAAGAACATGGTTTGGATATTGATGGGATATACAGAGTAAGTGGCAACCTCGCAGTGATC
CAGAAACTAAGGTTTGCAGTCAATCATGATGAGAAATTGGACTTGAATGACAGTAAATGGGAAGATATTCATGTCATTACTGGAGCCCTC
AAAATGTTTTTTCGAGAATTACCAGAACCTCTTTTTACATTTAATCATTTTAATGATTTTGTTAATGCAATTAAGCAAGAACCAAGACAG
CGAGTCGCTGCTGTTAAGGACCTAATCAGACAGTTGCCAAAGCCAAACCAAGACACAATGCAGATTCTTTTCCGACATCTCAGAAGAGTT
ATAGAAAATGGAGAGAAAAATCGAATGACCTATCAGAGTATAGCAATTGTTTTTGGTCCCACTCTATTAAAACCAGAAAAAGAGACTGGT
AATATAGCAGTTCATACTGTGTACCAGAATCAGATTGTAGAATTAATTCTTCTGGAACTGAGTTCCATCTTCGGACGTTGATTCTTACTG
AAGACAACCTGTGGAATAGAAGCTGGATTCCATCAGATTTCAAATGTTTATACACAATGTATTTTATTTTTTGGACCAAGCAGTGACTCT
TTGATTTTGCACTTTTTTTTTGAGGGATCAGAAGGGAAGGGGAGAGTCGAGATGTGTGTTAGGCCCTCATATTTGCTGCTTTGTTGCAAG
TTGATATAACTGCGTGTAATTATGAATTCATTTTATCCTGAATGTTTGCATTTCATACTCTGAATTTCAGTAAAAATCAAAACTTAAAAT
TCTAACCAGTCATATACACTGGATAATTTGGTAAGAAAACTGTATTTTTTTTCCCTGAAATTGGATAATGTACTTTCTTCTCAAGATTCA
TGACTTGATAGAACAATACTTTCAGTTATGTTGCAAAGGCTCTTGGGCATTTTAAACAAAATGAAGTATATCCATTTTGAAACCTGTGTA
TTTCTTTTTCGGGGTTTCTGCATGCAGTGGCAGTCTTAAGTGCCAAAATTCATTATAACCCCAAAATAACCCCTTGATGAAGGCTTGCTG
TCTTTTACTGTGTTACACAGCATCCTTACTGGATATCTTAGTTGCTTGTTTGGGCAGCACACTAATATTACTTAAAACACTGTGATATAC
TGGAGTTTTAGTTAGCGGAAGTCAGTTCAGGGCATTTTAGGGCTGTCTTGCTATACTGAATTGTAGCTAACAATCCTAATTATATCTAGT
ACCATACTGAGTTATTGGTATGACCCTGTGGAAACACACATTATTTTATGTAAATATAGGCTAAAGACTTAATGTCCTTTAGCTTGTGTA
TATAATTGTGTTGTATAGTCTCAGAGTACATTCTAACCCTACATTTCTAATCATTGTTATTGGTAATCTTTTCTGTGAATATTAGGTTTC
CTCCAGAAATAGTCCGTTATTTGGGAAAGTTAACTGTGTGCACTTTTAGATATTAACTACATTTACAGGCAAATCACTGTAATGAGAATG
GTACTGGAAAAATACTGAATAGACTTGCTAAATGGCACATGCACTACAAGAGGAACCTTTTGGGTTATTTAATATGTACAGAAAACATTA
GAAAAAATTTATTACAGAATTCTAATTCCAGTATGAATAGTGGAAACCCATCTGTAAATTAGATGGATGTTGGATGGAAAATGACATTGC
TAAATTTGAGAATTTCTTTTTACCTACTAATGTAGATTGCTTTGTATAATAAAACACAGGGTTTGGAAGGTTTTGTTACAGGGAGCATGG
TCTGTTGAAGATTTTTAAAATGTATTTTTCTAGATTAACTTCTGTACATGAAATGTCTAATAAAACTATAAGAGGTTTAGAGATTTTTCC
ATTGGAAATGTGCATTTTGGTTTCTAATTTTTTTGTTTTTTCATTTACTGGCATACTGTTATACCTCATTTTTAAAAATCAACTGAATCC
AATATTTCCTGTGGCAAATAACACTTTCCTCATTTCATACCTTTTCTCCTCTCTTCCATGCCAACATTTCTCCACCCACAACGTACACTT
TTTATTTCTCCATCAATATTTGAAAGCGAGTGATTTGTGACCAGGATTTTTTTTTCTTAGGGTTGCATTTATAATTTACAGATTGCCTTC
CTTGGGAACAAGTATTTTTTTGTATGATCTGTCTAAAAACCTCTCACCTGAATTTTGTGGTAGAAAGTCTGTATTTGTTGTTGTGAGCGT
GTTAAATTGATAACAAACCAAACTACTTGATAGCTAAAGCAGATTGTTTCGGGTGGGGAGAAAAAGCCCTAAATCAGAATGTTTATATTT
GCCTAAAGATGTCCTTAATAATACAATATGCTTTAGATCTTGCTTATTTAGTGATTGTATACCAGGAAAACAATTAGACTCAAATCAGTG
ATGTTCTTGTTCTTGGTGTTCATGAACATATATCAAAGATTAAAATTGTCCTGTGTTTCTTGTTTCAAGGTACGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGAAGTCTTAAATGTTTTATTAGTCTACAGCTAATCAGTTTATTGTAATATTGTATGTACAGTGAGATTAAT
GTCTTGCGTTTTCATCCTTTGTGAATTAAAAATTCTCACTTGTTTTGTAATAACAAAGCTAGTAATATTTTCCTGTCTTGACAGCTTGGT

>26884_26884_4_EPC1-ARHGAP12_EPC1_chr10_32635690_ENST00000319778_ARHGAP12_chr10_32120728_ENST00000375250_length(amino acids)=435AA_BP=0
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFT
KTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD
SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVE
EHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EPC1-ARHGAP12

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EPC1-ARHGAP12

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EPC1-ARHGAP12

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source