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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EPG5-DGKG (FusionGDB2 ID:26927)

Fusion Gene Summary for EPG5-DGKG

Fusion gene summary

Fusion gene information	Fusion gene name: EPG5-DGKG
	Fusion gene ID: 26927
		Hgene	Tgene
	Gene symbol	EPG5	DGKG
	Gene ID	57724	1608
	Gene name	ectopic P-granules autophagy protein 5 homolog	diacylglycerol kinase gamma
	Synonyms	HEEW1\|KIAA1632\|VICIS	DAGK3\|DGK-GAMMA
	Cytomap	18q12.3-q21.1	3q27.2-q27.3
	Type of gene	protein-coding	protein-coding
	Description	ectopic P granules protein 5 homolog	diacylglycerol kinase gammaDAG kinase gammadiacylglycerol kinase, gamma 90kDadiacylglyerol kinase gammadiglyceride kinase gamma
	Modification date	20200313	20200313
	UniProtAcc	Q9HCE0	P49619
	Ensembl transtripts involved in fusion gene	ENST00000585906, ENST00000282041,	ENST00000265022, ENST00000344484, ENST00000382164, ENST00000447054, ENST00000544847,
Fusion gene scores	* DoF score	11 X 11 X 5=605	14 X 11 X 6=924
	# samples	13	14
	** MAII score	log2(13/605*10)=-2.2184235191335 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/924*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EPG5 [Title/Abstract] AND DGKG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EPG5(43467720)-DGKG(185882756), # samples:1
Anticipated loss of major functional domain due to fusion event.	EPG5-DGKG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EPG5-DGKG seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DGKG	GO:0046486	glycerolipid metabolic process	22627129
Tgene	DGKG	GO:0046834	lipid phosphorylation	22627129

Fusion gene breakpoints across EPG5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DGKG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BI046967	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-

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Fusion Gene ORF analysis for EPG5-DGKG

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000585906	ENST00000265022	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
5UTR-3CDS	ENST00000585906	ENST00000344484	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
5UTR-3CDS	ENST00000585906	ENST00000382164	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
5UTR-3CDS	ENST00000585906	ENST00000447054	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
5UTR-3CDS	ENST00000585906	ENST00000544847	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
Frame-shift	ENST00000282041	ENST00000265022	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
Frame-shift	ENST00000282041	ENST00000344484	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
Frame-shift	ENST00000282041	ENST00000382164	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
Frame-shift	ENST00000282041	ENST00000544847	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-
In-frame	ENST00000282041	ENST00000447054	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000282041

EPG5

chr18

43467720

ENST00000447054

DGKG

chr3

185882756

5439

5144

5167

1710

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000282041	ENST00000447054	EPG5	chr18	43467720	-	DGKG	chr3	185882756	-	0.001622264	0.9983777

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Fusion Genomic Features for EPG5-DGKG

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPG5-DGKG

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:43467720/chr3:185882756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPG5 Q9HCE0	DGKG P49619
FUNCTION: Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391). {ECO:0000269\|PubMed:20550938, ECO:0000269\|PubMed:23222957, ECO:0000269\|PubMed:29130391}.	FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:8034597). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (PubMed:8034597). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). {ECO:0000250\|UniProtKB:Q91WG7, ECO:0000269\|PubMed:8034597}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPG5

chr18:43467720

chr3:185882756

ENST00000282041

1607_1633

1703

2580.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

188_199

792.0

Calcium binding

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

233_244

792.0

Calcium binding

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

188_199

767.0

Calcium binding

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

233_244

767.0

Calcium binding

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

188_199

753.0

Calcium binding

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

233_244

753.0

Calcium binding

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

151_156

792.0

Compositional bias

Note=Poly-Ser

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

151_156

767.0

Compositional bias

Note=Poly-Ser

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

151_156

753.0

Compositional bias

Note=Poly-Ser

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

175_210

792.0

Domain

EF-hand 1

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

220_255

792.0

Domain

EF-hand 2

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

430_564

792.0

Domain

DAGKc

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

175_210

767.0

Domain

EF-hand 1

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

220_255

767.0

Domain

EF-hand 2

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

430_564

767.0

Domain

DAGKc

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

175_210

753.0

Domain

EF-hand 1

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

220_255

753.0

Domain

EF-hand 2

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

430_564

753.0

Domain

DAGKc

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

271_321

792.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000265022

336_385

792.0

Zinc finger

Phorbol-ester/DAG-type 2

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

271_321

767.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000344484

336_385

767.0

Zinc finger

Phorbol-ester/DAG-type 2

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

271_321

753.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

DGKG

chr18:43467720

chr3:185882756

ENST00000382164

336_385

753.0

Zinc finger

Phorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for EPG5-DGKG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26927_26927_1_EPG5-DGKG_EPG5_chr18_43467720_ENST00000282041_DGKG_chr3_185882756_ENST00000447054_length(transcript)=5439nt_BP=5144nt
CAAAAACAAACGGTGACGGCGCCGCGGAAGGGTCTATGGCCGAGGCGGTGAAGCCCCAGCGCCGGGCCAAGGCCAAGGCCAGCCGGACTA
AAACAAAGGAAAAGAAGAAGTATGAAACTCCTCAGAGGGAAGAGTCCAGTGAAGTCTCCCTTCCAAAAACCTCCAGAGAGCAGGAAATCC
CTTCTCTAGCCTGTGAATTCAAAGGAGACCATCTGAAGGTGGTAACTGATTCCCAGCTCCAGGATGATGCCAGTGGACAAAATGAGAGTG
AAATGTTTGATGTACCACTCACCTCCTTAACTATAAGCAATGAAGAGTCCCTGACGTGTAACACAGAGCCCCCAAAGGAAGGGGGAGAGG
CCAGACCCTGTGTGGGGGACAGTGCAGTCACTCCAAAGGTCCACCCTGGAGACAATGTTGGAACTAAAGTAGAAACCCCCAAGAACTTCA
CAGAGGTAGAGGAAAATATGTCGGTACAAGGTGGACTTTCAGAAAGTGCACCCCAATCTAATTTTTCTTATACTCAGCCAGCAATGGAAA
ATATACAAGTCAGAGAAACTCAGAATAGTAAAGAAGACAAACAAGGCCTGGTTTGTTCTTCAGAGGTGCCACAGAATGTTGGCTTGCAGA
GTTCTTGCCCAGCCAAACATGGTTTTCAGACACCTAGAGTGAAGAAACTGTATCCCCAGTTGCCAGCTGAAATTGCTGGAGAAGCACCAG
CTTTGGTGGCAGTGAAACCCTTGCTTCGCAGTGAGCGACTCTACCCAGAACTCCCGTCTCAACTGGAACTAGTACCATTTACTAAAGAAC
AGCTAAAAATCTTGGAGCCTGGTTCATGGCTGGAAAATGTTGAGTCATATTTAGAAGAATTTGACAGCATGGCTCATCAAGACAGGCATG
AATTTTATGAGTTGCTTTTGAACTACTCACGATGTAGGAAGCAACTGCTGCTGGCTGAAGCTGAGCTGCTTACTCTGACATCTGATTGCC
AAAATGCTAAAAGTCGGCTGTGGCAGTTTAAGGAGGAACAAATGTCTGTACAGGGTATCTGTGCAGATCAAGTGAAAGTTTTCAGCTATC
ATCGCTACCAAAGAGTAGAAATGAATGAAAATGCACTGGTGGAGCTAAAGAAGCTATTCGATGCCAAATCTGAGCACCTCCACCAGACCC
TGGCCCTTCATTCTTATACTTCTGTGCTCTCAAGATTGCAAGTGGAGTCTTACATCTATGCATTGCTCAGTAGTTCAGCTGTTCTGAGAT
CTTCAGCAATTCACCAGCAAGGCCGAGCGTCTAAGCAGACAGAAAGCATTCCCTCTGATCTGTGTCAACTAAAGGAATGCATTAGTGTCT
TATTCATGTTCACCAGGAGAGTTAATGAAGATACTCAGTTTCATGATGATATTCTTCTCTGGCTGCAGAAATTGGTATCCGTGCTACAAA
GAGTTGGCTGTCCTGGAGATCACCTCTTCCTTCTAAACCATATTCTTCGATGCCCCGCTGGTGTTAGTAAATGGGCTGTTCCTTTTATCC
AGATCAAAGTGTTGCATAACCCATCAGGGGTCTTTCATTTTATGCAATCCCTTGCCCTGCTGATGTCTCCTGTCAAAAATCGAGCTGAGT
TTATGTGCCACATGAAGCCCAGCGAGCGGAAGCCATCCTCCTCAGGGCCTGGGTCTGGGACTTGGACGCTAGTAGACGAAGGAGGAGAAG
AGGATGAAGACCCTGAGACCAGTTGGATTCTCCTTAATGAAGATGATTTGGTTACCATTTTAGCACAGTTCCCCTTTCATGAACTCTTTC
AGCATCTTCTTGGGTTTAAAGCAAAAGGTGATTATTTACCTGAAACAACAAGACCTCAAGAGATGATGAAAATTTTTGCCTTTGCCAACT
CACTAGTGGAACTTCTGGCTGTGGGGTTAGAAACCTTTAATAGAGCACGCTATAGGCAGTTTGTGAAGCGAATTGGTTATATGATCAGGA
TGACTCTTGGTTATGTAAGTGACCATTGGGCACAGTATGTGAGCCATAACCAAGGCTCAGGATTGGCCCAACAGCCCTACTCTATGGAGA
AACTACAGGTTGAATTTGATGAACTGTTTTTGAGGGCTGTCCTACATGTGCTGAAGGCCAAAAGACTTGGCATTTGGCTGTTTATGTCCG
AGATGCCCTTTGGGACTCTGTCTGTGCAAATGCTGTGGAAGCTCTTCTACCTCATGCACCAGGTGGAGAGCGAGAACCTGCAGCAGCTCT
CCTCCTCCCTGCAGCCCGCCCAGTGCAAGCAGCAGCTCCAAGACCCAGAACATTTTACCAACTTTGAGAAGTGTCTTTCTTCTATGAATA
GCTCAGAAGAGATTTGCCTTCTGACTACCTTTGCTCAGATGGCTCAGGCCAGAAGAACCAATGTGGACGAAGACTTCATAAAAATTATTG
TTCTGGAGATATATGAGGTATCTTATGTCACCTTGTCTACCAGAGAGACTTTTTCAAAGGTTGGTCGAGAGCTTTTAGGGACTATCACAG
CTGTTCACCCTGAGATAATTTCCGTCCTTCTGGATAGAGTTCAAGAGACCATTGACCAGGTTGGAATGGTTTCTCTATACTTGTTTAAAG
AACTGCCTTTGTATCTTTGGCAACCTTCTGCATCTGAGATAGCGGTGATTCGGGATTGGTTATTGAATTACAACCTGACAGTGGTGAAGA
ATAAACTGGCCTGTGTTATTCTTGAAGGACTGAATTGGGGATTTGCTAAACAGGCTACCCTTCATCTGGATCAAGCAGTCCATGCTGAAG
TGGCTTTAATGGTTCTTGAAGCTTATCAGAAGTACCTTGCACAGAAGCCATATGCTGGGATTCTCTCTGAAAGTATGAAGCAGGTTTCAT
ATTTGGCCAGTATTGTTCGATATGGAGAGACACCCGAGACCTCATTTAACCAATGGGCCTGGAATTTAATCTTGAGGCTAAAACTGCACA
AAAACGATTATGGAATACAGCCGAATTGTCCAGCTGTTCCCTTCTCCGTCACTGTGCCTGACATGACAGAGTCACCCACGTTTCATCCTC
TCTTGAAGGCTGTGAAAGCGGGCATGCCCATTGGCTGTTATCTAGCCTTATCTATGACAGCTGTGGGCCACAGCATTGAGAAGTTCTGTG
CAGAAGGCATCCCACTATTGGGAATTCTGGTCCAGTCAAGACATTTGAGAACAGTGGTTCATGTCCTGGATAAGATTCTGCCTTTATTTT
ACCCTTGCCAGTATTACCTTCTGAAGAATGAGCAGTTTTTATCGCATCTCCTCTTGTTCCTACACTTGGACAGCGGTGTCCCTCAGGGTG
TCACACAACAGGTCACCCACAAGGTGGCACAGCACCTGACAGGAGCCAGCCATGGGGACAACGTGAAGCTTCTCAACAGCATGATCCAGG
CACACATATCTGTAAGCACTCAGCCCAATGAAGTGGGCCCCGTTGCTGTGTTGGAGTTCTGGGTTCAGGCTCTCATAAGCCAGCATCTCT
GGTACCGAGAACAACCTATCCTCTTCCTCATGGACCACTTGTGTAAAGCAGCTTTTCAGCTGATGCAGGAAGACTGCATACAGAAATTAC
TCTACCAACAACATAAGAATGCCTTGGGTTACCACTGTGACCGGAGTCTGCTCTCATCTTTGGTAAGCTGGATTGTGGCAGGCAACATCA
CTCCTTCCTTTGTGGAGGGCTTGGCCACGCCCACTCAGGTCTGGTTTGCCTGGACAGTGCTCAACATGGAATCCATCTTTGAAGAGGACT
CCCAGCTCCGGAGAGTTATTGAAGGGGAATTGGTGATAAACTCTGCTTTCACCCCTGACCAAGCTCTGAAGAAAGCCCAGACCCAGCTGA
AGCTCCCCATCGTGCCATCCCTCCAGAGGCTGCTGATTTATCGCTGGGCCCACCAGGCTCTGGTCACACCTTCTGATCACCCCCTCCTGC
CACTCATTTGGCAGAAGTTCTTCCTTCTGTATCTTCACCGTCCGGGACCACAGTATGGGTTACCCATAGATGGTTGTATTGGAAGAAGGT
TTTTTCAAAGTCCTGCTCATATCAATTTGTTGAAAGAAATGAAGAGACGTTTGACCGAGGTGGCTGACTTCCACCATGCTGCAAGCAAGG
CCCTCCGTGTTCCAGCAGAGGGCAGTGAAGGGCTGCCAGAGAGCCACTCTGGCACCCCTGGTTACCTGACTTCACCAGAACTGCACAAGG
AGCTGGTGAGGCTCTTCAATGTATATATATTATGGCTAGAAGATGAGAATTTTCAAAAAGGAGATACCTATATCCCTTCTCTACCAAAGC
ATTATGATATTCACAGGCTAGCAAAAGTGATGCAGAATCAGCAGGATCTGTGGATGGAGTATTTGAACATGGAGCGCATCTATCATGAGT
TTCAGGAGACTGTTGGTCTGTGGACACAGGCCAAGCTTGAGTCCCATTCCACACCCTGCAGTTTGTCCGTGCAGCTGGACTTCACTGATC
CTTTGCTGGCTAAAGAAAGGGTTTTAAGTAACTTGCGGAAGCATGAGGCTCCCCAGCCTCCCCTTGCTCTGCACCCGACGAAGCCTCCTG
TGCCAGTTATTTCCTCTGCTGTGCTATTGAGTCAGAAGGACGCCACCCAGCTGGTGTGCACAGACCTGAATCTGTTGCAACAGCAGGCCA
GAACCGCAGCTCTTCGGGAATCTCAGCAGGTTGCTCTGGATGGTGAGCTGTTAGACACAATGCCAAAGCAGTATGTGAATCGTGAAGAAC
AGACCACACTACATTTGGAGTGCAGAGGCAGCAGCGGTAAGAAATGCCAAGGAGCCGCAGTTGTCACGGTTCAGTTTGAAGGCATGCATA
AGAATGAAGCCATAAGCCAACAGCTTCATGTTTTACGGAAGGAAGTGAAGCAGTTGCAAGCAGAAGCTGCTAAACCACCATCACTTAATA
TTGTGGAAGCTGCTGTACATGCAGAAAACTTGATCACGGCCTTAGTGAATGCCTACAAGTTGCAGCCTACACCTGGGATTCAGAAAGTTG
GCATTAGCCTTTTCTTTACTATTGTGGATTACGTCAGCGATGAGACGCAGCGTCATCCCCCAACAAGGCAGTTCTTTACTTCATGTATTG
AGATCTTGGGACAGTGGGGCAGATCTACACCGGCCTGAAGAGTGCAGGCAGGAGGCTGGCCCAGTGCGCCTCTGTCACCATCAGGACAAA
CAAGCTGCTGCCAATGCAAGTGGATGGAGAACCCTGGATGCAGCCATGTTGCACGGAGGATCCCTTTTCCCCCAGAAATTACTCAATGCT
GAAACCTCTCAAAGTGGTATTAGAGACGCTGAAAGCACCATGGACGGGTTTTATGATCAGCAAGTCCCTTTTATGGTCCCAGGGAAATCT

>26927_26927_1_EPG5-DGKG_EPG5_chr18_43467720_ENST00000282041_DGKG_chr3_185882756_ENST00000447054_length(amino acids)=1710AA_BP=
MAEAVKPQRRAKAKASRTKTKEKKKYETPQREESSEVSLPKTSREQEIPSLACEFKGDHLKVVTDSQLQDDASGQNESEMFDVPLTSLTI
SNEESLTCNTEPPKEGGEARPCVGDSAVTPKVHPGDNVGTKVETPKNFTEVEENMSVQGGLSESAPQSNFSYTQPAMENIQVRETQNSKE
DKQGLVCSSEVPQNVGLQSSCPAKHGFQTPRVKKLYPQLPAEIAGEAPALVAVKPLLRSERLYPELPSQLELVPFTKEQLKILEPGSWLE
NVESYLEEFDSMAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLTSDCQNAKSRLWQFKEEQMSVQGICADQVKVFSYHRYQRVEMNENA
LVELKKLFDAKSEHLHQTLALHSYTSVLSRLQVESYIYALLSSSAVLRSSAIHQQGRASKQTESIPSDLCQLKECISVLFMFTRRVNEDT
QFHDDILLWLQKLVSVLQRVGCPGDHLFLLNHILRCPAGVSKWAVPFIQIKVLHNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSERKP
SSSGPGSGTWTLVDEGGEEDEDPETSWILLNEDDLVTILAQFPFHELFQHLLGFKAKGDYLPETTRPQEMMKIFAFANSLVELLAVGLET
FNRARYRQFVKRIGYMIRMTLGYVSDHWAQYVSHNQGSGLAQQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQML
WKLFYLMHQVESENLQQLSSSLQPAQCKQQLQDPEHFTNFEKCLSSMNSSEEICLLTTFAQMAQARRTNVDEDFIKIIVLEIYEVSYVTL
STRETFSKVGRELLGTITAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYLWQPSASEIAVIRDWLLNYNLTVVKNKLACVILEGLN
WGFAKQATLHLDQAVHAEVALMVLEAYQKYLAQKPYAGILSESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDYGIQPNCPA
VPFSVTVPDMTESPTFHPLLKAVKAGMPIGCYLALSMTAVGHSIEKFCAEGIPLLGILVQSRHLRTVVHVLDKILPLFYPCQYYLLKNEQ
FLSHLLLFLHLDSGVPQGVTQQVTHKVAQHLTGASHGDNVKLLNSMIQAHISVSTQPNEVGPVAVLEFWVQALISQHLWYREQPILFLMD
HLCKAAFQLMQEDCIQKLLYQQHKNALGYHCDRSLLSSLVSWIVAGNITPSFVEGLATPTQVWFAWTVLNMESIFEEDSQLRRVIEGELV
INSAFTPDQALKKAQTQLKLPIVPSLQRLLIYRWAHQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPIDGCIGRRFFQSPAHINLLK
EMKRRLTEVADFHHAASKALRVPAEGSEGLPESHSGTPGYLTSPELHKELVRLFNVYILWLEDENFQKGDTYIPSLPKHYDIHRLAKVMQ
NQQDLWMEYLNMERIYHEFQETVGLWTQAKLESHSTPCSLSVQLDFTDPLLAKERVLSNLRKHEAPQPPLALHPTKPPVPVISSAVLLSQ
KDATQLVCTDLNLLQQQARTAALRESQQVALDGELLDTMPKQYVNREEQTTLHLECRGSSGKKCQGAAVVTVQFEGMHKNEAISQQLHVL
RKEVKQLQAEAAKPPSLNIVEAAVHAENLITALVNAYKLQPTPGIQKVGISLFFTIVDYVSDETQRHPPTRQFFTSCIEILGQWGRSTPA

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Fusion Gene PPI Analysis for EPG5-DGKG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EPG5-DGKG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EPG5-DGKG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source