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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EPC2-MYH11 (FusionGDB2 ID:26909)

Fusion Gene Summary for EPC2-MYH11

Fusion gene summary

Fusion gene information	Fusion gene name: EPC2-MYH11
	Fusion gene ID: 26909
		Hgene	Tgene
	Gene symbol	EPC2	MYH11
	Gene ID	26122	4629
	Gene name	enhancer of polycomb homolog 2	myosin heavy chain 11
	Synonyms	EPC-LIKE	AAT4\|FAA4\|SMHC\|SMMHC
	Cytomap	2q23.1	16p13.11
	Type of gene	protein-coding	protein-coding
	Description	enhancer of polycomb homolog 2	myosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle
	Modification date	20200313	20200322
	UniProtAcc	.	P35749
	Ensembl transtripts involved in fusion gene	ENST00000258484, ENST00000409654,	ENST00000573908, ENST00000300036, ENST00000396324, ENST00000452625, ENST00000576790,
Fusion gene scores	* DoF score	12 X 11 X 3=396	44 X 55 X 10=24200
	# samples	12	62
	** MAII score	log2(12/396*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(62/24200*10)=-5.28659502177508 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EPC2 [Title/Abstract] AND MYH11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EPC2(149526741)-MYH11(15818065), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EPC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE837002	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-

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Fusion Gene ORF analysis for EPC2-MYH11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000258484	ENST00000573908	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
In-frame	ENST00000258484	ENST00000300036	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
In-frame	ENST00000258484	ENST00000396324	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
In-frame	ENST00000258484	ENST00000452625	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
In-frame	ENST00000258484	ENST00000576790	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
intron-3CDS	ENST00000409654	ENST00000300036	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
intron-3CDS	ENST00000409654	ENST00000396324	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
intron-3CDS	ENST00000409654	ENST00000452625	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
intron-3CDS	ENST00000409654	ENST00000576790	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-
intron-intron	ENST00000409654	ENST00000573908	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000258484	EPC2	chr2	149526741	-	ENST00000396324	MYH11	chr16	15818065	-	3663	1242	34	1374	446
ENST00000258484	EPC2	chr2	149526741	-	ENST00000452625	MYH11	chr16	15818065	-	3702	1242	34	1374	446
ENST00000258484	EPC2	chr2	149526741	-	ENST00000576790	MYH11	chr16	15818065	-	3087	1242	34	1374	446
ENST00000258484	EPC2	chr2	149526741	-	ENST00000300036	MYH11	chr16	15818065	-	2844	1242	34	1374	446

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000258484	ENST00000396324	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-	0.009926841	0.9900732
ENST00000258484	ENST00000452625	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-	0.010136104	0.98986393
ENST00000258484	ENST00000576790	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-	0.0113003	0.98869973
ENST00000258484	ENST00000300036	EPC2	chr2	149526741	-	MYH11	chr16	15818065	-	0.008971636	0.99102837

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Fusion Genomic Features for EPC2-MYH11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPC2-MYH11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:149526741/chr16:15818065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MYH11 P35749
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Muscle contraction.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

844_1934

1973.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

844_1934

1980.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

844_1934

2132.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

844_1934

1912.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

31_81

1973.0

Domain

Myosin N-terminal SH3-like

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

786_815

1973.0

Domain

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

85_783

1973.0

Domain

Myosin motor

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

31_81

1980.0

Domain

Myosin N-terminal SH3-like

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

786_815

1980.0

Domain

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

85_783

1980.0

Domain

Myosin motor

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

31_81

2132.0

Domain

Myosin N-terminal SH3-like

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

786_815

2132.0

Domain

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

85_783

2132.0

Domain

Myosin motor

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

31_81

1912.6666666666667

Domain

Myosin N-terminal SH3-like

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

786_815

1912.6666666666667

Domain

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

85_783

1912.6666666666667

Domain

Myosin motor

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

178_185

1973.0

Nucleotide binding

ATP

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

178_185

1980.0

Nucleotide binding

ATP

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

178_185

2132.0

Nucleotide binding

ATP

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

178_185

1912.6666666666667

Nucleotide binding

ATP

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

1935_1972

1973.0

Region

Note=C-terminal

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

661_683

1973.0

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000300036

762_776

1973.0

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

1935_1972

1980.0

Region

Note=C-terminal

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

661_683

1980.0

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000396324

762_776

1980.0

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

1935_1972

2132.0

Region

Note=C-terminal

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

661_683

2132.0

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000452625

762_776

2132.0

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

1935_1972

1912.6666666666667

Region

Note=C-terminal

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

661_683

1912.6666666666667

Region

Actin-binding

Tgene

MYH11

chr2:149526741

chr16:15818065

ENST00000576790

762_776

1912.6666666666667

Region

Actin-binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPC2

chr2:149526741

chr16:15818065

ENST00000258484

483_488

808.0

Compositional bias

Note=Poly-Ser

Hgene

EPC2

chr2:149526741

chr16:15818065

ENST00000258484

582_619

808.0

Compositional bias

Note=Gln-rich

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Fusion Gene Sequence for EPC2-MYH11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26909_26909_1_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000300036_length(transcript)=2844nt_BP=1242nt
GCCGCCCGGGCTGTTCCTGTAAGGCGGGGAGACAATGAGTAAACTCTCCTTCCGAGCGCGGGCGCTGGACGCCGCCAAGCCGCTGCCTAT
CTACCGCGGCAAGGACATGCCTGATCTCAACGACTGCGTCTCCATCAACCGGGCCGTGCCCCAGATGCCCACCGGGATGGAGAAGGAGGA
GGAATCGGAACATCATTTACAGCGAGCAATTTCAGCACAGCAAGTGTTTAGAGAAAAAAAAGAGAGTATGGTCATTCCTGTTCCTGAGGC
AGAGAGCAACGTCAACTATTACAATCGCTTGTACAAAGGAGAGTTTAAACAGCCAAAACAGTTCATTCATATTCAGCCTTTTAATCTAGA
CAACGAGCAACCAGATTATGATATGGATTCAGAAGATGAGACTTTATTAAATAGACTTAACAGAAAGATGGAAATTAAGCCTTTGCAATT
TGAAATTATGATTGACAGACTTGAAAAAGCCAGTTCTAATCAGCTTGTAACACTTCAAGAAGCAAAACTGCTGCTAAACGAAGATGATTA
CCTTATTAAAGCTGTATATGACTACTGGGTGAGAAAACGTAAAAACTGCAGGGGGCCATCCCTCATTCCTCAGATAAAACAAGAGAAAAG
AGATGGCTCTACCAACAATGACCCTTATGTTGCCTTTCGGAGAAGAACAGAGAAAATGCAAACTCGAAAGAATCGTAAGAATGATGAAGC
CTCTTATGAAAAGATGTTGAAACTGAGACGAGAATTTAGTAGAGCCATAACAATTTTGGAAATGATTAAGAGAAGAGAGAAAACAAAACG
AGAATTATTGCACTTAACCTTAGAAGTTGTGGAGAAAAGATACCATTTGGGAGACTATGGTGGTGAAATCCTTAATGAAGTAAAAATCAG
TAGATCAGAAAAAGAGTTATATGCCACTCCAGCAACTCTTCATAATGGAAATCATCACAAAGTTCAAGAATGTAAAACTAAGCACCCTCA
TCATTTGTCTTTGAAAGAAGAGGCTTCTGATGTGGTTCGTCAAAAGAAGAAGTACCCAAAGAAGCCTAAAGCAGAGGCTTTGATAACATC
TCAGCAACCCACTCCTGAGACATTGCCTGTGATCAATAAGAGTGACATTAAGCAATATGATTTTCACAGCTCAGATGAAGATGAATTTCC
ACAGCGGAAGAAGAAAATGATCCTGATGGTCCCTGTGCTTTCAGAAGGCGGGCAGGATGCCAGTATTATGCTGCGAGGAAACGAGACCTC
TTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTT
CAATGGAACCAAGGCCAGTGAATAAGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTC
CCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGC
ACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGA
GGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAA
TGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAA
GTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCG
CCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGC
CACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCT
GTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAAT
GAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAA
CGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAG
GAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACG
CAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTC
GAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGTTGTTAGCCGAGGAGAAAAACATCTCT
TCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAG
GCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGATGACGTGGGC

>26909_26909_1_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000300036_length(amino acids)=446AA_BP=
MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLY
KGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVR
KRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVE
KRYHLGDYGGEILNEVKISRSEKELYATPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQKKKYPKKPKAEALITSQQPTPETLPVI

--------------------------------------------------------------
>26909_26909_2_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000396324_length(transcript)=3663nt_BP=1242nt
GCCGCCCGGGCTGTTCCTGTAAGGCGGGGAGACAATGAGTAAACTCTCCTTCCGAGCGCGGGCGCTGGACGCCGCCAAGCCGCTGCCTAT
CTACCGCGGCAAGGACATGCCTGATCTCAACGACTGCGTCTCCATCAACCGGGCCGTGCCCCAGATGCCCACCGGGATGGAGAAGGAGGA
GGAATCGGAACATCATTTACAGCGAGCAATTTCAGCACAGCAAGTGTTTAGAGAAAAAAAAGAGAGTATGGTCATTCCTGTTCCTGAGGC
AGAGAGCAACGTCAACTATTACAATCGCTTGTACAAAGGAGAGTTTAAACAGCCAAAACAGTTCATTCATATTCAGCCTTTTAATCTAGA
CAACGAGCAACCAGATTATGATATGGATTCAGAAGATGAGACTTTATTAAATAGACTTAACAGAAAGATGGAAATTAAGCCTTTGCAATT
TGAAATTATGATTGACAGACTTGAAAAAGCCAGTTCTAATCAGCTTGTAACACTTCAAGAAGCAAAACTGCTGCTAAACGAAGATGATTA
CCTTATTAAAGCTGTATATGACTACTGGGTGAGAAAACGTAAAAACTGCAGGGGGCCATCCCTCATTCCTCAGATAAAACAAGAGAAAAG
AGATGGCTCTACCAACAATGACCCTTATGTTGCCTTTCGGAGAAGAACAGAGAAAATGCAAACTCGAAAGAATCGTAAGAATGATGAAGC
CTCTTATGAAAAGATGTTGAAACTGAGACGAGAATTTAGTAGAGCCATAACAATTTTGGAAATGATTAAGAGAAGAGAGAAAACAAAACG
AGAATTATTGCACTTAACCTTAGAAGTTGTGGAGAAAAGATACCATTTGGGAGACTATGGTGGTGAAATCCTTAATGAAGTAAAAATCAG
TAGATCAGAAAAAGAGTTATATGCCACTCCAGCAACTCTTCATAATGGAAATCATCACAAAGTTCAAGAATGTAAAACTAAGCACCCTCA
TCATTTGTCTTTGAAAGAAGAGGCTTCTGATGTGGTTCGTCAAAAGAAGAAGTACCCAAAGAAGCCTAAAGCAGAGGCTTTGATAACATC
TCAGCAACCCACTCCTGAGACATTGCCTGTGATCAATAAGAGTGACATTAAGCAATATGATTTTCACAGCTCAGATGAAGATGAATTTCC
ACAGCGGAAGAAGAAAATGATCCTGATGGTCCCTGTGCTTTCAGAAGGCGGGCAGGATGCCAGTATTATGCTGCGAGGAAACGAGACCTC
TTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTT
CAATGGAACCAAGGCCAGTGAATAAGCAACTTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAA
CCCAACAACAACCCAGAACAAAGCAAAACCCAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACC
CCTCACACAAGGAATATAAAAACCACCACCCTCCAGCCTGGGCAACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGC
GTGGTGGTACACACCTGTGGTCCCAGCTACTAGGGAGGCTGAGCCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTAT
AATTGCATCATTGCACTCCAGCCTGGGCAACAGAGACCCTGTCTCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGT
AAAAATTGAAGTTTGTATGATGTAAGAGATGAGAAAAACCCAACAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGA
CACTGAGTTTTTAGAAAAACATATCCACGGTAACCGGTCCCTGGCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGC
CGCCGGCCCCCACTCCCAATTCATTCCCTAACCTGCAAACCTTTCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTG
GTTTCCACACCTCAGACACGCACAGTTCACCAAGTGCCTTCTGTAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCA
GGAATGCTGCACTGTTTACACCCTGACTGTGCTTGCAGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGA
GGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGA
GGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCT
GCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGC
CCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTC
CAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGA
CGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGT
CCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGC
CAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCC
AAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAG
CGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAG
GGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAG
ATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAG
GGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGTTGTTAGCCGAGGAGAAA
AACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCC
CTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGAT

>26909_26909_2_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000396324_length(amino acids)=446AA_BP=
MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLY
KGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVR
KRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVE
KRYHLGDYGGEILNEVKISRSEKELYATPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQKKKYPKKPKAEALITSQQPTPETLPVI

--------------------------------------------------------------
>26909_26909_3_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000452625_length(transcript)=3702nt_BP=1242nt
GCCGCCCGGGCTGTTCCTGTAAGGCGGGGAGACAATGAGTAAACTCTCCTTCCGAGCGCGGGCGCTGGACGCCGCCAAGCCGCTGCCTAT
CTACCGCGGCAAGGACATGCCTGATCTCAACGACTGCGTCTCCATCAACCGGGCCGTGCCCCAGATGCCCACCGGGATGGAGAAGGAGGA
GGAATCGGAACATCATTTACAGCGAGCAATTTCAGCACAGCAAGTGTTTAGAGAAAAAAAAGAGAGTATGGTCATTCCTGTTCCTGAGGC
AGAGAGCAACGTCAACTATTACAATCGCTTGTACAAAGGAGAGTTTAAACAGCCAAAACAGTTCATTCATATTCAGCCTTTTAATCTAGA
CAACGAGCAACCAGATTATGATATGGATTCAGAAGATGAGACTTTATTAAATAGACTTAACAGAAAGATGGAAATTAAGCCTTTGCAATT
TGAAATTATGATTGACAGACTTGAAAAAGCCAGTTCTAATCAGCTTGTAACACTTCAAGAAGCAAAACTGCTGCTAAACGAAGATGATTA
CCTTATTAAAGCTGTATATGACTACTGGGTGAGAAAACGTAAAAACTGCAGGGGGCCATCCCTCATTCCTCAGATAAAACAAGAGAAAAG
AGATGGCTCTACCAACAATGACCCTTATGTTGCCTTTCGGAGAAGAACAGAGAAAATGCAAACTCGAAAGAATCGTAAGAATGATGAAGC
CTCTTATGAAAAGATGTTGAAACTGAGACGAGAATTTAGTAGAGCCATAACAATTTTGGAAATGATTAAGAGAAGAGAGAAAACAAAACG
AGAATTATTGCACTTAACCTTAGAAGTTGTGGAGAAAAGATACCATTTGGGAGACTATGGTGGTGAAATCCTTAATGAAGTAAAAATCAG
TAGATCAGAAAAAGAGTTATATGCCACTCCAGCAACTCTTCATAATGGAAATCATCACAAAGTTCAAGAATGTAAAACTAAGCACCCTCA
TCATTTGTCTTTGAAAGAAGAGGCTTCTGATGTGGTTCGTCAAAAGAAGAAGTACCCAAAGAAGCCTAAAGCAGAGGCTTTGATAACATC
TCAGCAACCCACTCCTGAGACATTGCCTGTGATCAATAAGAGTGACATTAAGCAATATGATTTTCACAGCTCAGATGAAGATGAATTTCC
ACAGCGGAAGAAGAAAATGATCCTGATGGTCCCTGTGCTTTCAGAAGGCGGGCAGGATGCCAGTATTATGCTGCGAGGAAACGAGACCTC
TTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTT
CAATGGAACCAAGGCCAGTGAATAAGCAACTTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAA
CCCAACAACAACCCAGAACAAAGCAAAACCCAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACC
CCTCACACAAGGAATATAAAAACCACCACCCTCCAGCCTGGGCAACGTAGTAAAACCTCATCTATACAAGAATTTAAAAATAAGCTGGGC
GTGGTGGTACACACCTGTGGTCCCAGCTACTAGGGAGGCTGAGCCAGGAAGAACGCTCCAGCCCAGGACTTCGAGGCTGCAATGAGCTAT
AATTGCATCATTGCACTCCAGCCTGGGCAACAGAGACCCTGTCTCAACCACCACCACCACCACCACCCCTACTACCCCTGTATTCAAGGT
AAAAATTGAAGTTTGTATGATGTAAGAGATGAGAAAAACCCAACAGGAAACACAGACACATCCTCCAGTTCTATCAATGGATTGTGCAGA
CACTGAGTTTTTAGAAAAACATATCCACGGTAACCGGTCCCTGGCAATTCTGTTTACATGAAATGGGGAGAAAGTCACCGAAATGGGTGC
CGCCGGCCCCCACTCCCAATTCATTCCCTAACCTGCAAACCTTTCCAACTTCTCACGTCAGGCCTTTGAGAATTCTTTCCCCCTCTCCTG
GTTTCCACACCTCAGACACGCACAGTTCACCAAGTGCCTTCTGTAGTCACATGAATTGAAAAGGAGACGCTGCTCCCACGGAGGGGAGCA
GGAATGCTGCACTGTTTACACCCTGACTGTGCTTAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGCAGAGAAAGGCAATGC
CAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAAGCTGCAGCGGGAGCT
GGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACAGGCGGCCACCAAGTC
GCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTACAAGGAGCAGGCCGA
GCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCGGCAGAACAAGGAGCT
CCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAAGATTGCACAGCTGGA
GGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCTGGAGGAGGAGCTGGA
GGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGAGAGGGCTCGCAAACA
AGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTTCAAAGAGAGCTGGAA
GATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCAGACCTCATGCAGCTA
CAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAGAAGCTGGAAGGGGAC
CTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTGCAGGTCCATGAGCTG
GAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTGCAAGCCACGGAGGAC
GCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAGCAGAATGAGGAGAAG
AGGAGGCAACTGCAGAGACAGTTGTTAGCCGAGGAGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGAGCTGAGGCAGAAGCC
AGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAGCGGACCAACAAAATG
CTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGATGACGTGGGCAAGAACCGGCAACTCGTGTCCAACCTGGAAAAGAAGCAGAGG

>26909_26909_3_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000452625_length(amino acids)=446AA_BP=
MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLY
KGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVR
KRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVE
KRYHLGDYGGEILNEVKISRSEKELYATPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQKKKYPKKPKAEALITSQQPTPETLPVI

--------------------------------------------------------------
>26909_26909_4_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000576790_length(transcript)=3087nt_BP=1242nt
GCCGCCCGGGCTGTTCCTGTAAGGCGGGGAGACAATGAGTAAACTCTCCTTCCGAGCGCGGGCGCTGGACGCCGCCAAGCCGCTGCCTAT
CTACCGCGGCAAGGACATGCCTGATCTCAACGACTGCGTCTCCATCAACCGGGCCGTGCCCCAGATGCCCACCGGGATGGAGAAGGAGGA
GGAATCGGAACATCATTTACAGCGAGCAATTTCAGCACAGCAAGTGTTTAGAGAAAAAAAAGAGAGTATGGTCATTCCTGTTCCTGAGGC
AGAGAGCAACGTCAACTATTACAATCGCTTGTACAAAGGAGAGTTTAAACAGCCAAAACAGTTCATTCATATTCAGCCTTTTAATCTAGA
CAACGAGCAACCAGATTATGATATGGATTCAGAAGATGAGACTTTATTAAATAGACTTAACAGAAAGATGGAAATTAAGCCTTTGCAATT
TGAAATTATGATTGACAGACTTGAAAAAGCCAGTTCTAATCAGCTTGTAACACTTCAAGAAGCAAAACTGCTGCTAAACGAAGATGATTA
CCTTATTAAAGCTGTATATGACTACTGGGTGAGAAAACGTAAAAACTGCAGGGGGCCATCCCTCATTCCTCAGATAAAACAAGAGAAAAG
AGATGGCTCTACCAACAATGACCCTTATGTTGCCTTTCGGAGAAGAACAGAGAAAATGCAAACTCGAAAGAATCGTAAGAATGATGAAGC
CTCTTATGAAAAGATGTTGAAACTGAGACGAGAATTTAGTAGAGCCATAACAATTTTGGAAATGATTAAGAGAAGAGAGAAAACAAAACG
AGAATTATTGCACTTAACCTTAGAAGTTGTGGAGAAAAGATACCATTTGGGAGACTATGGTGGTGAAATCCTTAATGAAGTAAAAATCAG
TAGATCAGAAAAAGAGTTATATGCCACTCCAGCAACTCTTCATAATGGAAATCATCACAAAGTTCAAGAATGTAAAACTAAGCACCCTCA
TCATTTGTCTTTGAAAGAAGAGGCTTCTGATGTGGTTCGTCAAAAGAAGAAGTACCCAAAGAAGCCTAAAGCAGAGGCTTTGATAACATC
TCAGCAACCCACTCCTGAGACATTGCCTGTGATCAATAAGAGTGACATTAAGCAATATGATTTTCACAGCTCAGATGAAGATGAATTTCC
ACAGCGGAAGAAGAAAATGATCCTGATGGTCCCTGTGCTTTCAGAAGGCGGGCAGGATGCCAGTATTATGCTGCGAGGAAACGAGACCTC
TTTCGTTCCTTCTAGAAGGTCTGGAGGACGTAGAGTTATTGAAAATGCAGATGGTTCTGAGGAGGAAACGGACACTCGAGACGCAGACTT
CAATGGAACCAAGGCCAGTGAATAAGCAACTTTCTACAGTTTTGCACCACGGCAAGAAAACCAAAAACCAAAACAAACAAACAAAAAAAA
CCCAACAACAACCCAGAACAAAGCAAAACCCAGCAGACTGTACTTAGCATTGTCTAAATCCATTCTCAAATTCCAAATATCACAGACACC
CCTCACACAAGGAATATAAAAACCACCACCCTCCAGCCTGGGCAACGTAAGGGCCCCCCCCACAGGAAACTTCGCAGTGATGCACCAGGC
AGAGAAAGGCAATGCCAGGGTCAAGCAGCTCAAGAGGCAGCTGGAGGAGGCAGAGGAGGAGTCCCAGCGCATCAACGCCAACCGCAGGAA
GCTGCAGCGGGAGCTGGATGAGGCCACGGAGAGCAACGAGGCCATGGGCCGCGAGGTGAACGCACTCAAGAGCAAGCTCAGAGAGAAACA
GGCGGCCACCAAGTCGCTGAAGCAGAAAGACAAGAAGCTGAAGGAAATCTTGCTGCAGGTGGAGGACGAGCGCAAGATGGCCGAGCAGTA
CAAGGAGCAGGCCGAGCAGCTCAGCAACGAGCTGGCCACAGAGCGCAGCACGGCCCAGAAGAATGAGAGTGCCCGGCAGCAGCTCGAGCG
GCAGAACAAGGAGCTCCGGAGCAAGCTCCACGAGATGGAGGGGGCCGTCAAGTCCAAGTTCAAGTCCACCATCGCGGCGCTGGAGGCCAA
GATTGCACAGCTGGAGGAGCAGGTCGAGCAGGAGGCCAGGAACGCACTCCAGGACGAGAAGCGCCGCCTGGAGGCCCGGATCGCCCAGCT
GGAGGAGGAGCTGGAGGAGGAGCAGGGCAACATGGAGGCCATGAGCGACCGGGTCCGCAAAGCCACACAGCAGGACCTCGCCGCCGCTGA
GAGGGCTCGCAAACAAGCGGACCTCGAGAAGGAGGAACTGGCAGAGGAGCTGGCCAGTAGCCTGTCGGGAAGGCTCAGATGAAGGACTTT
CAAAGAGAGCTGGAAGATGCCCGTGCCTCCAGAGATGAGATCTTTGCCACAGCCAAAGAGAATGAGAAGAAAGCCAAGAGCTTGGAAGCA
GACCTCATGCAGCTACAAGAGCTTCACGAGTATGAGACGGAACTGGAAGACGAGCGAAAGCAACGTGCCCTGGCAGCTGCAGCAAAGAAG
AAGCTGGAAGGGGACCTGAAAGACCTGGAGCTTCAGGCCGACTCTGCCATCAAGGGGAGGGAGGAAGCCATCAAGCAGCTACGCAAACTG
CAGGTCCATGAGCTGGAGAAGTCCAAGCGGGCCCTGGAGACCCAGATGGAGGAGATGAAGACGCAGCTGGAAGAGCTGGAGGACGAGCTG
CAAGCCACGGAGGACGCCAAACTGCGGCTGGAAGTCAACATGCAGGCGCTCAAGGGCCAGTTCGAAAGGGATCTCCAAGCCCGGGACGAG
CAGAATGAGGAGAAGAGGAGGCAACTGCAGAGACAGTTGTTAGCCGAGGAGAAAAACATCTCTTCCAAATACGCGGATGAGAGGGACAGA
GCTGAGGCAGAAGCCAGGGAGAAGGAAACCAAGGCCCTGTCCCTGGCTCGGGCCCTTGAAGAGGCCTTGGAAGCCAAAGAGGAACTCGAG
CGGACCAACAAAATGCTCAAAGCCGAAATGGAAGACCTGGTCAGCTCCAAGGATGACGTGGGCAAGAACCGGCAACTCGTGTCCAACCTG

>26909_26909_4_EPC2-MYH11_EPC2_chr2_149526741_ENST00000258484_MYH11_chr16_15818065_ENST00000576790_length(amino acids)=446AA_BP=
MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVNYYNRLY
KGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVR
KRKNCRGPSLIPQIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVE
KRYHLGDYGGEILNEVKISRSEKELYATPATLHNGNHHKVQECKTKHPHHLSLKEEASDVVRQKKKYPKKPKAEALITSQQPTPETLPVI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EPC2-MYH11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EPC2-MYH11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EPC2-MYH11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source