Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EPHA2-FBXO42 (FusionGDB2 ID:26952)

Fusion Gene Summary for EPHA2-FBXO42

Fusion gene summary

Fusion gene information	Fusion gene name: EPHA2-FBXO42
	Fusion gene ID: 26952
		Hgene	Tgene
	Gene symbol	EPHA2	FBXO42
	Gene ID	1969	54455
	Gene name	EPH receptor A2	F-box protein 42
	Synonyms	ARCC2\|CTPA\|CTPP1\|CTRCT6\|ECK	Fbx42\|JFK
	Cytomap	1p36.13	1p36.13
	Type of gene	protein-coding	protein-coding
	Description	ephrin type-A receptor 2epithelial cell receptor protein tyrosine kinasesoluble EPHA2 variant 1tyrosine-protein kinase receptor ECK	F-box only protein 42just one F-box and Kelch domain-containing protein
	Modification date	20200313	20200313
	UniProtAcc	P29317	Q6P3S6
	Ensembl transtripts involved in fusion gene	ENST00000358432, ENST00000461614,	ENST00000478089, ENST00000375592,
Fusion gene scores	* DoF score	6 X 5 X 4=120	10 X 11 X 6=660
	# samples	8	14
	** MAII score	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/660*10)=-2.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EPHA2 [Title/Abstract] AND FBXO42 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EPHA2(16474873)-FBXO42(16583254), # samples:3 FBXO42(16632298)-EPHA2(16451815), # samples:2
Anticipated loss of major functional domain due to fusion event.	FBXO42-EPHA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FBXO42-EPHA2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FBXO42-EPHA2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. FBXO42-EPHA2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EPHA2	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	18339848
Hgene	EPHA2	GO:0033628	regulation of cell adhesion mediated by integrin	10655584
Hgene	EPHA2	GO:0043491	protein kinase B signaling	19573808
Hgene	EPHA2	GO:0048013	ephrin receptor signaling pathway	10655584\|20861311
Hgene	EPHA2	GO:0051898	negative regulation of protein kinase B signaling	19573808

Fusion gene breakpoints across EPHA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXO42 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-VQ-AA6D-01A	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-
ChimerDB4	STAD	TCGA-VQ-AA6D	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-

Top

Fusion Gene ORF analysis for EPHA2-FBXO42

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000358432	ENST00000478089	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-
5CDS-intron	ENST00000358432	ENST00000478089	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-
5CDS-intron	ENST00000461614	ENST00000478089	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-
5CDS-intron	ENST00000461614	ENST00000478089	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-
In-frame	ENST00000358432	ENST00000375592	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-
In-frame	ENST00000358432	ENST00000375592	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-
In-frame	ENST00000461614	ENST00000375592	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-
In-frame	ENST00000461614	ENST00000375592	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358432	EPHA2	chr1	16474873	-	ENST00000375592	FBXO42	chr1	16583254	-	6461	978	155	2629	824
ENST00000461614	EPHA2	chr1	16474873	-	ENST00000375592	FBXO42	chr1	16583254	-	6358	875	13	2526	837
ENST00000358432	EPHA2	chr1	16474872	-	ENST00000375592	FBXO42	chr1	16583254	-	6461	978	155	2629	824
ENST00000461614	EPHA2	chr1	16474872	-	ENST00000375592	FBXO42	chr1	16583254	-	6358	875	13	2526	837

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358432	ENST00000375592	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-	0.000492148	0.9995079
ENST00000461614	ENST00000375592	EPHA2	chr1	16474873	-	FBXO42	chr1	16583254	-	0.001069309	0.99893063
ENST00000358432	ENST00000375592	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-	0.000492148	0.9995079
ENST00000461614	ENST00000375592	EPHA2	chr1	16474872	-	FBXO42	chr1	16583254	-	0.001069309	0.99893063

Top

Fusion Genomic Features for EPHA2-FBXO42

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EPHA2-FBXO42

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16474873/chr1:16583254)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPHA2 P29317	FBXO42 Q6P3S6
FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269\|PubMed:10655584, ECO:0000269\|PubMed:16236711, ECO:0000269\|PubMed:18339848, ECO:0000269\|PubMed:19573808, ECO:0000269\|PubMed:20679435, ECO:0000269\|PubMed:20861311, ECO:0000269\|PubMed:23358419, ECO:0000269\|PubMed:26158630, ECO:0000269\|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.	FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation. {ECO:0000269\|PubMed:19509332}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

28_206

274

977.0

Domain

Eph LBD

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

28_206

274

977.0

Domain

Eph LBD

Tgene

FBXO42

chr1:16474872

chr1:16583254

ENST00000375592

186_242

167

718.0

Repeat

Note=Kelch 2

Tgene

FBXO42

chr1:16474872

chr1:16583254

ENST00000375592

244_293

167

718.0

Repeat

Note=Kelch 3

Tgene

FBXO42

chr1:16474872

chr1:16583254

ENST00000375592

295_342

167

718.0

Repeat

Note=Kelch 4

Tgene

FBXO42

chr1:16474873

chr1:16583254

ENST00000375592

186_242

167

718.0

Repeat

Note=Kelch 2

Tgene

FBXO42

chr1:16474873

chr1:16583254

ENST00000375592

244_293

167

718.0

Repeat

Note=Kelch 3

Tgene

FBXO42

chr1:16474873

chr1:16583254

ENST00000375592

295_342

167

718.0

Repeat

Note=Kelch 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

188_325

274

977.0

Compositional bias

Note=Cys-rich

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

188_325

274

977.0

Compositional bias

Note=Cys-rich

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

328_432

274

977.0

Domain

Fibronectin type-III 1

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

438_529

274

977.0

Domain

Fibronectin type-III 2

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

613_875

274

977.0

Domain

Protein kinase

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

904_968

274

977.0

Domain

SAM

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

328_432

274

977.0

Domain

Fibronectin type-III 1

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

438_529

274

977.0

Domain

Fibronectin type-III 2

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

613_875

274

977.0

Domain

Protein kinase

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

904_968

274

977.0

Domain

SAM

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

974_976

274

977.0

Motif

PDZ-binding

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

974_976

274

977.0

Motif

PDZ-binding

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

619_627

274

977.0

Nucleotide binding

ATP

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

619_627

274

977.0

Nucleotide binding

ATP

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

24_537

274

977.0

Topological domain

Extracellular

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

559_976

274

977.0

Topological domain

Cytoplasmic

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

24_537

274

977.0

Topological domain

Extracellular

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

559_976

274

977.0

Topological domain

Cytoplasmic

Hgene

EPHA2

chr1:16474872

chr1:16583254

ENST00000358432

538_558

274

977.0

Transmembrane

Helical

Hgene

EPHA2

chr1:16474873

chr1:16583254

ENST00000358432

538_558

274

977.0

Transmembrane

Helical

Tgene

FBXO42

chr1:16474872

chr1:16583254

ENST00000375592

44_93

167

718.0

Domain

F-box

Tgene

FBXO42

chr1:16474873

chr1:16583254

ENST00000375592

44_93

167

718.0

Domain

F-box

Tgene

FBXO42

chr1:16474872

chr1:16583254

ENST00000375592

132_184

167

718.0

Repeat

Note=Kelch 1

Tgene

FBXO42

chr1:16474873

chr1:16583254

ENST00000375592

132_184

167

718.0

Repeat

Note=Kelch 1

Top

Fusion Gene Sequence for EPHA2-FBXO42

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>26952_26952_1_EPHA2-FBXO42_EPHA2_chr1_16474872_ENST00000358432_FBXO42_chr1_16583254_ENST00000375592_length(transcript)=6461nt_BP=978nt
GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGC
GTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCT
GCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAG
GGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCG
TGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCA
AGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGG
ACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCAC
GCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTG
TGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTG
ATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAG
TGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGGGTCCTATCCTT
CCCCCAAAGCTGGAGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACC
AGCCAGAGAGATTCTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCA
TGGCTGGCCACTCCTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGG
TCCTTGACCTTGAGCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAG
ATGATGCAACTATCTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTT
GGGCCTGGCAGCCACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGG
TGGTCTTCAGCCAGGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTC
TCGTTCCTGAAACCCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGA
GACCCAGGGCTCAAAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTG
GGAGTTTGTCTCCAGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTG
AAGGATACGACCTGAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATC
TGAATTGGGATCTGAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTG
AACAGACAAATGGTGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAG
CCATCAAAGCGATGTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGA
GTTTGAGCAGTGGAGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGG
GCCACCACCCTCCACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTA
AAGACACCAAGGAGAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGG
TACAAGGCAGGGGTGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACT
TTGTACGAGCAAAGAGATAATGTGTTCTAAACCCCTTTCCTTTTCTGTGGCTTTTAATTTGGAATTTTCCAGTGTGTAAGCATTTGGACT
GAGAATTGGGAAAACAAAATTACTCCCAGAAGCCAAAACTCTTTAATTCCCAACCGAAGTCACTCCAGGCTGGGATCAAATCTCCATTAA
GAAAAAAAATTATATATAAATATATATATATATATTATATAGCCAACTCTGTTGACAAAAAAAGGGAGAGATTTCCATCCTGGTTCAGAT
AAAGTTGTTGCTGTGTTTTAACAGGGGCTGGGCTGCCTTTTTCTACCTTGCTGGTAACTAGACCAAGAAGTTAGAGAATAGACTAACATC
AGTAACTTCCCAAAAGAAACTGAAGAGCCCCCTGTAAATCTTTATGTGGCCTTCTTGGAGTTAAAAAATGAAAGGGCATATGTAAGTTGC
AAAGGTGGAGGGTTTTAGACTCTCATGCTTCAGGTGCTGTCGGGGTAAAAGTAACTGTTTTTCCCCTTCTCTTAAAACCACAGAGGACCT
GTGACAGCTCTGCAGAAATGCCAGTGCCTGGCCCCCTCTTGCCTTTTATGGCTGAGGAAAGTTACCCAACAAAGGATTTTATTCCACATT
TGTGTGCCGGGTCATTGTGAAATAATGTTTATGCAGCCAACATCTGACCGCCTAGTAGTGTCCATTGGTCTTTGGAGTGCTTCTTGTGTG
TCTCAGAAAACATTTTGTGTCTGATTGTGGAAATTTCTGACAATCAATCATATTTGGTGGCAAGTTGCCAAAAAACATATTTATTCTCCT
CTTTCTTCCCTTAGAACATGGTACTTGGAAACTGCCTTTTCCATTCACTTACAGGCTGCTTTTTTCTTCTACCTTTTTTCTTTTCTTTTT
TTTTTTTCATATGTGGTGAAGTCCTAAAACCTGTCTGACTTTCTGTTTCTTTTACAAAGCTCAGGTGCCTACAGAAATCAGAAGCTGCTT
AGAAATACTTGTGGAACCCTTTCCCTGGTGTCACTAGGGGGCCAGTAGGGAATTCTAAGATGCCAATATTGTGAGAAATCTTTGAAGCAA
GCATCAAAAGATACTGTTTTTTCCCTATGGGCTTCTTTTTACTTCCAAAGCACATTGAGCACACTCATCCCATATTTGTAGAATGTGGAA
ATTGATTCTGGAAGGGAATTCCAATAACAGTTCTTTTTAGAAATGTTTTTTTCCTTGTGGTGACATATATTCCTCTTCCTGGCTATTGGC
AGGTGATGGAGTTGAGAATCATGTACTTGACTTCTTGACGCATGGCTGACCTCAGAAACAGCTCCATCCTTTGCACTTGTCTTCTTCATG
TGTCACCCAAATAGGGCTTGGGTTTTTACTTTCACTTCATTTCTGAGATTAAGGTGTAACCAAGTAGAGCATTTCTTTGCTTGATACAGA
AAGTTACTAGTCTCAACCATGGCCTGGGCATAGGAGATGTCAAAATAAGTTTATTTCAAATGGCACCATTTAAATAGGGATTTTTGGTGA
TTTCTCATCAGTGGAAAGAGGATTTTTGTTTTGCCTTTGTTTTGTTTTGAAATTTAAATCCTAATTTCAAAACATCACCTTGCCACCCTG
ACACTCCTCTTTTTATTATTAGCGTTTCTCAGGCACAAAGCCTGCTGCAGCTGGCCCTGGGTCCTGGCTTTCAGCCAGCATCTGGCAGCC
TAAGTGTACTGATAAGTGTGTTTTCTCCTGTTACATCATGCTGAATCCTTTCCCTTAGCCATTAGCTTTTATGATGTGGTCTTCGTAGGA
AAGCCACCCTGGTGCCAAGCCTAGCTTGTGGGGAGGGGTATGTGTTCCAGAAACTGCTCTTTGTGTTCCCTTCAATGAGGAAACAACATG
TGTCTACTTATGTGGCATCCAACTGCTTGGAGCTCCACACTTCCCTTTCGCGACTCAGGCTCTGGTGCTGTTGCCAATCCTTGCTTGGCA
AAGACTGTTCGATCATGTGGGGTCCTTATTTACAAGGGAAAGCTGGGCCAGAAGGCTAGCAATTCAGGTGTTACCGCTATTGCTGTACCT
TGTGTTAGGACATTGTGTTTGTGCATGGACTGTGCCTCCAAACTCAGTAGTTCCTATCTAAATATAAAGTATATTAGAAACCTGAAAGTA
CAGAATCTCAACCTTACAGTCTTTCCCTTAGTCCTGTGGCCTTCCTAAGCCAGCTGTTAACGTGTTGATTCCTTCCACTTCCCCCAAGTA
GGCAGGCAACAGATATGTTGATTGTCTTAGAAAGTAATCTGGTTCCTCTGAACTCCATTGAATTCCAGTTTGACGCATACTGCCTGGAAC
CAGACTGTTTGCTTACAGCTTTTTAAGAAAAATCTGCCTTGTCTGCCCCCATTATGGTTGGTCTTGGTAGCTCCTGGGCACTGTGGGCGT
GTACCATGGGAAAGTGATTCAACACAGTGAAGGTGATTGTCTCCTCAGGCCTCCTGAAGCCACCTGTGCGGTGGGACTTCACGTGTCTCG
GCCAAGGCGAGCATTTCCACAATGCCGTGGATGCTGCAGTCAGGCCAGATTGAACCATGACCCCATTTTTCACATGATACCAATTTTGTC
TTAAAATTCACTGAGAAAAATGAGACTAAATTTTTTTTAACCCTCAGGAGCACCTGAAGCAAATATTTATCCGTATTTATTGAAAATTCA
TTTTGTTTCTACTTGAAGCTTTAACCCCTTCCATTCCTGCAAGTGTGCCTTTTGAGAGCTCCCATGGCCTAGTGACTTCACTGGTCACCT
TGTCCATCTTACTTAAGAATTTTAGTCTCTCCCTACCCTCTTGGACAGAGCTTCCTGTTCTCTTATTTCACAGGTTATACAGCAGAGCGG
GTTTTGTGTTTTCATTCCTATTTCCACCCTTCATTTGGTTGGTGGACTCCACAACCTCACCCTACCCTACACTTTGGGAGCACAAATTTG
GTGTTGAAACAAGCTTAAATTTCATTTTAGGGCATACTGGGCTTACTCTCCTCCCAGCTGTCTGTGGATTGATTTGATTTTAATGTTCGA
GTTTTACAGCAACAGCTGAAAACCATGAACTATTCTAGGAACTGTGTTGGAACTCTTTAAAATAAAGAAAAGAGGAGGAGGAGGAGGAAG
AAAGAAAACCAACTTAAGAAGCCTTGACTTTGGAGGACAGAAAGCCACCAGCCAATGGAGAACAAAGAGATGTTTCCCTTTCCTTTCTTT
CACCTTGTCATTCTGGGTTTCCTTCTGCTTCACTCTTTCCTTCCCCCTTAAAAGTGGTATTCCTGGTTGGTCTGTCTGTCTGTCCTTGTC
CTTGTGGTGATCCTGGCATGGTGATATGCTCCACTTTGCATTATCCATGGTCTCTTACCAGCGCACAAGTCAGTGGGGAGGATCTAACCA
CGCCTGGTGGTGAGGAAGCTGAATTTCCAGGCCTGCGTCCCATGTAGCCTCTCCATGAACTGCAGAAGGCATGTTCTGCATGGTTACCAG
TAAGTGGCTCCCTCTCACCGTGTTCATTGTCAAATGAGAGCAAACTTTAGGTGTTGGCTCCATTGTACACTCTACTTGCTCTGCTCCCCT
CCCTCCAACCAGGGTTCATGTCAGTGCACACCCCATGTGCCCTGGCGAAGCTGGTGCTGTGAGTGATGTTTCCCATACAACTCAGGGATG
CCAGGTGGCTTACCCTGAGATAGTCATTTTGGGCACATAACAGTGTAGGAATGAAACATGGATTTCATTGATATTTAAATCTGTCAATTT

>26952_26952_1_EPHA2-FBXO42_EPHA2_chr1_16474872_ENST00000358432_FBXO42_chr1_16583254_ENST00000375592_length(amino acids)=824AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGS
RQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHP
ACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARG
DGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTV
GGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHS
LPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKY

--------------------------------------------------------------
>26952_26952_2_EPHA2-FBXO42_EPHA2_chr1_16474872_ENST00000461614_FBXO42_chr1_16583254_ENST00000375592_length(transcript)=6358nt_BP=875nt
GGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGG
GGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCG
GCCGCGGCGGCGCAGGGCAAGGAAGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGAT
GTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACG
TGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAA
CTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCT
GAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTC
CGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCT
GGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTG
GCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGGGTCCTATCCTTCCCCCAAAGCTGG
AGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACCAGCCAGAGAGATT
CTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCATGGCTGGCCACTC
CTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGGTCCTTGACCTTGA
GCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAGATGATGCAACTAT
CTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTTGGGCCTGGCAGCC
ACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGGTGGTCTTCAGCCA
GGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTCTCGTTCCTGAAAC
CCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGAGACCCAGGGCTCA
AAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTGGGAGTTTGTCTCC
AGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTGAAGGATACGACCT
GAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATCTGAATTGGGATCT
GAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTGAACAGACAAATGG
TGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAGCCATCAAAGCGAT
GTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGAGTTTGAGCAGTGG
AGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGGGCCACCACCCTCC
ACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTAAAGACACCAAGGA
GAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGGTACAAGGCAGGGG
TGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACTTTGTACGAGCAAA
GAGATAATGTGTTCTAAACCCCTTTCCTTTTCTGTGGCTTTTAATTTGGAATTTTCCAGTGTGTAAGCATTTGGACTGAGAATTGGGAAA
ACAAAATTACTCCCAGAAGCCAAAACTCTTTAATTCCCAACCGAAGTCACTCCAGGCTGGGATCAAATCTCCATTAAGAAAAAAAATTAT
ATATAAATATATATATATATATTATATAGCCAACTCTGTTGACAAAAAAAGGGAGAGATTTCCATCCTGGTTCAGATAAAGTTGTTGCTG
TGTTTTAACAGGGGCTGGGCTGCCTTTTTCTACCTTGCTGGTAACTAGACCAAGAAGTTAGAGAATAGACTAACATCAGTAACTTCCCAA
AAGAAACTGAAGAGCCCCCTGTAAATCTTTATGTGGCCTTCTTGGAGTTAAAAAATGAAAGGGCATATGTAAGTTGCAAAGGTGGAGGGT
TTTAGACTCTCATGCTTCAGGTGCTGTCGGGGTAAAAGTAACTGTTTTTCCCCTTCTCTTAAAACCACAGAGGACCTGTGACAGCTCTGC
AGAAATGCCAGTGCCTGGCCCCCTCTTGCCTTTTATGGCTGAGGAAAGTTACCCAACAAAGGATTTTATTCCACATTTGTGTGCCGGGTC
ATTGTGAAATAATGTTTATGCAGCCAACATCTGACCGCCTAGTAGTGTCCATTGGTCTTTGGAGTGCTTCTTGTGTGTCTCAGAAAACAT
TTTGTGTCTGATTGTGGAAATTTCTGACAATCAATCATATTTGGTGGCAAGTTGCCAAAAAACATATTTATTCTCCTCTTTCTTCCCTTA
GAACATGGTACTTGGAAACTGCCTTTTCCATTCACTTACAGGCTGCTTTTTTCTTCTACCTTTTTTCTTTTCTTTTTTTTTTTTCATATG
TGGTGAAGTCCTAAAACCTGTCTGACTTTCTGTTTCTTTTACAAAGCTCAGGTGCCTACAGAAATCAGAAGCTGCTTAGAAATACTTGTG
GAACCCTTTCCCTGGTGTCACTAGGGGGCCAGTAGGGAATTCTAAGATGCCAATATTGTGAGAAATCTTTGAAGCAAGCATCAAAAGATA
CTGTTTTTTCCCTATGGGCTTCTTTTTACTTCCAAAGCACATTGAGCACACTCATCCCATATTTGTAGAATGTGGAAATTGATTCTGGAA
GGGAATTCCAATAACAGTTCTTTTTAGAAATGTTTTTTTCCTTGTGGTGACATATATTCCTCTTCCTGGCTATTGGCAGGTGATGGAGTT
GAGAATCATGTACTTGACTTCTTGACGCATGGCTGACCTCAGAAACAGCTCCATCCTTTGCACTTGTCTTCTTCATGTGTCACCCAAATA
GGGCTTGGGTTTTTACTTTCACTTCATTTCTGAGATTAAGGTGTAACCAAGTAGAGCATTTCTTTGCTTGATACAGAAAGTTACTAGTCT
CAACCATGGCCTGGGCATAGGAGATGTCAAAATAAGTTTATTTCAAATGGCACCATTTAAATAGGGATTTTTGGTGATTTCTCATCAGTG
GAAAGAGGATTTTTGTTTTGCCTTTGTTTTGTTTTGAAATTTAAATCCTAATTTCAAAACATCACCTTGCCACCCTGACACTCCTCTTTT
TATTATTAGCGTTTCTCAGGCACAAAGCCTGCTGCAGCTGGCCCTGGGTCCTGGCTTTCAGCCAGCATCTGGCAGCCTAAGTGTACTGAT
AAGTGTGTTTTCTCCTGTTACATCATGCTGAATCCTTTCCCTTAGCCATTAGCTTTTATGATGTGGTCTTCGTAGGAAAGCCACCCTGGT
GCCAAGCCTAGCTTGTGGGGAGGGGTATGTGTTCCAGAAACTGCTCTTTGTGTTCCCTTCAATGAGGAAACAACATGTGTCTACTTATGT
GGCATCCAACTGCTTGGAGCTCCACACTTCCCTTTCGCGACTCAGGCTCTGGTGCTGTTGCCAATCCTTGCTTGGCAAAGACTGTTCGAT
CATGTGGGGTCCTTATTTACAAGGGAAAGCTGGGCCAGAAGGCTAGCAATTCAGGTGTTACCGCTATTGCTGTACCTTGTGTTAGGACAT
TGTGTTTGTGCATGGACTGTGCCTCCAAACTCAGTAGTTCCTATCTAAATATAAAGTATATTAGAAACCTGAAAGTACAGAATCTCAACC
TTACAGTCTTTCCCTTAGTCCTGTGGCCTTCCTAAGCCAGCTGTTAACGTGTTGATTCCTTCCACTTCCCCCAAGTAGGCAGGCAACAGA
TATGTTGATTGTCTTAGAAAGTAATCTGGTTCCTCTGAACTCCATTGAATTCCAGTTTGACGCATACTGCCTGGAACCAGACTGTTTGCT
TACAGCTTTTTAAGAAAAATCTGCCTTGTCTGCCCCCATTATGGTTGGTCTTGGTAGCTCCTGGGCACTGTGGGCGTGTACCATGGGAAA
GTGATTCAACACAGTGAAGGTGATTGTCTCCTCAGGCCTCCTGAAGCCACCTGTGCGGTGGGACTTCACGTGTCTCGGCCAAGGCGAGCA
TTTCCACAATGCCGTGGATGCTGCAGTCAGGCCAGATTGAACCATGACCCCATTTTTCACATGATACCAATTTTGTCTTAAAATTCACTG
AGAAAAATGAGACTAAATTTTTTTTAACCCTCAGGAGCACCTGAAGCAAATATTTATCCGTATTTATTGAAAATTCATTTTGTTTCTACT
TGAAGCTTTAACCCCTTCCATTCCTGCAAGTGTGCCTTTTGAGAGCTCCCATGGCCTAGTGACTTCACTGGTCACCTTGTCCATCTTACT
TAAGAATTTTAGTCTCTCCCTACCCTCTTGGACAGAGCTTCCTGTTCTCTTATTTCACAGGTTATACAGCAGAGCGGGTTTTGTGTTTTC
ATTCCTATTTCCACCCTTCATTTGGTTGGTGGACTCCACAACCTCACCCTACCCTACACTTTGGGAGCACAAATTTGGTGTTGAAACAAG
CTTAAATTTCATTTTAGGGCATACTGGGCTTACTCTCCTCCCAGCTGTCTGTGGATTGATTTGATTTTAATGTTCGAGTTTTACAGCAAC
AGCTGAAAACCATGAACTATTCTAGGAACTGTGTTGGAACTCTTTAAAATAAAGAAAAGAGGAGGAGGAGGAGGAAGAAAGAAAACCAAC
TTAAGAAGCCTTGACTTTGGAGGACAGAAAGCCACCAGCCAATGGAGAACAAAGAGATGTTTCCCTTTCCTTTCTTTCACCTTGTCATTC
TGGGTTTCCTTCTGCTTCACTCTTTCCTTCCCCCTTAAAAGTGGTATTCCTGGTTGGTCTGTCTGTCTGTCCTTGTCCTTGTGGTGATCC
TGGCATGGTGATATGCTCCACTTTGCATTATCCATGGTCTCTTACCAGCGCACAAGTCAGTGGGGAGGATCTAACCACGCCTGGTGGTGA
GGAAGCTGAATTTCCAGGCCTGCGTCCCATGTAGCCTCTCCATGAACTGCAGAAGGCATGTTCTGCATGGTTACCAGTAAGTGGCTCCCT
CTCACCGTGTTCATTGTCAAATGAGAGCAAACTTTAGGTGTTGGCTCCATTGTACACTCTACTTGCTCTGCTCCCCTCCCTCCAACCAGG
GTTCATGTCAGTGCACACCCCATGTGCCCTGGCGAAGCTGGTGCTGTGAGTGATGTTTCCCATACAACTCAGGGATGCCAGGTGGCTTAC
CCTGAGATAGTCATTTTGGGCACATAACAGTGTAGGAATGAAACATGGATTTCATTGATATTTAAATCTGTCAATTTCATTTTTTGTTAA

>26952_26952_2_EPHA2-FBXO42_EPHA2_chr1_16474872_ENST00000461614_FBXO42_chr1_16583254_ENST00000375592_length(amino acids)=837AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVI
DDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVE
NEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTP
SGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPAS
SSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVP
IPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELII

--------------------------------------------------------------
>26952_26952_3_EPHA2-FBXO42_EPHA2_chr1_16474873_ENST00000358432_FBXO42_chr1_16583254_ENST00000375592_length(transcript)=6461nt_BP=978nt
GGTTCTCACCCAACTTCCATTAAGGACTCGGGGCAGGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGC
GTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGGGGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCT
GCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCGGCCGCGGCGGCGCAGGGCAAGGAAGTGGTACTGCTGGACTTTGCTGCAGCTGGAG
GGGAGCTCGGCTGGCTCACACACCCGTATGGCAAAGGGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCG
TGTGCAACGTGATGTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCA
AGTTTACTGTACGTGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGG
ACTACGGCACCAACTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCAC
GCCACGTGAAGCTGAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTG
TGGCGCTGCTCTCCGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTG
ATGCACCTTCCCTGGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAG
TGGATGGCGAGTGGCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGGGTCCTATCCTT
CCCCCAAAGCTGGAGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACC
AGCCAGAGAGATTCTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCA
TGGCTGGCCACTCCTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGG
TCCTTGACCTTGAGCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAG
ATGATGCAACTATCTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTT
GGGCCTGGCAGCCACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGG
TGGTCTTCAGCCAGGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTC
TCGTTCCTGAAACCCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGA
GACCCAGGGCTCAAAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTG
GGAGTTTGTCTCCAGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTG
AAGGATACGACCTGAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATC
TGAATTGGGATCTGAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTG
AACAGACAAATGGTGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAG
CCATCAAAGCGATGTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGA
GTTTGAGCAGTGGAGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGG
GCCACCACCCTCCACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTA
AAGACACCAAGGAGAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGG
TACAAGGCAGGGGTGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACT
TTGTACGAGCAAAGAGATAATGTGTTCTAAACCCCTTTCCTTTTCTGTGGCTTTTAATTTGGAATTTTCCAGTGTGTAAGCATTTGGACT
GAGAATTGGGAAAACAAAATTACTCCCAGAAGCCAAAACTCTTTAATTCCCAACCGAAGTCACTCCAGGCTGGGATCAAATCTCCATTAA
GAAAAAAAATTATATATAAATATATATATATATATTATATAGCCAACTCTGTTGACAAAAAAAGGGAGAGATTTCCATCCTGGTTCAGAT
AAAGTTGTTGCTGTGTTTTAACAGGGGCTGGGCTGCCTTTTTCTACCTTGCTGGTAACTAGACCAAGAAGTTAGAGAATAGACTAACATC
AGTAACTTCCCAAAAGAAACTGAAGAGCCCCCTGTAAATCTTTATGTGGCCTTCTTGGAGTTAAAAAATGAAAGGGCATATGTAAGTTGC
AAAGGTGGAGGGTTTTAGACTCTCATGCTTCAGGTGCTGTCGGGGTAAAAGTAACTGTTTTTCCCCTTCTCTTAAAACCACAGAGGACCT
GTGACAGCTCTGCAGAAATGCCAGTGCCTGGCCCCCTCTTGCCTTTTATGGCTGAGGAAAGTTACCCAACAAAGGATTTTATTCCACATT
TGTGTGCCGGGTCATTGTGAAATAATGTTTATGCAGCCAACATCTGACCGCCTAGTAGTGTCCATTGGTCTTTGGAGTGCTTCTTGTGTG
TCTCAGAAAACATTTTGTGTCTGATTGTGGAAATTTCTGACAATCAATCATATTTGGTGGCAAGTTGCCAAAAAACATATTTATTCTCCT
CTTTCTTCCCTTAGAACATGGTACTTGGAAACTGCCTTTTCCATTCACTTACAGGCTGCTTTTTTCTTCTACCTTTTTTCTTTTCTTTTT
TTTTTTTCATATGTGGTGAAGTCCTAAAACCTGTCTGACTTTCTGTTTCTTTTACAAAGCTCAGGTGCCTACAGAAATCAGAAGCTGCTT
AGAAATACTTGTGGAACCCTTTCCCTGGTGTCACTAGGGGGCCAGTAGGGAATTCTAAGATGCCAATATTGTGAGAAATCTTTGAAGCAA
GCATCAAAAGATACTGTTTTTTCCCTATGGGCTTCTTTTTACTTCCAAAGCACATTGAGCACACTCATCCCATATTTGTAGAATGTGGAA
ATTGATTCTGGAAGGGAATTCCAATAACAGTTCTTTTTAGAAATGTTTTTTTCCTTGTGGTGACATATATTCCTCTTCCTGGCTATTGGC
AGGTGATGGAGTTGAGAATCATGTACTTGACTTCTTGACGCATGGCTGACCTCAGAAACAGCTCCATCCTTTGCACTTGTCTTCTTCATG
TGTCACCCAAATAGGGCTTGGGTTTTTACTTTCACTTCATTTCTGAGATTAAGGTGTAACCAAGTAGAGCATTTCTTTGCTTGATACAGA
AAGTTACTAGTCTCAACCATGGCCTGGGCATAGGAGATGTCAAAATAAGTTTATTTCAAATGGCACCATTTAAATAGGGATTTTTGGTGA
TTTCTCATCAGTGGAAAGAGGATTTTTGTTTTGCCTTTGTTTTGTTTTGAAATTTAAATCCTAATTTCAAAACATCACCTTGCCACCCTG
ACACTCCTCTTTTTATTATTAGCGTTTCTCAGGCACAAAGCCTGCTGCAGCTGGCCCTGGGTCCTGGCTTTCAGCCAGCATCTGGCAGCC
TAAGTGTACTGATAAGTGTGTTTTCTCCTGTTACATCATGCTGAATCCTTTCCCTTAGCCATTAGCTTTTATGATGTGGTCTTCGTAGGA
AAGCCACCCTGGTGCCAAGCCTAGCTTGTGGGGAGGGGTATGTGTTCCAGAAACTGCTCTTTGTGTTCCCTTCAATGAGGAAACAACATG
TGTCTACTTATGTGGCATCCAACTGCTTGGAGCTCCACACTTCCCTTTCGCGACTCAGGCTCTGGTGCTGTTGCCAATCCTTGCTTGGCA
AAGACTGTTCGATCATGTGGGGTCCTTATTTACAAGGGAAAGCTGGGCCAGAAGGCTAGCAATTCAGGTGTTACCGCTATTGCTGTACCT
TGTGTTAGGACATTGTGTTTGTGCATGGACTGTGCCTCCAAACTCAGTAGTTCCTATCTAAATATAAAGTATATTAGAAACCTGAAAGTA
CAGAATCTCAACCTTACAGTCTTTCCCTTAGTCCTGTGGCCTTCCTAAGCCAGCTGTTAACGTGTTGATTCCTTCCACTTCCCCCAAGTA
GGCAGGCAACAGATATGTTGATTGTCTTAGAAAGTAATCTGGTTCCTCTGAACTCCATTGAATTCCAGTTTGACGCATACTGCCTGGAAC
CAGACTGTTTGCTTACAGCTTTTTAAGAAAAATCTGCCTTGTCTGCCCCCATTATGGTTGGTCTTGGTAGCTCCTGGGCACTGTGGGCGT
GTACCATGGGAAAGTGATTCAACACAGTGAAGGTGATTGTCTCCTCAGGCCTCCTGAAGCCACCTGTGCGGTGGGACTTCACGTGTCTCG
GCCAAGGCGAGCATTTCCACAATGCCGTGGATGCTGCAGTCAGGCCAGATTGAACCATGACCCCATTTTTCACATGATACCAATTTTGTC
TTAAAATTCACTGAGAAAAATGAGACTAAATTTTTTTTAACCCTCAGGAGCACCTGAAGCAAATATTTATCCGTATTTATTGAAAATTCA
TTTTGTTTCTACTTGAAGCTTTAACCCCTTCCATTCCTGCAAGTGTGCCTTTTGAGAGCTCCCATGGCCTAGTGACTTCACTGGTCACCT
TGTCCATCTTACTTAAGAATTTTAGTCTCTCCCTACCCTCTTGGACAGAGCTTCCTGTTCTCTTATTTCACAGGTTATACAGCAGAGCGG
GTTTTGTGTTTTCATTCCTATTTCCACCCTTCATTTGGTTGGTGGACTCCACAACCTCACCCTACCCTACACTTTGGGAGCACAAATTTG
GTGTTGAAACAAGCTTAAATTTCATTTTAGGGCATACTGGGCTTACTCTCCTCCCAGCTGTCTGTGGATTGATTTGATTTTAATGTTCGA
GTTTTACAGCAACAGCTGAAAACCATGAACTATTCTAGGAACTGTGTTGGAACTCTTTAAAATAAAGAAAAGAGGAGGAGGAGGAGGAAG
AAAGAAAACCAACTTAAGAAGCCTTGACTTTGGAGGACAGAAAGCCACCAGCCAATGGAGAACAAAGAGATGTTTCCCTTTCCTTTCTTT
CACCTTGTCATTCTGGGTTTCCTTCTGCTTCACTCTTTCCTTCCCCCTTAAAAGTGGTATTCCTGGTTGGTCTGTCTGTCTGTCCTTGTC
CTTGTGGTGATCCTGGCATGGTGATATGCTCCACTTTGCATTATCCATGGTCTCTTACCAGCGCACAAGTCAGTGGGGAGGATCTAACCA
CGCCTGGTGGTGAGGAAGCTGAATTTCCAGGCCTGCGTCCCATGTAGCCTCTCCATGAACTGCAGAAGGCATGTTCTGCATGGTTACCAG
TAAGTGGCTCCCTCTCACCGTGTTCATTGTCAAATGAGAGCAAACTTTAGGTGTTGGCTCCATTGTACACTCTACTTGCTCTGCTCCCCT
CCCTCCAACCAGGGTTCATGTCAGTGCACACCCCATGTGCCCTGGCGAAGCTGGTGCTGTGAGTGATGTTTCCCATACAACTCAGGGATG
CCAGGTGGCTTACCCTGAGATAGTCATTTTGGGCACATAACAGTGTAGGAATGAAACATGGATTTCATTGATATTTAAATCTGTCAATTT

>26952_26952_3_EPHA2-FBXO42_EPHA2_chr1_16474873_ENST00000358432_FBXO42_chr1_16583254_ENST00000375592_length(amino acids)=824AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGS
RQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHP
ACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARG
DGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTV
GGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHS
LPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKY

--------------------------------------------------------------
>26952_26952_4_EPHA2-FBXO42_EPHA2_chr1_16474873_ENST00000461614_FBXO42_chr1_16583254_ENST00000375592_length(transcript)=6358nt_BP=875nt
GGAGGGGCAGAAGTTGCGCGCAGGCCGGCGGGCGGGAGCGGACACCGAGGCCGGCGTGCAGGCGTGCGGGTGTGCGGGAGCCGGGCTCGG
GGGGATCGGACCGAGAGCGAGAAGCGCGGCATGGAGCTCCAGGCAGCCCGCGCCTGCTTCGCCCTGCTGTGGGGCTGTGCGCTGGCCGCG
GCCGCGGCGGCGCAGGGCAAGGAAGTGGGACCTGATGCAGAACATCATGAATGACATGCCGATCTACATGTACTCCGTGTGCAACGTGAT
GTCTGGCGACCAGGACAACTGGCTCCGCACCAACTGGGTGTACCGAGGAGAGGCTGAGCGTATCTTCATTGAGCTCAAGTTTACTGTACG
TGACTGCAACAGCTTCCCTGGTGGCGCCAGCTCCTGCAAGGAGACTTTCAACCTCTACTATGCCGAGTCGGACCTGGACTACGGCACCAA
CTTCCAGAAGCGCCTGTTCACCAAGATTGACACCATTGCGCCCGATGAGATCACCGTCAGCAGCGACTTCGAGGCACGCCACGTGAAGCT
GAACGTGGAGGAGCGCTCCGTGGGGCCGCTCACCCGCAAAGGCTTCTACCTGGCCTTCCAGGATATCGGTGCCTGTGTGGCGCTGCTCTC
CGTCCGTGTCTACTACAAGAAGTGCCCCGAGCTGCTGCAGGGCCTGGCCCACTTCCCTGAGACCATCGCCGGCTCTGATGCACCTTCCCT
GGCCACTGTGGCCGGCACCTGTGTGGACCATGCCGTGGTGCCACCGGGGGGTGAAGAGCCCCGTATGCACTGTGCAGTGGATGGCGAGTG
GCTGGTGCCCATTGGGCAGTGCCTGTGCCAGGCAGGCTACGAGAAGGTGGAGGATGCCTGCCAGGGGTCCTATCCTTCCCCCAAAGCTGG
AGCAACTCTGGTCGTGTACAAGGACTTGCTAGTGCTGTTTGGTGGCTGGACGCGGCCAAGCCCTTATCCCCTACACCAGCCAGAGAGATT
CTTTGATGAAATACACACTTACTCACCCTCTAAAAATTGGTGGAACTGCATTGTGACAACCCATGGGCCACCTCCCATGGCTGGCCACTC
CTCCTGTGTGATAGATGATAAAATGATTGTCTTTGGTGGCTCTTTAGGATCCCGGCAAATGAGCAATGATGTCTGGGTCCTTGACCTTGA
GCAGTGGGCGTGGTCCAAGCCGAACATCTCTGGCCCCAGTCCTCATCCTCGAGGTGGCCAATCTCAGATTGTCATAGATGATGCAACTAT
CTTAATCCTCGGAGGGTGTGGCGGTCCCAATGCTCTATTCAAGGATGCTTGGTTGTTGCACATGCATTCTGGTCCTTGGGCCTGGCAGCC
ACTCAAGGTAGAAAATGAAGAGCATGGGGCCCCAGAACTGTGGTGCCATCCAGCTTGCCGGGTGGGACAGTGTGTGGTGGTCTTCAGCCA
GGCTCCTAGTGGGAGAGCCCCACTCAGCCCCAGTTTGAACTCTCGCCCATCACCTATCAGTGCCACTCCTCCAGCTCTCGTTCCTGAAAC
CCGAGAGTACCGCTCTCAGTCTCCAGTAAGAAGCATGGATGAAGCTCCTTGTGTTAACGGCCGCTGGGGAACACTGAGACCCAGGGCTCA
AAGGCAGACTCCTTCAGGTTCCCGGGAAGGGAGCCTTTCCCCAGCCAGAGGAGACGGCTCTCCTATCCTCAATGGTGGGAGTTTGTCTCC
AGGAACGGCAGCTGTGGGTGGCTCTTCTTTGGACAGTCCTGTACAGGCCATATCTCCAAGTACTCCATCTGCTCCTGAAGGATACGACCT
GAAAATAGGACTTTCTTTGGCCCCCCGACGAGGATCACTACCAGATCAGAAAGATCTGAGATTAGGATCCATAGATCTGAATTGGGATCT
GAAACCCGCTTCCAGTAGTAATCCCATGGATGGCATGGACAATAGGACAGTTGGGGGAAGTATGAGACACCCTCCTGAACAGACAAATGG
TGTGCATACCCCACCTCACGTGGCCAGTGCCCTTGCAGGGGCCGTCTCCCCAGGTGCCCTGCGTCGGAGTCTGGAAGCCATCAAAGCGAT
GTCCTCCAAAGGCCCCTCGGCCTCTGCAGCACTAAGTCCTCCTCTTGGGTCTTCTCCAGGCTCTCCTGGGAGCCAGAGTTTGAGCAGTGG
AGAAACAGTGCCCATCCCTCGCCCAGGGCCTGCCCAAGGAGATGGACATTCCTTACCTCCCATTGCTCGCCGCCTGGGCCACCACCCTCC
ACAGTCCCTAAATGTTGGCAAACCCCTATACCAGAGTATGAACTGCAAGCCCATGCAGATGTACGTGCTGGACATTAAAGACACCAAGGA
GAAGGGGCGGGTCAAATGGAAAGTATTTAATAGCAGTTCTGTGGTTGGACCTCCTGAAACCAGCCTGCATACCGTGGTACAAGGCAGGGG
TGAACTCATCATATTTGGAGGACTCATGGACAAGAAACAGAATGTGAAGTACTATCCAAAAACAAACGCCTTGTACTTTGTACGAGCAAA
GAGATAATGTGTTCTAAACCCCTTTCCTTTTCTGTGGCTTTTAATTTGGAATTTTCCAGTGTGTAAGCATTTGGACTGAGAATTGGGAAA
ACAAAATTACTCCCAGAAGCCAAAACTCTTTAATTCCCAACCGAAGTCACTCCAGGCTGGGATCAAATCTCCATTAAGAAAAAAAATTAT
ATATAAATATATATATATATATTATATAGCCAACTCTGTTGACAAAAAAAGGGAGAGATTTCCATCCTGGTTCAGATAAAGTTGTTGCTG
TGTTTTAACAGGGGCTGGGCTGCCTTTTTCTACCTTGCTGGTAACTAGACCAAGAAGTTAGAGAATAGACTAACATCAGTAACTTCCCAA
AAGAAACTGAAGAGCCCCCTGTAAATCTTTATGTGGCCTTCTTGGAGTTAAAAAATGAAAGGGCATATGTAAGTTGCAAAGGTGGAGGGT
TTTAGACTCTCATGCTTCAGGTGCTGTCGGGGTAAAAGTAACTGTTTTTCCCCTTCTCTTAAAACCACAGAGGACCTGTGACAGCTCTGC
AGAAATGCCAGTGCCTGGCCCCCTCTTGCCTTTTATGGCTGAGGAAAGTTACCCAACAAAGGATTTTATTCCACATTTGTGTGCCGGGTC
ATTGTGAAATAATGTTTATGCAGCCAACATCTGACCGCCTAGTAGTGTCCATTGGTCTTTGGAGTGCTTCTTGTGTGTCTCAGAAAACAT
TTTGTGTCTGATTGTGGAAATTTCTGACAATCAATCATATTTGGTGGCAAGTTGCCAAAAAACATATTTATTCTCCTCTTTCTTCCCTTA
GAACATGGTACTTGGAAACTGCCTTTTCCATTCACTTACAGGCTGCTTTTTTCTTCTACCTTTTTTCTTTTCTTTTTTTTTTTTCATATG
TGGTGAAGTCCTAAAACCTGTCTGACTTTCTGTTTCTTTTACAAAGCTCAGGTGCCTACAGAAATCAGAAGCTGCTTAGAAATACTTGTG
GAACCCTTTCCCTGGTGTCACTAGGGGGCCAGTAGGGAATTCTAAGATGCCAATATTGTGAGAAATCTTTGAAGCAAGCATCAAAAGATA
CTGTTTTTTCCCTATGGGCTTCTTTTTACTTCCAAAGCACATTGAGCACACTCATCCCATATTTGTAGAATGTGGAAATTGATTCTGGAA
GGGAATTCCAATAACAGTTCTTTTTAGAAATGTTTTTTTCCTTGTGGTGACATATATTCCTCTTCCTGGCTATTGGCAGGTGATGGAGTT
GAGAATCATGTACTTGACTTCTTGACGCATGGCTGACCTCAGAAACAGCTCCATCCTTTGCACTTGTCTTCTTCATGTGTCACCCAAATA
GGGCTTGGGTTTTTACTTTCACTTCATTTCTGAGATTAAGGTGTAACCAAGTAGAGCATTTCTTTGCTTGATACAGAAAGTTACTAGTCT
CAACCATGGCCTGGGCATAGGAGATGTCAAAATAAGTTTATTTCAAATGGCACCATTTAAATAGGGATTTTTGGTGATTTCTCATCAGTG
GAAAGAGGATTTTTGTTTTGCCTTTGTTTTGTTTTGAAATTTAAATCCTAATTTCAAAACATCACCTTGCCACCCTGACACTCCTCTTTT
TATTATTAGCGTTTCTCAGGCACAAAGCCTGCTGCAGCTGGCCCTGGGTCCTGGCTTTCAGCCAGCATCTGGCAGCCTAAGTGTACTGAT
AAGTGTGTTTTCTCCTGTTACATCATGCTGAATCCTTTCCCTTAGCCATTAGCTTTTATGATGTGGTCTTCGTAGGAAAGCCACCCTGGT
GCCAAGCCTAGCTTGTGGGGAGGGGTATGTGTTCCAGAAACTGCTCTTTGTGTTCCCTTCAATGAGGAAACAACATGTGTCTACTTATGT
GGCATCCAACTGCTTGGAGCTCCACACTTCCCTTTCGCGACTCAGGCTCTGGTGCTGTTGCCAATCCTTGCTTGGCAAAGACTGTTCGAT
CATGTGGGGTCCTTATTTACAAGGGAAAGCTGGGCCAGAAGGCTAGCAATTCAGGTGTTACCGCTATTGCTGTACCTTGTGTTAGGACAT
TGTGTTTGTGCATGGACTGTGCCTCCAAACTCAGTAGTTCCTATCTAAATATAAAGTATATTAGAAACCTGAAAGTACAGAATCTCAACC
TTACAGTCTTTCCCTTAGTCCTGTGGCCTTCCTAAGCCAGCTGTTAACGTGTTGATTCCTTCCACTTCCCCCAAGTAGGCAGGCAACAGA
TATGTTGATTGTCTTAGAAAGTAATCTGGTTCCTCTGAACTCCATTGAATTCCAGTTTGACGCATACTGCCTGGAACCAGACTGTTTGCT
TACAGCTTTTTAAGAAAAATCTGCCTTGTCTGCCCCCATTATGGTTGGTCTTGGTAGCTCCTGGGCACTGTGGGCGTGTACCATGGGAAA
GTGATTCAACACAGTGAAGGTGATTGTCTCCTCAGGCCTCCTGAAGCCACCTGTGCGGTGGGACTTCACGTGTCTCGGCCAAGGCGAGCA
TTTCCACAATGCCGTGGATGCTGCAGTCAGGCCAGATTGAACCATGACCCCATTTTTCACATGATACCAATTTTGTCTTAAAATTCACTG
AGAAAAATGAGACTAAATTTTTTTTAACCCTCAGGAGCACCTGAAGCAAATATTTATCCGTATTTATTGAAAATTCATTTTGTTTCTACT
TGAAGCTTTAACCCCTTCCATTCCTGCAAGTGTGCCTTTTGAGAGCTCCCATGGCCTAGTGACTTCACTGGTCACCTTGTCCATCTTACT
TAAGAATTTTAGTCTCTCCCTACCCTCTTGGACAGAGCTTCCTGTTCTCTTATTTCACAGGTTATACAGCAGAGCGGGTTTTGTGTTTTC
ATTCCTATTTCCACCCTTCATTTGGTTGGTGGACTCCACAACCTCACCCTACCCTACACTTTGGGAGCACAAATTTGGTGTTGAAACAAG
CTTAAATTTCATTTTAGGGCATACTGGGCTTACTCTCCTCCCAGCTGTCTGTGGATTGATTTGATTTTAATGTTCGAGTTTTACAGCAAC
AGCTGAAAACCATGAACTATTCTAGGAACTGTGTTGGAACTCTTTAAAATAAAGAAAAGAGGAGGAGGAGGAGGAAGAAAGAAAACCAAC
TTAAGAAGCCTTGACTTTGGAGGACAGAAAGCCACCAGCCAATGGAGAACAAAGAGATGTTTCCCTTTCCTTTCTTTCACCTTGTCATTC
TGGGTTTCCTTCTGCTTCACTCTTTCCTTCCCCCTTAAAAGTGGTATTCCTGGTTGGTCTGTCTGTCTGTCCTTGTCCTTGTGGTGATCC
TGGCATGGTGATATGCTCCACTTTGCATTATCCATGGTCTCTTACCAGCGCACAAGTCAGTGGGGAGGATCTAACCACGCCTGGTGGTGA
GGAAGCTGAATTTCCAGGCCTGCGTCCCATGTAGCCTCTCCATGAACTGCAGAAGGCATGTTCTGCATGGTTACCAGTAAGTGGCTCCCT
CTCACCGTGTTCATTGTCAAATGAGAGCAAACTTTAGGTGTTGGCTCCATTGTACACTCTACTTGCTCTGCTCCCCTCCCTCCAACCAGG
GTTCATGTCAGTGCACACCCCATGTGCCCTGGCGAAGCTGGTGCTGTGAGTGATGTTTCCCATACAACTCAGGGATGCCAGGTGGCTTAC
CCTGAGATAGTCATTTTGGGCACATAACAGTGTAGGAATGAAACATGGATTTCATTGATATTTAAATCTGTCAATTTCATTTTTTGTTAA

>26952_26952_4_EPHA2-FBXO42_EPHA2_chr1_16474873_ENST00000461614_FBXO42_chr1_16583254_ENST00000375592_length(amino acids)=837AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVI
DDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVE
NEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTP
SGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPAS
SSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVP
IPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELII

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EPHA2-FBXO42

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for EPHA2-FBXO42

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for EPHA2-FBXO42

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source