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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EPS8L2-B4GALNT4 (FusionGDB2 ID:27102) |
Fusion Gene Summary for EPS8L2-B4GALNT4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EPS8L2-B4GALNT4 | Fusion gene ID: 27102 | Hgene | Tgene | Gene symbol | EPS8L2 | B4GALNT4 | Gene ID | 64787 | 338707 |
| Gene name | EPS8 like 2 | beta-1,4-N-acetyl-galactosaminyltransferase 4 | |
| Synonyms | DFNB106|EPS8R2 | - | |
| Cytomap | 11p15.5 | 11p15.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | epidermal growth factor receptor kinase substrate 8-like protein 2EPS8-related protein 2epidermal growth factor receptor pathway substrate 8-related protein 2 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferaseNGalNAc-T1beta-1,4-N-acetyl-galactosaminyl transferase 4beta-1,4-N-acetylgalactosaminylt | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9H6S3 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000318562, ENST00000526198, ENST00000530636, ENST00000533256, ENST00000534449, | ENST00000329962, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EPS8L2 [Title/Abstract] AND B4GALNT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | EPS8L2(724829)-B4GALNT4(375461), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EPS8L2 | GO:0007266 | Rho protein signal transduction | 14565974 |
| Hgene | EPS8L2 | GO:0035023 | regulation of Rho protein signal transduction | 14565974 |
| Fusion gene breakpoints across EPS8L2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across B4GALNT4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-AP-A0LI-01A | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + |
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Fusion Gene ORF analysis for EPS8L2-B4GALNT4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000318562 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + |
| In-frame | ENST00000526198 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + |
| In-frame | ENST00000530636 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + |
| In-frame | ENST00000533256 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + |
| intron-3CDS | ENST00000534449 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000318562 | EPS8L2 | chr11 | 724829 | + | ENST00000329962 | B4GALNT4 | chr11 | 375461 | + | 4475 | 1814 | 17 | 4150 | 1377 |
| ENST00000533256 | EPS8L2 | chr11 | 724829 | + | ENST00000329962 | B4GALNT4 | chr11 | 375461 | + | 4596 | 1935 | 333 | 4271 | 1312 |
| ENST00000530636 | EPS8L2 | chr11 | 724829 | + | ENST00000329962 | B4GALNT4 | chr11 | 375461 | + | 4472 | 1811 | 209 | 4147 | 1312 |
| ENST00000526198 | EPS8L2 | chr11 | 724829 | + | ENST00000329962 | B4GALNT4 | chr11 | 375461 | + | 4309 | 1648 | 19 | 3984 | 1321 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000318562 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + | 0.004449047 | 0.995551 |
| ENST00000533256 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + | 0.004801274 | 0.9951988 |
| ENST00000530636 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + | 0.004165999 | 0.995834 |
| ENST00000526198 | ENST00000329962 | EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375461 | + | 0.003529327 | 0.9964707 |
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Fusion Genomic Features for EPS8L2-B4GALNT4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375460 | + | 0.041446622 | 0.9585533 |
| EPS8L2 | chr11 | 724829 | + | B4GALNT4 | chr11 | 375460 | + | 0.041446622 | 0.9585533 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EPS8L2-B4GALNT4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:724829/chr11:375461) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EPS8L2 | . |
| FUNCTION: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). {ECO:0000250|UniProtKB:Q99K30, ECO:0000269|PubMed:14565974}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EPS8L2 | chr11:724829 | chr11:375461 | ENST00000318562 | + | 16 | 21 | 46_202 | 520 | 716.0 | Domain | PID |
| Hgene | EPS8L2 | chr11:724829 | chr11:375461 | ENST00000530636 | + | 16 | 21 | 46_202 | 520 | 716.0 | Domain | PID |
| Hgene | EPS8L2 | chr11:724829 | chr11:375461 | ENST00000533256 | + | 17 | 22 | 46_202 | 520 | 716.0 | Domain | PID |
| Tgene | B4GALNT4 | chr11:724829 | chr11:375461 | ENST00000329962 | 7 | 20 | 449_590 | 261 | 1040.0 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EPS8L2 | chr11:724829 | chr11:375461 | ENST00000318562 | + | 16 | 21 | 492_551 | 520 | 716.0 | Domain | SH3 |
| Hgene | EPS8L2 | chr11:724829 | chr11:375461 | ENST00000530636 | + | 16 | 21 | 492_551 | 520 | 716.0 | Domain | SH3 |
| Hgene | EPS8L2 | chr11:724829 | chr11:375461 | ENST00000533256 | + | 17 | 22 | 492_551 | 520 | 716.0 | Domain | SH3 |
| Tgene | B4GALNT4 | chr11:724829 | chr11:375461 | ENST00000329962 | 7 | 20 | 108_278 | 261 | 1040.0 | Domain | PA14 | |
| Tgene | B4GALNT4 | chr11:724829 | chr11:375461 | ENST00000329962 | 7 | 20 | 1_15 | 261 | 1040.0 | Topological domain | Cytoplasmic | |
| Tgene | B4GALNT4 | chr11:724829 | chr11:375461 | ENST00000329962 | 7 | 20 | 37_1039 | 261 | 1040.0 | Topological domain | Lumenal | |
| Tgene | B4GALNT4 | chr11:724829 | chr11:375461 | ENST00000329962 | 7 | 20 | 16_36 | 261 | 1040.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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Fusion Gene Sequence for EPS8L2-B4GALNT4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >27102_27102_1_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000318562_B4GALNT4_chr11_375461_ENST00000329962_length(transcript)=4475nt_BP=1814nt TCGGGTGACTCCGCAACCTGTCGCTCAGGTTCCTCCTCTCCCGGCCCCGCCCCGGCCCGGCCCCGCCGAGCGTCCCACCCGCCCGCGGGA GACCTGGCGCCCCGGCCGAGGCGCGAACAGACGGACGCACCGGCGAGCGCCGAGGGGACAGGCCGAGCGCGGGGCGCCGGAGGCAGGTGT GGGACAGGCACTGGCCTCAGACCGGGGCCACACTGAGGTCTGCCCTTCTCCCGCTGGCCGCCACCCAAGACACCATGAGCCAGTCCGGGG CCGTGAGCTGCTGCCCGGGTGCCACCAATGGCAGCCTGGGCCGGTCCGACGGTGTGGCCAAGATGAGCCCCAAGGACCTGTTTGAGCAGA GGAAGAAGTATTCCAACTCCAACGTCATCATGCACGAGACCTCGCAGTACCACGTCCAGCACCTGGCCACATTCATCATGGACAAGAGCG AAGCCATCACGTCTGTGGACGACGCCATCCGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGG TGAACGACCAGTCGCTGCGGCTGCTGGACATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGG TCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCG ATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGA AGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGG ATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGG CCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGG CAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGG CACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCC AGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCT CCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGG GAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTC CTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCA TAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGG GCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGG ATGAGGTCCTAGAGTGGCGAGCTTTCCTGCCCGGCCTGAAGTTCGAGGTCATCAGCTCTGCTCACATCTCCCTGTACACAGATGAGTCAG CCTTGAAGATGGACCACGTGGCGCACGTCCCCCAGTCTCCAGCCAGCCACGTGGGGGGGCGTCCGCCGCAGGAGGAGACCAGCGCAGACA TGCTGCGGCCAGATCCCAGGGATACCTTTTTCCTCACTCCACGCATGGAATCTTCGAGCCTGGAGAACGTGCTGGAGCCCTGCGCCTACG CCCCCACCTACGTGGTCAAGGACTTCCCGATCGCCAGATACCAGGGCCTGCAATTTGTGTACCTGTCCTTCGTTTATCCCAACGACTACA CTCGCCTCACCCACATGGAGACGGACAACAAGTGCTTCTACCGCGAGTCTCCGCTGTATCTGGAGAGGTTTGGGTTCTATAAATACATGA AGATGGACAAGGAGGAGGGGGATGAGGATGAAGAAGACGAGGTGCAGCGCCGAGCCTTCCTCTTCCTCAACCCGGACGACTTCCTGGACG ACGAGGACGAGGGGGAGCTGCTCGACAGCCTGGAGCCCACCGAGGCGGCCCCGCCCAGGAGCGGCCCCCAGTCCCCCGCCCCAGCAGCCC CCGCCCAGCCCGGAGCCACCCTCGCCCCGCCGACCCCTCCCCGCCCCCGGGACGGGGGGACCCCCAGGCACTCCCGGGCCCTGAGCTGGG CCGCCAGGGCCGCCCGCCCTTTGCCGCTCTTCTTGGGCCGAGCTCCGCCCCCGCGCCCTGCAGTGGAGCAGCCGCCCCCAAAGGTGTACG TGACCAGGGTGCGGCCGGGACAGCGGGCATCCCCCCGGGCCCCAGCGCCGCGTGCGCCCTGGCCGCCCTTCCCTGGCGTCTTCCTGCACC CCAGGCCTCTGCCCAGAGTGCAGCTGCGGGCGCCCCCACGCCCACCCCGGCCCCACGGCCGCAGGACCGGCGGCCCCCAGGCCACACAGC CGAGGCCCCCAGCCCGGGCGCAGGCCACCCAAGGGGGCCGGGAGGGCCAGGCGCGCACGCTGGGACCTGCGGCGCCCACAGTGGACTCAA ACTTGTCCTCCGAAGCGCGGCCCGTGACCTCCTTCCTGAGCTTGTCCCAGGTGTCCGGGCCGCAGCTGCCCGGGGAGGGCGAAGAGGAGG AGGAAGGGGAGGACGATGGGGCCCCGGGCGACGAGGCCGCGTCGGAGGACAGCGAGGAGGCCGCGGGCCCGGCGCTCGGACGCTGGCGTG AGGACGCCATCGACTGGCAGCGCACGTTCAGCGTGGGCGCCGTGGACTTCGAGCTGCTGCGCTCGGACTGGAACGACCTGCGATGCAACG TTTCGGGGAACCTGCAGCTGCCGGAGGCGGAGGCCGTGGACGTGACCGCTCAGTACATGGAGCGGCTGAACGCGCGCCACGGCGGGCGCT TCGCGCTTCTGCGCATCGTGAACGTGGAGAAGCGCCGGGACTCGGCGCGAGGGAGTCGCTTCCTGCTGGAGCTGGAGCTGCAGGAGCGCG GGGGCGGCCGCCTGCGACTGTCCGAGTACGTCTTCCTGCGGCTGCCGGGAGCCCGCGTAGGGGATGCAGACGGAGAAAGTCCCGAACCCG CTCCCGCCGCCTCCGTGCGCCCCGACGGCCGCCCCGAGCTCTGCCGGCCACTGCGCCTGGCCTGGCGCCAGGACGTGATGGTTCACTTCA TCGTGCCAGTGAAAAACCAGGCACGGTGGGTGGCACAGTTCCTGGCGGACATGGCTGCGCTGCACGCGCGCACCGGGGACTCGCGTTTCA GCGTCGTCCTGGTGGATTTCGAGAGCGAGGATATGGACGTGGAGCGGGCCCTGCGCGCCGCGCGCCTGCCCCGGTACCAGTACCTGAGAC GAACCGGGAACTTCGAGCGCTCCGCCGGGCTGCAGGCGGGAGTGGACGCGGTAGAGGACGCCAGCAGCATCGTGTTCCTCTGCGACCTGC ACATCCACTTCCCACCCAACATCCTGGACGGCATCCGCAAGCACTGCGTGGAGGGCAGGCTGGCCTTCGCGCCCGTGGTCATGCGCCTGA GCTGCGGGAGCTCGCCCCGGGACCCCCACGGTTACTGGGAGGTGAACGGCTTTGGCCTTTTTGGGATCTACAAGTCGGACTTTGACCGGG TTGGAGGAATGAACACGGAGGAGTTCCGAGACCAGTGGGGGGGTGAAGACTGGGAGCTCCTGGACAGGGTCCTGCAGGCAGGGCTGGAGG TGGAGCGGCTCCGACTGCGGAATTTCTATCACCACTACCACTCCAAGAGGGGCATGTGGAGCGTCCGCAGCAGGAAGGGCTCTCGCACGG GGGCGTCTTGAGGACGGGCAGCCCCTCCCAGCCCCGGTGGGAGTCCCGAGGCAGCTGCTGGGGGCTGGGCTTTGAGCTCGGTCCCGAGAG ACCCGGCAGGGCTGGTCAGAGGGGCACAGCCACCGCCTGTGCCTGCCCCTCTCTGGCCCACTGGGCGTCGTGCCCCTCCCCGGAGAGGCA GCCTTCACGGCGGGTCAGGGCCTGGCCTTGGTCCCCACTCTGCGATGATTTCTGTGAAATTTTGCTGTAGCGATGACATTGTTTTCAGAA >27102_27102_1_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000318562_B4GALNT4_chr11_375461_ENST00000329962_length(amino acids)=1377AA_BP=790 MSLRFLLSRPRPGPAPPSVPPARGRPGAPAEARTDGRTGERRGDRPSAGRRRQVWDRHWPQTGATLRSALLPLAATQDTMSQSGAVSCCP GATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSL RLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEK IRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFK QLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPL LSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQK HSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEWRAFLPGLKFEVISSAHISLYTDESALKMDH VAHVPQSPASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARYQGLQFVYLSFVYPNDYTRLTHM ETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDEVQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGA TLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR VQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDD GAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVDVTAQYMERLNARHGGRFALLRI VNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGARVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKN QARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPP NILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRL -------------------------------------------------------------- >27102_27102_2_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000526198_B4GALNT4_chr11_375461_ENST00000329962_length(transcript)=4309nt_BP=1648nt GAGGTCTGCCCTTCTCCCGCTGGCCGCCACCCAAGACACCATGAGCCAGTCCGGGGCCGTGAGCTGCTGCCCGGGTGCCACCAATGGCAG CCTGGGCCGGTCCGACGGTGTGGCCAAGATGAGCCCCAAGGACCTGTTTGAGCAGAGGAAGAAGTATTCCAACTCCAACGTCATCATGCA CGAGACCTCGCAGTACCACGTCCAGCACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGGAA GCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATCGA GTCACAGAGTGCCCAGACCCCGGGTGCGAGTCGTGTCCGCGCGATGTACCCGCAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCA GCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCA CTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCG GCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCA GCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCA GGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGC CCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGT CCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCT GCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCC AGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCT GTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAG CGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGT GAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCC ACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCT ATCGGTGCTCAAGGATGAGGTCCTAGAGTGGCGAGCTTTCCTGCCCGGCCTGAAGTTCGAGGTCATCAGCTCTGCTCACATCTCCCTGTA CACAGATGAGTCAGCCTTGAAGATGGACCACGTGGCGCACGTCCCCCAGTCTCCAGCCAGCCACGTGGGGGGGCGTCCGCCGCAGGAGGA GACCAGCGCAGACATGCTGCGGCCAGATCCCAGGGATACCTTTTTCCTCACTCCACGCATGGAATCTTCGAGCCTGGAGAACGTGCTGGA GCCCTGCGCCTACGCCCCCACCTACGTGGTCAAGGACTTCCCGATCGCCAGATACCAGGGCCTGCAATTTGTGTACCTGTCCTTCGTTTA TCCCAACGACTACACTCGCCTCACCCACATGGAGACGGACAACAAGTGCTTCTACCGCGAGTCTCCGCTGTATCTGGAGAGGTTTGGGTT CTATAAATACATGAAGATGGACAAGGAGGAGGGGGATGAGGATGAAGAAGACGAGGTGCAGCGCCGAGCCTTCCTCTTCCTCAACCCGGA CGACTTCCTGGACGACGAGGACGAGGGGGAGCTGCTCGACAGCCTGGAGCCCACCGAGGCGGCCCCGCCCAGGAGCGGCCCCCAGTCCCC CGCCCCAGCAGCCCCCGCCCAGCCCGGAGCCACCCTCGCCCCGCCGACCCCTCCCCGCCCCCGGGACGGGGGGACCCCCAGGCACTCCCG GGCCCTGAGCTGGGCCGCCAGGGCCGCCCGCCCTTTGCCGCTCTTCTTGGGCCGAGCTCCGCCCCCGCGCCCTGCAGTGGAGCAGCCGCC CCCAAAGGTGTACGTGACCAGGGTGCGGCCGGGACAGCGGGCATCCCCCCGGGCCCCAGCGCCGCGTGCGCCCTGGCCGCCCTTCCCTGG CGTCTTCCTGCACCCCAGGCCTCTGCCCAGAGTGCAGCTGCGGGCGCCCCCACGCCCACCCCGGCCCCACGGCCGCAGGACCGGCGGCCC CCAGGCCACACAGCCGAGGCCCCCAGCCCGGGCGCAGGCCACCCAAGGGGGCCGGGAGGGCCAGGCGCGCACGCTGGGACCTGCGGCGCC CACAGTGGACTCAAACTTGTCCTCCGAAGCGCGGCCCGTGACCTCCTTCCTGAGCTTGTCCCAGGTGTCCGGGCCGCAGCTGCCCGGGGA GGGCGAAGAGGAGGAGGAAGGGGAGGACGATGGGGCCCCGGGCGACGAGGCCGCGTCGGAGGACAGCGAGGAGGCCGCGGGCCCGGCGCT CGGACGCTGGCGTGAGGACGCCATCGACTGGCAGCGCACGTTCAGCGTGGGCGCCGTGGACTTCGAGCTGCTGCGCTCGGACTGGAACGA CCTGCGATGCAACGTTTCGGGGAACCTGCAGCTGCCGGAGGCGGAGGCCGTGGACGTGACCGCTCAGTACATGGAGCGGCTGAACGCGCG CCACGGCGGGCGCTTCGCGCTTCTGCGCATCGTGAACGTGGAGAAGCGCCGGGACTCGGCGCGAGGGAGTCGCTTCCTGCTGGAGCTGGA GCTGCAGGAGCGCGGGGGCGGCCGCCTGCGACTGTCCGAGTACGTCTTCCTGCGGCTGCCGGGAGCCCGCGTAGGGGATGCAGACGGAGA AAGTCCCGAACCCGCTCCCGCCGCCTCCGTGCGCCCCGACGGCCGCCCCGAGCTCTGCCGGCCACTGCGCCTGGCCTGGCGCCAGGACGT GATGGTTCACTTCATCGTGCCAGTGAAAAACCAGGCACGGTGGGTGGCACAGTTCCTGGCGGACATGGCTGCGCTGCACGCGCGCACCGG GGACTCGCGTTTCAGCGTCGTCCTGGTGGATTTCGAGAGCGAGGATATGGACGTGGAGCGGGCCCTGCGCGCCGCGCGCCTGCCCCGGTA CCAGTACCTGAGACGAACCGGGAACTTCGAGCGCTCCGCCGGGCTGCAGGCGGGAGTGGACGCGGTAGAGGACGCCAGCAGCATCGTGTT CCTCTGCGACCTGCACATCCACTTCCCACCCAACATCCTGGACGGCATCCGCAAGCACTGCGTGGAGGGCAGGCTGGCCTTCGCGCCCGT GGTCATGCGCCTGAGCTGCGGGAGCTCGCCCCGGGACCCCCACGGTTACTGGGAGGTGAACGGCTTTGGCCTTTTTGGGATCTACAAGTC GGACTTTGACCGGGTTGGAGGAATGAACACGGAGGAGTTCCGAGACCAGTGGGGGGGTGAAGACTGGGAGCTCCTGGACAGGGTCCTGCA GGCAGGGCTGGAGGTGGAGCGGCTCCGACTGCGGAATTTCTATCACCACTACCACTCCAAGAGGGGCATGTGGAGCGTCCGCAGCAGGAA GGGCTCTCGCACGGGGGCGTCTTGAGGACGGGCAGCCCCTCCCAGCCCCGGTGGGAGTCCCGAGGCAGCTGCTGGGGGCTGGGCTTTGAG CTCGGTCCCGAGAGACCCGGCAGGGCTGGTCAGAGGGGCACAGCCACCGCCTGTGCCTGCCCCTCTCTGGCCCACTGGGCGTCGTGCCCC TCCCCGGAGAGGCAGCCTTCACGGCGGGTCAGGGCCTGGCCTTGGTCCCCACTCTGCGATGATTTCTGTGAAATTTTGCTGTAGCGATGA >27102_27102_2_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000526198_B4GALNT4_chr11_375461_ENST00000329962_length(amino acids)=1321AA_BP=734 MAATQDTMSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS KEKIWTQEMLLQVNDQSLRLLDIESQSAQTPGASRVRAMYPQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDE VEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAV LAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQN PSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPV DVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDE VLEWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSPASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAP TYVVKDFPIARYQGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDEVQRRAFLFLNPDDFLDDE DEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVT RVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNL SSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVS GNLQLPEAEAVDVTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGARVGDADGESPEPAP AASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRT GNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVG -------------------------------------------------------------- >27102_27102_3_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000530636_B4GALNT4_chr11_375461_ENST00000329962_length(transcript)=4472nt_BP=1811nt GGAGAGCGCTGGTGGTAGGGAGGCTTCTCCCGGTTCTGTGAGCAGCAGGACCCTCCCGAGGGCCTGACCGTGGAGGTAGCACTGCACACC CACTCCCTGTGGGCCGGAGCCAGGAGGCACTTCCTGGGTGTCGGAGCCCAGAAGGAAACCAGTGGCCGGGAAGCACCAGCTGGGTGTGGG ACAGGCACTGGCCTCAGACCGGGGCCACACTGAGGTCTGCCCTTCTCCCGCTGGCCGCCACCCAAGACACCATGAGCCAGTCCGGGGCCG TGAGCTGCTGCCCGGGTGCCACCAATGGCAGCCTGGGCCGGTCCGACGGTGTGGCCAAGATGAGCCCCAAGGACCTGTTTGAGCAGAGGA AGAAGTATTCCAACTCCAACGTCATCATGCACGAGACCTCGCAGTACCACGTCCAGCACCTGGCCACATTCATCATGGACAAGAGCGAAG CCATCACGTCTGTGGACGACGCCATCCGGAAGCTGGTGCAGCTGAGCTCCAAGGAGAAGATCTGGACCCAGGAGATGCTGCTGCAGGTGA ACGACCAGTCGCTGCGGCTGCTGGACATCGAGTCACAGGAGGAGCTGGAAGACTTCCCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCC TCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAGAGCAAGCCGGATGTCCACTTCTTCCACTGCGATG AGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGGCTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGG GACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCGGCGCCCATCCCCTTCCAGCACCGCGGCGGGGATT CCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTCCGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCG TGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGACATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAG CCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAGGCGCCAGCAGAGGGCGTCCTCACACTGCGGGCAC GGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATTAACTTGCTGGCAAAGCTGCAGAAGCACATCCAGA ACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTCAACACCTGCAGTGGCCCAGACATCGCACGCTCCG TCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTCCCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAG AGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTACGTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTG TGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATCGAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAA GAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTACCACCAGTCAGCTCCCCACATACTCACAGGGGCT ACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCCCGAAATGCCAACGAGCTATCGGTGCTCAAGGATG AGGTCCTAGAGTGGCGAGCTTTCCTGCCCGGCCTGAAGTTCGAGGTCATCAGCTCTGCTCACATCTCCCTGTACACAGATGAGTCAGCCT TGAAGATGGACCACGTGGCGCACGTCCCCCAGTCTCCAGCCAGCCACGTGGGGGGGCGTCCGCCGCAGGAGGAGACCAGCGCAGACATGC TGCGGCCAGATCCCAGGGATACCTTTTTCCTCACTCCACGCATGGAATCTTCGAGCCTGGAGAACGTGCTGGAGCCCTGCGCCTACGCCC CCACCTACGTGGTCAAGGACTTCCCGATCGCCAGATACCAGGGCCTGCAATTTGTGTACCTGTCCTTCGTTTATCCCAACGACTACACTC GCCTCACCCACATGGAGACGGACAACAAGTGCTTCTACCGCGAGTCTCCGCTGTATCTGGAGAGGTTTGGGTTCTATAAATACATGAAGA TGGACAAGGAGGAGGGGGATGAGGATGAAGAAGACGAGGTGCAGCGCCGAGCCTTCCTCTTCCTCAACCCGGACGACTTCCTGGACGACG AGGACGAGGGGGAGCTGCTCGACAGCCTGGAGCCCACCGAGGCGGCCCCGCCCAGGAGCGGCCCCCAGTCCCCCGCCCCAGCAGCCCCCG CCCAGCCCGGAGCCACCCTCGCCCCGCCGACCCCTCCCCGCCCCCGGGACGGGGGGACCCCCAGGCACTCCCGGGCCCTGAGCTGGGCCG CCAGGGCCGCCCGCCCTTTGCCGCTCTTCTTGGGCCGAGCTCCGCCCCCGCGCCCTGCAGTGGAGCAGCCGCCCCCAAAGGTGTACGTGA CCAGGGTGCGGCCGGGACAGCGGGCATCCCCCCGGGCCCCAGCGCCGCGTGCGCCCTGGCCGCCCTTCCCTGGCGTCTTCCTGCACCCCA GGCCTCTGCCCAGAGTGCAGCTGCGGGCGCCCCCACGCCCACCCCGGCCCCACGGCCGCAGGACCGGCGGCCCCCAGGCCACACAGCCGA GGCCCCCAGCCCGGGCGCAGGCCACCCAAGGGGGCCGGGAGGGCCAGGCGCGCACGCTGGGACCTGCGGCGCCCACAGTGGACTCAAACT TGTCCTCCGAAGCGCGGCCCGTGACCTCCTTCCTGAGCTTGTCCCAGGTGTCCGGGCCGCAGCTGCCCGGGGAGGGCGAAGAGGAGGAGG AAGGGGAGGACGATGGGGCCCCGGGCGACGAGGCCGCGTCGGAGGACAGCGAGGAGGCCGCGGGCCCGGCGCTCGGACGCTGGCGTGAGG ACGCCATCGACTGGCAGCGCACGTTCAGCGTGGGCGCCGTGGACTTCGAGCTGCTGCGCTCGGACTGGAACGACCTGCGATGCAACGTTT CGGGGAACCTGCAGCTGCCGGAGGCGGAGGCCGTGGACGTGACCGCTCAGTACATGGAGCGGCTGAACGCGCGCCACGGCGGGCGCTTCG CGCTTCTGCGCATCGTGAACGTGGAGAAGCGCCGGGACTCGGCGCGAGGGAGTCGCTTCCTGCTGGAGCTGGAGCTGCAGGAGCGCGGGG GCGGCCGCCTGCGACTGTCCGAGTACGTCTTCCTGCGGCTGCCGGGAGCCCGCGTAGGGGATGCAGACGGAGAAAGTCCCGAACCCGCTC CCGCCGCCTCCGTGCGCCCCGACGGCCGCCCCGAGCTCTGCCGGCCACTGCGCCTGGCCTGGCGCCAGGACGTGATGGTTCACTTCATCG TGCCAGTGAAAAACCAGGCACGGTGGGTGGCACAGTTCCTGGCGGACATGGCTGCGCTGCACGCGCGCACCGGGGACTCGCGTTTCAGCG TCGTCCTGGTGGATTTCGAGAGCGAGGATATGGACGTGGAGCGGGCCCTGCGCGCCGCGCGCCTGCCCCGGTACCAGTACCTGAGACGAA CCGGGAACTTCGAGCGCTCCGCCGGGCTGCAGGCGGGAGTGGACGCGGTAGAGGACGCCAGCAGCATCGTGTTCCTCTGCGACCTGCACA TCCACTTCCCACCCAACATCCTGGACGGCATCCGCAAGCACTGCGTGGAGGGCAGGCTGGCCTTCGCGCCCGTGGTCATGCGCCTGAGCT GCGGGAGCTCGCCCCGGGACCCCCACGGTTACTGGGAGGTGAACGGCTTTGGCCTTTTTGGGATCTACAAGTCGGACTTTGACCGGGTTG GAGGAATGAACACGGAGGAGTTCCGAGACCAGTGGGGGGGTGAAGACTGGGAGCTCCTGGACAGGGTCCTGCAGGCAGGGCTGGAGGTGG AGCGGCTCCGACTGCGGAATTTCTATCACCACTACCACTCCAAGAGGGGCATGTGGAGCGTCCGCAGCAGGAAGGGCTCTCGCACGGGGG CGTCTTGAGGACGGGCAGCCCCTCCCAGCCCCGGTGGGAGTCCCGAGGCAGCTGCTGGGGGCTGGGCTTTGAGCTCGGTCCCGAGAGACC CGGCAGGGCTGGTCAGAGGGGCACAGCCACCGCCTGTGCCTGCCCCTCTCTGGCCCACTGGGCGTCGTGCCCCTCCCCGGAGAGGCAGCC TTCACGGCGGGTCAGGGCCTGGCCTTGGTCCCCACTCTGCGATGATTTCTGTGAAATTTTGCTGTAGCGATGACATTGTTTTCAGAATTT >27102_27102_3_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000530636_B4GALNT4_chr11_375461_ENST00000329962_length(amino acids)=1312AA_BP=725 MRSALLPLAATQDTMSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIR KLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHED IESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKET QILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHF LFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWE VEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEWRAFLP GLKFEVISSAHISLYTDESALKMDHVAHVPQSPASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPI ARYQGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDEVQRRAFLFLNPDDFLDDEDEGELLDSL EPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRAS PRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTS FLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAE AVDVTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGARVGDADGESPEPAPAASVRPDGR PELCRPLRLAWRQDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGL QAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRD -------------------------------------------------------------- >27102_27102_4_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000533256_B4GALNT4_chr11_375461_ENST00000329962_length(transcript)=4596nt_BP=1935nt GTGACTCCGCAACCTGTCGCTCAGGTTCCTCCTCTCCCGGCCCCGCCCCGGCCCGGCCCCGCCGAGCGTCCCACCCGCCCGCGGGAGACC TGGCGCCCCGGCCGAGGCGCGAACAGACGGACGCACCGGCGAGCGCCGAGGGGACAGGCCGAGCGCGGGGCGCCGGAGGCAGGACCCTCC CGAGGGCCTGACCGTGGAGGTAGCACTGCACACCCACTCCCTGTGGGCCGGAGCCAGGAGGCACTTCCTGGGTGTCGGAGCCCAGAAGGA AACCAGTGGCCGGGAAGCACCAGCTGGGTGTGGGACAGGCACTGGCCTCAGACCGGGGCCACACTGAGGTCTGCCCTTCTCCCGCTGGCC GCCACCCAAGACACCATGAGCCAGTCCGGGGCCGTGAGCTGCTGCCCGGGTGCCACCAATGGCAGCCTGGGCCGGTCCGACGGTGTGGCC AAGATGAGCCCCAAGGACCTGTTTGAGCAGAGGAAGAAGTATTCCAACTCCAACGTCATCATGCACGAGACCTCGCAGTACCACGTCCAG CACCTGGCCACATTCATCATGGACAAGAGCGAAGCCATCACGTCTGTGGACGACGCCATCCGGAAGCTGGTGCAGCTGAGCTCCAAGGAG AAGATCTGGACCCAGGAGATGCTGCTGCAGGTGAACGACCAGTCGCTGCGGCTGCTGGACATCGAGTCACAGGAGGAGCTGGAAGACTTC CCGCTGCCCACGGTGCAGCGCAGCCAGACGGTCCTCAACCAGCTGCGCTACCCGTCTGTGCTGCTGCTCGTGTGCCAGGACTCGGAGCAG AGCAAGCCGGATGTCCACTTCTTCCACTGCGATGAGGTGGAGGCAGAGCTGGTGCACGAGGACATCGAGAGCGCGTTGGCCGACTGCCGG CTGGGCAAGAAGATGCGGCCGCAGACCCTGAAGGGACACCAGGAGAAGATTCGGCAGCGGCAGTCCATCCTGCCTCCTCCCCAGGGCCCG GCGCCCATCCCCTTCCAGCACCGCGGCGGGGATTCCCCGGAGGCCAAGAATCGCGTGGGCCCGCAGGTGCCACTCAGCGAGCCAGGTTTC CGCCGTCGGGAGTCGCAGGAGGAGCCGCGGGCCGTGCTGGCTCAGAAGATAGAGAAGGAGACGCAAATCCTCAACTGCGCCCTGGACGAC ATCGAGTGGTTTGTGGCCCGGCTGCAGAAGGCAGCCGAGGCTTTCAAGCAGCTGAACCAGCGGAAAAAGGGGAAGAAGAAGGGCAAGAAG GCGCCAGCAGAGGGCGTCCTCACACTGCGGGCACGGCCCCCCTCTGAGGGCGAGTTCATCGACTGCTTCCAGAAAATCAAGCTGGCGATT AACTTGCTGGCAAAGCTGCAGAAGCACATCCAGAACCCCAGCGCCGCGGAGCTCGTGCACTTCCTCTTCGGGCCTCTGGACCTGATCGTC AACACCTGCAGTGGCCCAGACATCGCACGCTCCGTCTCCTGCCCACTGCTCTCCCGAGATGCCGTGGACTTCCTGCGCGGCCACCTGGTC CCTAAGGAGATGTCGCTGTGGGAGTCACTGGGAGAGAGCTGGATGCGGCCCCGTTCCGAGTGGCCGCGGGAGCCACAGGTGCCCCTCTAC GTGCCCAAGTTCCACAGCGGCTGGGAGCCTCCTGTGGATGTGCTGCAGGAGGCCCCCTGGGAGGTGGAGGGGCTGGCGTCTGCCCCCATC GAGGAGGTGAGTCCAGTGAGCCGACAGTCCATAAGAAACTCCCAGAAGCACAGCCCCACTTCAGAGCCCACCCCCCCGGGGGATGCCCTA CCACCAGTCAGCTCCCCACATACTCACAGGGGCTACCAGCCAACACCAGCCATGGCCAAGTACGTCAAGATCCTGTATGACTTCACAGCC CGAAATGCCAACGAGCTATCGGTGCTCAAGGATGAGGTCCTAGAGTGGCGAGCTTTCCTGCCCGGCCTGAAGTTCGAGGTCATCAGCTCT GCTCACATCTCCCTGTACACAGATGAGTCAGCCTTGAAGATGGACCACGTGGCGCACGTCCCCCAGTCTCCAGCCAGCCACGTGGGGGGG CGTCCGCCGCAGGAGGAGACCAGCGCAGACATGCTGCGGCCAGATCCCAGGGATACCTTTTTCCTCACTCCACGCATGGAATCTTCGAGC CTGGAGAACGTGCTGGAGCCCTGCGCCTACGCCCCCACCTACGTGGTCAAGGACTTCCCGATCGCCAGATACCAGGGCCTGCAATTTGTG TACCTGTCCTTCGTTTATCCCAACGACTACACTCGCCTCACCCACATGGAGACGGACAACAAGTGCTTCTACCGCGAGTCTCCGCTGTAT CTGGAGAGGTTTGGGTTCTATAAATACATGAAGATGGACAAGGAGGAGGGGGATGAGGATGAAGAAGACGAGGTGCAGCGCCGAGCCTTC CTCTTCCTCAACCCGGACGACTTCCTGGACGACGAGGACGAGGGGGAGCTGCTCGACAGCCTGGAGCCCACCGAGGCGGCCCCGCCCAGG AGCGGCCCCCAGTCCCCCGCCCCAGCAGCCCCCGCCCAGCCCGGAGCCACCCTCGCCCCGCCGACCCCTCCCCGCCCCCGGGACGGGGGG ACCCCCAGGCACTCCCGGGCCCTGAGCTGGGCCGCCAGGGCCGCCCGCCCTTTGCCGCTCTTCTTGGGCCGAGCTCCGCCCCCGCGCCCT GCAGTGGAGCAGCCGCCCCCAAAGGTGTACGTGACCAGGGTGCGGCCGGGACAGCGGGCATCCCCCCGGGCCCCAGCGCCGCGTGCGCCC TGGCCGCCCTTCCCTGGCGTCTTCCTGCACCCCAGGCCTCTGCCCAGAGTGCAGCTGCGGGCGCCCCCACGCCCACCCCGGCCCCACGGC CGCAGGACCGGCGGCCCCCAGGCCACACAGCCGAGGCCCCCAGCCCGGGCGCAGGCCACCCAAGGGGGCCGGGAGGGCCAGGCGCGCACG CTGGGACCTGCGGCGCCCACAGTGGACTCAAACTTGTCCTCCGAAGCGCGGCCCGTGACCTCCTTCCTGAGCTTGTCCCAGGTGTCCGGG CCGCAGCTGCCCGGGGAGGGCGAAGAGGAGGAGGAAGGGGAGGACGATGGGGCCCCGGGCGACGAGGCCGCGTCGGAGGACAGCGAGGAG GCCGCGGGCCCGGCGCTCGGACGCTGGCGTGAGGACGCCATCGACTGGCAGCGCACGTTCAGCGTGGGCGCCGTGGACTTCGAGCTGCTG CGCTCGGACTGGAACGACCTGCGATGCAACGTTTCGGGGAACCTGCAGCTGCCGGAGGCGGAGGCCGTGGACGTGACCGCTCAGTACATG GAGCGGCTGAACGCGCGCCACGGCGGGCGCTTCGCGCTTCTGCGCATCGTGAACGTGGAGAAGCGCCGGGACTCGGCGCGAGGGAGTCGC TTCCTGCTGGAGCTGGAGCTGCAGGAGCGCGGGGGCGGCCGCCTGCGACTGTCCGAGTACGTCTTCCTGCGGCTGCCGGGAGCCCGCGTA GGGGATGCAGACGGAGAAAGTCCCGAACCCGCTCCCGCCGCCTCCGTGCGCCCCGACGGCCGCCCCGAGCTCTGCCGGCCACTGCGCCTG GCCTGGCGCCAGGACGTGATGGTTCACTTCATCGTGCCAGTGAAAAACCAGGCACGGTGGGTGGCACAGTTCCTGGCGGACATGGCTGCG CTGCACGCGCGCACCGGGGACTCGCGTTTCAGCGTCGTCCTGGTGGATTTCGAGAGCGAGGATATGGACGTGGAGCGGGCCCTGCGCGCC GCGCGCCTGCCCCGGTACCAGTACCTGAGACGAACCGGGAACTTCGAGCGCTCCGCCGGGCTGCAGGCGGGAGTGGACGCGGTAGAGGAC GCCAGCAGCATCGTGTTCCTCTGCGACCTGCACATCCACTTCCCACCCAACATCCTGGACGGCATCCGCAAGCACTGCGTGGAGGGCAGG CTGGCCTTCGCGCCCGTGGTCATGCGCCTGAGCTGCGGGAGCTCGCCCCGGGACCCCCACGGTTACTGGGAGGTGAACGGCTTTGGCCTT TTTGGGATCTACAAGTCGGACTTTGACCGGGTTGGAGGAATGAACACGGAGGAGTTCCGAGACCAGTGGGGGGGTGAAGACTGGGAGCTC CTGGACAGGGTCCTGCAGGCAGGGCTGGAGGTGGAGCGGCTCCGACTGCGGAATTTCTATCACCACTACCACTCCAAGAGGGGCATGTGG AGCGTCCGCAGCAGGAAGGGCTCTCGCACGGGGGCGTCTTGAGGACGGGCAGCCCCTCCCAGCCCCGGTGGGAGTCCCGAGGCAGCTGCT GGGGGCTGGGCTTTGAGCTCGGTCCCGAGAGACCCGGCAGGGCTGGTCAGAGGGGCACAGCCACCGCCTGTGCCTGCCCCTCTCTGGCCC ACTGGGCGTCGTGCCCCTCCCCGGAGAGGCAGCCTTCACGGCGGGTCAGGGCCTGGCCTTGGTCCCCACTCTGCGATGATTTCTGTGAAA TTTTGCTGTAGCGATGACATTGTTTTCAGAATTTCCAAGAGTTCTGTCTGTTCTGTTTTTTATTCAGAATGAAATGAAATATTTTTTTTA >27102_27102_4_EPS8L2-B4GALNT4_EPS8L2_chr11_724829_ENST00000533256_B4GALNT4_chr11_375461_ENST00000329962_length(amino acids)=1312AA_BP=725 MRSALLPLAATQDTMSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIR KLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHED IESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKET QILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHF LFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWE VEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEWRAFLP GLKFEVISSAHISLYTDESALKMDHVAHVPQSPASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPI ARYQGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDEVQRRAFLFLNPDDFLDDEDEGELLDSL EPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRAS PRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTS FLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAE AVDVTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGARVGDADGESPEPAPAASVRPDGR PELCRPLRLAWRQDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGL QAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for EPS8L2-B4GALNT4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EPS8L2-B4GALNT4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EPS8L2-B4GALNT4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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